The DOI matches its Crossref record; 58 of the 59 references it cites were found in a registry or an index.
Evidence of proatherogenic inflammation in polycystic ovary syndrome
Open accessAbstract
Women with polycystic ovary syndrome (PCOS) have chronic low-level inflammation that can increase the risk of atherogenesis. We measured circulating proatherogenic inflammatory mediators in women with PCOS (8 lean: body mass index, 18-25 kg/m(2); 8 obese: body mass index, 30-40 kg/m(2)) and weight-matched controls (8 lean, 8 obese). Blood samples were obtained fasting and 2 hours after glucose ingestion to measure interleukin-6 (IL-6), soluble intercellular adhesion molecule-1 (sICAM-1), monocyte chemotactic protein-1 (MCP-1), C-reactive protein (CRP), matrix metalloproteinase-2, plasminogen activator inhibitor-1 (PAI-1), and activated nuclear factor kappaB in mononuclear cells. Truncal fat was determined by dual-energy x-ray absorptiometry. Fasting MCP-1 levels were elevated in lean women with PCOS compared with lean controls (159.9 +/- 14.1 vs 121.2 +/- 5.4 pg/mL, P < .02). Hyperglycemia failed to suppress matrix metalloproteinase-2 in lean women with PCOS compared with lean controls (1.7 +/- 1.2 vs -4.8 +/- 1.6 pg/mL, P < .002). Among women with PCOS, obese individuals exhibited higher fasting sICAM-1 (16.1 +/- 0.8 vs 10.5 +/- 1.0 ng/mL, P < .03) and PAI-1 (6.1 +/- 0.7 vs 3.4 +/- 0.8 ng/mL, P < .03) levels. Trend analysis revealed higher (P < .005) IL-6, sICAM-1, CRP, PAI-1, systolic and diastolic blood pressures, triglycerides, fasting insulin, and homeostasis model assessment of insulin resistance index in women with PCOS compared with weight-matched controls, and the highest levels in the obese regardless of PCOS status. Fasting MCP-1 levels correlated with activated nuclear factor kappaB during hyperglycemia (P < .05) and androstenedione (P < .004). Truncal fat correlated with fasting IL-6 (P < .004), sICAM-1 (P < .006), CRP (P < .0009), and PAI-1 (P < .02). We conclude that both PCOS and obesity contribute to a proatherogenic state; but in women with PCOS, abdominal adiposity and hyperandrogenism may exacerbate the risk of atherosclerosis.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Overweight women with PCOS have been characterized by elevated markers of inflammation relative to weight-matched healthy controls (47)(48)(49).”
From A Lower-Carbohydrate, Higher-Fat Diet Reduces Abdominal and Intermuscular Fat and Increases Insulin Sensitivity in Adults at Risk of Type 2 Diabetes (2015) · cites this paper as [48]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Matthews, D. R., Hosker, J. P., Rudenski, A. S., Naylor, B. A., Treacher, D. F., & Turner, R. C. (1985) · Diabetologia · doi:10.1007/bf00280883 · Cited by 31,502
Grundy, S. M., Bilheimer, D. W., Chait, A., Clark, L. T., Denke, M. A., Havel, R. J., Hazzard, W. R., Hulley, S. B., Hunninghake, D. B., Kreisberg, R. A., et al. (1993) · JAMA · doi:10.1001/jama.269.23.3015 · Cited by 27,944
Expert Panel on Detection, E. (2001) · JAMA: The Journal of the American Medical Association · doi:10.1001/jama.285.19.2486 · Cited by 26,011
Obesity is associated with macrophage accumulation in adipose tissue
