Combination therapy based on nano codelivery for overcoming cancer drug resistance

Cancer immunoediting: from immunosurveillance to tumor escape

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Analysis of nanoparticle delivery to tumours

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Cancer drug resistance: an evolving paradigm

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Drug Resistance and the Solid Tumor Microenvironment

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Smart nanoparticles for cancer therapy

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Advances in drug delivery systems, challenges and future directions

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Multifunctional nanoparticle-mediated combining therapy for human diseases

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Lactate and lactylation in cancer

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Liposomes for Tumor Targeted Therapy: A Review

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Battling Chemoresistance in Cancer: Root Causes and Strategies to Uproot Them

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Nanoliposomes in Cancer Therapy: Marketed Products and Current Clinical Trials

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Codelivery of Phytochemicals with Conventional Anticancer Drugs in Form of Nanocarriers

Kumar, G., Virmani, T., Sharma, A., & Pathak, K. (2023) · Pharmaceutics · doi:10.3390/pharmaceutics15030889 · Cited by 90

Pharmaceutical liposomal delivery—specific considerations of innovation and challenges

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Multifunctional Lipid Bilayer Nanocarriers for Cancer Immunotherapy in Heterogeneous Tumor Microenvironments, Combining Immunogenic Cell Death Stimuli with Immune Modulatory Drugs

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Nanotechnology-empowered strategies in treatment of skin cancer

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Polymersomes as the Next Attractive Generation of Drug Delivery Systems: Definition, Synthesis and Applications

Fonseca, M., Jarak, I., Victor, F., Domingues, C., Veiga, F., & Figueiras, A. (2024) · Materials · doi:10.3390/ma17020319 · Cited by 76

Targeting lactate metabolism and immune interaction in breast tumor via protease-triggered delivery

Zhao, P., Wang, S., Jiang, J., Gao, Y., Wang, Y., Zhao, Y., Zhang, J., Zhang, M., & Huang, Y. (2023) · Journal of Controlled Release · doi:10.1016/j.jconrel.2023.05.024 · Cited by 61

Fabrication of anionic dextran-coated micelles for aptamer targeted delivery of camptothecin and survivin-shRNA to colon adenocarcinoma

Sanati, S., Taghavi, S., Abnous, K., Taghdisi, S. M., Babaei, M., Ramezani, M., & Alibolandi, M. (2021) · Gene Therapy · doi:10.1038/s41434-021-00234-0 · Cited by 60

Cervical cancer: Novel treatment strategies offer renewed optimism

yadav, G., Srinivasan, G., & jain, A. (2024) · Pathology - Research and Practice · doi:10.1016/j.prp.2024.155136 · Cited by 55

Craft of Co-encapsulation in Nanomedicine: A Struggle To Achieve Synergy through Reciprocity

Bhattacharjee, S. (2022) · ACS Pharmacology & Translational Science · doi:10.1021/acsptsci.2c00033 · Cited by 53

Co‐Delivery of Precisely Prescribed Multi‐Prodrug Combination by an Engineered Nanocarrier enables Efficient Individualized Cancer Chemotherapy

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Targeting glycolysis for cancer therapy using drug delivery systems

Huang, Y. (2022) · Journal of Controlled Release · doi:10.1016/j.jconrel.2022.12.003 · Cited by 51

Nanomedicine-driven molecular targeting, drug delivery, and therapeutic approaches to cancer chemoresistance

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Nanomedicines for combating multidrug resistance of cancer

Zhu, Y., Jia, H., Duan, Q., & Wu, F. (2021) · Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology · doi:10.1002/wnan.1715 · Cited by 47

Recent advances in the development of biocompatible nanocarriers and their cancer cell targeting efficiency in photodynamic therapy

Kumar, S. S. D., & Abrahamse, H. (2022) · Frontiers in Chemistry · doi:10.3389/fchem.2022.969809 · Cited by 39

