Structural basis for defects of Keap1 activity provoked by its point mutations in lung cancer
Padmanabhan, Balasundaram, Tong, Kit I., Ohta, Tsutomu, Nakamura, Yoshihiro, Scharlock, Maria, Ohtsuji, Makiko, Kang, Moon-Il, Kobayashi, Akira +2 more·2006·Molecular Cell
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- Increased susceptibility to hepatocarcinogenicity of Nrf2‐deficient mice exposed to 2‐amino‐3‐methylimidazo[4,5‐f]quinolineYasuki Kitamura, Takashi Umemura, Keita Kanki, Yukio Kodama, Sachiko Kitamoto, Koichi Saito, Ken Itoh, Masayuki P. Yamamoto, Toshiaki Masegi, Akiyoshi Nishikawa et al. · 2006 · Cancer Science
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- The p65 Isoform of Nrf1 Is a Dominant Negative Inhibitor of ARE-mediated TranscriptionWeiping Wang, Annie M. Kwok, Jefferson Y. Chan · 2007 · Journal of Biological Chemistry
- Novel role of the muskelin–RanBP9 complex as a nucleocytoplasmic mediator of cell morphology regulationManojkumar Valiyaveettil, Amber A. Bentley, Priya R. Gursahaney, Rajaa Hussien, Ritu Chakravarti, Nina Kureishy, Søren Prag, Josephine Clare Adams · 2008 · The Journal of Cell Biology
- Nrf2: bane or blessing in cancer?Mingjun Xiang, Akhileshwar Namani, ShiJun Wu, XiaoLi Wang · 2014 · Journal of Cancer Research and Clinical Oncology
- Lipid mediators involved in the oxidative stress and antioxidant defence of human lung cancer cellsAgnieszka Gęgotek, Jacek Nikliński, Neven Žarković, Kamelija Žarković, Georg Waeg, Wojciech Łuczaj, Radosław Charkiewicz, Elźbieta Skrzydlewska · 2016 · Redox Biology
- Emerging Substrate Proteins of Kelch-like ECH Associated Protein 1 (Keap1) and Potential Challenges for the Development of Small-Molecule Inhibitors of the Keap1-Nuclear Factor Erythroid 2‑Related Factor 2 (Nrf2) Protein–Protein InteractionYong Zhang, Zeyu Shi, Yujun Zhou, Qiong Xiao, Hongyue Wang, Ying Peng · 2020 · Journal of Medicinal Chemistry
- Inhibitor of Nrf2 (INrf2 or Keap1) Protein Degrades Bcl-xL via Phosphoglycerate Mutase 5 and Controls Cellular ApoptosisSuryakant K. Niture, Anil K. Jaiswal · 2011 · Journal of Biological Chemistry · Retracted
- Prothymosin-α Mediates Nuclear Import of the INrf2/Cul3·Rbx1 Complex to Degrade Nuclear Nrf2Suryakant K. Niture, Anil K. Jaiswal · 2009 · Journal of Biological Chemistry · Retracted
- p62-Dependent Phase Separation of Patient-Derived KEAP1 Mutations and NRF2Erica W. Cloer, Priscila F. Siesser, Emily M. Cousins, Dennis Goldfarb, David D. Mowrey, Joseph S. Harrison, Seth Weir, Nikolay V. Dokholyan, Michael B. Major · 2018 · Molecular and Cellular Biology
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- Cellular Modulators of the NRF2/KEAP1 Signaling Pathway in Prostate CancerGiovanni Tossetta, Sonia Fantone, Daniela Marzioni, Roberta Mazzucchelli A · 2023 · Frontiers in Bioscience-Landmark
- The see-saw of Keap1-Nrf2 pathway in cancerPoorti Pandey, Alok Kumar Singh, Mritunjai Singh, Mallika Tewari, Hari Shankar Shukla, Indrajeet Singh Gambhir · 2017 · Critical Reviews in Oncology/Hematology
