Effects of short-term very low-calorie diet on intramyocellular lipid and insulin sensitivity in nondiabetic and type 2 diabetic subjects
Open accessAbstract
The study aimed to analyze the effects of a short-term very low-calorie diet (VLCD) on intramyocellular lipid (IMCL), total body fat, and insulin sensitivity in a group of obese nondiabetic and type 2 diabetic subjects. Seven untreated type 2 diabetic and 5 obese nondiabetic individuals were studied before and after a 6-day VLCD using proton magnetic resonance spectroscopy to quantify IMCL, dual-energy x-ray absorptiometry to assess body fat, and hyperinsulinemic-euglycemic clamps to measure peripheral insulin sensitivity. In both groups, decrements in total body fat mass and body mass index were small but statistically significant. In contrast, the diet resulted in a pronounced reduction in IMCL compared with baseline values in nondiabetic subjects (56% decrease) and type 2 diabetic subjects (40% decrease) (P < .05), and this was accompanied by an overall 9.3% increase in maximally stimulated glucose disposal rate (P < .01). Intramyocellular lipid was significantly correlated with insulin sensitivity (r = -0.69, P < .01) and waist circumference (r = 0.72 and 0.83, baseline and postdiet, respectively; both P < .01), but neither IMCL nor insulin sensitivity was related to measures of general adiposity such as body mass index, percentage of body fat, or total body fat (P = not significant). In conclusion, short-term VLCD is accompanied by small decrements in general adiposity, marked decrease in IMCL, and an increase in insulin sensitivity in nondiabetic and type 2 diabetic subjects. Therefore, rapid amelioration of insulin resistance by VLCD can be partially explained by loss of IMCL both in nondiabetic and type 2 diabetic subjects in the absence of substantial changes in total body fat. These observations are consistent with the idea that insulin resistance is more directly related to IMCL rather than to body fat per se.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Ectopic fat accumulation in liver, pancreas and muscle impairs organ functions, resulting in hyperglycaemia, commonly associated with hypertension and dyslipidaemia.
“Ectopic fat accumulation in liver, pancreas and muscle impairs organ functions, resulting in hyperglycaemia, commonly associated with hypertension and dyslipidaemia [2, 3].”
During an intensive weight loss programme, or early after bariatric surgery, there are significant improvements in hepatic and muscle insulin sensitivity, and pancreatic first-phase insulin secretion, with rapid loss of ectopic fat from skeletal muscle and liver.
“During an intensive weight loss programme, or early after bariatric surgery, there are already significant improvements in hepatic and muscle insulin sensitivity, and pancreatic first-phase insulin secretion, with rapid loss of ectopic fat from skeletal muscle and liver [2, 3, 6].”
Cites
Report of the Expert Committee on the Diagnosis and Classification of Diabetes Mellitus
The Expert Committee on the Diagnosis and Classification of Diabetes Mellitus* (2002) · Diabetes Care · doi:10.2337/diacare.25.2007.s5 · Cited by 10,320 · see citing works
Report of the Expert Committee on the Diagnosis and Classification of Diabetes Mellitus
The Expert Committee on the Diagnosis and Classification of Diabetes Mellitus (1997) · Diabetes Care · doi:10.2337/diacare.20.7.1183 · Cited by 6,220 · see citing works
Report of the Expert Committee on the Diagnosis and Classification of Diabetes Mellitus
The Expert Committee on the Diagnosis and Classification of Diabetes Mellitus (2003) · Diabetes Care · doi:10.2337/diacare.26.2007.s5 · Cited by 2,689 · see citing works
Improved Method for Accurate and Efficient Quantification of MRS Data with Use of Prior Knowledge
Vanhamme, L., van den Boogaart, A., & Huffel, S. V. (1997) · Journal of Magnetic Resonance · doi:10.1006/jmre.1997.1244 · Cited by 1,631 · see citing works
Krssak, M., Falk Petersen, K., Dresner, A., DiPietro, L., Vogel, S. M., Rothman, D. L., Shulman, G. I., & Roden, M. (1999) · Diabetologia · doi:10.1007/s001250051123 · Cited by 1,264 · see citing works
