Excretory/secretory antigens from Dirofilaria immitis adult worms interact with the host fibrinolytic system involving the vascular endothelium
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Dirofilaria immitis is the causative agent of canine and feline heartworm disease. The parasite can survive for long periods of time (7 years or more) in the circulatory system of immunocompetent reservoirs, producing usually a chronic inflammatory vascular disease. In addition, the simultaneous death of groups of adult worms can trigger an acute disease characterized by the exacerbation of inflammatory reactions and the emergence of serious thromboembolic events. In the context of the D. immitis/host relationships, the aim of this study was to investigate the interaction between the excretory/secretory antigens from D. immitis adult worms (DiES) and the fibrinolytic system of the host. Using an enzyme-linked immunosorbent assay we showed that DiES extract is able to bind plasminogen and generate plasmin, although this fact requires the presence of the tissue plasminogen activator (t-PA). Moreover, we established that DiES extract enhances t-PA expression in cultured vascular endothelial cells. Additionally, 10 plasminogen-binding proteins from DiES extract were identified by mass spectrometry (HSP60, actin-1/3, actin, actin 4, transglutaminase, GAPDH, Ov87, LOAG_14743, galectin and P22U). The data suggest that DiES antigens interact with the environment of the parasite regulating the activation of the fibrinolytic system of the host with involvement of the vascular endothelium in the process.
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Several molecules in DiE/S (HSP60, actin, GAPDH, galectin, P22U) have plasminogen-binding capacities.
“The plasminogen-binding capacities of several molecules present in DiE/S, such as HSP60, actin, GAPDH, galectin, and P22U, have been demonstrated (156).”
From Human and animal dirofilariasis: The emergence of a zoonotic mosaic (2012) · cites this paper as [156]
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Self-citationCollado-Cuadrado, M., la Puente, A. B., Montero‐Calle, A., Vázquez-Ávila, S., Barderas, R., Sotillo, J., Carretón, E., Pericacho, M., & Morchón, R. (2026) · Parasites & Vectors · doi:10.1186/s13071-026-07307-2
Self-citationNew Insights Into Pathogenesis, Diagnostics, and Therapeutic Options for Canine Angiostrongylosis
Elgueta, I., Lewis, D., Morgan, E. R., & Helm, J. (2026) · Journal of Veterinary Emergency and Critical Care · doi:10.1111/vec.70132
Bifidobacterium - Human Host Interaction: Role of Human Plasminogen
Centanni, M. (2012) · AMS Dottorato Institutional Doctoral Theses Repository (University of Bologna) · doi:10.6092/unibo/amsdottorato/4677
- Authors
- González-Miguel, J., Morchón, R., Mellado, I., Carretón, E., Montoya-Alonso, J. A., & Simón, F.
- Affiliations
- Universidad de Salamanca (ES)
- Universidad de Las Palmas de Gran Canaria (ES)
- Venue
- Molecular and Biochemical Parasitology
- Publisher
- Elsevier BV
- Published
- 2012-02
- Volume
- 181
- Issue
- 2
- Pages
- 134-140
- ISSN
- 0166-6851 (ISSN-L)
- OpenAlex
- W2026126834
- Cited by
- 55
- References
- 39
- Citations by year
- 2026: 3 · 2025: 3 · 2024: 3 · 2023: 4 · 2022: 2 · 2021: 5 · 2020: 5 · 2019: 2 · 2018: 5 · 2017: 5 · 2016: 3 · 2015: 5 · 2014: 3 · 2013: 4 · 2012: 3
- FWCI
- 2.16
- Type
- journal article
- Language
- en
- Open access
- green
- api.elsevier.com
- Licence
- cc-by-nc-nd
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- Locations
- Molecular and Biochemical Parasitology (publishedVersion)
- PubMed (publishedVersion)
- DIGITAL.CSIC (Spanish National Research Council (CSIC)) (submittedVersion, cc-by-nc-nd)
- Acceda (Universidad de Las Palmas de Gran Canaria) (submittedVersion)
- Funders
- Agencia de Desarrollo Económico de Castilla y León
- Junta de Castilla y León (SA090/A09)
- Topics
- Health Sciences › Medicine › Infectious Diseases › Parasitic Diseases Research and Treatment
- Health Sciences › Veterinary › Small Animals › Helminth infection and control
- Life Sciences › Immunology and Microbiology › Parasitology › Parasites and Host Interactions
- Keywords
- Dirofilaria immitis, heartworm disease, excretory-secretory antigens, fibrinolysis, plasminogen, plasmin, tissue plasminogen activator, vascular endothelium, plasminogen-binding protein, host-parasite interactions, thromboembolism, canine heartworm disease
- MeSH terms
- Animals, Antigens, Helminth, Cell Line, Dirofilaria immitis, Dirofilariasis, Endothelium, Vascular, Fibrinolysin, Fibrinolysis, Host-Parasite Interactions, Humans, Plasminogen, Protein Binding
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