Weisberg, S. P., McCann, D., Desai, M., Rosenbaum, M., Leibel, R. L., & Ferrante, A. W. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200319246 · Cited by 10,041
(1998) · PsycEXTRA Dataset · doi:10.1037/e565682010-001 · Cited by 9,453
(2004) · Fertility and Sterility · doi:10.1016/j.fertnstert.2003.10.004 · Cited by 9,050
Inflammation in atherosclerosis
Libby, P. (2002) · Nature · doi:10.1038/nature01323 · Cited by 8,315
The Rotterdam ESHRE/ASRM-sponsored PCOS consensus workshop group (2004) · Human Reproduction · doi:10.1093/humrep/deh098 · Cited by 6,138
Ridker, P. M., Hennekens, C. H., Buring, J. E., & Rifai, N. (2000) · New England Journal of Medicine · doi:10.1056/nejm200003233421202 · Cited by 5,850
Nuclear Factor-κB — A Pivotal Transcription Factor in Chronic Inflammatory Diseases
Barnes, P. J., & Karin, M. (1997) · New England Journal of Medicine · doi:10.1056/nejm199704103361506 · Cited by 4,622
Cited by
Sorted by citations
Circulating inflammatory markers in polycystic ovary syndrome: a systematic review and metaanalysis
Escobar-Morreale, H. F., Luque‐Ramírez, M., & González, F. (2010) · Fertility and Sterility · doi:10.1016/j.fertnstert.2010.11.036 · Cited by 538
Self-citationGonzález, F. (2012) · Steroids · doi:10.1016/j.steroids.2011.12.003 · Cited by 515
Self-citationA brief insight into the etiology, genetics, and immunology of polycystic ovarian syndrome (PCOS)
Siddiqui, S., Mateen, S., Ahmad, R., & Moin, S. (2022) · Journal of Assisted Reproduction and Genetics · doi:10.1007/s10815-022-02625-7 · Cited by 404
Is PCOS an inflammatory process?
Duleba, A. J., & Dokras, A. (2012) · Fertility and Sterility · doi:10.1016/j.fertnstert.2011.11.023 · Cited by 327
Roles of oxidative stress in polycystic ovary syndrome and cancers
Zuo, T., Zhu, M., & Xu, W. (2016) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2016/8589318 · Cited by 319
The role of low-grade inflammation in the polycystic ovary syndrome
Repaci, A., Gambineri, A., & Pasquali, R. (2010) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2010.08.002 · Cited by 310
Polycystic ovary syndrome current status and future perspective
Naz, R. K. (2014) · Frontiers in Bioscience-Elite · doi:10.2741/e695 · Cited by 273
Rençber, S. F., Özbek, S. K., Eraldemir, F. C., Sezer, Z., Kum, T., Ceylan, S., & Güzel, E. (2018) · Journal of Ovarian Research · doi:10.1186/s13048-018-0427-7 · Cited by 236
Meta-analysis of cardiovascular disease risk markers in women with polycystic ovary syndrome
Toulis, K. A., Goulis, D. G., Mintziori, G., Kintiraki, E., Eukarpidis, E., Mouratoglou, S., Pavlaki, A., Stergianos, S., Poulasouchidou, M., Tzellos, T., et al. (2011) · Human Reproduction Update · doi:10.1093/humupd/dmr025 · Cited by 229
Savant, S. S., Sriramkumar, S., & O’Hagan, H. M. (2018) · Cancers · doi:10.3390/cancers10080251 · Cited by 215
Baranova, A. V., Tran, T., Birerdinc, A., & Younossi, Z. M. (2011) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2011.04579.x · Cited by 146
Fruzzetti, F., Perini, D., Russo, M., Bucci, F., & Gadducci, A. (2017) · Gynecological Endocrinology · doi:10.1080/09513590.2016.1236078 · Cited by 135
