Efecto placebo y contexto terapéutico: un reto en investigación clínica

Placebo and Opioid Analgesia-- Imaging a Shared Neuronal Network

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Adaptive Coding of Reward Value by Dopamine Neurons

Tobler, P. N., Fiorillo, C. D., & Schultz, W. (2005) · Science · doi:10.1126/science.1105370 · Cited by 1,276 · see citing works

Neuropharmacological dissection of placebo analgesia: expectation-activated opioid systems versus conditioning-activated specific subsystems

Amanzio, M., & Benedetti, F. (1999) · The Journal of Neuroscience · doi:10.1523/jneurosci.19-01-00484.1999 · Cited by 899 · see citing works

Publication bias in clinical trials due to statistical significance or direction of trial results

Hopewell, S., Loudon, K., Clarke, M. J., Oxman, A. D., & Dickersin, K. (2009) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.mr000006.pub3 · Cited by 898 · see citing works

The neuroscience of placebo effects: connecting context, learning and health

Wager, T. D., & Atlas, L. Y. (2015) · Nature Reviews Neuroscience · doi:10.1038/nrn3976 · Cited by 844 · see citing works

Expectation in perceptual decision making: neural and computational mechanisms

Summerfield, C., & de Lange, F. P. (2014) · Nature Reviews Neuroscience · doi:10.1038/nrn3838 · Cited by 832 · see citing works

Methodological problems in the measurement of pain: a comparison between the verbal rating scale and the visual analogue scale

Ohnhaus, E. E., & Adler, R. (1975) · Pain · doi:10.1016/0304-3959(75)90075-5 · Cited by 797 · see citing works

The Placebo Effect: Dissolving the Expectancy Versus Conditioning Debate.

Stewart‐Williams, S., & Podd, J. (2004) · Psychological Bulletin · doi:10.1037/0033-2909.130.2.324 · Cited by 664 · see citing works

Placebo and Nocebo Effects Are Defined by Opposite Opioid and Dopaminergic Responses

Scott, D. J., Stohler, C. S., Egnatuk, C. M., Wang, H., Koeppe, R. A., & Zubieta, J.-K. (2008) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2007.34 · Cited by 637 · see citing works

When words are painful: unraveling the mechanisms of the nocebo effect

Benedetti, F., Lanotte, M., Lopiano, L., & Colloca, L. (2007) · Neuroscience · doi:10.1016/j.neuroscience.2007.02.020 · Cited by 636 · see citing works

What Happened at Hawthorne?: New evidence suggests the Hawthorne effect resulted from operant reinforcement contingencies.

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Overt versus covert treatment for pain, anxiety, and Parkinson's disease

Colloca, L., Lopiano, L., Lanotte, M., & Benedetti, F. (2004) · The Lancet Neurology · doi:10.1016/s1474-4422(04)00908-1 · Cited by 551 · see citing works

Sham device v inert pill: randomised controlled trial of two placebo treatments

Kaptchuk, T. J., Stason, W. B., Davis, R. B., Legedza, A., Schnyer, R. N., Kerr, C. E., Stone, D. A., Nam, B. H., Kirsch, I., & Goldman, R. H. (2006) · BMJ · doi:10.1136/bmj.38726.603310.55 · Cited by 535 · see citing works

Do medical devices have enhanced placebo effects?

Kaptchuk, T. J., Goldman, P., Stone, D. A., & Stason, W. B. (2000) · Journal of Clinical Epidemiology · doi:10.1016/s0895-4356(00)00206-7 · Cited by 463 · see citing works

How Placebos Change the Patient's Brain

Benedetti, F., Carlino, E., & Pollo, A. (2011) · Neuropsychopharmacology · doi:10.1038/npp.2010.81 · Cited by 446 · see citing works

Response variability to analgesics: a role for non-specific activation of endogenous opioids

Amanzio, M., Pollo, A., Maggi, G., & Benedetti, F. (2001) · Pain · doi:10.1016/s0304-3959(00)00486-3 · Cited by 420 · see citing works

