Cited by 15Nanoparticle-Based Drug DeliveryBone Tissue Engineering MaterialsAdvanced Drug Delivery Systems

Drug Delivery Based on Nanotechnology for Target Bone Disease

Yang, Xiaosong, Chen, Shizhu, Liu, Xiao, Yu, Miao, Liu, Xiaoguang·2019·Current Drug Delivery

Abstract

Bone diseases are a serious problem in modern human life. With the coming acceleration of global population ageing, this problem will become more and more serious. Due to the specific physiological characteristics and local microenvironment of bone tissue, it is difficult to deliver drugs to the lesion site. Therefore, the traditional orthopedic medicine scheme has the disadvantages of high drug frequency, large dose and relatively strong side effects. How to target deliver drugs to the bone tissue or even target cells is the focus of the development of new drugs. Nano drug delivery system with a targeting group can realize precise delivery of orthopedic drugs and effectively reduce the systemic toxicity. In addition, the application of bone tissue engineering scaffolds and biomedical materials to realize in situ drug delivery also are research hotspot. In this article, we briefly review the application of nanotechnology in targeted therapies for bone diseases.

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Crossref · 10.2174/1567201816666190917123948

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Authors
Yang, X., Chen, S., Liu, X., Yu, M., & Liu, X.
Affiliations
  • Peking University Third Hospital (CN)
  • National Center for Nanoscience and Technology (CN)
Corresponding author
Liu, Xiaoguang
Venue
Current Drug Delivery
Published
2019-12-04
Volume
16
Issue
9
Pages
782-792
ISSN
1567-2018 (ISSN-L)
OpenAlex
W2973952558
Cited by
15
References
107
Citations by year
2025: 2 · 2024: 2 · 2023: 4 · 2022: 3 · 2021: 4
FWCI
0.11
Type
journal article
Language
en
Open access
closed
Locations
  • Current Drug Delivery (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
  • Physical Sciences › Engineering › Biomedical Engineering › Bone Tissue Engineering Materials
  • Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
Keywords
targeted drug delivery, bone disease, nanomedicine, bone scaffolds, local drug delivery, systemic toxicity reduction, population aging
MeSH terms
Animals, Bone Cements, Bone Diseases, Humans, Drug Delivery Systems, Nanotechnology, Tissue Scaffolds

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