Smoking cessation predicts amelioration of microalbuminuria in newly diagnosed type 2 diabetes mellitus: a 1-year prospective study
Abstract
The objective of the study was to assess the effect of smoking cessation on microalbuminuria in subjects with newly diagnosed type 2 diabetes mellitus (DM). From 500 smokers newly diagnosed with type 2 DM and microalbuminuria, only 193 (96 men/97 women; age, 56.4 ± 7.8 years) agreed to participate and were educated on smoking cessation, diet, and exercise. Pharmacological interventions were not different among the studied groups. All subjects were contacted by phone monthly with emphasis on smoking cessation. Anthropometric, biochemical parameters and urine specimens were obtained at baseline and at 12-month follow-up. Microalbuminuria was defined as an albumin to creatinine ratio of 30 to 299.9 μg/mg creatinine. Ankle brachial pressure index was determined by ultrasound. A total of 120 (62.2%) subjects quit smoking. Prevalence of microalbuminuria was reduced at 1 year to 72.6% in the subjects who quit smoking and to 22.5% in those who continued smoking (P = .015). Multivariate logistic regression analysis demonstrated that independently associated with the reduction in albumin to creatinine ratio (84.8 vs 28.7 μg/mg creatinine) were amelioration of glycemic control (P < .001), blood pressure (P = .02), dyslipidemia (P = .02), and insulin resistance (P = .05). Smoking cessation also reduced the prevalence of peripheral vascular disease (P = .03) and neuropathy (P = .04). From the pharmacological and lifestyle interventions, smoking cessation had the highest and an independent contribution to the reduction of microalbuminuria (P < .001). Smoking cessation in newly diagnosed type 2 DM patients is associated with amelioration of metabolic parameters, blood pressure, and the reduction of microalbuminuria. Stricter counseling about the importance of quitting smoking upon type 2 DM diagnosis is necessary to protect against the development of diabetic nephropathy and vascular complications.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In people who smoke with newly diagnosed type 2 diabetes, smoking cessation is associated with amelioration of metabolic parameters and reduced blood pressure and albuminuria at 1 year.
“One study in people who smoke who had newly diagnosed type 2 diabetes found that smoking cessation was associated with amelioration of metabolic parameters and reduced blood pressure and albuminuria at 1 year (293).”
From 5. Facilitating Positive Health Behaviors and Well-being to Improve Health Outcomes:<i>Standards of Care in Diabetes—2023</i> (2023) · cites this paper as [293]
Cites
International physical activity questionnaire: 12-country reliability and validity
CRAIG, C. L., MARSHALL, A. L., SJ??STR??M, M., BAUMAN, A. E., BOOTH, M. L., AINSWORTH, B. E., PRATT, M., EKELUND, U., YNGVE, A., SALLIS, J. F., et al. (2003) · Medicine & Science in Sports & Exercise · doi:10.1249/01.mss.0000078924.61453.fb · Cited by 21,619 · see citing works
Diagnosis and Classification of Diabetes Mellitus
American Diabetes Association (2010) · Diabetes Care · doi:10.2337/dc11-s062 · Cited by 14,019 · see citing works
Multifactorial intervention and cardiovascular disease in patients with type 2 diabetes
Gæde, P., Vedel, P., Larsen, N., Jensen, G. V. H., Parving, H.-H., & Pedersen, O. (2003) · New England Journal of Medicine · doi:10.1056/nejmoa021778 · Cited by 4,378 · see citing works
Treating tobacco use and dependence-Clinical practice guideline
Mc, F. (2000) · Medical Entomology and Zoology · Cited by 3,616 · see citing works
Treating Tobacco Use and Dependence
(2008) · PEDIATRICS · doi:10.1542/peds.2008-1627 · Cited by 2,701 · see citing works
Anderson, E. N. (1977) · Journal of California Anthropology, The · Cited by 2,550 · see citing works
Microalbuminuria Predicts Clinical Proteinuria and Early Mortality in Maturity-Onset Diabetes
Mogensen, C. E. (1984) · New England Journal of Medicine · doi:10.1056/nejm198402093100605 · Cited by 1,918 · see citing works
Diabetic nephropathy: diagnosis, prevention, and treatment
Gross, J. L., de Azevedo, M. J., Silveiro, S. P., Canani, L. H., Caramori, M. L., & Zelmanovitz, T. (2005) · Diabetes Care · doi:10.2337/diacare.28.1.164 · Cited by 1,839 · see citing works
Adler, A., Stevens, R., Manley, S. E., Bilous, R., Cull, C. A., Holman, R. R., & UKPDS Group (2003) · Kidney International · doi:10.1046/j.1523-1755.2003.00712.x · Cited by 1,800 · see citing works
Diagnosis and Classification of Diabetes Mellitus
American Diabetes Association (2004) · Diabetes Care · doi:10.2337/diacare.27.2007.s5 · Cited by 1,668 · see citing works
Vascular risk factors and diabetic neuropathy
Tesfaye, S., Chaturvedi, N., Eaton, S. E. M., Ward, J. D., Manes, C., Ionescu-Tirgoviste, C., Witte, D. R., & Fuller, J. H. (2005) · New England Journal of Medicine · doi:10.1056/nejmoa032782 · Cited by 1,323 · see citing works
Cryer, P. E., Haymond, M. W., Santiago, J. V., & Shah, S. D. (1976) · New England Journal of Medicine · doi:10.1056/nejm197609092951101 · Cited by 1,101 · cited 2× · see citing works
“[42] Cryer PE, Haymond MW, Santiago JV, et al.”
