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Cited by 343Diabetes, Cardiovascular Risks, and LipoproteinsDiabetes Treatment and ManagementDiabetes Management and Education

The DOI matches its Crossref record; 33 of the 33 references it cites were found in a registry or an index.

Effect of lifestyle intervention in patients with type 2 diabetes: A meta-analysis

Open access
Chen, Liang, Pei, Jian-Hao, Kuang, Jian, Chen, Hong-Mei, Chen, Zhong, Li, Zhong-Wen, Yang, Hua-Zhang·2015·Metabolism
DOI 10.1016/j.metabol.2014.10.018
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Abstract

OBJECTIVE: The effect of lifestyle intervention on clinical risk factors in patients with type 2 diabetes is unclear. The aim of this meta-analysis was to evaluate the effects of comprehensive lifestyle change, such as diet, exercise, and education, on clinical markers that are risk-factors for cardiovascular disease in patients with type 2 diabetes. METHODS: We searched Medline, Cochrane, EMBASE, and Google Scholar (up to August 31, 2013) for randomized controlled trials that compared standard of care (control group) with treatment regimens that included changes in lifestyle (intervention group). The primary outcome was reduction in risk factors of cardiovascular disease including body mass index (BMI), glycated hemoglobin (HbA1c), systolic blood pressure (SBP), diastolic blood pressure (DBP), high-density lipoprotein cholesterol (HDL-c), and low-density lipoprotein cholesterol (LDL-c). RESULTS: A total of 16 studies were included in the meta-analysis. The standardized difference in means of change from baseline significantly favored the intervention compared with the control group in BMI (-0.29; 95% CI, -0.52 to -0.06, P=0.014), HbA1c (-0.37; 95% CI, -0.59 to -0.14, P=0.001), SBP (-0.16: 95% CI, -0.29 to -0.03, P=0.016), DBP (-0.27, 95% CI=-0.41 to -0.12, P<0.001). There was no difference between the intervention and control groups in HDL-c (0.05; 95% CI, -0.10 to 0.21; P=0.503) and LDL-c (-0.14; 95% CI, -0.29 to 0.02; P=0.092). CONCLUSIONS: The meta-analysis found that lifestyle intervention showed significant benefit in risk factors that are known to be associated with development of cardiovascular disease in patients with type 2 diabetes.

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Metadata

Authors
Chen, L., Pei, J.-H., Kuang, J., Chen, H.-M., Chen, Z., Li, Z.-W., & Yang, H.-Z.
Affiliations
Guangdong General Hospital (CN)
Corresponding author
Chen, Liang
ORCID
Venue
Metabolism
Publisher
Elsevier BV
Published
2015-02
Volume
64
Issue
2
Pages
338-347
ISSN
0026-0495 (ISSN-L)
DOI
10.1016/j.metabol.2014.10.018
OpenAlex
W2085848038
Cited by
343
References
33
Citations by year
2026: 12 · 2025: 33 · 2024: 28 · 2023: 24 · 2022: 39 · 2021: 43 · 2020: 42 · 2019: 37 · 2018: 26 · 2017: 22 · 2016: 19 · 2015: 17
FWCI
3.13
Type
journal article
Language
en
Open access
Licence
Locations
  • Metabolism (publishedVersion, cc-by-nc-nd)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Education
Keywords
type 2 diabetes, lifestyle intervention, cardiovascular risk factors, HbA1c, body mass index, blood pressure, HDL cholesterol, LDL cholesterol, diet, physical activity, diabetes education
MeSH terms
Cardiovascular Diseases, Combined Modality Therapy, Diabetes Mellitus, Type 2, Diabetic Angiopathies, Humans, Life Style, Risk Factors, Randomized Controlled Trials as Topic, Diabetic Cardiomyopathies

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