Commercial Features of Placebo and Therapeutic Efficacy

Waber, R. L., Shiv, B., Carmon, Z., & Ariely, D. (2008) · JAMA · doi:10.1001/jama.299.9.1016 · Cited by 383 · see citing works

The contributions of suggestion, desire, and expectation to placebo effects in irritable bowel syndrome patients

Vase, L., Robinson, M. E., Verne, N. G., & Price, D. D. (2003) · Pain · doi:10.1016/s0304-3959(03)00073-3 · Cited by 373 · see citing works

Dissociation of dopamine release in the nucleus accumbens from intracranial self-stimulation

Garris, P. A., Kilpatrick, M., Bunin, M. A., Michael, D., Walker, Q. D., & Wightman, R. M. (1999) · Nature · doi:10.1038/18019 · Cited by 327 · see citing works

Influence of the method of drug administration on analgesic response

Levine, J. D., & Gordon, N. C. (1984) · Nature · doi:10.1038/312755a0 · Cited by 322 · see citing works

Differential Effectiveness of Placebo Treatments

Meißner, K., Fässler, M., Rücker, G., Kleijnen, J., Hróbjartsson, A., Schneider, A., Antes, G., & Linde, K. (2013) · JAMA Internal Medicine · doi:10.1001/jamainternmed.2013.10391 · Cited by 308 · see citing works

Nonopioid placebo analgesia is mediated by CB1 cannabinoid receptors

Benedetti, F., Amanzio, M., Rosato, R., & Blanchard, C. (2011) · Nature Medicine · doi:10.1038/nm.2435 · Cited by 289 · see citing works

Placebo and naloxone can alter post-surgical pain by separate mechanisms

Gracely, R. H., Dubner, R. A., Wolskee, P. J., & Deeter, W. R. (1983) · Nature · doi:10.1038/306264a0 · Cited by 262 · see citing works

Patient and practitioner influences on the placebo effect in irritable bowel syndrome.

Kelley, J. M., Lembo, A. J., Ablon, J. S., Villanueva, J. J., Conboy, L. A., Levy, R., Marci, C. D., Kerr, C. E., Kirsch, I., Jacobson, E. E., et al. (2009) · Psychosomatic Medicine · doi:10.1097/psy.0b013e3181acee12 · Cited by 208 · see citing works

Differences in Adverse Effect Reporting in Placebo Groups in SSRI and Tricyclic Antidepressant Trials: A Systematic Review and Meta-Analysis

Rief, W., Nestoriuc, Y., von Lilienfeld-Toal, A., Dogan, I., Schreiber, F., Hofmann, S. G., Barsky, A. J., & Avorn, J. (2009) · Drug Safety · doi:10.2165/11316580-000000000-00000 · Cited by 202 · see citing works

Activation likelihood estimation meta-analysis of brain correlates of placebo analgesia in human experimental pain

Amanzio, M., Benedetti, F., Porro, C. A., Palermo, S., & Cauda, F. (2013) · Human Brain Mapping · doi:10.1002/hbm.21471 · Cited by 202 · see citing works

Regression to the mean in treated versus untreated chronic pain

Whitney, C. W., & Korff, M. V. (1992) · Pain · doi:10.1016/0304-3959(92)90032-7 · Cited by 178 · see citing works

What are the main methodological problems in the estimation of placebo effects?

Hróbjartsson, A. (2002) · Journal of Clinical Epidemiology · doi:10.1016/s0895-4356(01)00496-6 · Cited by 171 · see citing works

Placebo studies and ritual theory: a comparative analysis of Navajo, acupuncture and biomedical healing

Kaptchuk, T. (2011) · Philosophical Transactions of the Royal Society B: Biological Sciences · doi:10.1098/rstb.2010.0385 · Cited by 164 · see citing works

A meta-analysis of brain mechanisms of placebo analgesia: consistent findings and unanswered questions

Atlas, L. Y., & Wager, T. D. (2014) · Handbook of Experimental Pharmacology · doi:10.1007/978-3-662-44519-8_3 · Cited by 162 · see citing works

Pretreatment Nausea in Cancer Chemotherapy: A Conditioned Response?*

Nesse, R. M., Carli, T., Curtis, G. C., & Kleinman, P. D. (1980) · Psychosomatic Medicine · doi:10.1097/00006842-198001000-00004 · Cited by 159 · see citing works