The effects of old, new and emerging medicines on metabolic aberrations in PCOS
Bargiota, Α., & Diamanti‐Kandarakis, E. (2012) · Therapeutic Advances in Endocrinology and Metabolism · doi:10.1177/2042018812437355 · Cited by 120
Bisphenol A (BPA) and its potential role in the pathogenesis of the polycystic ovary syndrome (PCOS)
Rutkowska, A. Z., & Rachoń, D. (2014) · Gynecological Endocrinology · doi:10.3109/09513590.2013.871517 · Cited by 108
Relationship between hyperandrogenism, obesity, inflammation and polycystic ovary syndrome
Nehir, A., Baştu, E., Demiral, İ., Bulut, H., Doğan, M., & Buyru, F. (2016) · Gynecological Endocrinology · doi:10.3109/09513590.2016.1155208 · Cited by 99
Gower, B. A., & Goss, A. M. (2015) · The Journal of Nutrition · doi:10.3945/jn.114.195065 · Cited by 98
Oxidative stress and cardiovascular complications in polycystic ovarian syndrome
Hyderali, B. N., & Mala, K. (2015) · European Journal of Obstetrics & Gynecology and Reproductive Biology · doi:10.1016/j.ejogrb.2015.05.005 · Cited by 96
Creatsa, M. G., Armeni, E., Stamatelopoulos, K. S., Rizos, D., Georgiopoulos, G. A., Kazani, M. V., Alexandrou, A. P., Dendrinos, S., Augoulea, A., Papamichael, C. M., et al. (2011) · Metabolism · doi:10.1016/j.metabol.2011.06.005 · Cited by 93
The physiological basis of complementary and alternative medicines for polycystic ovary syndrome
Raja-Khan, N. T., Stener‐Victorin, E., Wu, X., & Legro, R. S. (2011) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00667.2010 · Cited by 88
Srnovršnik, T., Virant‐Klun, I., & Pinter, B. (2023) · Life · doi:10.3390/life13010138 · Cited by 88
Holmes, S., Singh, M., Su, C., & Cunningham, R. L. (2016) · Endocrinology · doi:10.1210/en.2015-1738 · Cited by 73
Marouf, B. H., Dana, O. I., Hassan, A. H., & Ali, O. J. (2022) · Journal of Inflammation Research · doi:10.2147/jir.s379725 · Cited by 72
Identification and treatment of metabolic complications in pediatric obesity
Ode, K. L., Frohnert, B. I., & Nathan, B. M. (2009) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-009-9115-7 · Cited by 64
Ghanei, N., Rezaei, N., Amiri, G. A., Zayeri, F., Makki, G., & Nasseri, E. (2018) · Journal of Functional Foods · doi:10.1016/j.jff.2017.12.047 · Cited by 62
Pandey, V., Singh, A., Singh, A. K., Krishna, A., Pandey, U., & Tripathi, Y. B. (2016) · Reproductive Biology · doi:10.1016/j.repbio.2015.12.005 · Cited by 60
Hu, W., Qiao, J., Yan, Y., Wang, L., & Li, R. (2011) · European Journal of Obstetrics & Gynecology and Reproductive Biology · doi:10.1016/j.ejogrb.2011.03.015 · Cited by 56
Mohamadin, A. M., Habib, F., & Elahi, T. F. (2009) · Pathophysiology · doi:10.1016/j.pathophys.2009.11.004 · Cited by 54
Younis, A. I., Hawkins, K. C., Mahini, H., Butler, W. J., & Garelnabi, M. (2014) · Journal of Assisted Reproduction and Genetics · doi:10.1007/s10815-014-0237-9 · Cited by 53
Lindholm, A., Blomquist, C. H., Bixo, M., Dahlbom, I., Hansson, T., Poromaa, I. S., & Burén, J. (2011) · Human Reproduction · doi:10.1093/humrep/der096 · Cited by 51
Imbalanced circulating matrix metalloproteinases in polycystic ovary syndrome