Kelley, D. E., Goodpaster, B., Wing, R. R., & Simoneau, J.-A. (1999) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1999.277.6.e1130 · Cited by 1,096 · see citing works
Petersen, K. F., Dufour, S., Befroy, D., Lehrke, M., Hendler, R. E., & Shulman, G. I. (2005) · Diabetes · doi:10.2337/diabetes.54.3.603 · Cited by 911 · see citing works
Lipid oxidation is reduced in obese human skeletal muscle
Kim, J.-Y., Hickner, R. C., Cortright, R. L., Dohm, G. L., & Houmard, J. A. (2000) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.2000.279.5.e1039 · Cited by 634 · see citing works
Boden, G., Lebed, B., Schatz, M., Homko, C., & Lemieux, S. (2001) · Diabetes · doi:10.2337/diabetes.50.7.1612 · Cited by 597 · see citing works
Resistin, Adiponectin, Ghrelin, Leptin, and Proinflammatory Cytokines: Relationships in Obesity
Vendrell, J. J., Broch, M., Vilarrasa, N., Molina, A., Gómez, J. M., Gutiérrez, C., Simón, I., Soler, J., & Richart, C. (2004) · Obesity Research · doi:10.1038/oby.2004.118 · Cited by 552 · see citing works
Intramuscular lipid content is increased in obesity and decreased by weight loss
Goodpaster, B. H., Theriault, R., Watkins, S. C., & Kelley, D. E. (2000) · Metabolism · doi:10.1016/s0026-0495(00)80010-4 · Cited by 526 · see citing works
The Effect of Insulin Treatment on Insulin Secretion and Insulin Action in Type II Diabetes Mellitus
Garvey, W. T., Olefsky, J. M., Griffin, J., Hamman, R. F., & Kolterman, O. G. (1985) · Diabetes · doi:10.2337/diab.34.3.222 · Cited by 488 · see citing works
Self-citationImpaired free fatty acid utilization by skeletal muscle in non-insulin-dependent diabetes mellitus.
Kelley, D. E., & Simoneau, J. A. (1994) · Journal of Clinical Investigation · doi:10.1172/jci117600 · Cited by 487 · see citing works
Adiponectin Multimeric Complexes and the Metabolic Syndrome Trait Cluster
Lara‐Castro, C., Luo, N., Wallace, P., Klein, R. L., & Garvey, W. T. (2006) · Diabetes · doi:10.2337/diabetes.55.01.06.db05-1105 · Cited by 480 · see citing works
Self-citationNaressi, A., Couturier, C., Castang, I., de Beer, R., & Graveron‐Demilly, D. (2001) · Computers in Biology and Medicine · doi:10.1016/s0010-4825(01)00006-3 · Cited by 461 · see citing works
Insulin Resistance in Morbid Obesity
Greco, A. V., Mingrone, G., Giancaterini, A., Manco, M., Morroni, M., Cinti, S., Granzotto, M., Vettor, R., Camastra, S., & Ferrannini, E. (2002) · Diabetes · doi:10.2337/diabetes.51.1.144 · Cited by 442 · see citing works
Bachmann, O. P., Dahl, D. B., Brechtel, K., Machann, J., Haap, M., Maier, T., Loviscach, M., Stumvoll, M., Claussen, C. D., Schick, F., et al. (2001) · Diabetes · doi:10.2337/diabetes.50.11.2579 · Cited by 369 · see citing works
Schick, F., Eismann, B., Jung, W., Bongers, H., Bunse, M., & Lutz, O. (1993) · Magnetic Resonance in Medicine · doi:10.1002/mrm.1910290203 · Cited by 349 · see citing works
Tamura, Y., Tanaka, Y., Sato, F., Choi, J. B., Watada, H., Niwa, M., Kinoshita, J., Ooka, A., Kumashiro, N., Igarashi, Y., et al. (2005) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2004-1959 · Cited by 334 · see citing works
Ghrelin and Adipose Tissue Regulatory Peptides: Effect of Gastric Bypass Surgery in Obese Humans
Holdstock, C., Engström, B. E., Öhrvall, M., Lind, L., Sundbom, M., & Karlsson, F. A. (2003) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2002-021734 · Cited by 315 · see citing works
Skeletal muscle fat oxidation: Timing and flexibility are everything
Kelley, D. E. (2005) · Journal of Clinical Investigation · doi:10.1172/jci25758 · Cited by 298 · see citing works
Dagenais, G. R., Tancredi, R. G., & Zierler, K. L. (1976) · Journal of Clinical Investigation · doi:10.1172/jci108486 · Cited by 238 · see citing works
Giannopoulou, I., Fernhall, B., Carhart, R. L., Weinstock, R. S., Baynard, T., Figueroa, A., & Kanaley, J. A. (2005) · Metabolism · doi:10.1016/j.metabol.2005.01.033 · Cited by 232 · see citing works
Oakes, N. D., Bell-Anderson, K. S., Furler, S. M., Camilleri, S., Saha, A. K., Ruderman, N. B., Chisholm, D. J., & Kraegen, E. W. (1997) · Diabetes · doi:10.2337/diab.46.12.2022 · Cited by 176 · see citing works
