Structural basis for defects of Keap1 activity provoked by its point mutations in lung cancer
Padmanabhan, Balasundaram, Tong, Kit I., Ohta, Tsutomu, Nakamura, Yoshihiro, Scharlock, Maria, Ohtsuji, Makiko, Kang, Moon-Il, Kobayashi, Akira +2 more·2006·Molecular Cell
Cited by (749)
Items 501–600 of 749
- Effect of stable inhibition of NRF2 on doxorubicin sensitivity in human ovarian carcinoma OV90 cellsSarala Manandhar, Sangwhan Lee, Mi‐Kyoung Kwak · 2010 · Archives of Pharmacal Research
- Nuclear factor erythroid 2 (NF-E2)-related factor 2 (Nrf2) in non-small cell lung cancerZhi Zeng, Ziyao Wang, Yukun Li, Dongmei Ye, Juan Zeng, Jiali Hu, Pi-feng Chen, Jiao Xiao, Juan Zou, Zhenhua Li · 2020 · Life Sciences
- Synthesis, in vitro and in silico antitumor evaluation of 3-(2,6-dichlorophenyl)-1,5-diphenylpentane-1,5‑dione: Structure, spectroscopic, RDG, Hirshfeld and DFT based analysesA. Dhandapani, S. Veeramanikandan, Raju Suresh Kumar, Abdulrahman Ibrahim Almansour, Natarajan Arumugam, S. Subashchandrabose, Joghee Suresh, Arulraj Ramalingam, Duraikannu Gajalakshmi · 2021 · Journal of Molecular Structure
- Genetic Variations and Haplotype Structures of Transcriptional Pactor Nrf2 and Its Cytosolic Reservoir Protein Keap1 in JapaneseHiromi Fukushima‐Uesaka, Yoshiro Saito, Keiko Maekawa, Naoyuki Kamatani, Hiroshi Kajio, Nobuaki Kuzuya, Mitsuhiko Noda, Kazuki Yasuda, Jun‐ichi Sawada · 2007 · Drug Metabolism and Pharmacokinetics
- Crosstalk between NRF2 and Dicer through metastasis regulating MicroRNAs; mir-34a, mir-200 family and mir-103/107 familyHeba K. Nabih · 2020 · Archives of Biochemistry and Biophysics
- Modulating Nrf2 to control lipid peroxidation and ferroptosis: implications for cancer managementRamazan Tunc, İlker Ateş, Beyza Yılmaz, Alessandro Medoro, Sergio Davinelli, Síbel Süzen, Luciano Saso · 2025 · Frontiers in Oncology
- A549 cell proliferation inhibited by RNAi mediated silencing of the Nrf2 geneBo Zhang, Chen Xie, Jing Zhong, Hanyin Chen, Hongying Zhang, Xiaoqin Wang · 2014 · Bio-Medical Materials and Engineering
- Nrf2-Mediated Heme Oxygenase-1 Upregulation as Adaptive Survival Response to Glucose Deprivation-Induced Apoptosis in HepG2 CellsHee Geum Lee, Meihua Li, Eun-Joo Joung, Hye‐Kyung Na, Young‐Nam Cha, Young‐Joon Surh · 2010 · Antioxidants and Redox Signaling
- PML nuclear bodies, membrane-less domains acting as ROS sensors?Michiko Niwa‐Kawakita, Hsin-Chieh Wu, Hugues de Thé, Valérie Lallemand-Breitenbach · 2017 · Seminars in Cell and Developmental Biology
- Revisiting the role of hypoxia-inducible factors and nuclear factor erythroid 2-related factor 2 in regulating macrophage inflammation and metabolismKenneth K. Y. Ting · 2024 · Frontiers in Cellular and Infection Microbiology
- Purification, identification, and mechanism of action of novel antioxidant peptides from quinoa (Chenopodium quinoa wild.) protein hydrolysateHuan-Huan Xiao, Xueying Li, Yingying Chen, Jin-Xiang Zhou, Ting Zhang, Qiang-Ming Li, Li‐Hua Pan, Jian‐Ping Luo, Xue‐Qiang Zha · 2025 · Food Chemistry