Gomes, V. A., Vieira, C. S., Jacob‐Ferreira, A. L., Belo, V. D. A., Soares, G. M., Fernandes, J. B. F., Ferriani, R. A., & Tanus-Santos, J. E. (2011) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-011-0793-6 · Cited by 51
Hyperandrogenism exerts an anti-inflammatory effect in obese women with polycystic ovary syndrome
González, F., Sia, C. L., Stanczyk, F. Z., Blair, H. E., & Krupa, M. E. (2012) · Endocrine · doi:10.1007/s12020-012-9728-6 · Cited by 48
Self-citationChoi, Y. S., Yang, H. I., Cho, S., Jung, J. A., Jeon, Y. E., Kim, H. Y., Seo, S. K., & Lee, B. S. (2012) · Steroids · doi:10.1016/j.steroids.2012.08.005 · Cited by 46
Hatziagelaki, E. E., Pergialiotis, V., Kannenberg, J. M., Trakakis, E., Tsiavou, A., Markgraf, D. F., Carstensen‐Kirberg, M., Pacini, G., Roden, M., Dimitriadis, G., et al. (2019) · Experimental and Clinical Endocrinology & Diabetes · doi:10.1055/a-0992-9114 · Cited by 46
Polycystic Ovary Syndrome and Hyperandrogenic States
Chang, R. J., & Dumesic, D. A. (2019) · Elsevier eBooks · doi:10.1016/b978-0-323-47912-7.00021-4 · Cited by 41
Pournaderi, P. S., Yaghmaei, P., Khodaei, H., Noormohammadi, Z., & Hejazi, S. H. (2017) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2017.01.057 · Cited by 41
Rondanelli, M., Perna, S., Faliva, M. A., Monteferrario, F., Repaci, E., & Allieri, F. (2014) · Archives of Gynecology and Obstetrics · doi:10.1007/s00404-014-3433-z · Cited by 44
Essah, P. A., Arrowood, J. A., Cheang, K. I., Adawadkar, S., Stovall, D. W., & Nestler, J. E. (2011) · Fertility and Sterility · doi:10.1016/j.fertnstert.2011.05.091 · Cited by 37
Fadlalmola, H. A., Elhusein, A. M., Al‐Sayaghi, K. M., Albadrani, M. S., Swamy, D. S. V., Mamanao, D. M., El-Amin, E. I., Ibrahim, S. E., & Abbas, S. M. (2023) · Pan African Medical Journal · doi:10.11604/pamj.2023.44.134.32404 · Cited by 38
Cardiometabolic biomarkers in women with polycystic ovary syndrome
van der Ham, K., Louwers, Y. V., & Laven, J. S. E. (2022) · Fertility and Sterility · doi:10.1016/j.fertnstert.2022.03.008 · Cited by 39
Role of adipokines in the ovarian function: Oogenesis and steroidogenesis
Nikanfar, S., Oghbaei, H., Rezaei, Y. R., Zarezadeh, R., Jafari-Gharabaghlou, D., Nejabati, H. R., Bahrami, Z., Bleisinger, N., Samadi, N., Fattahi, A., et al. (2021) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2021.105852 · Cited by 32
Rashad, N. M., El‐Shal, A. S., & Abdelaziz, A. M. (2012) · Journal of Reproductive Immunology · doi:10.1016/j.jri.2012.10.007 · Cited by 32
Nikołajuk, A., Kowalska, I., Karczewska‐Kupczewska, M., Adamska, A., Otziomek, E., Wołczyński, S., Kinalska, I., Górska, M., & Strączkowski, M. (2010) · Diabetes · doi:10.2337/db09-1316 · Cited by 31
The Effect on Inflammation of Adherence to the Mediterranean Diet in Polycystic Ovary Syndrome
Dazıroğlu, M. E. Ç., & Tek, N. A. (2023) · Current Nutrition Reports · doi:10.1007/s13668-023-00451-6 · Cited by 32
Gao, H. Y., Meng, J., Xu, M., Zhang, S., Bishwajit, G., Liu, J., Yao, P., Yan, H., Wang, D., & Liu, L. (2013) · PLoS ONE · doi:10.1371/journal.pone.0067727 · Cited by 31
Glucose ingestion stimulates atherothrombotic inflammation in polycystic ovary syndrome
González, F., Kirwan, J. P., Rote, N. S., & Minium, J. (2012) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00491.2012 · Cited by 30