Oakes, N. D., Bell, K. S., Furler, S. M., Camilleri, S., Saha, A. K., Ruderman, N. B., Chisholm, D. J., & Kraegen, E. W. (1997) · Diabetes · doi:10.2337/diabetes.46.12.2022 · Cited by 176 · see citing works
The “Obese Insulin-Sensitive” Adolescent: Importance of Adiponectin and Lipid Partitioning
Weiss, R., Taksali, S. E., Dufour, S., Yeckel, C. W., Papademetris, X., Cline, G. W., Tamborlane, W. V., Dziura, J., Shulman, G. I., & Caprio, S. (2005) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2004-2305 · Cited by 161 · see citing works
Décombaz, J., Schmitt, B., Ith, M., Decarli, B., Diem, P., Kreis, R., Hoppeler, H. H., & Boesch, C. (2001) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.2001.281.3.r760 · Cited by 154 · see citing works
Hwang, J.-H., Pan, J. W., Heydari, S., Hetherington, H. P., & Stein, D. T. (2001) · Journal of Applied Physiology · doi:10.1152/jappl.2001.90.4.1267 · Cited by 137 · see citing works
The effect of insulin treatment on insulin secretion and insulin action in type II diabetes mellitus
Garvey, W. T., Olefsky, J. M., Griffin, J., et al. (1985) · Diabetes · doi:10.2337/diabetes.34.3.222 · Cited by 125 · see citing works
Self-citationLarson‐Meyer, D. E., Newcomer, B. R., & Hunter, G. R. (2002) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.2002.282.1.e95 · Cited by 123 · see citing works
Self-citationIntramyocellular Lipid Content and Molecular Adaptations in Response to a 1‐Week High‐Fat Diet
Schrauwen‐Hinderling, V. B., Kooi, M. E., Hesselink, M. K. C., Moonen‐Kornips, E., Schaart, G., Mustard, K. J., Hardie, D. G., Saris, W. H. M., Nicolay, K., & Schrauwen, P. (2005) · Obesity Research · doi:10.1038/oby.2005.259 · Cited by 112 · see citing works
Muscle-associated triglyceride measured by computed tomography and magnetic resonance spectroscopy
Larson‐Meyer, D. E., Smith, S. R., Heilbronn, L. K., Kelley, D. E., Ravussin, E., Newcomer, B. R., & The Look AHEAD Adipose Research Group (2006) · Obesity · doi:10.1038/oby.2006.10 · Cited by 111 · see citing works
Self-citationDiet, Insulin Resistance, and Obesity: Zoning in on Data for Atkins Dieters Living in South Beach
Lara-Castro, C., & Garvey, W. T. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2004-0683 · Cited by 106 · see citing works
Self-citationRico‐Sanz, J., Thomas, E. L., Jenkinson, G., Mierisová, Š., Iles, R. A., & Bell, J. D. (1999) · Journal of Applied Physiology · doi:10.1152/jappl.1999.87.6.2068 · Cited by 91 · see citing works
Effect of weight loss on muscle lipid content in morbidly obese subjects
Gray, R. E., Tanner, C. J., Pories, W. J., MacDonald, K. G., & Houmard, J. A. (2003) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00371.2002 · Cited by 81 · see citing works
Mousavinasab, F., Tähtinen, T., Jokelainen, J. J., Koskela, P. U., Vanhala, M. J., Oikarinen, J. A., & Keinanen-Kiukaanniemi, S. M. (2005) · Endocrine · doi:10.1385/endo:26:1:065 · Cited by 26 · see citing works
Fabris, R., Mingrone, G., Milan, G., Manco, M., Granzotto, M., Pozza, A. D., Scarda, A., Serra, R., Greco, A. V., Federspil, G., et al. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-031343 · Cited by 17 · see citing works
High‐resolution chemical shift imaging for the assessment of intramuscular lipids
Newcomer, B. R., Lawrence, J. C., Buchthal, S. D., & den Hollander, J. A. (2007) · Magnetic Resonance in Medicine · doi:10.1002/mrm.21209 · Cited by 16 · see citing works
Self-citation
Flagged first, then by citations
Cited by
Sorted by citations
Adams, S. H., Hoppel, C. L., Lok, K. H., Zhao, L., Wong, S. W., Minkler, P. E., Hwang, D. H., Newman, J. W., & Garvey, W. T. (2009) · The Journal of Nutrition · doi:10.3945/jn.108.103754 · Cited by 598 · see citing works
Self-citationDietary fat and carbohydrates differentially alter insulin sensitivity during caloric restriction
Kirk, E., Reeds, D. N., Finck, B. N., Mayurranjan, M. S., Patterson, B. W., & Klein, S. (2009) · Gastroenterology · doi:10.1053/j.gastro.2009.01.048 · Cited by 440 · see citing works
Fiehn, O., Garvey, W. T., Newman, J. W. I., Lok, K. H., Hoppel, C. L., & Adams, S. H. (2010) · PLoS ONE · doi:10.1371/journal.pone.0015234 · Cited by 418 · see citing works
Self-citationEctopic fat and insulin resistance: pathophysiology and effect of diet and lifestyle interventions.