- p62 functions as a signal hub in metal carcinogenesisZhuo Zhang, Max Costa · 2021 · Seminars in Cancer Biology
- An inhibitor of interaction between the transcription factor NRF2 and the E3 ubiquitin ligase adapter β-TrCP delivers anti-inflammatory responses in mouse liverRaquel Fernández-Ginés, José Antonio Encinar, John D. Hayes, Baldomero Oliva, Marı́a Isabel Rodrı́guez-Franco, Ana Isabel Rojo, Antonio Cuadrado · 2022 · Redox Biology
- Nrf2 degron-fused reporter system: a new tool for specific evaluation of Nrf2 inducersYosuke Hirotsu, Fumiki Katsuoka, Ken Itoh, Masayuki P. Yamamoto · 2011 · Genes to Cells
- Knockdown of Nrf2 radiosensitizes glioma cells by inducing redox stress and apoptosis in hypoxiaTing Fang Tang, Yue Jia, Hui Liang, Yanling Han, Zixiang Cong, Handong Wang, Xiangjun Ji · 2022 · Translational Cancer Research
- Role of nitric oxide in the response to photooxidative stress in prostate cancer cellsFrancesca D’Este, Emilia Della Pietra, Gretta Veronica Badillo Pazmay, Luigi Emilio Xodo, Valentina Rapozzi · 2020 · Biochemical Pharmacology
- Small molecule screen identifies pyrimethamine as an inhibitor of NRF2-driven esophageal hyperplasiaChorlada Paiboonrungruang, Zhaohui Xiong, David R. Lamson, Yahui Li, Brittany M. Bowman, Julius Chembo, Caizhi David Huang, Jianying Li, Eric W. Livingston, Jon E. Frank et al. · 2023 · Redox Biology
- Cell death classification: A new insight based on molecular mechanismsSepehr Dehghan, Nasim Kheshtchin, Shaghayegh Hassannezhad, Maryam Soleimani · 2023 · Experimental Cell Research
- Mutational and Expressional Analyses of NRF2 and KEAP1 in SarcomasEun Mi Je, Chang Hyeok An, Nam Jin Yoo, Sug Hyung Lee · 2012 · Tumori Journal
- Keap1 mutations in lung cancer patientsHidefumi Sasaki, Ayumi Suzuki, Masayuki Shitara, Katsuhiro Okuda, Yu Hikosaka, Satoru Moriyama, Motoki Yano, Yoshitaka Fujii · 2013 · Oncology Letters
- Design, Synthesis, and Initial Evaluation of Affinity-Based Small-Molecule Probes for Fluorescent Visualization and Specific Detection of Keap1Mengchen Lu, Hai-shan Zhou, Qidong You, Zhengyu Jiang · 2016 · Journal of Medicinal Chemistry
- Structures of Thymosin ProteinsKayt L. Hoch, David E. Volk · 2016 · Vitamins and hormones
- Aromatase Inhibitor–Mediated Downregulation of INrf2 (Keap1) Leads to Increased Nrf2 and Resistance in Breast CancerRaju Khatri, Preeti Shah, Rupa Guha, Feyruz Virgilia Rassool, Alan E. Tomkinson, Angela M. H. Brodie, Anil K. Jaiswal · 2015 · Molecular Cancer Therapeutics · Retracted
- Squamous cell carcinomas of the lung and of the head and neck: new insights on molecular characterizationValentina Polo, Giulia Pasello, Stefano Frega, Adolfo Gino Favaretto, Haralabos Koussis, PierFranco Conte, Laura Bonanno · 2016 · Oncotarget
- A novel yeast model detects Nrf2 and Keap1 interactions with Hsp90Vy Ngo, Anne M. Brickenden, Hansen Liu, Cynthia Yeung, Wing‐Yiu Choy, Martin L. Duennwald · 2022 · Disease Models & Mechanisms