Bio-nanomaterials: Promising anticancer properties and treatment strategies

Elemike, E. E., Onunkwo, I. C., Ughumiakpor, O., Alawuru, F., Mukoro, A., Ishom, P., Obarakpor, F., Hossain, I., & Aziza, A. E. (2025) · Nano TransMed · doi:10.1016/j.ntm.2025.100076 · Cited by 42

Surfactant-Enabled Nanocarriers in Breast Cancer Therapy: Targeted Delivery and Multidrug Resistance Reversal

Jadhav, A., & Nagaraj, K. (2025) · Pharmaceutics · doi:10.3390/pharmaceutics17060779 · Cited by 35

Understanding the implications of co-delivering therapeutic agents in a nanocarrier to combat multidrug resistance (MDR) in breast cancer

Fulfager, A., & Yadav, K. S. (2021) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2021.102405 · Cited by 32

A review on tumor-targeting liposomes: Fabrication, mechanism and applications

Basak, S., Das, T. K., & Ganguly, S. (2025) · Biochemical Pharmacology · doi:10.1016/j.bcp.2025.117460 · Cited by 32

Emerging concepts in designing next-generation multifunctional nanomedicine for cancer treatment

Chakraborty, K., Tripathi, A., Mishra, S., Mallick, A. M., & Roy, R. S. (2022) · Bioscience Reports · doi:10.1042/bsr20212051 · Cited by 30

Combining β-Carotene with 5-FU via Polymeric Nanoparticles as a Novel Therapeutic Strategy to Overcome uL3-Mediated Chemoresistance in p53-Deleted Colorectal Cancer Cells

Carotenuto, P., Pecoraro, A., Brignola, C., Barbato, A., Franco, B., Longobardi, G., Conte, C., Quaglia, F., Russo, G., & Russo, A. (2023) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.2c00876 · Cited by 26

Strategy for Traceless Codrug Delivery with Platinum(IV) Prodrug Complexes Using Self-Immolative Linkers

Lee, V. E. Y., Lim, Z. C., Chew, S. L., & Ang, W. H. (2021) · Inorganic Chemistry · doi:10.1021/acs.inorgchem.0c03299 · Cited by 26

Regulation of the PI3K/AKT/mTOR signaling pathway with synthesized bismuth oxide nanoparticles from Ginger (Zingiber officinale) extract: Mitigating the proliferation of colorectal cancer cells

Zhou, Y., Zhang, H., Cheng, Z., & Wang, H. (2021) · Arabian Journal of Chemistry · doi:10.1016/j.arabjc.2021.103607 · Cited by 24

Dual-loaded liposomal carriers to combat chemotherapeutic resistance in breast cancer

El‐Tanani, M., Nsairat, H., Aljabali, A. A. A., Matalka, I. I., Alkilany, A. M., & Tambuwala, M. M. (2024) · Expert Opinion on Drug Delivery · doi:10.1080/17425247.2024.2311812 · Cited by 24

Recent Progress of Novel Nanotechnology Challenging the Multidrug Resistance of Cancer

Zhang, C., Zhou, X., Zhang, H., Han, X., Li, B., Yang, R., & Zhou, X. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.776895 · Cited by 23

Teaching new tricks to old dogs: A review of drug repositioning of disulfiram for cancer nanomedicine

Zhao, P., Tang, X., & Huang, Y. (2021) · Open Research (University of Surrey) · doi:10.1002/viw.20200127 · Cited by 22

Lipid-based nanoparticle-mediated combination therapy for breast cancer management: a comprehensive review

Gupta, P., Neupane, Y. R., Aqil, M., Kohli, K., & Sultana, Y. (2023) · Drug Delivery and Translational Research · doi:10.1007/s13346-023-01366-z · Cited by 22

Recent Trends in Nanomedicine-Based Strategies to Overcome Multidrug Resistance in Tumors

Khan, M. M., & Torchilin, V. P. (2022) · Cancers · doi:10.3390/cancers14174123 · Cited by 20

Promoted cellular uptake and intracellular cargo release of ICG/DOX-carrying hybrid polymeric nanoassemblies upon acidity-activated PEG detachment to enhance cancer photothermal/chemo combination therapy