Snel, M., Jonker, J. T., Schoones, J., Lamb, H., de Roos, A., Pijl, H., Smit, J. W. A., Meinders, A. E., & Jazet, I. M. (2012) · International Journal of Endocrinology · doi:10.1155/2012/983814 · Cited by 368 · see citing works
Limitations in the Use of Indices Using Glucose and Insulin Levels to Predict Insulin Sensitivity
Pisprasert, V., Ingram, K. H., Lopez-Davila, M. F., Munoz, A. J., & Garvey, W. T. (2013) · Diabetes Care · doi:10.2337/dc12-0840 · Cited by 302 · see citing works
Self-citationZhang, L., Keung, W., Samokhvalov, V., Wang, W. J., & Lopaschuk, G. D. (2009) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2009.09.014 · Cited by 257 · see citing works
Insulin resistance and insulin sensitizing agents
Mastrototaro, L., & Roden, M. (2021) · Metabolism · doi:10.1016/j.metabol.2021.154892 · Cited by 259 · see citing works
Isbell, J. M., Tamboli, R. A., Hansen, E. N., Saliba, J., Dunn, J. P., Phillips, S. E., Marks–Shulman, P. A., & Abumrad, N. N. (2010) · Diabetes Care · doi:10.2337/dc09-2107 · Cited by 248 · see citing works
Kahleova, H., Petersen, K. F., Shulman, G. I., Alwarith, J., Rembert, E., Tura, A., Hill, M., Holubkov, R., & Barnard, N. D. (2020) · JAMA Network Open · doi:10.1001/jamanetworkopen.2020.25454 · Cited by 206 · see citing works
Churuangsuk, C., Hall, J., Reynolds, A., Griffin, S. J., Combet, E., & Lean, M. E. J. (2022) · Diabetologia · doi:10.1007/s00125-021-05577-2 · Cited by 204 · see citing works
Free fatty acids and skeletal muscle insulin resistance
Kraegen, E. W., & Cooney, G. J. (2008) · Current Opinion in Lipidology · doi:10.1097/01.mol.0000319118.44995.9a · Cited by 206 · see citing works
Fatty acid metabolism, energy expenditure and insulin resistance in muscle.
Turner, N., Cooney, G., Kraegen, E., & Bruce, C. (2014) · Journal of Endocrinology · doi:10.1530/joe-13-0397 · Cited by 203 · see citing works
Intramuscular lipid metabolism, insulin action, and obesity
Consitt, L. A., Bell, J. A., & Houmard, J. A. (2009) · IUBMB Life · doi:10.1002/iub.142 · Cited by 180 · see citing works
Intracellular Lipid Accumulation in Liver and Muscle and the Insulin Resistance Syndrome
Lara‐Castro, C., & Garvey, W. T. (2008) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/j.ecl.2008.09.002 · Cited by 163 · see citing works
Self-citationEckardt, K., Taube, A., & Eckel, J. (2011) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-011-9168-2 · Cited by 157 · see citing works
The Effect of Exercise and Nutrition on Intramuscular Fat Metabolism and Insulin Sensitivity
Shaw, C. S., Clark, J., & Wagenmakers, A. J. M. (2010) · Annual Review of Nutrition · doi:10.1146/annurev.nutr.012809.104817 · Cited by 128 · see citing works
Diabetes incidence and glucose intolerance prevalence increase with higher outdoor temperature
Blauw, L. L., Aziz, N. A., Tannemaat, M. R., Blauw, C. A., de Craen, A. J. M., Pijl, H., & Rensen, P. C. N. (2017) · BMJ Open Diabetes Research & Care · doi:10.1136/bmjdrc-2016-000317 · Cited by 124 · see citing works
Grams, J. M., & Garvey, W. T. (2015) · Current Obesity Reports · doi:10.1007/s13679-015-0155-x · Cited by 122 · see citing works
Self-citationMalandrucco, I., Pasqualetti, P., Giordani, I., Manfellotto, D., Marco, F. D., Alegiani, F., Sidoti, A. M., Picconi, F., Flaviani, A. D., Frajese, G., et al. (2012) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.111.023697 · Cited by 110 · see citing works