- Exploring new strategies for grafting binding peptides onto protein loops using a consensus‐designed tetratricopeptide repeat scaffoldSarah K. Madden, Albert Perez‐Riba, Laura S. Itzhaki · 2019 · Protein Science
- NRF2-dependent suppression of selenoprotein P expression promotes intracellular selenium metabolic remodeling and upregulation of antioxidant selenoproteins in hepatocellular carcinomaKotoko Arisawa, Moeka Natori, Tetta Hiranuma, Misaki Shimizu, Yuto Yamazaki, Yasuhiro Miki, Takashi Toyama, Yoshiro Saito · 2025 · Redox Biology
- Bidirectional regulation of KEAP1 BTB domain-based sensor activityTakafumi Suzuki, Kenji Takagi, Tatsuro Iso, Huaichun Wen, Anqi Zhang, Tetsuya Hatakeyama, Hiraku Oshima, Tsunehiro Mizushima, Masayuki P. Yamamoto · 2025 · Redox Biology
- Modulation of Nrf2 and Mitochondrial Function: Pharmacological ImplicationsLuciano Saso, İlker Ateş, Ramazan Tunc, Beyza Yılmaz, Marialucia Gallorini, Simone Carradori, Síbel Süzen · 2025 · Pharmaceuticals
- MTX-211 Inhibits GSH Synthesis through Keap1/NRF2/GCLM Axis and Exerts Antitumor Effects in Bladder CancerBing Hu, Ru Chen, Ming Jiang, Situ Xiong, An Xie, Xiaoqiang Liu, Bin Fu · 2023 · International Journal of Molecular Sciences
- Tumor suppressor KEAP1 promotes HSPA9 degradation, controlling mitochondrial biogenesis in breast cancerBing Han, Fang Zhen, Yue Sun, Bin Sun, Hongyi Wang, Wei Liu, Jian Huang, Xiao Liang, Yaru Wang, Xuesong Chen et al. · 2024 · Cell Reports
- Regulation of blood pressure and renal electrolyte balance by Cullin-RING ligasesShinichi Uchida · 2014 · Current Opinion in Nephrology & Hypertension
- Association of single-nucleotide polymorphisms of the KEAP1 gene with the risk of various human diseases and its functional impact using in silico analysisDhamodharan Umapathy, Ponjayanthi Balashanmugam, Dornadula Sireesh, Elango Bhakkiyalakshmi, Kunka Mohanram Ramkumar · 2018 · Pharmacological Research
- Nrf2 and the Nrf2-Interacting Network in Respiratory Inflammation and DiseasesJennifer Carlson, Lindsey Price, Huai Deng · 2020 · Progress in inflammation research
- The NRF2 Activation and Antioxidative Response Are Not Impaired Overall during Hyperoxia-Induced Lung Epithelial Cell DeathHaranatha R. Potteti, Narsa M. Reddy, Tom K. Hei, Dhananjaya V. Kalvakolanu, Sekhar P. Reddy · 2013 · Oxidative Medicine and Cellular Longevity
- A Step toward NRF2‐DNA Interaction Inhibitors by Fragment‐Based NMR MethodsSven Brüschweiler, Julian E. Fuchs, Gerd Bader, Darryl B. McConnell, Robert Konrat, Moriz Mayer · 2021 · ChemMedChem
- Base excision repair accessory factors in senescence avoidance and resistance to treatmentsElise Vickridge, Camila Cristina Fraga Faraco, Alain Nepveu · 2022 · Cancer Drug Resistance
- Genetic, metabolic and immunological features of cancers with NRF2 addictionHiroshi Kitamura, Haruna Takeda, Hozumi Motohashi · 2022 · FEBS Letters