- NFE2L2 Mutations Enhance Radioresistance in Head and Neck Cancer by Modulating Intratumoral Myeloid CellsLi Guan, Dhanya K. Nambiar, Hongbin Cao, Vignesh Viswanathan, Shirley Kwok, Angela Bik‐Yu Hui, Yuan Hou, Rachel Hildebrand, Rie von Eyben, Brittany Holmes et al. · 2023 · Cancer Research
- The Role of Nrf2 and Cytoprotection in Regulating Chemotherapy Resistance of Human Leukemia CellsStuart A. Rushworth, David J. MacEwan · 2011 · Cancers
- RNAi in Clinical StudiesPaulina Kubowicz, Dorota Żelaszczyk, Elżbieta Pękala · 2013 · Current Medicinal Chemistry
- Oxeiptosis—a cell death pathway to mitigate damage caused by radicalsPietro Scaturro, Andreas Pichlmair · 2018 · Cell Death and Differentiation
- Dual neuroprotective pathways of a pro‐electrophilic compound via HSF‐1‐activated heat‐shock proteins and Nrf2‐activated phase 2 antioxidant response enzymesTakumi Satoh, Tayebeh Rezaie, Masaaki Seki, Carmen R. Sunico, Takahito Tabuchi, Tomomi Kitagawa, Mika Yanagitai, Mutsumi Senzaki, Chihiro Kosegawa, Hideharu Taira et al. · 2011 · Journal of Neurochemistry
- Cullin 3 as a novel target in diverse pathologiesAna Cristina Andérica‐Romero, Irma Gabriela González-Herrera, Abel Santamarı́a, José Pedraza‐Chaverrí · 2013 · Redox Biology
- The Role of the Thioredoxin Detoxification System in Cancer Progression and ResistanceMirna Jovanović, Ana Podolski-Renić, Mikhail Krasavin, Milica Pešić · 2022 · Frontiers in Molecular Biosciences
- NRF2 transcriptionally activates the heat shock factor 1 promoter under oxidative stress and affects survival and migration potential of MCF7 cellsSoumyadip Paul, Suvranil Ghosh, Sukhendu Mandal, Subrata Sau, Mahadeb Pal · 2018 · Journal of Biological Chemistry
- The subcellular localization and activity of cortactin is regulated by acetylation and interaction with Keap1Akihiro Ito, Tadahiro Shimazu, Satoko Maeda, Asad Ali Shah, Tatsuhiko Tsunoda, Shun‐ichiro Iemura, Tohru Natsume, Takafumi Suzuki, Hozumi Motohashi, Masayuki P. Yamamoto et al. · 2015 · Science Signaling
- Epigenetic versus Genetic Deregulation of the KEAP1/NRF2 Axis in Solid Tumors: Focus on Methylation and Noncoding RNAsFederico Pio Fabrizio, Angelo Sparaneo, Domenico Trombetta, Lucia Anna Muscarella · 2018 · Oxidative Medicine and Cellular Longevity
- Direct Keap1-kelch inhibitors as potential drug candidates for oxidative stress-orchestrated diseases: A review on In silico perspectiveIbrahim Damilare Boyenle, Ukachi Chiamaka Divine, Rofiat Oluwabusola Adeyemi, Kehinde Sulaimon Ayinde, Olamide Tosin Olaoba, Chowdhry Apu, Lei Du, Qian Lü, Xiaoxing Yin, Temitope Isaac Adelusi · 2021 · Pharmacological Research
- DDRGK1 Enhances Osteosarcoma Chemoresistance via Inhibiting KEAP1‐Mediated NRF2 UbiquitinationXin Wang, Tangjun Zhou, Xiao Yang, Xiankun Cao, Gu Jin, Pu Zhang, Jiadong Guo, Kewei Rong, Baixing Li, Yibin Hu et al. · 2023 · Advanced Science