A Review on the Traditional Chinese Medicinal Herbs and Formulae with Hypolipidemic Effect
Sham, T.-T., Chan, C.-O., Wang, Y., Jian-mei, Y., Mok, D. K., & Chan, S. (2014) · BioMed Research International · doi:10.1155/2014/925302 · Cited by 107 · see citing works
Metabolic Changes Following a 1-Year Diet and Exercise Intervention in Patients With Type 2 Diabetes
Albu, J., Heilbronn, L. K., Kelley, D. E., Smith, S. R., Azuma, K., Berk, E. S., Pi-Sunyer, X., & Ravussin, É. (2009) · Diabetes · doi:10.2337/db09-1239 · Cited by 102 · see citing works
Imaging methods for analyzing body composition in human obesity and cardiometabolic disease
Seabolt, L., Welch, E., & Silver, H. (2015) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.12842 · Cited by 87 · see citing works
Lima, M. M. D. O., Pareja, J. C., Alegre, S. M., Geloneze, S. R., Kahn, S. E., Astiarraga, B., Chaim, É. A., & Geloneze, B. (2010) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2010-0085 · Cited by 99 · see citing works
Thalacker‐Mercer, A. E., Ingram, K. H., Guo, F., Ilkayeva, O., Newgard, C. B., & Garvey, W. T. (2013) · Diabetes · doi:10.2337/db13-0396 · Cited by 92 · see citing works
Self-citationAntoni, R., Johnston, K. L., Collins, A. L., & Robertson, M. D. (2016) · British Journal Of Nutrition · doi:10.1017/s0007114515005346 · Cited by 68 · see citing works
Mashayekhi, M., Nian, H., Mayfield, D., Devin, J. K., Gamboa, J. L., Yu, C., Silver, H. J., Niswender, K. D., Luther, J. M., & Brown, N. J. (2023) · Diabetes · doi:10.2337/db23-0356 · Cited by 67 · see citing works
Ingram, K. H., Lara‐Castro, C., Gower, B. A., Makowsky, R., Allison, D. B., Newcomer, B. R., Muñoz, A. J., Beasley, T. M., Lawrence, J. C., Lopez-Ben, R. R., et al. (2011) · Obesity · doi:10.1038/oby.2011.45 · Cited by 52 · see citing works
Self-citationDuivenvoorde, L. P. M., van Schothorst, E. M., Bunschoten, A., & Keijer, J. (2011) · Journal of Molecular Endocrinology · doi:10.1530/jme-11-0001 · Cited by 48 · see citing works
Translating aetiological insight into sustainable management of type 2 diabetes
Taylor, R., & Barnes, A. C. (2017) · Diabetologia · doi:10.1007/s00125-017-4504-z · Cited by 45 · see citing works
Studies in Insulin Resistance following Very Low Calorie Diet and/or Gastric Bypass Surgery
Foo, J., Krebs, J. D., Hayes, M. T., Bell, D. A., Macartney-Coxson, D. P., Croft, T., & Stubbs, R. S. (2011) · Obesity Surgery · doi:10.1007/s11695-011-0527-6 · Cited by 38 · see citing works
The effect of diet and exercise on lipid droplet dynamics in human muscle tissue
Daemen, S., van Polanen, N., & Hesselink, M. K. C. (2018) · Journal of Experimental Biology · doi:10.1242/jeb.167015 · Cited by 36 · see citing works
Glund, S., Schoelch, C., Thomas, L. H., Niessen, H. G., Stiller, D., Roth, G. J., & Neubauer, H. (2012) · Diabetologia · doi:10.1007/s00125-012-2554-9 · Cited by 35 · see citing works
Guest, N., Raj, S., Landry, M., Mangels, A. R., Pawlak, R., Senkus, K., Handu, D., & Rozga, M. (2024) · Advances in Nutrition · doi:10.1016/j.advnut.2024.100294 · Cited by 29 · see citing works
Hage, M. P., Safadi, B. Y., Salti, I., & Nasrallah, M. (2012) · ISRN Endocrinology · doi:10.5402/2012/504756 · Cited by 33 · see citing works
Teeuwisse, W. M., Widya, R. L., Paulides, M., Lamb, H. J., Smit, J. W. A., Roos, A., van Buchem, M. A., Pijl, H., & van der Grond, J. (2012) · Diabetes · doi:10.2337/db11-1835 · Cited by 33 · see citing works
