The DOI matches its Crossref record; 53 of the 53 references it cites were found in a registry or an index.
Candida albicans biofilms: building a heterogeneous, drug-tolerant environment
Abstract
Fungi are able to form biofilms on medical implants, causing serious infections. A better understanding of fungal biofilm formation is necessary to develop tools for detection or prevention and to identify new antifungal strategies. This review explores recent advances in the characterization at the molecular level of fungal biofilms, especially those formed by the yeast Candida albicans: the identification of complex transcriptional networks that control their formation; the pivotal role of the extracellular matrix in biofilm antifungal tolerance; and the knowledge gained on the physiology of biofilm cells and heterogeneity within these communities. These findings may help develop new, targeted therapeutic strategies.
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“In addition to the 6 master transcriptional regulators discussed above, another 44 transcriptional regulators have been identified; if any of these is deleted, some aspect of C. albicans biofilm formation is affected under at least one condition (Table 1; revised from 61 and 18).”
From Candida albicans Biofilms and Human Disease (2015) · cites this paper as [18]
In the citing paper
“Current antifungal drugs have only two specific targets (ergosterol biosynthesis and 1,3-β-D-glucan synthesis)”
From Candida albicans Biofilms and Human Disease (2015) · cites this paper as [18]
In the citing paper
“and it is widely believed that antifungal drugs with new mechanisms of action are needed (4, 18, 79).”
From Candida albicans Biofilms and Human Disease (2015) · cites this paper as [18]
Citations
Cites
Bacterial Biofilms: A Common Cause of Persistent Infections
Costerton, J. W., Stewart, P. S., & Greenberg, E. P. (1999) · Science · doi:10.1126/science.284.5418.1318 · Cited by 12,167
Flemming, H.-C., & Wingender, J. (2010) · Nature Reviews Microbiology · doi:10.1038/nrmicro2415 · Cited by 10,137
Biofilms: Survival Mechanisms of Clinically Relevant Microorganisms
Donlan, R. M., & Costerton, J. W. (2002) · Clinical Microbiology Reviews · doi:10.1128/cmr.15.2.167-193.2002 · Cited by 6,644
Biofilms as Complex Differentiated Communities
Stoodley, P., Sauer, K., Davies, D. G., & Costerton, J. W. (2002) · Annual Review of Microbiology · doi:10.1146/annurev.micro.56.012302.160705 · Cited by 3,151
Physiological heterogeneity in biofilms
Stewart, P. S., & Franklin, M. J. (2008) · Nature Reviews Microbiology · doi:10.1038/nrmicro1838 · Cited by 2,483
Chandra, J., Kuhn, D. M., Mukherjee, P. K., Hoyer, L. L., McCormick, T., & Ghannoum, M. A. (2001) · Journal of Bacteriology · doi:10.1128/jb.183.18.5385-5394.2001 · Cited by 1,578
Evolving concepts in biofilm infections
Hall‐Stoodley, L., & Stoodley, P. (2009) · Cellular Microbiology · doi:10.1111/j.1462-5822.2009.01323.x · Cited by 1,138
A Recently Evolved Transcriptional Network Controls Biofilm Development in Candida albicans
Nobile, C. J., Fox, E. P., Nett, J. E., Sorrells, T. R., Mitrovich, Q. M., Hernday, A. D., Tuch, B. B., Andes, D. R., & Johnson, A. D. (2012) · Cell · doi:10.1016/j.cell.2011.10.048 · Cited by 711
Genetic control of Candida albicans biofilm development
Finkel, J. S., & Mitchell, A. P. (2010) · Nature Reviews Microbiology · doi:10.1038/nrmicro2475 · Cited by 641
Biofilm formation by Candida species on the surface of catheter materials in vitro
Hawser, S. P., & Douglas, L. J. (1994) · Infection and Immunity · doi:10.1128/iai.62.3.915-921.1994 · Cited by 599
Cited by
Sorted by citations
The Fungal Cell Wall: Structure, Biosynthesis, and Function
Gow, N. A. R., Latge, J.-P., & Munro, C. A. (2017) · Microbiology Spectrum · doi:10.1128/microbiolspec.funk-0035-2016 · Cited by 1,423
Candida albicans Biofilms and Human Disease
Nobile, C. J., & Johnson, A. D. (2015) · Annual Review of Microbiology · doi:10.1146/annurev-micro-091014-104330 · Cited by 1,057
Candida albicans—The Virulence Factors and Clinical Manifestations of Infection
Talapko, J., Juzbašić, M., Matijević, T., Pustijanac, E., Bekić, S., Kotris, I., & Škrlec, I. (2021) · Journal of Fungi · doi:10.3390/jof7020079 · Cited by 794
“The biofilm cells form a hypoxic environment and increase the expression of genes involved in glycolysis, fatty acid metabolism, and ergosterol synthesis [45].”
BackgroundCandida albicans biofilms: development, regulation, and molecular mechanisms
Gulati, M., & Nobile, C. J. (2016) · Microbes and Infection · doi:10.1016/j.micinf.2016.01.002 · Cited by 738
Mechanisms of Antifungal Drug Resistance
Cowen, L. E., Sanglard, D., Howard, S. J., Rogers, P. D., & Perlin, D. S. (2015) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a019752 · Cited by 647
Metadata
- Authors
- Bonhomme, J., & d’Enfert, C.
- Affiliations
- Centre Hospitalier Universitaire de Caen Normandie (FR)
- Institut Pasteur (FR)
- Corresponding author
- d’Enfert, Christophe
- Venue
- Current Opinion in Microbiology
- Publisher
- Elsevier BV
- Published
- 2013-08
- Volume
- 16
- Issue
- 4
- Pages
- 398-403
- ISSN
- 1369-5274 (ISSN-L)
- OpenAlex
- W2077255553
- Cited by
- 120
- References
- 53
- Citations by year
- 2026: 3 · 2025: 8 · 2024: 7 · 2023: 7 · 2022: 1 · 2021: 8 · 2020: 4 · 2019: 11 · 2018: 11 · 2017: 9 · 2016: 12 · 2015: 16 · 2014: 16 · 2013: 6
- FWCI
- 2.21
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Current Opinion in Microbiology (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion)
- Funders
- Agence Nationale de la Recherche (ANR-08-MIE-033-01, ANR-10-01)
- French Government's Investissement d’Avenir program, Laboratoire d’Excellence (ANR-10-LABX-62-IBEID)
- European Commission (PITN-GA-2008-214004)
- Fondation pour la Recherche Médicale (DEA20080713005)
- Topics
- Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bacterial biofilms and quorum sensing
- Keywords
- Candida albicans, fungal biofilms, biofilm heterogeneity, antifungal drug tolerance, extracellular matrix, transcriptional regulatory networks, biofilm physiology, medical device infections
- MeSH terms
- Antifungal Agents, Candida albicans, Drug Tolerance, Biofilms
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