Molecular analysis of the β-tubulin gene of human hookworms as a basis for possible benzimidazole resistance on Pemba Island

Albonico, Marco; Wright, Victoria; Bickle, Quentin

doi:10.1016/j.molbiopara.2003.12.008

Cited by 75Helminth infection and controlParasites and Host InteractionsParasitic Diseases Research and Treatment

Molecular analysis of the β-tubulin gene of human hookworms as a basis for possible benzimidazole resistance on Pemba Island

Albonico, Marco, Wright, Victoria, Bickle, Quentin·2004·Molecular and Biochemical Parasitology

DOI 10.1016/j.molbiopara.2003.12.008

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The resistance might also arise in various ways, including point mutations or deletion of β-tubulin isotype 1 or 2, microtubule-associated proteins, or others.
“The resistance might also arise in various ways, including point mutations or deletion of β-tubulin isotype 1 or 2, microtubule-associated proteins, or others [334,335].”
From Albendazole and Mebendazole as Anti-Parasitic and Anti-Cancer Agents: an Update (2021) · cites this paper as [335]
Thereafter, low efficacies of mebendazole or albendazole against hookworms were repeatedly reported; for example, in Pemba Island, Zanzibar, Vietnam, and Ghana.
“Thereafter, low efficacies of mebendazole or albendazole against hookworms were repeatedly reported; for example, in Pemba Island, Zanzibar [335,337], Vietnam [338], and Ghana [339].”
From Albendazole and Mebendazole as Anti-Parasitic and Anti-Cancer Agents: an Update (2021) · cites this paper as [335]
Molecular studies revealed no evidence for the β-tubulin mutation at amino acid residue 200 (Phe/Tyr) in hookworms from Pemba Island.
“However, molecular studies revealed no evidence for the β-tubulin mutation at amino acid residue 200 (Phe/Tyr) [335].”
From Albendazole and Mebendazole as Anti-Parasitic and Anti-Cancer Agents: an Update (2021) · cites this paper as [335]
These findings should provide some concern to the global health community, as the scale-up of mass drug administration for soil-transmitted helminths is now placing similar selection pressures for benzimidazole resistance in human hookworms and reduced efficacies are widely reported.
“Consequently, these findings should provide some concern to the global health community, as the scale-up of mass drug administration for soil-transmitted helminths (STH) is now placing similar selection pressures for benzimidazole resistance in human hookworms and reduced efficacies are widely reported [91–96].”
From Multiple drug resistance in the canine hookworm Ancylostoma caninum: an emerging threat? (2019) · cites this paper as [95]

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Additional file 2 of Improving stool sample processing and pyrosequencing for quantifying benzimidazole resistance alleles in Trichuris trichiura and Necator americanus pooled eggs
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Additional file 1 of Improving stool sample processing and pyrosequencing for quantifying benzimidazole resistance alleles in Trichuris trichiura and Necator americanus pooled eggs
Gandasegui, J., Grau-Pujol, B., Cambra-Pellejà, M., Escola, V., Demontis, M. A., Cossa, A., Jamine, J. C., Balaña‐Fouce, R., van Lieshout, L., Muñóz, J., et al. (2021) · Figshare · doi:10.6084/m9.figshare.16681562

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Authors: Albonico, M., Wright, V., & Bickle, Q.
Affiliations: Fondazione Ivo de Carneri ETS (IT)
London School of Hygiene & Tropical Medicine (GB)
Corresponding author: Bickle, Quentin
ORCID: Albonico, Marco
Wright, Victoria
Bickle, Quentin
Venue: Molecular and Biochemical Parasitology
Publisher: Elsevier BV
Published: 2004-04
Volume: 134
Issue: 2
Pages: 281-284
ISSN: 0166-6851 (ISSN-L)
DOI: 10.1016/j.molbiopara.2003.12.008
OpenAlex: W2095303104
Cited by: 75
References: 31
Citations by year: 2025: 1 · 2024: 3 · 2022: 4 · 2021: 7 · 2020: 2 · 2019: 7 · 2018: 4 · 2017: 1 · 2016: 2 · 2015: 3 · 2014: 7 · 2013: 4 · 2012: 2
FWCI: 8.64
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Molecular and Biochemical Parasitology (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Veterinary › Small Animals › Helminth infection and control
Life Sciences › Immunology and Microbiology › Parasitology › Parasites and Host Interactions
Health Sciences › Medicine › Infectious Diseases › Parasitic Diseases Research and Treatment
Keywords: Ancylostoma ceylanicum, hookworm, benzimidazole resistance, albendazole resistance, beta-tubulin gene, ivermectin, nitazoxanide, host-parasite interactions, serum iron, worm recovery, adult worm morphology, soil-transmitted helminths, Pemba Island
MeSH terms: Amino Acid Sequence, Ancylostoma, Ancylostomatoidea, Animals, Antinematodal Agents, Base Sequence, Benzimidazoles, Drug Resistance, Hookworm Infections, Molecular Sequence Data, Tanzania, Tubulin, Necator americanus, Genes, Helminth, DNA, Complementary, DNA, Helminth, Mutation, Missense

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Molecular analysis of the β-tubulin gene of human hookworms as a basis for possible benzimidazole resistance on Pemba Island

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