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Yin Yang 1

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MDM2’s social network

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RYBP stabilizes p53 by modulating MDM2

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Developing Targeted Therapies That Exploit Aberrant Histone Ubiquitination in Cancer

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Cutaneous Papillomavirus E6 Proteins Must Interact with p300 and Block p53-Mediated Apoptosis for Cellular Immortalization and Tumorigenesis

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A New Twist in the Feedback Loop: Stress-Activated MDM2 Destabilization is Required for p53 Activation

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Tip60 and p400 are both required for UV‐induced apoptosis but play antagonistic roles in cell cycle progression

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A p53-independent role of Mdm2 in estrogen-mediated activation of breast cancer cell proliferation

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Balance of Yin and Yang: Ubiquitylation-Mediated Regulation of p53 and c-Myc

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The biological impact of the human master regulator p53 can be altered by mutations that change the spectrum and expression of its target genes

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Ubiquitin–Proteasome System in Spermatogenesis

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RNA content in the nucleolus alters p53 acetylation via MYBBP1A

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Structural analysis of MDM2 RING separates degradation from regulation of p53 transcription activity

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Silencing of the Lats2 tumor suppressor overrides a p53-dependent oncogenic stress checkpoint and enables mutant H-Ras-driven cell transformation

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Biochemical and Biophysical Characterization of a Chimeric TRIM21-TRIM5α Protein

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E3 Ligases Determine Ubiquitination Site and Conjugate Type by Enforcing Specificity on E2 Enzymes

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Melatonin induces the apoptosis and inhibits the proliferation of human gastric cancer cells via blockade of the AKT/MDM2 pathway

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Escape from p53-mediated tumor surveillance in neuroblastoma: switching off the p14ARF-MDM2-p53 axis

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Histone Ubiquitylation and the Regulation of Transcription

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Nickel compounds induce histone ubiquitination by inhibiting histone deubiquitinating enzyme activity

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The Ubiquitin-Specific Protease USP7 Modulates the Replication of Kaposi's Sarcoma-Associated Herpesvirus Latent Episomal DNA

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Histone H2B ubiquitination: the cancer connectionPreprint

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Chromatin modifiers Mdm2 and RNF2 prevent RNA:DNA hybrids that impair DNA replication

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MDM2 recruitment of lysine methyltransferases regulates p53 transcriptional output

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Histone monoubiquitination by Clock-Bmal1 complex marks Per1 and Per2 genes for circadian feedback

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Mdm2 in growth signaling and cancer

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The p53-mediated cytotoxicity of photodynamic therapy of cancer: Recent advances

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RNA-binding E3 ubiquitin ligases: novel players in nucleic acid regulation

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Genome-wide identification of novel expression signatures reveal distinct patterns and prevalence of binding motifs for p53, nuclear factor-κB and other signal transcription factors in head and neck squamous cell carcinoma

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Mdm2 and MdmX as Regulators of Gene Expression

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USP7 enforces heterochromatinization of p53 target promoters by protecting SUV39H1 from MDM2-mediated degradation.

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Deubiquitinating enzyme regulation of the p53 pathway: A lesson from Otub1

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Histone Monoubiquitination in Chromatin Remodelling: Focus on the Histone H2B Interactome and Cancer

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A Critical Role for Noncoding 5S rRNA in Regulating Mdmx Stability

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Targeting the MDM2/MDM4 Interaction Interface as a Promising Approach for p53 Reactivation Therapy

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Mechanistic Studies of MDM2-mediated Ubiquitination in p53 Regulation

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Excess HDM2 Impacts Cell Cycle and Apoptosis and Has a Selective Effect on p53-dependent Transcription

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Control of Cell Proliferation and Growth by Myc Proteins

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Mdm2 as a chromatin modifier

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Writing Histone Monoubiquitination in Human Malignancy—The Role of RING Finger E3 Ubiquitin Ligases

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Requirement for human Mps1/TTK in oxidative DNA damage repair and cell survival through MDM2 phosphorylation

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Chromatin-Bound p53 Anchors Activated Smads and the mSin3A Corepressor To Confer Transforming Growth Factor β-Mediated Transcription Repression

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USP7/HAUSP stimulates repair of oxidative DNA lesions

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MDM2 and MDMX in Cancer and Development

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Epigenetic modification and a role for the E3 ligase RNF40 in cancer development and metastasis

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MEL-18 loss mediates estrogen receptor–α downregulation and hormone independence

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Splicing Up Mdm2 for Cancer Proteome Diversity

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Histone Ubiquitylation by Mdm2

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Mdm2 RING Mutation Enhances p53 Transcriptional Activity and p53-p300 Interaction

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The Role of Histone H2B Ubiquitylation and its Related Factors in Transcriptional Regulation in Mammalian Cells

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Unlocking the Mdm2-p53 loop: Ubiquitin is the key

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Structural and Functional Characterization of the Human Mdm2 and MdmX RING Domains

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