- The synergistic effects of PRDX5 and Nrf2 on lung cancer progression and drug resistance under oxidative stress in the zebrafish modelsSitong Qian, Ying Fang, Chengyun Yao, YONGSHENG WANG, ZHI ZHANG, XIAOHUA WANG, Jin Gao, YONG FENG, Lei Sun, RUNYUE ZOU et al. · 2022 · Oncology Research Featuring Preclinical and Clinical Cancer Therapeutics
- Targeting kelch-like (KLHL) proteins: achievements, challenges and perspectivesYangguo Zhou, Qiong Zhang, Ziquan Zhao, Xiuqi Hu, Qidong You, Zhengyu Jiang · 2024 · European Journal of Medicinal Chemistry
- ΔNp63α promotes radioresistance in esophageal squamous cell carcinoma through the PLEC-KEAP1-NRF2 feedback loopTao Jin, Mian Mao, Yuhai Lu, Liyuan Deng, Shuhan Yu, Xiaofei Zeng, Weikun Jia, Zhiqiang Wu, Chenghua Li, Ruidong Ma et al. · 2024 · Cell Death and Disease
- Spotlite: Web Application and Augmented Algorithms for Predicting Co-Complexed Proteins from Affinity Purification – Mass Spectrometry DataDennis Goldfarb, Bridgid E. Hast, Wei Wang, Michael B. Major · 2014 · Journal of Proteome Research
- Thermodynamic profiling of inhibitors of Nrf2:Keap1 interactionsHamid R. Nasiri, Sandra Linge, Dirk Ullmann · 2015 · Bioorganic & Medicinal Chemistry Letters
- The complex role of NRF2 in cancer: A genomic viewPraslicka, Brandon John, Kerins, Michael John, Ooi, Aikseng · 2016 · Current Opinion in Toxicology
- Different Inhibition of Nrf2 by Two Keap1 Isoforms α and β to Shape Malignant Behaviour of Human Hepatocellular CarcinomaFeilong Chen, Mei Xiao, Jing Feng, Reziyamu Wufuer, Keli Liu, Shaofan Hu, Yiguo Zhang · 2022 · International Journal of Molecular Sciences
- Unique and overlapping roles of NRF2 and NRF1 in transcriptional regulationHiroki Sekine, Hozumi Motohashi · 2023 · Journal of Clinical Biochemistry and Nutrition
- Imperative connotation of SODs in cancer: Emerging targets and multifactorial role of actionBiswajit Panda, Ankita Tripathy, Srimanta Patra, Bandana Kullu, Shams S. M. Tabrez, Mrutyunjay Jena · 2024 · IUBMB Life
- The role of modulation of antioxidant enzyme systems in the treatment of neurodegenerative diseasesSybil Akua Okyerewa Obuobi, Sanzhar Karatayev, Christina L. L. Chai, Pui Lai Rachel Ee, Péter Mátyus · 2016 · Journal of Enzyme Inhibition and Medicinal Chemistry
- Clinical potential of the Hippo-YAP pathway in bladder cancerXin Cheng, Kecheng Lou, Liang Ding, Xiaofeng Zou, Ruohui Huang, Gang Xu, Junrong Zou, Guoxi Zhang · 2022 · Frontiers in Oncology
- The Role of Single-Nucleotide Polymorphisms in Cholangiocarcinoma: A Systematic ReviewGuanwu Wang, Lara Rosaline Heij, Dong Liu, Edgar Dahl, Sven Arke Lang, Tom Florian Ulmer, Tom Luedde, Ulf P. Neumann, Jan Bednarsch · 2022 · Cancers
- Alantolactone triggers oxeiptosis in human ovarian cancer cells via Nrf2 signaling pathwayMahdieh Nasirzadeh, Somayeh Atari-Hajipirloo, Shiva Gholizadeh‐Ghaleh Aziz, Yousef Rasmi, Ghader Babaei, Shahriar Alipour · 2023 · Biochemistry and Biophysics Reports