Hung, Y.-N., Liu, Y., Chou, Y.-H., Hu, S., Cheng, B., & Chiang, W. (2021) · European Polymer Journal · doi:10.1016/j.eurpolymj.2021.110944 · Cited by 19

Nanoparticle technologies in precision oncology and personalized vaccine development: Challenges and advances

İmani, S., Moradi, S., Faraj, T. A., Hassanpoor, P., Musapour, N., Najmaldin, S. K., Abdulhamd, A. H., Mohammadi, A. T., Taha, C. H., & Aminnezhad, S. (2025) · International Journal of Pharmaceutics X · doi:10.1016/j.ijpx.2025.100353 · Cited by 18

Silibinin-Loaded Nanostructured Lipid Carriers for Growth Inhibition of Cisplatin-Resistant Ovarian Cancer Cells

Jafari, S., Bakhshaei, A., Eskandani, M., & Molavi, O. (2022) · Assay and Drug Development Technologies · doi:10.1089/adt.2022.060 · Cited by 18

Drug delivery systems for tissue engineering: exploring novel strategies for enhanced regeneration

de Oliveira, J. L., da Silva, M. E. X., Hotza, D., Sayer, C., & Immich, A. P. S. (2024) · Journal of Nanoparticle Research · doi:10.1007/s11051-024-06074-4 · Cited by 18

Development and validation of HPLC method for simultaneous estimation of erlotinib and niclosamide from liposomes optimized by screening design

Padakanti, A. P., Pawar, S. D., Kumar, P., & Chella, N. (2023) · Journal of Liposome Research · doi:10.1080/08982104.2022.2162540 · Cited by 17

The related miRNAs involved in doxorubicin resistance or sensitivity of various cancers: an update

Torki, Z., Ghavi, D., Hashemi, S., Rahmati, Y., Rahmanpour, D., Pornour, M., & Alivand, M. R. (2021) · Cancer Chemotherapy and Pharmacology · doi:10.1007/s00280-021-04337-8 · Cited by 17

Permanently Charged Cationic Lipids—Evolution from Excipients to Therapeutic Lipids

Pushpa Ragini, S., Banerjee‬‬‬‬‬‬‬‬‬, R., Drummond, C. J., & Conn, C. E. (2024) · Small Science · doi:10.1002/smsc.202300270 · Cited by 17

Nanotechnology-mediated combinational drug delivery approach for cancer therapy

Handa, M., Khairnar, P., Kesharwani, P., & Shukla, R. (2022) · Elsevier eBooks · doi:10.1016/b978-0-323-85873-1.00008-3 · Cited by 15

GSH/pH dual responsive chitosan nanoparticles for reprogramming M2 macrophages and overcoming cancer chemoresistance

Zhao, X., Zheng, C., Wang, Y., Hao, J., & Liu, Y. (2023) · Biomaterials Science · doi:10.1039/d3bm01741a · Cited by 15

Quercetin-polysaccharides based hydrogels: A review of applications, molecular associations, chemical and biological modifications, toxicological implications and future perspectives

Ashfaq, M., Ali, S., & Summer, M. (2025) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2025.144845 · Cited by 16

Enhanced Codelivery of Gefitinib and Azacitidine for Treatment of Metastatic-Resistant Lung Cancer Using Biodegradable Lipid Nanoparticles

Elzayat, E. M., Sherif, A. Y., Nasr, F. A., Attwa, M. W., Alshora, D. H., Ahmad, S. F., & Alqahtani, A. S. (2023) · Materials · doi:10.3390/ma16155364 · Cited by 14

Polyethylenimine-based iron oxide nanoparticles enhance cisplatin toxicity in ovarian cancer cells in the presence of a static magnetic field

Ashoori, F., Verdom, B. H., Satari, M., & Abdolmaleki, P. (2023) · Frontiers in Oncology · doi:10.3389/fonc.2023.1217800 · Cited by 17

Preparation, Optimization, and In-Vitro Evaluation of Brusatol- and Docetaxel-Loaded Nanoparticles for the Treatment of Prostate Cancer