Morning Light Treatment Hastens the Antidepressant Effect of Citalopram: A Placebo-Controlled Trial

Benedetti, F., Colombo, C., Pontiggia, A., Bernasconi, A., Florita, M., & Smeraldi, E. (2003) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.v64n0605 · Cited by 152 · see citing works

Analgesic responses to morphine and placebo in individuals with postoperative pain

Levine, J. D., Gordon, N. C., Smith, J., & Fields, H. L. (1981) · Pain · doi:10.1016/0304-3959(81)90099-3 · Cited by 151 · see citing works

Placebo effect studies are susceptible to response bias and to other types of biases

Hróbjartsson, A., Kaptchuk, T. J., & Miller, F. G. (2011) · Journal of Clinical Epidemiology · doi:10.1016/j.jclinepi.2011.01.008 · Cited by 150 · see citing works

Placebo mechanisms and reward circuitry: clues from Parkinson's disease

de la Fuente‐Fernández, R., Schulzer, M., & Stoessl, A. J. (2004) · Biological Psychiatry · doi:10.1016/j.biopsych.2003.11.019 · Cited by 133 · see citing works

Cortical and subcortical responses to high and low effective placebo treatments

Geuter, S., Eippert, F., Attar, C. H., & Büchel, C. (2012) · NeuroImage · doi:10.1016/j.neuroimage.2012.11.029 · Cited by 130 · see citing works

Predictors of the placebo analgesia response in randomized controlled trials of chronic pain

Vase, L., Vollert, J., Finnerup, N. B., Miao, X., Atkinson, G., Marshall, S. F., Németh, R., Lange, B., Liss, C., Price, D. D., et al. (2015) · Pain · doi:10.1097/j.pain.0000000000000217 · Cited by 120 · see citing works

Effect of Oxytocin on Placebo Analgesia: A Randomized Study

Kessner, S., Sprenger, C., Wrobel, N., Wiech, K., & Bingel, U. (2013) · JAMA · doi:10.1001/jama.2013.277446 · Cited by 114 · see citing works

Belief or Need? Accounting for individual variations in the neurochemistry of the placebo effect

Zubieta, J.-K., Yau, W. W., Scott, D., & Stohler, C. S. (2005) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2005.08.006 · Cited by 112 · see citing works

The silent healer: The role of communication in placebo effects

Bensing, J. M., & Verheul, W. (2010) · Patient Education and Counseling · doi:10.1016/j.pec.2010.05.033 · Cited by 111 · see citing works

Conditioning, Expectancy, and the Placebo Effect: Comment on Stewart-Williams and Podd (2004).

Kirsch, I. (2004) · Psychological Bulletin · doi:10.1037/0033-2909.130.2.341 · Cited by 111 · see citing works

A randomised clinical trial of the effect of informed consent on the analgesic activity of placebo and naproxen in cancer pain.

Bergmann, J., Chassany, O., Gandiol, J., Deblois, P., Ja, K., Jm, S., Caulin, C., & Dahan, R. (1994) · PubMed · Cited by 100 · see citing works

Are All Placebo Effects Equal? Placebo Pills, Sham Acupuncture, Cue Conditioning and Their Association

Kong, J., Spaeth, R. B., Cook, A., Kirsch, I., Claggett, B. L., Vangel, M. G., Gollub, R. L., Smoller, J. W., & Kaptchuk, T. J. (2013) · PLoS ONE · doi:10.1371/journal.pone.0067485 · Cited by 98 · see citing works

Autonomic and emotional responses to open and hidden stimulations of the human subthalamic region

Benedetti, F., Colloca, L., Lanotte, M., Bergamasco, B., Torre, E., & Lopiano, L. (2004) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2004.01.010 · Cited by 78 · see citing works

Placebo neural systems: nitric oxide, morphine and the dopamine brain reward and motivation circuitries.

