Cited by 599Exercise and Physiological ResponsesAdipokines, Inflammation, and Metabolic DiseasesCardiovascular and exercise physiology

Muscle‐derived interleukin‐6: possible biological effects

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Pedersen, Bente Klarlund, Steensberg, Adam, Schjerling, Peter·2001·The Journal of Physiology

Abstract

Interleukin‐6 (IL‐6) is produced locally in working skeletal muscle and can account for the increase in plasma IL‐6 during exercise. The production of IL‐6 during exercise is related to the intensity and duration of the exercise, and low muscle glycogen content stimulates the production. Muscle‐derived IL‐6 is released into the circulation during exercise in high amounts and is likely to work in a hormone‐like fashion, exerting an effect on the liver and adipose tissue, thereby contributing to the maintenance of glucose homeostasis during exercise and mediating exercise‐induced lipolysis. Muscle‐derived IL‐6 may also work to inhibit the effects of pro‐inflammatory cytokines such as tumour necrosis factor α. The latter cytokine is produced by adipose tissue and inflammatory cells and appears to play a pathogenetic role in insulin resistance and atherogenesis.

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Crossref · 10.1111/j.1469-7793.2001.0329c.xd

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Authors
Pedersen, B. K., Steensberg, A., & Schjerling, P.
Affiliations
University of Copenhagen (DK)
Corresponding author
Pedersen, Bente Klarlund
Venue
The Journal of Physiology
Publisher
Wiley
Published
2001-10
Volume
536
Issue
2
Pages
329-337
ISSN
  • 0022-3751 (ISSN-L)
  • 1469-7793
OpenAlex
W2149631937
Cited by
599
References
98
Citations by year
2026: 15 · 2025: 21 · 2024: 13 · 2023: 27 · 2022: 38 · 2021: 38 · 2020: 29 · 2019: 22 · 2018: 34 · 2017: 31 · 2016: 22 · 2015: 29 · 2014: 25 · 2013: 25 · 2012: 23
FWCI
4.53
Type
journal article
Language
en
Open access
Locations
  • The Journal of Physiology (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Rehabilitation › Exercise and Physiological Responses
  • Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
  • Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
Keywords
interleukin-6, skeletal muscle, physical activity, muscle glycogen, glucose homeostasis, TNF-α, insulin resistance, atherogenesis, adipose tissue, inflammatory cytokines
MeSH terms
Physical Exertion, Humans, Interleukin-6, Muscle, Skeletal

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