How to build a biofilm: a fungal perspective

Blankenship, Jill R; Mitchell, Aaron P

doi:10.1016/j.mib.2006.10.003

Cited by 530Antifungal resistance and susceptibilityBacterial biofilms and quorum sensingFungal and yeast genetics research

How to build a biofilm: a fungal perspective

Blankenship, Jill R, Mitchell, Aaron P·2006·Current Opinion in Microbiology

DOI 10.1016/j.mib.2006.10.003

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Abstract

Biofilms are differentiated masses of microbes that form on surfaces and are surrounded by an extracellular matrix. Fungal biofilms, especially those of the pathogen Candida albicans, are a cause of infections associated with medical devices. Such infections are particularly serious because biofilm cells are relatively resistant to many common antifungal agents. Several in vitro models have been used to elucidate the developmental stages and processes required for C. albicans biofilm formation, and recent studies have begun to define biofilm genetic control. It is clear that cell-substrate and cell-cell interactions, hyphal differentiation and extracellular matrix production are key steps in biofilm development. Drug resistance is acquired early in biofilm formation, and appears to be governed by different mechanisms in early and late biofilms. Quorum sensing might be an important factor in dispersal of biofilm cells. The past two years have seen the emergence of several genomic strategies to uncover global events in biofilm formation and directed studies to understand more specific events, such as hyphal formation, in the biofilm setting.

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Morphogenesis is a critical part of biofilm formation.
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Authors: Blankenship, J. R., & Mitchell, A. P.
Corresponding author: Mitchell, Aaron P
ORCID: Blankenship, Jill R
Mitchell, Aaron P
Venue: Current Opinion in Microbiology
Publisher: Elsevier BV
Published: 2006-12
Volume: 9
Issue: 6
Pages: 588-594
ISSN: 1369-5274 (ISSN-L)
DOI: 10.1016/j.mib.2006.10.003
OpenAlex: W2067409920
Cited by: 530
References: 45
Citations by year: 2026: 5 · 2025: 15 · 2024: 19 · 2023: 20 · 2022: 30 · 2021: 24 · 2020: 26 · 2019: 26 · 2018: 23 · 2017: 31 · 2016: 25 · 2015: 35 · 2014: 41 · 2013: 31 · 2012: 39
FWCI: 2.56
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Current Opinion in Microbiology (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health
National Institute of Allergy and Infectious Diseases (R01AI067703, F32AI071439)
Topics: Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bacterial biofilms and quorum sensing
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
Keywords: fungal biofilms, Candida albicans, medical device infections, antifungal resistance, biofilm formation, extracellular matrix, hyphal differentiation, cell-substrate interaction, cell-cell interactions, quorum sensing, biofilm dispersal, in vitro biofilm model
MeSH terms: Candida albicans, Candidiasis, Cell Adhesion, Humans, Signal Transduction, Biofilms, Drug Resistance, Fungal

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How to build a biofilm: a fungal perspective

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