Candida albicans the main opportunistic pathogenic fungus in humans
Open accessAbstract
Candida albicans is a commensal of the mammalian microbiome and the primary pathogenic fungus of humans. It becomes a severe health problem in immunocompromised patients and can cause a wide variety of mucosal and systemic infections. The interaction between C. albicans and host cells is characterized by the expression of virulence factors such as adhesins and invasins, the secretion of hydrolytic enzymes, a transition from yeast to filamentous hyphae form, and the ability to form biofilms; these features collectively result in cell adhesion, invasion, and damage. This review describes complex commensal interactions of C. albicans with host cells and the cellular events that it triggers in a pathogenic environment. We also review the host immune response induced by C. albicans antigens and the mechanisms developed by this fungus to avoid the action of antifungal agents. Candida albicans es un comensal del microbioma de mamíferos y el principal hongo patógeno de humanos. En pacientes inmunocomprometidos se convierte en un grave problema de salud por causar una amplia variedad de infecciones en mucosas y sistémicas. La interacción entre C. albicans y las células del huésped lleva a la expresión de factores de virulencia, como adhesinas e invasinas, a la secreción de enzimas hidrolíticas y a la transición de levadura a hifa filamentosa, capaz de para formar biopelículas, lo que genera adherencia, invasión y daño celular. En esta revisión describimos la compleja interacción comensal de C. albicans con la célula huésped y los eventos celulares que ejecuta en un ambiente patogénico. También se revisa la respuesta inmunitaria del huésped inducida por antígenos de C. albicans y los mecanismos desarrollados por este hongo para evitar la acción de agentes antifúngicos.
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CANDIDEMIA, UMA BREVE REVISÃO BIBLIOGRÁFICA
Silva, J. V. D., Ribeiro‐Dias, F., & Amaral, A. C. (2024) · RECISATEC - REVISTA CIENTÍFICA SAÚDE E TECNOLOGIA · doi:10.47820/recisatec.v4i2.353
Badu, K., Boateng, A. O., Duah, I. O., Akuffo, K. O., & Gyimah, L. (2024) · Research Square · doi:10.21203/rs.3.rs-4656890/v1
Salivary proteins modulate Candida albicans virulence and may prevent oropharingeal candidiasis
Curvelo, J. A. D. R., Barreto, A. L. S., Bayona-Pacheco, B. L., de Moraes, D. C., Portela, M. B., Ferreira‐Pereira, A., Adade, C. M., Souto-Padrón, T. C. B. S., & Soares, R. M. D. A. (2024) · Brazilian Journal of Microbiology · doi:10.1007/s42770-024-01517-5
Jayachandran, V. P., Varghese, N., Rupesh, S., Thomas, A. S., Sameer, K., & Thomas, N. G. (2024) · Journal of Pharmacy And Bioallied Sciences · doi:10.4103/jpbs.jpbs_1143_24
Jihad, M. F., & Salih, M. B. (2025) · Ukrainian Journal of Nephrology and Dialysis · doi:10.31450/ukrjnd.1(85).2025.05
The Association Between Oral Candidiasis and ABO Blood Type in Infants in Kirkuk City, Iraq
Abdullah, I. T., Noori, A., Mohammed, B. L., & Beebany, S. (2024) · Iranian Journal of Medical Microbiology · doi:10.30699/ijmm.18.5.301
- Authors
- Macias-Paz, I. U., Pérez-Hernández, S., Tavera-Tapia, A., Luna-Arias, J. P., Guerra-Cárdenas, J. E., & Reyna-Beltrán, E.
- Affiliations
- Autonomous University of Tamaulipas (MX)
- Venue
- Revista Argentina de Microbiología
- Publisher
- Elsevier BV
- Published
- 2023-04
- Volume
- 55
- Issue
- 2
- Pages
- 189-198
- ISSN
- 0325-7541 (ISSN-L)
- OpenAlex
- W4309288401
- Cited by
- 141
- References
- 99
- Citations by year
- 2026: 30 · 2025: 58 · 2024: 37 · 2023: 16
- FWCI
- 13.54
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Revista Argentina de Microbiología (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Funders
- Instituto Politécnico Nacional
- Consejo Nacional de Ciencia y Tecnología (346900)
- Faculty of Medicine, American University of Beirut
- Universidad Autónoma de Tamaulipas
- Topics
- Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
- Health Sciences › Medicine › Epidemiology › Fungal Infections and Studies
- Keywords
- Candida albicans, opportunistic fungal infection, commensalism, host-pathogen interaction, virulence factors, adhesins, invasin, biofilm, host immune response, antifungal resistance, immunocompromised patients
- MeSH terms
- Animals, Antifungal Agents, Candida albicans, Candidiasis, Humans, Mammals, Hyphae, Virulence Factors
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