- Novel protein–protein interaction inhibitor of Nrf2–Keap1 discovered by structure-based virtual screeningHao-Peng Sun, Zhengyu Jiang, Ming-Ye Zhang, Mengchen Lu, Tingting Yang, Yang Pan, Hao‐Ze Huang, Xiaojin Zhang, Qidong You · 2013 · MedChemComm
- Activation of Nrf2 by Microcystin-LR Provides Advantages for Liver Cancer Cell GrowthNanqin Gan, Xiaoyun Sun, Lirong Song · 2010 · Chemical Research in Toxicology
- Modification of platinum sensitivity by KEAP1/NRF2 signals in non-small cell lung cancerYijun Tian, Kongming Wu, Qian Liu, Na Han, Li Zhang, Qian Chu, Yuan Chen · 2016 · Journal of Hematology & Oncology
- Overview of redox regulation by Keap1–Nrf2 system in toxicology and cancerMikiko Suzuki, Akihito Otsuki, Nadine Keleku-Lukwete, Masayuki P. Yamamoto · 2016 · Current Opinion in Toxicology
- Structural Biology of CRL Ubiquitin LigasesDomnița-Valeria Rusnac, Ning Zheng · 2020 · Advances in experimental medicine and biology
- Formation, signaling functions, and metabolisms of nitrated cyclic nucleotideTomohiro Sawa, Hideshi Ihara, Tomoaki Ida, Shigemoto Fujii, Motohiro Nishida, Takaaki Akaike · 2013 · Nitric Oxide
- Geldanamycin-Derived HSP90 Inhibitors Are Synthetic Lethal with NRF2Liam Baird, Takafumi Suzuki, Yu Takahashi, Eiji Hishinuma, D. Saigusa, M. Yamamoto · 2020 · Molecular and Cellular Biology
- Induction of Heme Oxygenase-1 Inhibits Cell Death in Crotonaldehyde-Stimulated HepG2 Cells via the PKC-δ -p38 -Nrf2 PathwaySeung Eun Lee, Hana Yang, Seong Il Jeong, Young-Ho Jin, Cheung-Seog Park, Yong Seek Park · 2012 · PLoS ONE
- The polycomb group protein EZH2 inhibits lung cancer cell growth by repressing the transcription factor Nrf2Ziming Li, Ling Xu, Naiwang Tang, Yunhua Xu, Xiangyun Ye, Shengping Shen, Xiaomin Niu, Shun Lü, Zhiwei Chen · 2014 · FEBS Letters
- Anthocyanins from Hibiscus syriacus L. Inhibit Oxidative Stress-Mediated Apoptosis by Activating the Nrf2/HO-1 Signaling PathwayIlandarage Menu Neelaka Molagoda, Kyoung Tae Lee, Yung Hyun Choi, Gi‐Young Kim · 2020 · Antioxidants
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- Cross-Regulations among NRFs and KEAP1 and Effects of their Silencing on Arsenic-Induced Antioxidant Response and Cytotoxicity in Human KeratinocytesRui Zhao, Yongyong Hou, Qiang Zhang, Courtney Georgette Woods, Peng Xue, Jingqi Fu, Kathy Yarborough, Dawei Guan, Melvin E. Andersen, Jingbo Pi · 2012 · Environmental Health Perspectives
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- Select Heterozygous Keap1 Mutations Have a Dominant-Negative Effect on Wild-Type Keap1 In VivoTakafumi Suzuki, Jonathan M. Maher, Masayuki P. Yamamoto · 2010 · Cancer Research
- Emerging Screening Approaches in the Development of Nrf2–Keap1 Protein–Protein Interaction InhibitorsChung‐Hang Leung, Jia-Tong Zhang, Guan‐Jun Yang, Hao Liu, Quan‐Bin Han, Dik‐Lung Ma · 2019 · International Journal of Molecular Sciences
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