Obanda, D. N., & Cefalu, W. T. (2013) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2012.12.014 · Cited by 32 · see citing works
The Flexibility of Ectopic Lipids
Loher, H., Kreis, R., Boesch, C., & Christ, E. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17091554 · Cited by 33 · see citing works
Food insecurity, type 2 diabetes, and hyperglycaemia: A systematic review and meta‐analysis
Beltrán, S., Arenas, D. J., Pharel, M., Montgomery, C. T., López-Hinojosa, I. J., & DeLisser, H. M. (2021) · Endocrinology Diabetes & Metabolism · doi:10.1002/edm2.315 · Cited by 31 · see citing works
Campbell, T. M., Campbell, E., Attia, J., Ventura, K., Mathews, T., Chhabra, K. H., Blanchard, L., Wixom, N., Faniyan, T. S., Peterson, D. R., et al. (2023) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2023.110814 · Cited by 32 · see citing works
A low-calorie diet with or without interval exercise training improves adiposopathy in obese women
Gilbertson, N. M., Eichner, N. Z. M., Heiston, E. M., Gaitán, J. M., François, M. E., Mehaffey, J. H., Hassinger, T. E., Hallowell, P. T., WELTMAN, A. L., & Malin, S. K. (2019) · Applied Physiology Nutrition and Metabolism · doi:10.1139/apnm-2018-0717 · Cited by 28 · see citing works
Meienberg, F., Yee, M. S., Johnston, D. G., Cox, J., Robinson, S., Bell, J. D., Thomas, E. L., Taylor-Robinson, S. D., & Godsland, I. F. (2016) · Clinical Endocrinology · doi:10.1111/cen.13042 · Cited by 26 · see citing works
Numao, S., Kawano, H., Endo, N., Yamada, Y., Konishi, M., Takahashi, M., & Sakamoto, S. (2013) · Metabolism · doi:10.1016/j.metabol.2013.05.005 · Cited by 24 · see citing works
Ke, B., Shi, L., Zhang, J., Ding-sheng, C. H. E. N., Meng, J., & Qin, J. (2012) · 中医杂志:英文版 · doi:10.1016/s0254-6272(13)60010-2 · Cited by 23 · see citing works
Dearing, C. G., Morano, R. L., Ptaskiewicz, E., Mahbod, P., Scheimann, J. R., Franco, A. C. G., Wulsin, L. R., & Myers, B. (2021) · Hormones and Behavior · doi:10.1016/j.yhbeh.2021.105060 · Cited by 22 · see citing works
Seyfried, F., Bueter, M., Spliethoff, K., Miras, A. D., Abegg, K., Lutz, T. A., & le Roux, C. W. (2014) · Obesity Surgery · doi:10.1007/s11695-014-1301-3 · Cited by 22 · see citing works
Muo, I. M., MacDonald, S. D., Madan, R., Park, S.-J., Gharib, A. M., Martinez, P. E., Walter, M. F., Yang, S. B., Rodante, J. A., Courville, A. B., et al. (2019) · Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy · doi:10.2147/dmso.s182953 · Cited by 21 · see citing works
Li, T., Chen, K., Liu, G., Huang, L., Chen, L., Wang, Q., Hu, C., & Hou, L. (2016) · Pediatric Research · doi:10.1038/pr.2016.273 · Cited by 21 · see citing works
Chen, D., Li, C., Michalsen, A., Keßler, C. S., Huang, Y., Meng, J., Ke, B., Wang, Y., Zhang, J., & Qin, J. (2012) · European Journal of Integrative Medicine · doi:10.1016/j.eujim.2011.12.011 · Cited by 19 · see citing works
Šrámková, V., Rossmeislová, L., Krauzová, E., Kračmerová, J., Koc, M., Langin, D., Štich, V., & Šiklová, M. (2016) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2016-2161 · Cited by 19 · see citing works
Ding-sheng, C. H. E. N., Ke, B., Huang, Y., Meng, J., Zhang, J., Chen, Z., Michalsen, A., & Qin, J. (2011) · 中医杂志:英文版 · doi:10.1016/s0254-6272(11)60038-1 · Cited by 19 · see citing works
Plant Foods, Healthy Plant-Based Diets, and Type 2 Diabetes: A Review of the Evidence
del Carmen Fernández-Fígares Jiménez, M. (2024) · Nutrition Reviews · doi:10.1093/nutrit/nuad099 · Cited by 20 · see citing works