Self-citationWu, Z., Fang, L., Li, Y., Yan, Y., Thakur, A., Cheng, J., & Sun, Y. (2021) · American Journal of Reproductive Immunology · doi:10.1111/aji.13407 · Cited by 29
Aydoğdu, A., Taşçı, İ., Tapan, S., Başaran, Y., Aydoğan, Ü., Meriç, C., Sönmez, A., Aydogdu, S., Akbulut, H., Taşlıpınar, A., et al. (2012) · Gynecological Endocrinology · doi:10.3109/09513590.2011.652719 · Cited by 27
Riley, J. K., & Jungheim, E. S. (2016) · Fertility and Sterility · doi:10.1016/j.fertnstert.2016.07.1069 · Cited by 27
Küçük, M., Altınkaya, S. Ö., Nergiz, S., Sezer, S. D., Yüksel, H., Bağlı, İ., & Yıldız, G. (2014) · Gynecological Endocrinology · doi:10.3109/09513590.2014.895981 · Cited by 26
Insights on the NF-κB system in polycystic ovary syndrome, attractive therapeutic targets
Tan, W., Zhang, J., Dai, F., Yang, D., Gu, R., Tang, L., Liu, H., & Cheng, Y. (2023) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-023-04736-w · Cited by 25
Relationship between IL-17 and ambulatory blood pressure inpolycystic ovary syndrome
Foroozanfard, F., Soleimani, A., Arbab, E., Samimi, M., & Tamadon, M. R. (2016) · Journal of Nephropathology · doi:10.15171/jnp.2017.04 · Cited by 25
Raja-Khan, N. T., Agito, K., Shah, J., Stetter, C., Gustafson, T. S., Socolow, H., Kunselman, A. R., Reibel, D. K., & Legro, R. S. (2015) · Contemporary Clinical Trials · doi:10.1016/j.cct.2015.01.021 · Cited by 28
Fruzzetti, F., Capozzi, A., Canu, A., & Lello, S. (2019) · Gynecological Endocrinology · doi:10.1080/09513590.2018.1540573 · Cited by 24
Kabiri, N., Tabandeh, M. R., & Tabatabaie, S. R. F. (2014) · DARU Journal of Pharmaceutical Sciences · doi:10.1186/2008-2231-22-39 · Cited by 22
Perović, M., Wugalter, K. A., & Einstein, G. (2022) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2022.101038 · Cited by 21
Tao, T., Li, S., Zhao, A., Zhang, Y., & Liu, W. Y. (2012) · European Journal of Endocrinology · doi:10.1530/eje-12-0340 · Cited by 20
Elevated Circulating Levels of Tissue Factor in Polycystic Ovary Syndrome
González, F., Kirwan, J. P., Rote, N. S., & Minium, J. (2012) · Clinical and Applied Thrombosis/Hemostasis · doi:10.1177/1076029612436673 · Cited by 21
Self-citationHemostatic and Fibrinolytic Abnormalities in Polycystic Ovary Syndrome
Zoppini, G., Bonora, E., Moghetti, P., & Targher, G. (2014) · Seminars in Thrombosis and Hemostasis · doi:10.1055/s-0034-1384512 · Cited by 21
Morrison, S. A., Goss, A. M., Azziz, R., Raju, D. A., & Gower, B. A. (2016) · Human Reproduction · doi:10.1093/humrep/dew279 · Cited by 21
Luo, Y.-S., He, Q., Sun, M.-X., Qiao, F.-X., Liu, Y., Xu, C.-L., Xu, Z., Zhao, S.-C., Wang, H., Qi, Z., et al. (2022) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2022.109934 · Cited by 20
Zhang, W., Wu, Y., Yuan, Y., Wang, L., Yu, B., Li, X., Yao, Z., & Liang, B. (2024) · Computers in Biology and Medicine · doi:10.1016/j.compbiomed.2024.109239 · Cited by 21
Atabekoğlu, C. S., Sönmezer, M., Özmen, B., Gürsoy, A. Y., Akbıyık, F., Taşçı, T., & Aytaç, R. (2010) · Fertility and Sterility · doi:10.1016/j.fertnstert.2010.08.030 · Cited by 20
Alpha Lipoic Acid Efficacy in PCOS Treatment: What Is the Truth?