Adekiya, T. A., Moore, M., Thomas, M. A., Lake, G., Hudson, T., & Adesina, S. K. (2024) · Pharmaceutics · doi:10.3390/pharmaceutics16010114 · Cited by 14

Overcoming drug resistance with specific nano scales to targeted therapy: Focused on metastatic cancers

Kadhum, W. R., Majeed, A. A., Saleh, R. O., Ali, E., Alhajlah, S. H., Alwaily, E. R., Mustafa, Y. F., Ghildiyal, P., Alawadi, A. H., & Alsalamy, A. (2024) · Pathology - Research and Practice · doi:10.1016/j.prp.2024.155137 · Cited by 14

Nanomedicine-based drug delivery strategies for the treatment of atherosclerosis

Lin, Y., Lin, R., Lin, H.-B., & Shen, S. (2024) · Medicine in Drug Discovery · doi:10.1016/j.medidd.2024.100189 · Cited by 14

Combining Nanocarrier-Assisted Delivery of Molecules and Radiotherapy

Gomes, E. R., & Franco, M. S. (2022) · Pharmaceutics · doi:10.3390/pharmaceutics14010105 · Cited by 16

Advances in Nanomedicine Design: Multidisciplinary Strategies for Unmet Medical Needs

Ahmed, T., Liu, F.-C. F., Lu, B., Lip, H., Park, E., Alradwan, I. A., Liu, J. F., He, C., Zetrini, A., Zhang, T., et al. (2022) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.2c00038 · Cited by 14

Self-Assembled Micelles of Amphiphilic PEGylated Drugs for Cancer Treatment

Amili, M. A., Zhu, J., Wang, Z., & Guo, S. (2021) · Current Drug Targets · doi:10.2174/1389450122666201231130702 · Cited by 14

Targeted Codelivery of Prodigiosin and Simvastatin Using Smart BioMOF: Functionalization by Recombinant Anti-VEGFR1 scFv

Mirzaeinia, S., Zeinali, S., Budiša, N., & Karbalaei‐Heidari, H. R. (2022) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2022.866275 · Cited by 13

Rational design of oral delivery nanosystems for hypoglycemic peptides

Peng, T., Shao, X., Li, L., Liu, H., Song, W., Hou, J., Zhong, H., Ding, Y., & Huang, Y. (2023) · Nano Today · doi:10.1016/j.nantod.2023.102031 · Cited by 13

Nanoengineering Solutions for Cancer Therapy: Bridging the Gap between Clinical Practice and Translational Research

Garg, P. K., Pareek, S., Kulkarni, P., Salgia, R., & Singhal, S. S. (2024) · Journal of Clinical Medicine · doi:10.3390/jcm13123466 · Cited by 13

Functionalized Lipid Nanocarriers for Simultaneous Delivery of Docetaxel and Tariquidar to Chemoresistant Cancer Cells

Kim, C. H., Lee, S. K., Choi, J. Y., Lyu, M. J., Jung, H. M., Goo, Y. T., Kang, M. J., & Choi, Y. W. (2023) · Pharmaceuticals · doi:10.3390/ph16030349 · Cited by 12

Complex formulation strategies to overcome the delivery hurdles of lapatinib in metastatic breast cancer

Singh, N., Reddy, K. P., Das, P., Kishor, B. K., & Datta, P. (2023) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2023.104315 · Cited by 12

Artificial Intelligence (AI): It?s Role in Drug Discovery and Novel Drug Delivery System

Hujuri, C. D. L. (2024) · International Journal of Science and Research (IJSR) · doi:10.21275/sr24219203948 · Cited by 12

Functional combination of resveratrol and tamoxifen to overcome tamoxifen‐resistance in breast cancer cells

Radwan, A. M., Abosharaf, H. A., Sharaky, M. M., Abdelmonem, R., & Effat, H. (2024) · Archiv der Pharmazie · doi:10.1002/ardp.202400261 · Cited by 11

