Cited by 410Antibiotic Resistance in BacteriaGut microbiota and healthPharmaceutical and Antibiotic Environmental Impacts

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Horizontal transfer of antibiotic resistance genes in the human gut microbiome

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McInnes, Ross S, McCallum, Gregory E, Lamberte, Lisa E, van Schaik, Willem·2020·Current Opinion in Microbiology

DOI 10.1016/j.mib.2020.02.002

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Abstract

Infections caused by antibiotic-resistant bacteria are a major threat to public health. The pathogens causing these infections can acquire antibiotic resistance genes in a process termed horizontal gene transfer (HGT). HGT is a common event in the human gut microbiome, that is, the microbial ecosystem of the human intestinal tract. HGT in the gut microbiome can occur via different mechanisms of which transduction and conjugation have been best characterised. Novel bioinformatic tools and experimental approaches have been developed to determine the association of antibiotic resistance genes with their microbial hosts and to quantify the extent of HGT in the gut microbiome. Insights from studies into HGT in the gut microbiome may lead to the development of novel interventions to minimise the spread of antibiotic resistance genes among commensals and opportunistic pathogens.

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Authors: McInnes, R. S., McCallum, G. E., Lamberte, L. E., & van Schaik, W.
Affiliations: University of Birmingham (GB)
Corresponding author: Lamberte, Lisa E
ORCID: McInnes, Ross S
McCallum, Gregory E
Lamberte, Lisa E
Venue: Current Opinion in Microbiology
Publisher: Elsevier BV
Published: 2020-02
Volume: 53
Pages: 35-43
ISSN: 1369-5274 (ISSN-L)
DOI: 10.1016/j.mib.2020.02.002
OpenAlex: W3009269518
Cited by: 401
References: 83
Citations by year: 2026: 49 · 2025: 90 · 2024: 79 · 2023: 69 · 2022: 59 · 2021: 41 · 2020: 14
FWCI: 3.37
Type: journal article
Language: en
Open access: green
research.birmingham.ac.uk
Licence: cc-by-nc-nd
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Current Opinion in Microbiology (publishedVersion)
PubMed (publishedVersion)
University of Birmingham Research Portal (University of Birmingham) (submittedVersion, cc-by-nc-nd)
Funders: Biotechnology and Biological Sciences Research Council
Wellcome Trust
Royal Society
Medical Research Council
Topics: Health Sciences › Medicine › Microbiology (medical) › Antibiotic Resistance in Bacteria
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Physical Sciences › Environmental Science › Pollution › Pharmaceutical and Antibiotic Environmental Impacts
Keywords: horizontal gene transfer, antibiotic resistance genes, human gut microbiome, transduction, conjugation, antibiotic resistance spread, commensal bacteria, opportunistic pathogens
MeSH terms: Gastrointestinal Microbiome, Animals, Anti-Bacterial Agents, Bacteria, Bacterial Proteins, Humans, Gene Transfer, Horizontal, Drug Resistance, Bacterial

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Horizontal transfer of antibiotic resistance genes in the human gut microbiome

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