Cited by 327Ovarian function and disordersEndometriosis Research and TreatmentReproductive Biology and Fertility

Is PCOS an inflammatory process?

Open access
Duleba, Antoni J., Dokras, Anuja·2012·Fertility and Sterility

Abstract

PRO--PCOS is associated with low-grade systemic inflammation as evidenced by elevation of multiple markers of inflammation such as C-reactive protein, interleukin-18, monocyte chemoattractant protein-1 and white blood cell count as well as endothelial dysfunction and increased oxidative stress. CON--Current studies examining the evidence for low grade inflammation in PCOS are small, heterogeneous for the diagnosis, confounded by degree of adiposity and do not consistently demonstrate a clinically relevant increase in the above mentioned biomarkers.

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Crossref · 10.1016/j.fertnstert.2011.11.023

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  1. [8]Ridker PM Buring JE Cook NR Rifai N C-reactive protein, the metabolic syndrome, and risk of incident cardiovascular events: an 8-year follow-up of 14 719 initially healthy American women Circulation 2003 107 391 7 12551861
  2. [63]Ridker PM C-reactive protein and the prediction of cardiovascular events among those at intermediate risk: moving an inflammatory hypothesis toward consensus J Am Coll Cardiol 2007 49 2129 38 17531663

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Authors
Duleba, A. J., & Dokras, A.
Affiliations
University of Pennsylvania (US)
Venue
Fertility and Sterility
Publisher
Elsevier BV
Published
2012-01
Volume
97
Issue
1
Pages
7-12
ISSN
0015-0282 (ISSN-L)
OpenAlex
W2087004090
Cited by
327
References
68
Citations by year
2026: 16 · 2025: 29 · 2024: 40 · 2023: 34 · 2022: 35 · 2021: 38 · 2020: 27 · 2019: 26 · 2018: 19 · 2017: 18 · 2016: 12 · 2015: 12 · 2014: 14 · 2013: 4 · 2012: 3
FWCI
7.50
Type
journal article
Language
en
Open access
Locations
  • Fertility and Sterility (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
Eunice Kennedy Shriver National Institute of Child Health and Human Development (R01HD050656)
Topics
  • Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
  • Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Reproductive Biology and Fertility
Keywords
polycystic ovary syndrome, low-grade inflammation, C-reactive protein, IL-18, MCP-1, white blood cell count, endothelial dysfunction, oxidative stress, adiposity
MeSH terms
C-Reactive Protein, Female, Humans, Infections, Inflammation, Ovary, Polycystic Ovary Syndrome, Vasculitis, Biomarkers, Cytokines, Glycation End Products, Advanced, Oxidative Stress, Atherosclerosis

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