BackgroundAmerican Diabetes Association (2004) · Diabetes Care · doi:10.2337/diacare.27.2007.s79 · Cited by 1,034 · see citing works
Stress Hormones, Proinflammatory and Antiinflammatory Cytokines, and Autoimmunity
ELENKOV, I. J., & CHROUSOS, G. P. (2002) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2002.tb04229.x · Cited by 983 · see citing works
Adverse Health Effects of Chronic Exposure to Low-Level Cadmium in Foodstuffs and Cigarette Smoke
Satarug, S., & Moore, M. R. (2004) · Environmental Health Perspectives · doi:10.1289/ehp.6751 · Cited by 871 · see citing works
Regression of Microalbuminuria in Type 1 Diabetes
Perkins, B. A., Ficociello, L., Silva, K. H., Finkelstein, D. M., Warram, J. H., & Królewski, A. S. (2003) · New England Journal of Medicine · doi:10.1056/nejmoa021835 · Cited by 799 · see citing works
Pirkle, J. L. (1996) · JAMA · doi:10.1001/jama.275.16.1233 · Cited by 707 · see citing works
Poggio, E. D., Wang, X., Greene, T., Lente, F. V., & Hall, P. M. (2004) · Journal of the American Society of Nephrology · doi:10.1681/asn.2004060447 · Cited by 643 · see citing works
Parving, H., Lewis, J., Ravid, M., Remuzzi, G., & Hunsicker, L. (2006) · Kidney International · doi:10.1038/sj.ki.5000377 · Cited by 527 · see citing works
Cost-Effectiveness of Interventions to Prevent and Control Diabetes Mellitus: A Systematic Review
Li, R., Zhang, P., Barker, L. E., Chowdhury, F. M., & Zhang, X. (2010) · Diabetes Care · doi:10.2337/dc10-0843 · Cited by 491 · see citing works
Kondo, T., Hayashi, M., Takeshita, K., Numaguchi, Y., Kobayashi, K., Iino, S., Inden, Y., & Murohara, T. (2004) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000135655.52088.c5 · Cited by 456 · see citing works
Peripheral arterial disease in diabetes—a review
Jude, E., Eleftheriadou, I., & Tentolouris, N. (2010) · Diabetic Medicine · doi:10.1111/j.1464-5491.2009.02866.x · Cited by 321 · see citing works
Self-citationCigarette Smoking Influences Cytokine Production and Antioxidant Defences
Tappia, P. S., Troughton, K. L., Langley‐Evans, S. C., & Grimble, R. F. (1995) · Clinical Science · doi:10.1042/cs0880485 · Cited by 222 · see citing works
Voulgari, Tentolouris, N., & Papadogiannis, D. E. (2010) · Vascular Health and Risk Management · doi:10.2147/vhrm.s11681 · Cited by 208 · see citing works
Self-citationEffects of Smoking and Smoking Cessation on Endothelial Function
Johnson, H. M., Gossett, L. K., Piper, M. E., Aeschlimann, S. E., Korcarz, C. E., Baker, T. B., Fiore, M. C., & Stein, J. H. (2010) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2010.03.002 · Cited by 193 · see citing works
Broms, U., Silventoinen, K., Lahelma, E. T., Koskenvuo, M. J., & Kaprio, J. A. (2004) · Nicotine & Tobacco Research · doi:10.1080/14622200410001696637 · Cited by 177 · see citing works
Orth, S. R. (2002) · Journal of the American Society of Nephrology · doi:10.1097/01.asn.0000018401.82863.fd · Cited by 176 · see citing works
Mortality in Diabetic and Nondiabetic Patients After Amputations Performed From 1990 to 1995
Tentolouris, N., Al-Sabbagh, S., Walker, M. G., et al. (2004) · Diabetes Care · doi:10.2337/diacare.27.7.1598 · Cited by 175 · see citing works
Self-citationTousoulis, D., Andreou, I., Antoniades, C. A., Tentolouris, C. A., & Stefanadis, C. (2008) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2008.05.034 · Cited by 157 · see citing works
Canga‐Armayor, N., de Irala, J., Vara, E., Duaso, M. J., Ferrer, A., & Martínez‐González, M. Á. (2000) · Diabetes Care · doi:10.2337/diacare.23.10.1455 · Cited by 145 · see citing works
Nicotine: the link between cigarette smoking and the progression of renal injury?
