Antibiotic susceptibility of probiotic strains: Is it reasonable to combine probiotics with antibiotics?
Abstract
Objective The main goal of this study was to determine the in vitro susceptibility of strains collected from marketed probiotics to antibiotics used to treat community-acquired infections.Methods The minimum inhibitory concentrations (MICs) of 16 antibiotics were determined using a gradient strip (E test) or the agar dilution method for fidaxomicin.Results The probiotics demonstrated various antibiotic patterns. Bacterial probiotics are generally susceptible to most prescribed antibiotics orally administered, whereas yeast probiotics, such as Saccharomyces boulardii, are resistant.Conclusion Special attention must be paid to co-prescriptions of antibiotics and probiotics to ensure that the probiotic strain is not susceptible.
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Bacterial probiotics are often sensitive to commonly used antibiotics (e.g., penicillin, tetracycline, and ofloxacin), limiting their viability during therapy.
“However, bacterial probiotics are often sensitive to commonly used antibiotics (e.g., penicillin, tetracycline, and ofloxacin), limiting their viability during therapy.6,7”
From Safety and efficacy concerns in Indian probiotics: Insights from whole-genome sequencing and <i>in vitro</i> assessment (2026) · cites this paper as [6]
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Mechanistic study of the immune defense function of the CRISPR1-Cas system in Enterococcus faecalis
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- Authors
- Neut, C., Mahieux, S., & Dubreuil, L. J.
- Affiliations
- Inserm (FR)
- Corresponding author
- Dubreuil, L.J.
- Venue
- Médecine et Maladies Infectieuses
- Publisher
- Elsevier BV
- Published
- 2017-11
- Volume
- 47
- Issue
- 7
- Pages
- 477-483
- ISSN
- 0399-077X (ISSN-L)
- OpenAlex
- W2745090517
- Cited by
- 96
- References
- 14
- Citations by year
- 2026: 13 · 2025: 13 · 2024: 15 · 2023: 13 · 2022: 9 · 2021: 16 · 2020: 9 · 2019: 3 · 2018: 5
- FWCI
- 5.23
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Médecine et Maladies Infectieuses (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Life Sciences › Immunology and Microbiology › Applied Microbiology and Biotechnology › Antibiotic Use and Resistance
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Antibiotic Resistance in Bacteria
- Keywords
- probiotics, antibiotic susceptibility, antibiotic resistance, community-acquired infections, minimum inhibitory concentration, fidaxomicin, Saccharomyces boulardii, probiotic bacteria
- MeSH terms
- Saccharomyces boulardii, Fidaxomicin, Aminoglycosides, Anti-Bacterial Agents, Bacillus, Bifidobacterium, Drug Resistance, Microbial, Lactobacillus, Microbial Sensitivity Tests, Probiotics, Drug Resistance, Fungal
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