Fricchione, G. L., & Stefano, G. B. (2005) · PubMed · Cited by 77 · see citing works

Effects of overshadowing on conditioned nausea in cancer patients: an experimental study

Stockhorst, U., Wiener, J. A., Klosterhalfen, S., Klosterhalfen, W., Aul, C., & Steingrüber, H.-J. (1998) · Physiology & Behavior · doi:10.1016/s0031-9384(98)00135-8 · Cited by 65 · see citing works

Role of classical conditioning in learning gastrointestinal symptoms

Stockhorst, U. (2007) · World Journal of Gastroenterology · doi:10.3748/wjg.v13.i25.3430 · Cited by 59 · see citing works

The Biochemical Bases for Reward

de la Fuente‐Fernández, R., & Stoessl, A. J. (2002) · Evaluation & the Health Professions · doi:10.1177/0163278702238052 · Cited by 55 · see citing works

Anticipatory Symptoms and Anticipatory Immune Responses in Pediatric Cancer Patients Receiving Chemotherapy: Features of a Classically Conditioned Response?

Stockhorst, U., Spennes-Saleh, S., Körholz, D., Göbel, U., Schneider, M. E., Steingrüber, H.-J., & Klosterhalfen, S. (2000) · Brain Behavior and Immunity · doi:10.1006/brbi.1999.0581 · Cited by 55 · see citing works

Formation of food aversions in cancer patients receiving repeated infusions of chemotherapy

Jacobsen, P. B., Bovbjerg, D. H., Schwartz, M. D., Andrykowski, M. A., Collier, A. F., Gilewski, T. A., Norton, L., & Redd, W. H. (1993) · Behaviour Research and Therapy · doi:10.1016/0005-7967(93)90004-e · Cited by 55 · see citing works

Relationship of Perceptual Characteristics to Efficacy of Placebos

Buckalew, L. W., & Ross, S. (1981) · Psychological Reports · doi:10.2466/pr0.1981.49.3.955 · Cited by 48 · see citing works

Changes in Clinical Trials Methodology Over Time: A Systematic Review of Six Decades of Research in Psychopharmacology

Brunoni, A. R., Tadini, L., & Fregni, F. (2010) · PLoS ONE · doi:10.1371/journal.pone.0009479 · Cited by 39 · see citing works

Variables Assoicated with Anticiplatory Nausea and Vomiting in Pediatric Cancer Patients Receiving Ondansetron Antiemetic Theraphy

Tyc, V. L., Mulhern, R. K., Barclay, D. R., Smith, B. F., & Bieberich, A. A. (1997) · Journal of Pediatric Psychology · doi:10.1093/jpepsy/22.1.45 · Cited by 35 · see citing works

Placebo treatment can alter primary visual cortex activity and connectivity.

Schienle, A., Ubel, S., & Scharmüller, W. (2014) · Neuroscience · doi:10.1016/j.neuroscience.2014.01.016 · Cited by 28 · see citing works

The story of O – is oxytocin the mediator of the placebo response?

Enck, P., & Klosterhalfen, S. (2009) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2009.01285.x · Cited by 25 · see citing works

Neural mechanism of placebo effects and cognitive reappraisal in emotion regulation.

Zhang, W., Guo, J., Zhang, J., & Luo, J. (2013) · Progress in Neuro-psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2012.10.020 · Cited by 25 · see citing works

Intracortical modulation, and not spinal inhibition, mediates placebo analgesia

Martini, M., Lee, M., Valentini, E., & Iannetti, G. D. (2014) · European Journal of Neuroscience · doi:10.1111/ejn.12807 · Cited by 24 · see citing works

Are the colors and shapes of current psychotropics designed to maximize the placebo response?

Khan, A., Bomminayuni, E. P., Bhat, A. S., Faucett, J., & Brown, W. A. (2010) · Psychopharmacology · doi:10.1007/s00213-010-1874-z · Cited by 23 · see citing works

Meta-analyses of pain studies: What we have learned

Häuser, W., & Tölle, T. R. (2015) · Best Practice & Research Clinical Rheumatology · doi:10.1016/j.berh.2015.04.021 · Cited by 11 · see citing works

Placebo Effects: Biological, Clinical and Ethical Advances

Finniss, D., Kaptchuk, T., Miller, F. G., & Benedetti, F. (2010) · The Lancet · doi:10.1016/s0140-6736(09)61706-2 · Cited by 5 · see citing works