Enhancing Chemosensitivity in Drug-Resistant Breast Cancer Cells Using β-Cyclodextrin-Loaded Quercetin and Doxorubicin Inclusion Complex via Modulating SRC/PI3K/Akt Pathway

Pawar, C. S., Balamurugan, K., Baskar, S., Prasad, N. R., & Khan, H. A. (2025) · Applied Biochemistry and Biotechnology · doi:10.1007/s12010-025-05219-y · Cited by 11

In Situ Nanoparticle Self-Assembly for Combination Delivery of Therapeutics to Non-Small Cell Lung Cancer

Hatami, E., Nagesh, P. K. B., Chauhan, N., Jaggi, M., Chauhan, S., & Yallapu, M. (2022) · ACS Applied Bio Materials · doi:10.1021/acsabm.1c01158 · Cited by 10

A technical note on emerging combination approach involved in the onconanotherapeutics

Iqubal, M. K., Kaur, H., Md, S., Alhakamy, N. A., Iqubal, A., Ali, J., & Baboota, S. (2022) · Drug Delivery · doi:10.1080/10717544.2022.2132018 · Cited by 12

Phytochemical analysis and evaluation of acute toxicity and antioxidant, antibacterial, and anti-inflammatory activities of ethanolic extracts from branches and leaves of Jacaranda rugosa

Rocha-Filho, C. A. A., de Araújo, L. C. C., Silva, P. M., Machado, J. C. B., Ferreira, M. R. A., Soares, L. A. L., Silva, M. V., Silva, T. G., Napoleão, T. H., & Paiva, P. M. G. (2020) · South African Journal of Botany · doi:10.1016/j.sajb.2020.08.026 · Cited by 9

Polydopamine-Coated Copper-Substituted Mesoporous Silica Nanoparticles for Dual Cancer Therapy

Busa, P., Koutavarapu, R., & Kuthati, Y. (2022) · Coatings · doi:10.3390/coatings12010060 · Cited by 8

Dual-crosslinked injectable in situ forming Alginate/CaCl2/Pluronic F127/α-Cyclodextrin hydrogels incorporating Doxorubicin and graphene-based nanomaterials for cancer chemo-photothermal therapy

Gonçalves, J. J., Melo, B. L., Pouso, M. R., Correia, I. J., & de Melo‐Diogo, D. (2025) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2025.107520 · Cited by 7

Assembly of nanostructured lipid carriers loaded gefitinib and simvastatin as hybrid therapy for metastatic breast cancer: Codelivery and repurposing approach

Sherif, A. Y., Harisa, G. I., Shahba, A. A.-W., Nasr, F. A., Taha, E. I., & Alqahtani, A. S. (2023) · Drug Development Research · doi:10.1002/ddr.22097 · Cited by 6

Effect of the Combination of Synthetic Anthelmintics with Carvacryl Acetate in Emulsions with and without a Sodium Alginate Matrix on Haemonchus contortus

Ximenes, L. F., Pinheiro, H. N., Filho, J. V. D. A., André, W. P. P., Abreu, F. O. M. D. S., Cardial, M. R. L., Castelo‐Branco, D. D. S. C. M., Melo, A. C. F. L., Lopes, F. F. D. S., de Morais, S. M., et al. (2024) · Animals · doi:10.3390/ani14071007 · Cited by 6

Exosome-immobilized porous microspheres for efficiently combined and prolonged cancer treatment

Lee, A., Lee, J. H., So, C., Kim, I. G., & Mok, H. (2024) · Biotechnology and Bioprocess Engineering · doi:10.1007/s12257-024-00139-w · Cited by 6

“Actual” peptide properties required for nanoparticle development in precision cancer therapeutic delivery

Zaiki, Y., Yap, P., Gan, C., Rani, M. F. A., Traini, D., & Wong, T. W. (2025) · Journal of Controlled Release · doi:10.1016/j.jconrel.2025.113866 · Cited by 7

Nanoparticle-based combination of LMWH and doxorubicin for the efficient treatment of hepatocellular carcinoma with portal vein tumor thrombus

