Low-grade inflammation may play a role in the etiology of the metabolic syndrome in patients with coronary heart disease: the HIFMECH Study
Abstract
Risk of coronary heart disease has been related to insulin resistance, but the mechanism for this is incompletely understood. Variables attributed to insulin resistance are associated with low-grade inflammation. A case-control study was performed of 469 male myocardial infarction (MI) survivors aged < 60 years and 575 control subjects recruited from centers in northern and southern Europe. Principal factor analysis was used to explore correlations between insulin resistance and inflammatory variables. Three factors resulted: (a) "Metabolic Syndrome" (insulin/proinsulin/ triglyceride/body mass index [BMI]); (b) "Inflammation" (fibrinogen/C-reactive protein [CRP]/interleukin-6 [IL-6]); and (c) "Blood Pressure" (systolic and diastolic blood pressure). The "Metabolic Syndrome" factor was related to the "Inflammation" factor (largely independently of obesity), the "Blood Pressure" factor, smoking, and south location (all P < or = .0002). There were significant relationships between all 3 factors and case status (P < or = .0002). Markers of low-grade inflammation are strongly related to metabolic syndrome variables independently of obesity. This raises the possibility that links between insulin resistance and cardiovascular disease could, in part, represent common consequences of low-grade inflammation.
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MetS consists of elements that do not aggregate by chance alone and are causally inter-related, and each element contributes independently to an increased risk for ASCVD.
“MetS consists of elements that do not aggregate by chance alone and are causally inter-related, and each element contributes independently to an increased risk for ASCVD (3).”
From The CardioMetabolic Health Alliance (2015) · cites this paper as [3]
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- Authors
- Yudkin, J. S., Juhan-Vague, I., Hawe, E., Humphries, S. E., di Minno, G., Margaglione, M., Tremoli, E., Kooistra, T., Morange, P. E., Lundman, P., Mohamed-Ali, V, & Hamsten, A.
- Affiliations
- University College London (GB)
- The Royal Free Hospital (GB)
- Casa Sollievo della Sofferenza (IT)
- University of Milan (IT)
- Netherlands Organisation for Applied Scientific Research (NL)
- Hôpital de la Timone (FR)
- Karolinska University Hospital (SE)
- Corresponding author
- Yudkin, J.S
- Venue
- Metabolism
- Publisher
- Elsevier BV
- Published
- 2004-07
- Volume
- 53
- Issue
- 7
- Pages
- 852-857
- ISSN
- 0026-0495 (ISSN-L)
- OpenAlex
- W2123585924
- Cited by
- 153
- References
- 40
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 2 · 2023: 2 · 2022: 7 · 2021: 2 · 2020: 4 · 2019: 6 · 2018: 2 · 2017: 4 · 2016: 4 · 2015: 7 · 2014: 8 · 2013: 9 · 2012: 4
- FWCI
- 11.69
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Metabolism (publishedVersion)
- PubMed (publishedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Topics
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Health Sciences › Medicine › Oncology › Inflammatory Biomarkers in Disease Prognosis
- Keywords
- low-grade inflammation, metabolic syndrome, coronary artery disease, insulin resistance, myocardial infarction survivors, C-reactive protein, fibrinogen, interleukin-6, blood pressure, obesity
- MeSH terms
- Aged, Blood Pressure, Coronary Disease, Europe, Factor Analysis, Statistical, Fibrinolysis, Humans, Inflammation, Male, Middle Aged, Myocardial Infarction, Risk Factors, Cohort Studies, Body Mass Index, Cluster Analysis, Survivors, Thrombophilia, Metabolic Syndrome
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