The Role of Expectation and Beliefs on the Effects of Non-Invasive Brain Stimulation

Braga, M., Barbiani, D., Andani, M. E., Villa‐Sánchez, B., Tinazzi, M., & Fiorio, M. (2021) · Brain Sciences · doi:10.3390/brainsci11111526 · Cited by 59 · see citing works

Improved cancer-related fatigue in a randomised clinical trial: methylphenidate no better than placebo

Centeno, C., Rojí, R., Portela, M. A., Santiago, A. D., Cuervo, M. Á., Ramos, D., Gandara, A., Salgado, E., Gagnon, B., & Rubiales, Á. S. (2020) · BMJ Supportive & Palliative Care · doi:10.1136/bmjspcare-2020-002454 · Cited by 33 · see citing works

Pain assessment in advanced dementia. Validity of the German PAINAD—a prospective double-blind randomised placebo-controlled trial

Lukas, A., Hagg-Grün, U., Mayer, B., Fischer, T., & Schüler, M. (2018) · Pain · doi:10.1097/j.pain.0000000000001430 · Cited by 28 · see citing works

Placebo response in trials of drug treatments for cancer-related fatigue: a systematic review, meta-analysis and meta-regression

Rojí, R., Stone, P. C., Ricciardi, F., & Candy, B. (2020) · BMJ Supportive & Palliative Care · doi:10.1136/bmjspcare-2019-002163 · Cited by 22 · see citing works

Effectiveness of Neural Mobilization Techniques in the Management of Musculoskeletal Neck Disorders with Nerve-Related Symptoms: A Systematic Review and Meta-Analysis with a Mapping Report

Varangot‐Reille, C., Cuenca‐Martínez, F., Arribas‐Romano, A., Bertoletti-Rodríguez, R., Gutiérrez-Martín, Á., Mateo-Perrino, F., Suso‐Martí, L., Blanco‐Díaz, M., Calatayud, J., & Casaña, J. (2021) · Pain Medicine · doi:10.1093/pm/pnab300 · Cited by 20 · see citing works

Therapeutic ultrasound versus injection of local anesthetic in the treatment of women with chronic pelvic pain secondary to abdominal myofascial syndrome: a randomized clinical trial

Baltazar, M. C. D. V., Russo, J. A. D. O., Lucca, V. D., Mitidieri, A. M. D. S., da Silva, A. P. M., Ferreira, M. B. C., Poli‐Neto, O. B., & Silva, J. C. R. E. (2022) · BMC Women s Health · doi:10.1186/s12905-022-01910-y · Cited by 12 · see citing works

Behavior Modification Techniques on Patients with Chronic Pain in the Context of COVID-19 Telerehabilitation: An Umbrella Review

Cuenca-Martínez, F., Calatayud, J., Suso-Martí, L., Varangot-Reille, C., Herranz-Gómez, A., Blanco-Díaz, M., & Casaña, J. (2022) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph19095260 · Cited by 7 · see citing works

Efficacy evaluation of Chinese herbal medicine, VGH-BPH1, for patients with benign prostatic hyperplasia: A randomized, double-blind, placebo-controlled, and crossover study

Tran, D. N. H., Yeh, H., Huang, W. J., Wu, P., Liao, Y.-J., Hwang, S., Kung, Y., Yang, J.-L., Wu, T., Hsu, C.-H., et al. (2022) · Journal of the Chinese Medical Association · doi:10.1097/jcma.0000000000000717 · Cited by 6 · see citing works

The influence of verbal suggestions in the management of musculoskeletal pain: a narrative review

Cuyúl-Vásquez, I., Barría, J. A., Perez, N. F., & Fuentes, J. (2019) · Physical Therapy Reviews · doi:10.1080/10833196.2019.1639011 · Cited by 6 · see citing works

The power of the placebo effect in diabetes: A systematic review and meta-analysis

Gossenheimer, A. N., de Freitas, M. B., Borges, R. D. P., Pohlmann, L., Dalzochio, M. B., Todendi, P. F., Ziegelmann, P. K., Teló, G. H., & Schaan, B. D. (2023) · Primary care diabetes · doi:10.1016/j.pcd.2023.03.006 · Cited by 3 · see citing works