Zhang, X., Li, B., Lu, Z., Lu, Z., Zhao, G., Xu, S., Wu, Z., Chu, T., Qi, F., Wu, S., et al. (2023) · Nano Today · doi:10.1016/j.nantod.2023.101787 · Cited by 6

Advancing healthcare: Exploring recent innovations in drug delivery systems

Hoque, M., Hossain, M. S., Akram, T., & Das, S. (2023) · International Journal of Multidisciplinary Research and Growth Evaluation · doi:10.54660/.ijmrge.2023.4.5.50-55 · Cited by 6

Liposomal Nanocarriers Containing siRNA as Small Molecule-Based Drugs to Overcome Cancer Drug Resistance

Safaei, M., Khalighi, F., Behabadi, F. A., Abpeikar, Z., Goodarzi, A., Kouhpayeh, S. A., Najafipour, S., & Ramezani, V. (2023) · Nanomedicine · doi:10.2217/nnm-2023-0176 · Cited by 6

Liposomal Drug Delivery: Progress, Clinical Outlook, and Ongoing Challenges

Tiwari, C., Tomer, J., & Kumar, D. (2024) · Recent Advances in Drug Delivery and Formulation · doi:10.2174/0126673878300031240703070511 · Cited by 9

Collaboration of Hprt/K-RAS/c-Myc mutation in the oncogenesis of T-lymphocytic leukemia: a comparative study

Kadry, M. O., Abdel‐Hamid, A. Z., & Megeed, R. M. A. (2024) · Future Science OA · doi:10.2144/fsoa-2023-0111 · Cited by 5

Nanotherapeutics against malaria: A decade of advancements in experimental models

Avalos‐Padilla, Y., & Fernàndez‐Busquets, X. (2024) · Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology · doi:10.1002/wnan.1943 · Cited by 5

Titanium dioxide nanostructure-loaded Adriamycin surmounts resistance in breast cancer therapy: ABCA/P53/C-myc crosstalk

Megeed, R. M. A., Abdel‐Hamid, A. Z., & Kadry, M. O. (2024) · Future Science OA · doi:10.2144/fsoa-2023-0107 · Cited by 6

Monitoring the efficacy of chemotherapeutic drugs using dark field imaging

Khoubafarin, S., Kharel, A., Malla, S., Nath, P., Kaur, D., Tiwari, A. K., & Ray, A. (2022) · Label-free Biomedical Imaging and Sensing (LBIS) · doi:10.1117/12.2609874 · Cited by 5

Combination Therapy for Overcoming Multidrug Resistance in Breast Cancer Through Hedgehog Signaling Pathway Regulation

Liu, Y., Yang, Y., & Qi, X. (2025) · Pharmaceutics · doi:10.3390/pharmaceutics17050572 · Cited by 4

Artificial Intelligence in Drug Discovery and Delivery: Advancements and Applications

Mahjoub, M. A., & Sheikholislam, Z. (2023) · Journal of Biomedical Research & Environmental Sciences · doi:10.37871/jbres1778 · Cited by 5

Polyvinylpyrrolidone Assisted One-Pot Synthesis of Size-Tunable Cocktail Nanodrug for Multifunctional Combat of Cancer

Wang, C., Pan, J., Chen, S., Qiu, L., Hu, H., Ji, L., Wang, J., Liu, W., & Ni, X. (2024) · International Journal of Nanomedicine · doi:10.2147/ijn.s459428 · Cited by 4

Phenylboronic acid-functionalized co-delivery micelles with synergistic effect and down-regulation of HIF-1alpha to overcome multidrug resistance

Huang, Y., He, Y., Xia, X., Quan, H., & Yu, J. (2021) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2021.102346 · Cited by 4

Peptomer Linkers Enable Kinetic Control over Co‐Delivery of Multiple Chemotherapeutics

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Chitosan capped-NLCs enhanced codelivery of gefitinib and simvastatin into MDR HCC: impact of compositions on cell death, JNK3, and Telomerase

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