Treat Obesity to Treat Type 2 Diabetes Mellitus
Sulu, C., & Yumuk, V. (2024) · Diabetes Therapy · doi:10.1007/s13300-024-01536-3 · Cited by 18 · see citing works
Garvey, W. T. (2016) · Diabetes Care · doi:10.2337/dc16-1611 · Cited by 14 · see citing works
Self-citationNylén, C., Lundell, L., Massart, J., Zierath, J., & Näslund, E. (2019) · American Journal of Physiology. Endocrinology and Metabolism · doi:10.1152/ajpendo.00253.2018 · Cited by 8 · see citing works
Iglesias‐Carres, L., & Neilson, A. P. (2021) · Food & Function · doi:10.1039/d1fo02782d · Cited by 9 · see citing works
Lawrence, J. C., Gower, B. A., Garvey, W. T., Muñoz, A. J., Darnell, B. E., Oster, R. A., Buchthal, S. D., Goran, M. I., & Newcomer, B. R. (2010) · The Open Obesity Journal · doi:10.2174/1876823701002010137 · Cited by 9 · see citing works
Self-citationMarinis, Y. Z. D., Sun, J., Bompada, P., Omella, J. D., Luan, C., Halu, A., Renström, E., Sharma, A., & Ridderstråle, M. (2017) · Obesity · doi:10.1002/oby.21899 · Cited by 8 · see citing works
[Very low calorie diets in clinical management of morbid obesity].
López, F. J. V., Martín, C. C., García, M. J. A., Vera, P. S., & Cunill, J. L. P. (2013) · PubMed · doi:10.3305/nh.2013.28.2.6285 · Cited by 8 · see citing works
Chaves, W. F., Pinheiro, I. L., da Silva, L. O., Lima-Oliveira, D. P., Muniz, G. D. S., BARRETO, Á. D. N., da Silva, B. J., Manhães‐de‐Castro, R., & Aragão, R. D. S. (2020) · Life Sciences · doi:10.1016/j.lfs.2020.118224 · Cited by 7 · see citing works
Saiyalam, C., Shantavasinkul, P. C., Chirnaksorn, S., Rattanakaemakorn, P., Taonam, N., Rodphech, V., Putadechakum, S., Rattanasiri, S., Sirivarasai, J., Ongphiphadhanakul, B., et al. (2024) · Nutrients · doi:10.3390/nu16152407 · Cited by 6 · see citing works
Effects of antidiabetic agents on lipid metabolism of skeletal muscle: A narrative review
Xu, M., Lv, D., Wei, H., Li, Z., Jin, S., Liu, Q., Zhang, Y., & Liu, Y. (2025) · Diabetes Obesity and Metabolism · doi:10.1111/dom.16189 · Cited by 4 · see citing works
de la Maza, M. P., Hirsch, S., Jara, N., Leiva, L., Barrera, G., Silva, C., Pañella, L., Henríquez, S., & Bunout, D. C. (2014) · PubMed · doi:10.3305/nh.2015.31.3.7979 · Cited by 4 · see citing works
MRS studies of muscle and heart in obesity and diabetes
Prompers, J., & Nicolay, K. (2016) · Encyclopedia of Magnetic Resonance · doi:10.1002/9780470034590.emrstm1462 · Cited by 2 · see citing works
London, A., Schaufuss, A., Považan, M., Dichman, M.-L., Merhout, J., Dirksen, C., Madsbad, S., Siebner, H. R., Lundsgaard, A., Fritzen, A. M., et al. (2025) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgaf382 · Cited by 5 · see citing works
Sambashivaiah, S., Bhadra, R., Bhattacharya, S., & Kurpad, A. (2023) · Journal of the Indian Institute of Science · doi:10.1007/s41745-022-00349-2 · Cited by 3 · see citing works
Valkovič, L., Klepochová, R., & Krššák, M. (2018) · InTech eBooks · doi:10.5772/intechopen.77107 · Cited by 3 · see citing works
Whitfield, P. L., Hall, R. M., Théaude, L., Sixtus, R. P., Kanaan, R., Holley, A. S., Umpleby, A. M., Weatherall, M., ROWLANDS, D. S., & Krebs, J. D. (2024) · PubMed Central · doi:10.6133/apjcn.202406_33(2).0007 · Cited by 2 · see citing works
Ethnic Differences in Insulin Resistance as a Mediator of Cancer Disparities
Hasson, R. E., & Goran, M. I. (2014) · Springer eBooks · doi:10.1007/978-3-319-06103-0_8 · Cited by 2 · see citing works