Influence of motivational placebo-related factors on the effects of exercise treatment in depressive adolescents

Wunram, H. L., Hamacher, S., Oberste, M., Neufang, S., Belke, L., Jänicke, F., Gräf, C., Schönaü, E., Bender, S., & Fricke, O. (2021) · European Child & Adolescent Psychiatry · doi:10.1007/s00787-021-01742-5 · Cited by 3 · see citing works

Quels sont les principes thérapeutiques qui guident la pratique clinique de la Reconstruction posturale ? Enquête auprès de douze kinésithérapeutes

Galvañ-Serrano, C., Pecout, D., & Ehret, J. (2021) · Kinésithérapie la Revue · doi:10.1016/j.kine.2021.11.006 · Cited by 1 · see citing works

REPRINTED WITH PERMISSION OF IASP – Pain assessment in advanced dementia. Validity of the German PAINAD – a prospective double-blind randomised placebo-controlled trial

Lukas, A., Hagg-Grün, U., Mayer, B., Flscher, T., & Schüler, M. (2019) · Ból · doi:10.5604/01.3001.0013.2997

Can theta burst stimulation safely influence auditory hearing thresholds in healthy young adults?

Pinto, N., Oliveira, Í. B. C., Ferreira, J., Gama, J. M. R., & Pato, M. V. (2019) · Clinical Neurophysiology · doi:10.1016/j.clinph.2019.07.019

Efecto nocebo

Madridejos, R., & Diego, L. (2019) · FMC - Formación Médica Continuada en Atención Primaria · doi:10.1016/j.fmc.2018.11.004

La respuesta placebo en el consumo de cocaína: una revisión sistemática

Rueda, E., & Navarro, J. F. (2022) · Psiquiatría Biológica · doi:10.1016/j.psiq.2022.100370

Estructura y contenidos del imaginario ritual de limpia en los Andes Ecuatorianos

Quezada, C. R. S., & Sarmiento, L. A. B. (2023) · LATAM Revista Latinoamericana de Ciencias Sociales y Humanidades · doi:10.56712/latam.v4i2.809

Therapeutic expectancy in physiotherapy

Rubio, C. J. C., Pastor-Galiano, V., & CHICA, B. T. (2023) · Physiotherapy Theory and Practice · doi:10.1080/09593985.2023.2264378

The effect of physiotherapists' explanation of therapeutic virtual reality on treatment expectations in healthy people and people with chronic musculoskeletal pain: Two online RCTs

Slatman, S., van Lankveld, W., Staal, J. B., van Goor, H., Ostelo, R., Westendorp, J., & Knoop, J. (2025) · PEC Innovation · doi:10.1016/j.pecinn.2025.100443

Placebo effect and therapeutic context: A challenge in clinical research

Morral, A., Urrútia, G., & Bonfill, X. (2017) · Medicina Clínica (English Edition) · doi:10.1016/j.medcle.2017.06.010 · Cited by 12 · see citing works

Intravascular pulmonary echinococcosis

Sánchez, J. Á. S., Hernández, P. G., Sánchez, M. J. M., & Acuña, H. Y. S. (2017) · Medicina Clínica (English Edition) · doi:10.1016/j.medcle.2017.06.003

Localized cutaneous leishmaniasis

Flores-Terry, M. Á., López-Nieto, M., de Boom, R. C.-C., & Garrido-Martín, J. A. (2017) · Medicina Clínica (English Edition) · doi:10.1016/j.medcle.2017.06.001

Primary gynecological care in multicultural areas

Nicolau, P., del Amo, E., & Carreras, R. (2017) · Medicina Clínica (English Edition) · doi:10.1016/j.medcle.2017.06.009 · Cited by 2 · see citing works

Contextual factors, placebo and nocebo effects in physical therapy: clinical relevance and impact on research

Rossettini, G. (2018) · CINECA IRIS Institutial Research Information System (University of Genoa) · doi:10.15167/rossettini-giacomo_phd2018-05-17