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Evidence of proatherogenic inflammation in polycystic ovary syndrome
Open accessAbstract
Women with polycystic ovary syndrome (PCOS) have chronic low-level inflammation that can increase the risk of atherogenesis. We measured circulating proatherogenic inflammatory mediators in women with PCOS (8 lean: body mass index, 18-25 kg/m(2); 8 obese: body mass index, 30-40 kg/m(2)) and weight-matched controls (8 lean, 8 obese). Blood samples were obtained fasting and 2 hours after glucose ingestion to measure interleukin-6 (IL-6), soluble intercellular adhesion molecule-1 (sICAM-1), monocyte chemotactic protein-1 (MCP-1), C-reactive protein (CRP), matrix metalloproteinase-2, plasminogen activator inhibitor-1 (PAI-1), and activated nuclear factor kappaB in mononuclear cells. Truncal fat was determined by dual-energy x-ray absorptiometry. Fasting MCP-1 levels were elevated in lean women with PCOS compared with lean controls (159.9 +/- 14.1 vs 121.2 +/- 5.4 pg/mL, P < .02). Hyperglycemia failed to suppress matrix metalloproteinase-2 in lean women with PCOS compared with lean controls (1.7 +/- 1.2 vs -4.8 +/- 1.6 pg/mL, P < .002). Among women with PCOS, obese individuals exhibited higher fasting sICAM-1 (16.1 +/- 0.8 vs 10.5 +/- 1.0 ng/mL, P < .03) and PAI-1 (6.1 +/- 0.7 vs 3.4 +/- 0.8 ng/mL, P < .03) levels. Trend analysis revealed higher (P < .005) IL-6, sICAM-1, CRP, PAI-1, systolic and diastolic blood pressures, triglycerides, fasting insulin, and homeostasis model assessment of insulin resistance index in women with PCOS compared with weight-matched controls, and the highest levels in the obese regardless of PCOS status. Fasting MCP-1 levels correlated with activated nuclear factor kappaB during hyperglycemia (P < .05) and androstenedione (P < .004). Truncal fat correlated with fasting IL-6 (P < .004), sICAM-1 (P < .006), CRP (P < .0009), and PAI-1 (P < .02). We conclude that both PCOS and obesity contribute to a proatherogenic state; but in women with PCOS, abdominal adiposity and hyperandrogenism may exacerbate the risk of atherosclerosis.
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“Overweight women with PCOS have been characterized by elevated markers of inflammation relative to weight-matched healthy controls (47)(48)(49).”
From A Lower-Carbohydrate, Higher-Fat Diet Reduces Abdominal and Intermuscular Fat and Increases Insulin Sensitivity in Adults at Risk of Type 2 Diabetes (2015) · cites this paper as [48]
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Circulating inflammatory markers in polycystic ovary syndrome: a systematic review and metaanalysis
Escobar-Morreale, H. F., Luque‐Ramírez, M., & González, F. (2010) · Fertility and Sterility · doi:10.1016/j.fertnstert.2010.11.036 · Cited by 538
Self-citationGonzález, F. (2012) · Steroids · doi:10.1016/j.steroids.2011.12.003 · Cited by 515
Self-citationA brief insight into the etiology, genetics, and immunology of polycystic ovarian syndrome (PCOS)
Siddiqui, S., Mateen, S., Ahmad, R., & Moin, S. (2022) · Journal of Assisted Reproduction and Genetics · doi:10.1007/s10815-022-02625-7 · Cited by 404
Is PCOS an inflammatory process?
Duleba, A. J., & Dokras, A. (2012) · Fertility and Sterility · doi:10.1016/j.fertnstert.2011.11.023 · Cited by 327
Roles of oxidative stress in polycystic ovary syndrome and cancers
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Metadata
- Authors
- González, F., Rote, N. S., Minium, J., & Kirwan, J. P.
- Affiliations
- Mayo Clinic (US)
- Case Western Reserve University (US)
- Cleveland Clinic (US)
- Corresponding author
- González, Frank
- Venue
- Metabolism
- Publisher
- Elsevier BV
- Published
- 2009-07
- Volume
- 58
- Issue
- 7
- Pages
- 954-962
- ISSN
- 0026-0495 (ISSN-L)
- PMC
- PMC2737595
- OpenAlex
- W1968511949
- Cited by
- 135
- References
- 59
- Citations by year
- 2026: 4 · 2025: 7 · 2024: 6 · 2023: 8 · 2022: 10 · 2021: 5 · 2020: 6 · 2019: 6 · 2018: 6 · 2017: 3 · 2016: 10 · 2015: 7 · 2014: 13 · 2013: 3 · 2012: 16
- FWCI
- 16.15
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health
- University at Buffalo
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (HD-048535, R03HD048535)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Keywords
- polycystic ovary syndrome, low-grade inflammation, atherogenesis, obesity, truncal fat, interleukin-6, soluble intercellular adhesion molecule-1, MCP-1, C-reactive protein, plasminogen activator inhibitor-1, MMP-2, nuclear factor-kappaB, hyperglycemia, insulin resistance, androstenedione, blood pressure, dyslipidemia, fasting insulin
- MeSH terms
- Adult, Androgens, C-Reactive Protein, Female, Glucose Tolerance Test, Humans, Obesity, Polycystic Ovary Syndrome, Absorptiometry, Photon, Interleukin-6, NF-kappa B, Plasminogen Activator Inhibitor 1, Intercellular Adhesion Molecule-1, Chemokine CCL2, Matrix Metalloproteinase 2, Electrophoretic Mobility Shift Assay, Atherosclerosis, Young Adult
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