Structural basis for defects of Keap1 activity provoked by its point mutations in lung cancer

Padmanabhan, Balasundaram, Tong, Kit I., Ohta, Tsutomu, Nakamura, Yoshihiro, Scharlock, Maria, Ohtsuji, Makiko, Kang, Moon-Il, Kobayashi, Akira +2 more·2006·Molecular Cell
DOI 10.1016/j.molcel.2006.01.013

Cited by (749)

Items 701–749 of 749

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  22. Salvianolic acid B attenuates drug-induced liver injury in an Nrf2-dependent mechanism via covalently modifying Keap1 at Cys395/Cys434
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  30. Virtual Screening of the p62/SQSTM1–KEAP1 Interaction Interface in KRAS-Mutant Colorectal Cancer: Pan-Kelch Binding and a p62-Selective Aminobenzothiazole Scaffold
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  32. BindingDB Entry 50046585: Design, Synthesis, and Evaluation of Triazole Derivatives That Induce Nrf2 Dependent Gene Products and Inhibit the Keap1-Nrf2 Protein-Protein Interaction.
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  33. BindingDB Entry 50006254: Non-electrophilic modulators of the canonical Keap1/Nrf2 pathway.
    BindingDB · 2020 · UC San Diego
  34. BindingDB Entry 50022106: Targeting kelch-like (KLHL) proteins: achievements, challenges and perspectives.
    BindingDB · 2025 · UC San Diego
  35. BindingDB Entry 50009857: Design, Synthesis, and Initial Evaluation of Affinity-Based Small-Molecule Probes for Fluorescent Visualization and Specific Detection of Keap1.
    BindingDB · 2021 · UC San Diego
  36. BindingDB Entry 50011387: Optimization of linear and cyclic peptide inhibitors of KEAP1-NRF2 protein-protein interaction.
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  37. BindingDB Entry 50001541: Discovery of a head-to-tail cyclic peptide as the Keap1-Nrf2 protein-protein interaction inhibitor with high cell potency.
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  38. BindingDB Entry 50018665: Targeting mutated GTPase KRAS in tumor therapies.
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  39. BindingDB Entry 50010105: Nuclear Factor Erythroid 2-Related Factor 2 (Nrf2) Inhibition: An Emerging Strategy in Cancer Therapy.
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  40. BindingDB Entry 50008721: Structure-Activity and Structure-Conformation Relationships of Aryl Propionic Acid Inhibitors of the Kelch-like ECH-Associated Protein 1/Nuclear Factor Erythroid 2-Related Factor 2 (KEAP1/NRF2) Protein-Protein Interaction.
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  41. BindingDB Entry 50020171: Medicinal Chemistry Insights into the Development of Small-Molecule Kelch-Like ECH-Associated Protein 1-Nuclear Factor Erythroid 2-Related Factor 2 (Keap1-Nrf2) Protein-Protein Interaction Inhibitors.
    BindingDB · 2024 · UC San Diego
  42. BindingDB Entry 50019686: Stapled Peptides as Direct Inhibitors of Nrf2-sMAF Transcription Factors.
    BindingDB · 2024 · UC San Diego
  43. BindingDB Entry 50018333: Recent progress in Keap1-Nrf2 protein-protein interaction inhibitors.
    BindingDB · 2024 · UC San Diego
  44. BindingDB Entry 50012354: Mining Natural Products for Macrocycles to Drug Difficult Targets.
    BindingDB · 2022 · UC San Diego
  45. BindingDB Entry 50015271: Importance of Binding Site Hydration and Flexibility Revealed When Optimizing a Macrocyclic Inhibitor of the Keap1-Nrf2 Protein-Protein Interaction.
    BindingDB · 2023 · UC San Diego
  46. BindingDB Entry 50047995: Discovery and Development of Kelch-like ECH-Associated Protein 1. Nuclear Factor Erythroid 2-Related Factor 2 (KEAP1:NRF2) Protein-Protein Interaction Inhibitors: Achievements, Challenges, and Future Directions.
    BindingDB · 2018 · UC San Diego
  47. BindingDB Entry 50047646: Monoacidic Inhibitors of the Kelch-like ECH-Associated Protein 1: Nuclear Factor Erythroid 2-Related Factor 2 (KEAP1:NRF2) Protein-Protein Interaction with High Cell Potency Identified by Fragment-Based Discovery.
    BindingDB · 2017 · UC San Diego
  48. BindingDB Entry 50044159: Discovery of potent Keap1-Nrf2 protein-protein interaction inhibitor based on molecular binding determinants analysis.
    BindingDB · 2015 · UC San Diego
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