Jaimes, E. A., Tian, R.-X., & Raij, L. R. (2006) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00693.2006 · Cited by 143 · see citing works
Kong, C. (2001) · Atherosclerosis · doi:10.1016/s0021-9150(00)00664-x · Cited by 138 · see citing works
Nilsson, P., Guðbjörnsdóttir, S., Eliasson, B., & Cederholm, J. (2004) · Diabetes & Metabolism · doi:10.1016/s1262-3636(07)70117-9 · Cited by 134 · see citing works
Effects of Smoking on Systemic and Intrarenal Hemodynamics
Orth, S. R. (2004) · Journal of the American Society of Nephrology · doi:10.1097/01.asn.0000093461.36097.d5 · Cited by 131 · see citing works
Analysis of Metabolic Parameters as Predictors of Risk in the RENAAL Study
Appel, G. B., Radhakrishnan, J., Avram, M. M., DeFronzo, R. A., Escobar‐Jiménez, F., Campos, M. M., Burgess, E. D., Hille, D. A., Dickson, T. Z., Shahinfar, S., et al. (2003) · Diabetes Care · doi:10.2337/diacare.26.5.1402 · Cited by 108 · see citing works
Cigarette Smoking Exacerbates and Its Cessation Ameliorates Renal Injury in Type 2 Diabetes
Chuahirun, T., Hudson, C., Seipel, T., Khanna, A., Simoni, J. M., Harrist, R. B., & Wesson, D. E. (2004) · The American Journal of the Medical Sciences · doi:10.1097/00000441-200402000-00001 · Cited by 94 · see citing works
Effects of smoking on the heart and peripheral circulation
Trap‐Jensen, J. (1988) · American Heart Journal · doi:10.1016/0002-8703(88)90647-3 · Cited by 94 · see citing works
Effects of smoking on renal function in patients with type 1 and type 2 diabetes mellitus
Orth, S. R., Schroeder, T., Ritz, E., & Ferrari, P. (2005) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/gfi022 · Cited by 85 · see citing works
Panagiotakos, D. B., Pitsavos, C. E., Chrysohoou, C. A., Skoumas, J., Toutouza, M., Belegrinos, D., Toutouzas, P. K., & Stefanadis, C. (2003) · Annals of Epidemiology · doi:10.1016/s1047-2797(03)00117-0 · Cited by 84 · see citing works
Hua, P., Feng, W., Ji, S., et al. (2010) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00293.2010 · Cited by 80 · see citing works
Phisitkul, K., Hegazy, K., Chuahirun, T., Hudson, C., Wesson, D. E., Simoni, J. M., & Rajab, H. (2008) · The American Journal of the Medical Sciences · doi:10.1097/maj.0b013e318156b799 · Cited by 75 · see citing works
Explanations for the Lower Rates of Diabetic Neuropathy in Indian Asians Versus Europeans
Abbott, C. A., Chaturvedi, N., Malik, R. A., Salgami, E. V., Yates, A. P., Pemberton, P. W., & Boulton, A. J. M. (2010) · Diabetes Care · doi:10.2337/dc09-2067 · Cited by 69 · see citing works
Francus, T., Romano, P. M., Manzo, G., et al. (1992) · Cellular Immunology · doi:10.1016/0008-8749(92)90320-o · Cited by 64 · see citing works
Cigarette smoke condensate aggravates renal injury in the renal ablation model
Odoni, G., Ogata, E., Viedt, C., Amann, K., Ritz, E., & Orth, S. R. (2002) · Kidney International · doi:10.1046/j.1523-1755.2002.00382.x · Cited by 62 · see citing works
The gap between guidelines and practice in the treatment of type 2 diabetes
Jenssen, T. G., Tonstad, S., Claudi, T., Midthjell, K., & Cooper, J. G. (2008) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2007.12.025 · Cited by 60 · see citing works
