Drug Delivery Based on Nanotechnology for Target Bone Disease
Abstract
Bone diseases are a serious problem in modern human life. With the coming acceleration of global population ageing, this problem will become more and more serious. Due to the specific physiological characteristics and local microenvironment of bone tissue, it is difficult to deliver drugs to the lesion site. Therefore, the traditional orthopedic medicine scheme has the disadvantages of high drug frequency, large dose and relatively strong side effects. How to target deliver drugs to the bone tissue or even target cells is the focus of the development of new drugs. Nano drug delivery system with a targeting group can realize precise delivery of orthopedic drugs and effectively reduce the systemic toxicity. In addition, the application of bone tissue engineering scaffolds and biomedical materials to realize in situ drug delivery also are research hotspot. In this article, we briefly review the application of nanotechnology in targeted therapies for bone diseases.
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Due to exosome carriers, great progress in the management of drug delivery to the bone has been made.
“Due to the advent of exosome carriers, great progress in the management of drug delivery to the bone has been made [85].”
From The Therapeutic Potential and Clinical Significance of Exosomes as Carriers of Drug Delivery System (2022) · cites this paper as [85]
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- Authors
- Yang, X., Chen, S., Liu, X., Yu, M., & Liu, X.
- Affiliations
- Peking University Third Hospital (CN)
- National Center for Nanoscience and Technology (CN)
- Corresponding author
- Liu, Xiaoguang
- Venue
- Current Drug Delivery
- Publisher
- Bentham Science Publishers Ltd.
- Published
- 2019-12-04
- Volume
- 16
- Issue
- 9
- Pages
- 782-792
- ISSN
- 1567-2018 (ISSN-L)
- OpenAlex
- W2973952558
- Cited by
- 15
- References
- 107
- Citations by year
- 2025: 2 · 2024: 2 · 2023: 4 · 2022: 3 · 2021: 4
- FWCI
- 0.11
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Current Drug Delivery (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Physical Sciences › Engineering › Biomedical Engineering › Bone Tissue Engineering Materials
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
- Keywords
- targeted drug delivery, bone disease, nanomedicine, bone scaffolds, local drug delivery, systemic toxicity reduction, population aging
- MeSH terms
- Animals, Bone Cements, Bone Diseases, Humans, Drug Delivery Systems, Nanotechnology, Tissue Scaffolds
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