Anyiam, O., & IDRIS, I. R. (2025) · Expert Review of Endocrinology & Metabolism · doi:10.1080/17446651.2025.2527791 · Cited by 1 · see citing works
Formuladiäten bei der Behandlung des Typ-2-Diabetes
Martin, S., & Kempf, K. (2014) · Der Diabetologe · doi:10.1007/s11428-013-1112-5 · Cited by 1 · see citing works
Hirsch, S., Jara, N. C., Leiva, L., Barrera, G., Silva, C., Pañella, L., Henríquez, S., & Bunout, D. C. (2015)
Effects of high-fat feeding on skeletal muscle insulin signalling in sarcolipin knockout mice
Sayer, R. A. (2010) · UWSpace (University of Waterloo)
Lara‐Castro, C., & Garvey, W. T. (2009) · Humana Press eBooks · doi:10.1007/978-1-60327-542-2_15
Self-citationCardiac Energy Metabolism in Heart Failure Associated with Obesity and Diabetes
Lopaschuk, G. D. (2014) · Springer eBooks · doi:10.1007/978-1-4939-1227-8_5
Metabolic effects of dipeptyl peptidase 4 inhibitor in type 2 diabetes
Macauley, M. (2016)
Cirurgia bariátrica e exérese de tecido adiposo visceral (omentectomia)
Lima, M. M. D. O. (2015) · doi:10.47749/t/unicamp.2015.946312
The impact of very-low-calorie diets on ectopic fat deposition
Rayner, J. J., & Abdesselam, I. (2023) · Elsevier eBooks · doi:10.1016/b978-0-12-822186-0.00008-0
Anyiam, O., Phillips, B. E., Quinn, K., Wilkinson, D. J., Smith, K., Atherton, P. J., & IDRIS, I. R. (2024) · Clinical Nutrition · doi:10.1016/j.clnu.2024.10.033
Kahleová, H., Petersen, K. F., Shulman, G. I., Znayenko‐Miller, T., Dufour, S., Brennan, H., Maracine, C., Tura, A., Holubkov, R., & Barnard, N. D. (2026) · BMJ Open Diabetes Research & Care · doi:10.1136/bmjdrc-2026-006472
Moreira, R. J. (2013) · Americanae (AECID Library)
- Authors
- Lara-Castro, C., Newcomer, B. R., Rowell, J., Wallace, P., Shaughnessy, S. M., Munoz, A. J., Shiflett, A. M., Rigsby, D. Y., Lawrence, J. C., Bohning, D. E., Buchthal, S., & Garvey, W. T.
- Venue
- Metabolism
- Publisher
- Elsevier BV
- Published
- 2008-01
- Volume
- 57
- Issue
- 1
- Pages
- 1-8
- ISSN
- 0026-0495 (ISSN-L)
- PMC
- PMC2271155
- OpenAlex
- W2149294575
- Cited by
- 82
- References
- 36
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 5 · 2023: 5 · 2021: 5 · 2020: 2 · 2019: 2 · 2018: 3 · 2017: 4 · 2016: 8 · 2015: 4 · 2014: 6 · 2013: 6 · 2012: 8
- FWCI
- 3.34
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Metabolism (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- U.S. Department of Veterans Affairs (I01CX000432)
- National Institutes of Health (5p01hl055782-10)
- National Heart, Lung, and Blood Institute (P01 HL-055782, P01 HL 55782)
- National Institute of Diabetes and Digestive and Kidney Diseases (DK-38765, R01DK038765, P30-DK56336, P30DK056336)
- National Center for Research Resources (MO1 RR-00032, M01RR000032)
- Topics
- Health Sciences › Medicine › Physiology › Diet and metabolism studies
- Health Sciences › Medicine › Physiology › Dietary Effects on Health
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Keywords
- very low calorie diet, intramyocellular lipid, insulin sensitivity, insulin resistance, type 2 diabetes, obesity, fat mass, glucose disposal, waist circumference, fat-free mass
- MeSH terms
- Adult, Blood Glucose, Body Composition, Energy Intake, Calorimetry, Indirect, Diabetes Mellitus, Type 2, Diet, Reducing, Female, Glucose Tolerance Test, Homeostasis, Humans, Insulin, Lipids, Male, Middle Aged, Obesity, Reference Values, Glucose Clamp Technique, Body Mass Index, Overweight
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review