The DOI matches its Crossref record; 201 of the 201 references it cites were found in a registry or an index.
Unus pro omnibus, omnes pro uno: A novel, evidence-based, unifying theory for the pathogenesis of endometriosis
Open accessAbstract
The theory of retrograde menstruation as aetiopathogenesis of endometriosis formulated by John Sampson in 1927 shows clear shortcomings: this does not explain why retrograde menstruation is a physiological process that affects 90% of women, while endometriosis occurs in only 10% of cases; it also does not explain the endometriotic foci distant from the pelvis, nor explains the cases of endometriosis in male patients. The immunological alterations of the peritoneal fluid explains the effects of disease, such as the inhibition of the physiological processes of cytolysis, but does not explain the cause. There is evidence to support the hypothesis that ectopic müllerian remnants of the endometrium, endocervix and endosalpinx are items from the genital ridge leaked during organogenesis. It is known that tissues derived from coelomatic epithelial and mesenchymal cells have the potential to metaplastically differentiate into epithelium and stroma. In addition, the phenotype of the ectopic endometrial cells is significantly different from those ectopic. There is scientific evidence that, during organogenesis, the genes of the Homeobox and Wingless family play a fundamental role in the differentiation of the ducts of Muller and development of the anatomical structure of the urogenital tract. We present here a hypothesis that deregulation of genes and the Wnt signaling pathway Wnt/β-catenin leads to aberrations and deregulation within the mesoderm, thus, may cause aberrant placement of stem cells. In addition, immune cells, adhesion molecules, extracellular matrix metalloproteinase and pro-inflammatory cytokines activate/alter peritoneal microenvironment, creating the conditions for differentiation, adhesion, proliferation and survival of ectopic endometrial cells.
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Cited by
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Pathogenesis of endometriosis: The genetic/epigenetic theory
Koninckx, P. R., Ussia, A., Adamyan, L., Wattiez, A., Gomel, V., & Martin, D. C. (2019) · Fertility and Sterility · doi:10.1016/j.fertnstert.2018.10.013 · Cited by 427
Della Corte, L., Di Filippo, C., Gabrielli, O., Reppuccia, S., La Rosa, V. L., Ragusa, R., Fichera, M., Commodari, E., Bifulco, G., & Giampaolino, P. (2020) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph17134683 · Cited by 387
Pathogenesis of deep endometriosis
Gordts, S., Koninckx, P., & Brosens, I. (2017) · Fertility and Sterility · doi:10.1016/j.fertnstert.2017.08.036 · Cited by 241
Dawson, A., Llauradó Fernandez, M., Anglesio, M., Yong, P. J., & Carey, M. S. (2018) · ecancermedicalscience · doi:10.3332/ecancer.2018.803 · Cited by 106
Endometriosis and polycystic ovary syndrome are diametric disorders
Dinsdale, N. L., & Crespi, B. J. (2021) · Evolutionary Applications · doi:10.1111/eva.13244 · Cited by 90
“…events are mediated by effects of prenatal testosterone on expression of reproductive developmental genes including HOXA10 (Cermik et al., 2003; He et al., 2018) as well as other genes involved in cell apoptosis, migration, and proliferation (Knapczyk- Stwora et al., 2019; Laganà et al., 2017).”
BackgroundQi, Q., Liu, X., Zhang, Q., & Guo, S.-W. (2020) · Scientific Reports · doi:10.1038/s41598-020-57997-6 · Cited by 44
Catamenial pneumothorax caused by thoracic endometriosis
Maniglio, P., Ricciardi, E., Meli, F., Vitale, S. G., Noventa, M., Vitagliano, A., Valenti, G., La Rosa, V. L., Laganà, A. S., & Caserta, D. (2018) · Radiology Case Reports · doi:10.1016/j.radcr.2017.09.003 · Cited by 41
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Song, S. Y., Park, M., Lee, G. W., Lee, K. H., Chang, H. K., Kwak, S. M., & Yoo, H. J. (2018) · European Journal of Obstetrics & Gynecology and Reproductive Biology · doi:10.1016/j.ejogrb.2018.10.014 · Cited by 24
Ferrari, F., Valenti, G., Forte, S., Ardighieri, L., Iraci Sareri, M., Barra, F., Sartori, E., & Odicino, F. (2021) · Journal of Obstetrics and Gynaecology Research · doi:10.1111/jog.14635 · Cited by 8
Metadata
- Authors
- Laganà, A. S., Vitale, S. G., Salmeri, F. M., Triolo, O., Ban Frangež, H., Vrtačnik-Bokal, E., Stojanovska, L., Apostolopoulos, V., Granese, R., & Sofo, V.
- Affiliations
- University of Messina (IT)
- Victoria University (AU)
- Corresponding author
- Laganà, Antonio Simone
- ORCID
- Venue
- Medical Hypotheses
- Publisher
- Elsevier BV
- Published
- 2017-06
- Volume
- 103
- Pages
- 10-20
- ISSN
- 0306-9877 (ISSN-L)
- OpenAlex
- W2603229157
- Cited by
- 221
- References
- 201
- Citations by year
- 2026: 6 · 2025: 7 · 2024: 8 · 2023: 18 · 2022: 22 · 2021: 34 · 2020: 55 · 2019: 35 · 2018: 27 · 2017: 8
- FWCI
- 39.62
- Type
- journal article
- Language
- en
- Open access
- green
- vuir.vu.edu.au
- Licence
- cc-by-nc-nd
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- Locations
- Medical Hypotheses (publishedVersion)
- PubMed (publishedVersion)
- Victoria University Research Repository (Victoria University) (submittedVersion, cc-by-nc-nd)
- UNICA IRIS Institutional Research Information System (University of Cagliari) (submittedVersion)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
- Health Sciences › Medicine › Obstetrics and Gynecology › Ectopic Pregnancy Diagnosis and Management
- Health Sciences › Medicine › Obstetrics and Gynecology › Gynecological conditions and treatments
- Keywords
- endometriosis, pathogenesis, retrograde menstruation, Müllerian ducts, Wnt/β-catenin signaling, homeobox genes, wingless gene, organogenesis, peritoneal microenvironment, ectopic endometrial cells, stem cells, extracellular matrix metalloproteinases, inflammatory cytokines, adhesion molecules
- MeSH terms
- Animals, Bone Marrow Cells, Cell Differentiation, Endometriosis, Endometrium, Female, Humans, Immune System, Inflammation, Menstruation, Mesoderm, Models, Theoretical, Peritoneum, Stem Cells, Uterus, Signal Transduction, Cell Adhesion Molecules, Cytokines, Homeodomain Proteins, Matrix Metalloproteinases, Organogenesis, Wnt Proteins, beta Catenin, Mice
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