Guarano, A., Capozzi, A., Cristodoro, M., Simone, N. D., & Lello, S. (2023) · Nutrients · doi:10.3390/nu15143209 · Cited by 26
Decreased Adiponectin Levels in Polycystic Ovary Syndrome, Independent of Body Mass Index
Sharifi, F., Hajihosseini, R., Mazloomi, S., Amirmogaddami, H., & Nazem, H. (2009) · Metabolic Syndrome and Related Disorders · doi:10.1089/met.2009.0036 · Cited by 19
Saturated fat ingestion stimulates proatherogenic inflammation in polycystic ovary syndrome
González, F., Considine, R. V., Abdelhadi, O. A., Xue, J., & Acton, A. J. (2021) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00213.2021 · Cited by 24
Self-citationHepatic steatosis in overweight/obese females: Newscreening method for those at risk
Tarantino, G., Pizza, G., Colao, A., Pasanisi, F., Conca, P., Colicchio, P., Finelli, C., Contaldo, F., Somma, C. D., & Savastano, S. (2009) · World Journal of Gastroenterology · doi:10.3748/wjg.15.5693 · Cited by 18
Koiou, E., Τζιόμαλος, Κ., Dinas, K. D., Katsikis, I., Kandaraki, E., Tsourdi, E. A., Mavridis, S., & Panidis, D. (2011) · Endocrine Journal · doi:10.1507/endocrj.ej11-0023 · Cited by 18
BALDANI, D. P., SKRGATIC, L., CERNE, J. Z., OGUIC, S. K., GERSAK, B. M., & GERSAK, K. (2015) · Molecular Medicine Reports · doi:10.3892/mmr.2014.3117 · Cited by 18
Adipose-androgen crosstalk in polycystic ovary syndrome: mechanisms and therapeutic implications
Ni, M., Lei, H., Ye, T., & Wang, Y. (2025) · Frontiers in Endocrinology · doi:10.3389/fendo.2025.1731179 · Cited by 25
Polycystic Ovary Syndrome: Focus on Platelets and Prothrombotic Risk
Dasanu, C. A., Clark, B. A., Ichim, T. E., & Alexandrescu, D. T. (2011) · Southern Medical Journal · doi:10.1097/smj.0b013e31820c0172 · Cited by 17
Pepene, C. E. (2012) · Gynecological Endocrinology · doi:10.3109/09513590.2011.632792 · Cited by 17
Yousuf, S. D., Rashid, F., Mattoo, T., Shekhar, C., Mudassar, S., Zargar, M. A., & Ganie, M. A. (2016) · Journal of Pediatric and Adolescent Gynecology · doi:10.1016/j.jpag.2016.06.010 · Cited by 16
Yamada‐Nomoto, K., Yoshino, O., Akiyama, I., Iwase, A., Ono, Y., Nakamura, T., Harada, M., Nakashima, A., Shima, T., Ushijima, A., et al. (2017) · American Journal of Reproductive Immunology · doi:10.1111/aji.12669 · Cited by 16
Diagnostic and prognostic biomarkers in Polycystic Ovary Syndrome
Singh, I., Moar, K., & Maurya, P. K. (2025) · Clinica Chimica Acta · doi:10.1016/j.cca.2025.120425 · Cited by 18
Kılıç, D., Kılıç, İ. D., Sevgican, C. İ., Kilic, O., Alataş, E., Arslan, M., Avcı, E., & Güler, T. (2020) · Journal of obstetrics and gynaecology research · doi:10.1111/jog.14543 · Cited by 15
Relation between C-reactive protein and body mass index in patients with polycystic ovarian syndrome
Moradi, S., Mollabashi, M., & Kerman, S. R. J. (2010) · Gynecological Endocrinology · doi:10.3109/09513590.2010.501876 · Cited by 15
Ibuprofen Reduces Testosterone Level in Women With Polycystic Ovary Syndrome
Banaszewska, B., Ożegowska, K., Polska, M., Pawelczyk, L. A., Chang, R. J., & Dulęba, A. J. (2022) · Journal of the Endocrine Society · doi:10.1210/jendso/bvac128 · Cited by 14
