Consumption of black and green tea has no effect on inflammation, haemostasis and endothelial markers in smoking healthy individuals

de Maat, MPM; Pijl, H; Kluft, C; Princen, HMG

doi:10.1038/sj.ejcn.1601084

Cited by 101Tea Polyphenols and EffectsPhytochemicals and Antioxidant ActivitiesCoffee research and impacts

Consumption of black and green tea has no effect on inflammation, haemostasis and endothelial markers in smoking healthy individuals

de Maat, MPM, Pijl, H, Kluft, C, Princen, HMG·2000·European Journal of Clinical Nutrition

DOI 10.1038/sj.ejcn.1601084

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Abstract

Objective Firstly, to study the effect of tea and tea polyphenols on cardiovascular risk indicators of the inflammatory system (IL6, IL1beta and TNF-alpha, CRP), and on haemostasis and endothelial proteins with an acute phase behaviour (fibrinogen, vWF, PAI-1, FVIIa and u-PA). Secondly, to study the relationship between plasma levels of antioxidants (alpha-tocopherol, beta-carotene and vitamin C) and these acute-phase, cardiovascular risk indicators.Design Randomized study.Subjects Sixty-four smoking healthy volunteers were recruited by newspaper advertisements; there were five dropouts.Intervention Four-week administration of black tea, green tea, green tea polyphenol isolate and mineral water ( 13-16 per group).Measures Plasma levels of the inflammatory markers IL6, IL1beta, TNF-alpha, CRP, fibrinogen, vWF, PAI-1, FVIIa and u-PA and of the antioxidants alpha-tocopherol, beta-carotene and vitamin C.Results Different dosages of tea polyphenols had no effect on inflammation, haemostasis and endothelial markers. There was a significant negative correlation between the levels of the antioxidant beta-carotene and the inflammation markers IL6 and fibrinogen (r = -0.35 and r = -0.37, respectively, P<0.01) in this group of smokers. Remarkably, there was a significant positive correlation between the levels of the antioxidant alpha-tocopherol and the inflammation marker IL6 (r = 0.28, P<0.05).Conclusions Tea drinking had no effect on the levels of the inflammation, haemostasis and endothelial cardiovascular risk factors measured. We did observe a relationship between the antioxidant variables alpha-tocopherol and beta-carotene and inflammation markers in this group of healthy smoking subjects.

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In another Nurses' Health Study subgroup, alpha-linolenic acid intake is associated with lower IL-6 and sVCAM-1 concentrations.
“In a second study on another subgroup of the Nurses' Health Study, a-linolenic acid intakes were not associated with CRP, sICAM-1, sE-selectin or sTNFR2 concentrations but were associated with lower IL-6 and sVCAM-1 concentrations (373)”
From Dietary factors and low-grade inflammation in relation to overweight and obesity (2011) · cites this paper as [373]
In another Nurses' Health Study subgroup, alpha-linolenic acid intake is not associated with CRP, sICAM-1, sE-selectin or sTNFR2 concentrations.
“In a second study on another subgroup of the Nurses' Health Study, a-linolenic acid intakes were not associated with CRP, sICAM-1, sE-selectin or sTNFR2 concentrations but were associated with lower IL-6 and sVCAM-1 concentrations (373)”
From Dietary factors and low-grade inflammation in relation to overweight and obesity (2011) · cites this paper as [373]
Dietary intake of EPA+DHA is inversely associated with CRP, sICAM-1, sVCAM-1 and sE-selectin concentrations in subgroups of the Physicians' Health Study and Nurses' Health Study.
“Data from subgroups of the Physicians' Health Study and the Nurses' Health Study showed inverse associations between the dietary intake of EPA þ DHA and concentrations of CRP, sTNFR1 and sTNFR2 (583) , and CRP, sICAM-1, sVCAM-1 and sE-selectin (373) .”
From Dietary factors and low-grade inflammation in relation to overweight and obesity (2011) · cites this paper as [373]

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Authors: de Maat, M., Pijl, H., Kluft, C., & Princen, H.
Affiliations: Leiden University Medical Center (NL)
Netherlands Organisation for Applied Scientific Research (NL)
ORCID: Pijl, H
Kluft, C
Venue: European Journal of Clinical Nutrition
Publisher: Springer Science and Business Media LLC
Published: 2000-10-01
Volume: 54
Issue: 10
Pages: 757-763
ISSN: 0954-3007 (ISSN-L)
1476-5640
DOI: 10.1038/sj.ejcn.1601084
OpenAlex: W2022934178
Cited by: 101
References: 0
Citations by year: 2025: 3 · 2024: 2 · 2023: 1 · 2022: 4 · 2021: 1 · 2020: 4 · 2019: 2 · 2018: 1 · 2017: 1 · 2016: 3 · 2015: 4 · 2014: 6 · 2013: 8 · 2012: 5
FWCI: 1.94
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
www.springer.com/tdm (vor)
Locations: European Journal of Clinical Nutrition (publishedVersion)
PubMed (publishedVersion)
TNO Repository (submittedVersion)
Topics: Health Sciences › Medicine › Pathology and Forensic Medicine › Tea Polyphenols and Effects
Health Sciences › Medicine › Biochemistry › Phytochemicals and Antioxidant Activities
Health Sciences › Medicine › Pharmacology › Coffee research and impacts
Keywords: black tea, green tea, tea polyphenols, inflammation, hemostasis, endothelial function, smoking, cardiovascular risk factors, interleukin-6, fibrinogen, vascular endothelial growth factor, plasminogen activator inhibitor-1, vitamin C, alpha-tocopherol, beta-carotene, antioxidants
MeSH terms: Acute-Phase Reaction, Adult, Antioxidants, C-Reactive Protein, Cardiovascular Diseases, Endothelium, Vascular, Female, Fibrinogen, Flavonoids, Hemostasis, Humans, Inflammation, Male, Middle Aged, Netherlands, Phenols, Polymers, Risk Factors, Smoking, Tea, Biomarkers, Polyphenols

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Consumption of black and green tea has no effect on inflammation, haemostasis and endothelial markers in smoking healthy individuals

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