Murray, R. P., Connett, J. E., Istvan, J. A., et al. (2002) · Nicotine & Tobacco Research · doi:10.1080/14622200210141266 · Cited by 59 · see citing works
Boulton, A. J. (1998) · PubMed · Cited by 52 · see citing works
Persson, L., & Hjalmarson, A. I. M. (2006) · Scandinavian Journal of Primary Health Care · doi:10.1080/02813430500439395 · Cited by 50 · see citing works
Added benfluorex in obese insulin-requiring type 2 diabetes.
Leuténegger, M., Bauduceau, B., Brun, J., et al. (1998) · PubMed · Cited by 50 · see citing works
Identification and management of diabetic nephropathy in the diabetes clinic.
Craig, K., Donovan, K., Munnery, M., Owens, D., Williams, J. D., & Phillips, A. (2003) · Diabetes Care · doi:10.2337/diacare.26.6.1806 · Cited by 47 · see citing works
Takahashi, N., Anan, F., Nakagawa, M., et al. (2004) · Metabolism · doi:10.1016/j.metabol.2004.03.024 · Cited by 40 · see citing works
Matsui, Y., Kario, K., Ishikawa, J., et al. (2005) · Hypertension Research · doi:10.1291/hypres.28.631 · Cited by 36 · see citing works
Sauriasari, R., Sakano, N., Wang, D.-H., et al. (2010) · Hypertension Research · doi:10.1038/hr.2010.154 · Cited by 36 · see citing works
Clinical impact of reducing microalbuminuria in patients with type 2 diabetes mellitus
Araki, S., Haneda, M., Koya, D., Kashiwagi, A., Uzu, T., & Kikkawa, R. (2008) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2008.09.031 · Cited by 35 · see citing works
New Biochemical Markers in Acute Coronary Syndromes
Tousoulis, D., Kampoli, A., Stefanadi, E., et al. (2008) · Current Medicinal Chemistry · doi:10.2174/092986708784534965 · Cited by 34 · see citing works
Learning from large cardiovascular clinical trials: classical cardiovascular risk factors.
Kempler, P. (2005) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2005.03.005 · Cited by 30 · see citing works
Voulgari, C., Moyssakis, I. E., Perrea, D. N., Kyriaki, D., Katsilambros, N. L., & Tentolouris, N. (2010) · Diabetic Medicine · doi:10.1111/j.1464-5491.2010.03120.x · Cited by 30 · see citing works
Self-citationAnan, F., Shimomura, T., Kaku, T., Kaneda, K., Imagawa, M., Tsukagawa, H., Masaki, T., Nawata, T., Yonemochi, H., Eshima, N., et al. (2007) · Metabolism · doi:10.1016/j.metabol.2007.08.007 · Cited by 25 · see citing works
Anan, F., Shimomura, T., Imagawa, M., et al. (2007) · Metabolism · doi:10.1016/j.metabol.2007.01.003 · Cited by 24 · see citing works
Lipoprotein (a) as a risk factor for silent cerebral infarction in hemodialysis patients
Fukunaga, N., Anan, F., Kaneda, K., et al. (2008) · Metabolism · doi:10.1016/j.metabol.2008.01.033 · Cited by 10 · see citing works
Poulsen, M. K., Henriksen, J. E., Vach, W., Dahl, J. S., Møller, J. E., Johansen, A. H. D., Gerke, O., Haghfelt, T. H., Høilund‐Carlsen, P. F., & Beck‐Nielsen, H. (2010) · Diabetologia · doi:10.1007/s00125-009-1646-7 · Cited by 10 · see citing works
Albareda, M., Sánchez, L., González, J., et al. (2009) · Metabolism · doi:10.1016/j.metabol.2009.03.028 · Cited by 9 · see citing works
Anan, F., Masaki, T., Takahashi, N., Nakagawa, M., Yonemochi, H., Eshima, N., Saikawa, T., & Yoshimatsu, H. (2007) · Metabolism · doi:10.1016/j.metabol.2006.10.001 · Cited by 8 · see citing works