Dogan, B. A., Arduç, A., Tuna, M. M., Karakılıç, E., Duran, İ. D., Tütüncü, Y., Berker, D. S., & Güler, S. (2014) · Intern J Endocrinol Metab · doi:10.5812/ijem.18642 · Cited by 14
Rey-Roldán, E. B., Lana, M. B. P., Galluzzo, L., Blanco, G., Onetto, C., Straminsky, V., & Nolting, M. (2012) · Gynecological Endocrinology · doi:10.3109/09513590.2012.730581 · Cited by 14
Cavalcante, R. B. D. M., Leão, L. M. C. S. M., Tavares, A. B. W., Lopes, K. G., & Kraemer‐Aguiar, L. G. (2024) · Hormone and Metabolic Research · doi:10.1055/a-2386-9281 · Cited by 13
Genetic Variation in the Mcp-1 Gene Promoter Associated with the Risk of Polycystic Ovary Syndrome
Li, L., Ryoo, J. E., Lee, K.-J., Choi, B. C., & Baek, K. (2015) · PLoS ONE · doi:10.1371/journal.pone.0123045 · Cited by 13
Impact of interlukin-6 on central obesity measures in women with polycystic ovarian syndrome
Alissa, E. M., Algarni, S. A., Khaffji, A. J., & Mansouri, N. M. A. (2020) · Journal of Obstetrics and Gynaecology · doi:10.1080/01443615.2019.1697219 · Cited by 13
Increased serum C-reactive protein levels in normal weight women with polycystic ovary syndrome.
Makedos, A., Goulis, D. G., Arvanitidou, M., Mintziori, G., Papanikolaou, A., Makedou, A., & Panidis, D. (2011) · PubMed Central · Cited by 13
Makedos, A., Goulis, D. G., Papanikolaou, A., & Panidis, D. (2010) · Angiology · doi:10.1177/0003319709361198 · Cited by 13
The polycystic ovary syndrome (pcos) status and cardiovascular risk in young women
Ilie, I. R. P., Pepene, C. E., Marian, I., Mocan, T., Hazi, G. M., Dragotoiu, G., Ilie, R., MOCAN, L. C., & Duncea, I. (2010) · Open Medicine · doi:10.2478/s11536-010-0054-1 · Cited by 11
Evidence of mononuclear cell preactivation in the fasting state in polycystic ovary syndrome
González, F., Kirwan, J. P., Rote, N. S., & Minium, J. (2014) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2014.06.044 · Cited by 10
Self-citationOn the Intimate Relationship of Adiposity to Polycystic Ovary Syndrome
Rosenfield, R. L., & Dumesic, D. A. (2025) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgaf527 · Cited by 11
Polycystic ovary syndrome and related inflammation in radiomics; relationship with patient outcome
Zheng, C.-Y., Yu, Y., & Bai, X. (2023) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2023.02.013 · Cited by 9
Effect of colchicine on polycystic ovary syndrome: an experimental study
Gözükara, İ., Pınar, N., Özcan, O., Özgür, T., Dokuyucu, R., Kurt, R. K., Kucur, S. K., & Aksoy, A. N. (2015) · Archives of Gynecology and Obstetrics · doi:10.1007/s00404-015-3933-5 · Cited by 9
Aldrighi, J. M., Tsutsui, J. M., Kowastch, I., Ribeiro, A. L., Scapinelli, A., Tamanaha, S., de Oliveira, R. M., & Mathias, W. (2014) · Echocardiography · doi:10.1111/echo.12849 · Cited by 9
Ferreira, S. R., Goyeneche, A. A., Heber, M. F., Abruzzese, G. A., Ferrer, M. J., Telleria, C. M., & Motta, A. B. (2021) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2020.111045 · Cited by 8
Polycystic ovary syndrome and immune deregulation: what do hormones want to say?
