Inflammatory markers of atherosclerosis are decreased after moderate consumption of cava (sparkling wine) in men with low cardiovascular risk
Open accessAbstract
Atherosclerosis is considered a low-grade inflammatory disease. Polyphenol-rich alcoholic beverages (red wine) have shown a more pronounced antiinflammatory effect than polyphenol-free alcoholic beverages (gin). However, no studies to our knowledge have evaluated the antiinflammatory effects of alcoholic beverages with medium-level polyphenol content such as cava (sparkling wine). We enrolled 20 healthy men (aged 34 +/- 9 y) in a randomized crossover study to receive 30 g ethanol/d as cava or gin for 28 d. Before both interventions, subjects abstained from alcohol for 2 wk. Inflammatory biomarkers of atherosclerosis and expression of adhesion molecules on peripheral leukocytes were measured before and after each intervention. Likewise, dietary intake and exercise were also evaluated. Expression of lymphocyte function-associated antigen-1 (LFA-1), very late activation antigen-4 (VLA-4), Sialyl-Lewis(x) (SLe(x)), and CD40 on monocytes decreased after cava intake (all P < 0.05), whereas only SLe(x) was reduced after gin intake (P = 0.036). Circulating markers of atherosclerosis including vascular cell adhesion molecule-1, E-selectin, and P-selectin decreased after both interventions (all P < 0.05). High-sensitivity C-reactive protein, intercellular adhesion molecule-1 (ICAM-1), IL-6, monocyte chemoattractant protein-1 (MCP-1), and CD40L were diminished only after cava intake (all P < 0.05). The effects of cava on circulating CD40L, ICAM-1, and MCP-1, and monocyte surface expression of CD40, LFA-1, and VLA-4 were greater than those of gin (all P < 0.05). In conclusion, both cava and gin showed antiinflammatory properties; however, cava had a greater protective effect, probably due its polyphenol content.
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Alpha-linolenic acid at 8.1 g/d for 12 weeks is less effective against a more healthy background diet than against a less healthy background diet.
“The study of Paschos et al. (601) is enlightening because it showed that a-linolenic acid (8•1 g/d for 12 weeks) was less effective (i.e.induced fewer and smaller effects) against a more healthy, than against a less healthy, background diet.”
From Dietary factors and low-grade inflammation in relation to overweight and obesity (2011) · cites this paper as [601]
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Research works printed but not linked: 1
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Dietary factors and low-grade inflammation in relation to overweight and obesity
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- Authors
- Vázquez-Agell, M., Sacanella, E., Tobias, E., Monagas, M., Antúnez, E., Zamora-Ros, R., Andrés-Lacueva, C., Lamuela-Raventós, R. M., Fernández-Solá, J., Nicolás, J. M., & Estruch, R.
- Affiliations
- Instituto de Salud Carlos III (ES)
- Corresponding author
- Sacanella, Emilio
- ORCID
- Sacanella, Emilio
- Venue
- The Journal of Nutrition
- Publisher
- Elsevier BV
- Published
- 2007-10
- Volume
- 137
- Issue
- 10
- Pages
- 2279-2284
- ISSN
- 0022-3166 (ISSN-L)
- OpenAlex
- W1931998965
- Cited by
- 86
- References
- 40
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 2 · 2023: 4 · 2021: 2 · 2020: 4 · 2019: 5 · 2018: 3 · 2017: 3 · 2016: 3 · 2015: 5 · 2014: 2 · 2013: 5 · 2012: 11
- FWCI
- 5.19
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Journal of Nutrition (publishedVersion)
- PubMed (publishedVersion)
- Dipòsit Digital de la Universitat de Barcelona (Universitat de Barcelona) (submittedVersion)
- RECERCAT (Consorci de Serveis Universitaris de Catalunya) (submittedVersion)
- Topics
- Health Sciences › Medicine › Pathology and Forensic Medicine › Alcohol Consumption and Health Effects
- Health Sciences › Medicine › Biochemistry › Phytochemicals and Antioxidant Activities
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
- Keywords
- cava, sparkling wine, gin, alcoholic beverages, atherosclerosis, inflammation, polyphenols, anti-inflammatory activity, adhesion molecules, monocytes, VCAM-1, E-selectin, P-selectin, C-reactive protein, ICAM-1, MCP-1, CD40, LFA-1, VLA-4, sialyl Lewis X, low cardiovascular risk
- MeSH terms
- Adult, Diet, Homocysteine, Humans, Inflammation, Male, Middle Aged, Patient Compliance, Risk Factors, Wine, Biomarkers, Exercise, Down-Regulation, Cell Adhesion Molecules, Atherosclerosis
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