Acute effect of drinking red and white wines on circulating levels of inflammation-sensitive molecules in men with coronary artery disease
Abstract
There is evidence that moderate consumption of red wine with its high content of polyphenolic antioxidants may be more protective than white wine against development of coronary artery disease (CAD). The aim of this study was to compare the acute effects of ingestion of red wine and white wine on markers of inflammation in men with CAD. Thirteen men with angiographically-proven CAD were studied in a cross-over trial. The men consumed 4 mL/kg (2 to 3 glasses) red wine and white wine in random order during a light meal and with at least a week between interventions. Later, the men also consumed an isoenergetic nonalcoholic beverage (control) in the same study protocol. Venous blood was taken at baseline, 1 hour, and 6 hours after the drinks. Plasma interleukin-6 (IL-6), vascular cell adhesion molecule-1 (VCAM-1), intercellular adhesion molecule-1 (ICAM-1), blood alcohol, plasma lipids, and plasma polyphenols were measured. Mean +/- SD blood alcohol was 6.5 +/- 2.2 mmol/L and 6.9 +/- 1.1 mmol/L at 1 hour and returned to baseline at 6 hours after intake of red wine and white wine, respectively. Plasma IL-6 concentration increased significantly (P =.01) during 6 hours after ingestion of red wine (56%) and white wine (63%). The increase in plasma IL-6 concentration after ingestion of wine was significantly higher (P =.045) compared with the corresponding increase (11%) following intake of the nonalcoholic beverage. Plasma IL-6 levels at 6 hours (r =.631, P =.02) were correlated significantly with plasma alcohol levels at 1 hour after ingestion of red wine. These data suggest that moderate wine intake may acutely increase plasma levels of IL-6 in men with CAD. It is possible that this increase in plasma IL-6 is a response to alcohol-induced oxidative stress in the liver.
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Walnuts may exert anti-inflammatory effects primarily in the endothelium rather than a general anti-inflammatory effect.
“This suggests that rather than a general anti-inflammatory effect, walnuts may exert anti-inflammatory effects primarily in the endothelium.”
From Dietary factors and low-grade inflammation in relation to overweight and obesity (2011) · cites this paper as [371]
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- Authors
- Williams, M. J. A., Sutherland, W. H. F., Whelan, A. P., McCormick, M. P., & de Jong, S. A.
- Affiliations
- University of Otago (NZ)
- Venue
- Metabolism
- Publisher
- Elsevier BV
- Published
- 2004-03
- Volume
- 53
- Issue
- 3
- Pages
- 318-323
- ISSN
- 0026-0495 (ISSN-L)
- OpenAlex
- W2166997243
- Cited by
- 70
- References
- 40
- Citations by year
- 2025: 2 · 2024: 5 · 2023: 2 · 2021: 1 · 2020: 5 · 2018: 7 · 2017: 2 · 2016: 2 · 2015: 6 · 2014: 3 · 2013: 3 · 2012: 6
- FWCI
- 2.46
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pathology and Forensic Medicine › Alcohol Consumption and Health Effects
- Health Sciences › Medicine › Biochemistry › Phytochemicals and Antioxidant Activities
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
- Keywords
- red wine, white wine, coronary artery disease, interleukin-6, inflammatory markers, VCAM-1, ICAM-1, blood alcohol, polyphenols, oxidative stress, alcohol consumption
- MeSH terms
- Aged, Ethanol, Blood Glucose, Blood Pressure, Coronary Artery Disease, Endothelium, Vascular, Flavonoids, Heart Rate, Humans, Lipids, Lipoproteins, Male, Middle Aged, Phenols, Wine, Interleukin-6, Intercellular Adhesion Molecule-1, Inflammation Mediators, Vascular Cell Adhesion Molecule-1, Polyphenols
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