de Valk (1998) · doi:10.1002/(sici)1096-9136(199806)15:6
Flagged first, then by citations
Cited by
Sorted by citations
Standards of medical care in diabetes—2014
American Diabetes Association (2014) · Diabetes Care · doi:10.2337/dc14-s014 · Cited by 4,572 · see citing works
Standards of medical care in diabetes—2013
American Diabetes Association (2013) · Diabetes Care · doi:10.2337/dc13-s011 · Cited by 4,369 · see citing works
5. Lifestyle Management:<i>Standards of Medical Care in Diabetes—2019</i>
American Diabetes Association (2019) · Diabetes Care · doi:10.2337/dc19-s005 · Cited by 700 · see citing works
4. Lifestyle Management: <i>Standards of Medical Care in Diabetes—2018</i>
American Diabetes Association (2018) · Diabetes Care · doi:10.2337/dc18-s004 · Cited by 563 · see citing works
ElSayed, N. A., Aleppo, G., Aroda, V. R., Bannuru, R. R., Brown, F. M., Bruemmer, D., Collins, B. S., Hilliard, M. E., Isaacs, D., Johnson, E. L., et al. (2023) · Diabetes Care · doi:10.2337/dc23-s005 · Cited by 362 · see citing works
American Diabetes Association Professional Practice Committee (2022) · Diabetes Care · doi:10.2337/dc22-s005 · Cited by 445 · see citing works
American Diabetes Association Professional Practice Committee, ElSayed, N. A., McCoy, R. G., Aleppo, G., Balapattabi, K., Beverly, E. A., Briggs Early, K., Bruemmer, D., Echouffo-Tcheugui, J. B., Eichorst, B., et al. (2025) · Diabetes Care · doi:10.2337/dc25-s005 · Cited by 305 · see citing works
American Diabetes Association (2017) · Diabetes Care · doi:10.2337/dc17-s007 · Cited by 281 · see citing works
on behalf of CCMR-3B STUDY Investigators, Huang, Y., Li, J., Zhu, X., Sun, J., Ji, L., Hu, D., Pan, C., Tan, W., Jiang, S., et al. (2017) · Acta Diabetologica · doi:10.1007/s00592-017-0981-2 · Cited by 21 · see citing works
- Authors
- Voulgari, C., Katsilambros, N., & Tentolouris, N.
- Affiliations
- Laiko General Hospital of Athens (GR)
- Corresponding author
- Voulgari, Christina
- Venue
- Metabolism
- Publisher
- Elsevier BV
- Published
- 2011-10
- Volume
- 60
- Issue
- 10
- Pages
- 1456-1464
- ISSN
- 0026-0495 (ISSN-L)
- OpenAlex
- W2031537135
- Cited by
- 90
- References
- 64
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 5 · 2023: 8 · 2022: 7 · 2021: 3 · 2020: 6 · 2019: 7 · 2018: 3 · 2017: 9 · 2016: 10 · 2015: 7 · 2014: 6 · 2013: 8 · 2012: 5
- FWCI
- 4.36
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Physiology › Smoking Behavior and Cessation
- Health Sciences › Medicine › Nephrology › Chronic Kidney Disease and Diabetes
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Keywords
- smoking cessation, microalbuminuria, type 2 diabetes, newly diagnosed diabetes, diabetic nephropathy, glycemic control, blood pressure, dyslipidemia, insulin resistance, peripheral vascular disease, diabetic neuropathy, lifestyle intervention, smoking cessation counseling
- MeSH terms
- Smoking Prevention, Aged, Albuminuria, Diabetes Mellitus, Type 2, Diabetic Nephropathies, Female, Humans, Male, Middle Aged, Prognosis, Prospective Studies, Smoking, Time Factors, Prevalence, Smoking Cessation, Age of Onset, Recovery of Function
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