Johnson, B. S., & Laloraya, M. (2022) · Exploration of Immunology · doi:10.37349/ei.2022.00058 · Cited by 8
Lam, U. D. P., Lerchbaum, E., Schweighofer, N., Trummer, O., Eberhard, K., Genser, B., Pieber, T. R., & Obermayer-Pietsch, B. M. (2014) · Gene · doi:10.1016/j.gene.2013.12.055 · Cited by 8
Serum lipoprotein(a) and lipid profile in polycystic ovarian syndrome
Ravi, B. V., Swetha, R., & Nalini, K. (2015) · The Journal of Clinical and Scientific Research · doi:10.15380/2277-5706.jcsr.14.007 · Cited by 8
Kunjantarachot, A., Pabalan, N., Jarjanazi, H., Christofolini, D. M., Montagna, E., Barbosa, C. P., & Bianco, B. A. V. (2020) · Reproductive Biology and Endocrinology · doi:10.1186/s12958-020-00665-1 · Cited by 7
Balık, A. Ö., Vural, F., Alpoğan, O., Özoğul, M., & Dönmez, E. E. (2022) · Gynecological Endocrinology · doi:10.1080/09513590.2022.2112942 · Cited by 7
Yousuf, S. D., Ganie, M. A., Zargar, M. A., Parvez, T., & Rashid, F. (2016) · Asian Pacific Journal of Cancer Prevention · doi:10.7314/apjcp.2016.17.3.1583 · Cited by 7
Noroozzadeh, M., Behboudi‐Gandevani, S., Mosaffa, N., Tohidi, M., & Tehrani, F. R. (2019) · Gynecological Endocrinology · doi:10.1080/09513590.2019.1576613 · Cited by 8
Obesity, Metabolic Dysfunction, and Inflammation in Polycystic Ovary Syndrome
Aubuchon, M., Bickhaus, J. A., & González, F. (2013) · Springer eBooks · doi:10.1007/978-1-4614-8394-6_8 · Cited by 7
Self-citation
Metadata
- Authors
- González, F., Rote, N. S., Minium, J., & Kirwan, J. P.
- Affiliations
- Mayo Clinic (US)
- Case Western Reserve University (US)
- Cleveland Clinic (US)
- Corresponding author
- González, Frank
- Venue
- Metabolism
- Publisher
- Elsevier BV
- Published
- 2009-07
- Volume
- 58
- Issue
- 7
- Pages
- 954-962
- ISSN
- 0026-0495 (ISSN-L)
- PMC
- PMC2737595
- OpenAlex
- W1968511949
- Cited by
- 135
- References
- 59
- Citations by year
- 2026: 4 · 2025: 7 · 2024: 6 · 2023: 8 · 2022: 10 · 2021: 5 · 2020: 6 · 2019: 6 · 2018: 6 · 2017: 3 · 2016: 10 · 2015: 7 · 2014: 13 · 2013: 3 · 2012: 16
- FWCI
- 16.15
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health
- University at Buffalo
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (HD-048535, R03HD048535)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Keywords
- polycystic ovary syndrome, low-grade inflammation, atherogenesis, obesity, truncal fat, interleukin-6, soluble intercellular adhesion molecule-1, MCP-1, C-reactive protein, plasminogen activator inhibitor-1, MMP-2, nuclear factor-kappaB, hyperglycemia, insulin resistance, androstenedione, blood pressure, dyslipidemia, fasting insulin
- MeSH terms
- Adult, Androgens, C-Reactive Protein, Female, Glucose Tolerance Test, Humans, Obesity, Polycystic Ovary Syndrome, Absorptiometry, Photon, Interleukin-6, NF-kappa B, Plasminogen Activator Inhibitor 1, Intercellular Adhesion Molecule-1, Chemokine CCL2, Matrix Metalloproteinase 2, Electrophoretic Mobility Shift Assay, Atherosclerosis, Young Adult
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