- CRL2KLHDC3 mediates p14ARF N-terminal ubiquitylation degradation to promote non-small cell lung carcinoma progressionYang Liu, Yuewen Luo, Shumei Yan, Yifan Lian, Shiyu Wu, Miao Xu, Lin Feng, Xu Zhang, Rong Li, Xiantao Zhang et al. · 2022 · Oncogene
- Discovery of a Kelch-like ECH-associated protein 1-inhibitory tetrapeptide and its structural characterizationSatoshi Sogabe, Kotaro Sakamoto, Yusuke Kamada, Akito Kadotani, Yasunori Fukuda, Junichi Sakamoto · 2017 · Biochemical and Biophysical Research Communications
- An Overview of the Genomic Characterization of Hepatocellular CarcinomaSun Y. Yim, Ju-Seog Lee · 2021 · Journal of Hepatocellular Carcinoma
- A kelch family protein Nd1-L functions as a metastasis suppressor in cancer cells via Rho family proteins mediated mechanismEtsuro Hatano · 2009 · International Journal of Oncology
- Targeting the Nrf2-Prx1 Pathway with Selenium to Enhance the Efficacy and Selectivity of Cancer TherapyYun-Jeong Kim, Sun‐Hee Baek, Paul N. Bogner, Clement C.Y. Ip, Youcef M. Rustum, Marwan Fakih, Nithya Ramnath, Young‐Mee Park · 2007
- Nrf2 in Host Defense: Over the RainbowHye‐Youn Cho, Mi‐Kyoung Kwak, Jingbo Pi · 2013 · Oxidative Medicine and Cellular Longevity
- Computational Assessment of Carotenoids as Keap1-Nrf2 Protein–Protein Interaction Inhibitors: Implications for Antioxidant StrategiesAlessandro Medoro, Tassadaq Hussain Jafar, Fabio Sallustio, Giovanni Scapagnini, Luciano Saso, Sergio Davinelli · 2024 · Biochemistry (Moscow)
- A Naturally-Occurring Dominant-Negative Inhibitor of Keap1 Competitively against Its Negative Regulation of Nrf2Lu Qiu, Meng Wang, Yuping Zhu, Yuancai Xiang, Yiguo Zhang · 2018 · International Journal of Molecular Sciences
- Regulation of post-translational modifications of muskelin by protein kinase CSøren Prag, Adèle De Arcangelis, Elisabeth Georges‐Labouesse, Josephine Clare Adams · 2006 · The International Journal of Biochemistry & Cell Biology
- Screening approaches for the identification of Nrf2-Keap1 protein-protein interaction inhibitors targeting hot spot residuesWataru Asano, Rie Hantani, Toru Uhara, François Debaene, Akihiro Nomura, Keishi Yamaguchi, Tsuyoshi Adachi, Kazuki Otake, Kazuhito Harada, Yoshiji Hantani · 2023 · SLAS DISCOVERY
- New Cu (II) and Zn (II) metal chelates derived from azo‐Schiff bases: Synthesis, DNA/BSA binding, anticancer activity and molecular docking studiesSevgi Kahraman, Özge Güngör, Sultan Erkan, Işık Didem Karagöz, Muhammet Köse, Mükerrem Kurtoğlu · 2024 · Applied Organometallic Chemistry
- NRF2 Is a Potential Modulator of Hyperresistance to Arsenic Toxicity in Stem‐Like KeratinocytesXiafang Wu, Bei Yang, Yuxin Hu, Ru Bao Sun, Huihui Wang, Jingqi Fu, Yongyong Hou, Jingbo Pi, Yuanyuan Xu · 2017 · Oxidative Medicine and Cellular Longevity
- Targeted substrate degradation by Kelch controls the actin cytoskeleton during ring canal expansionAndrew M. Hudson, Katelynn M. Mannix, Julianne A. Gerdes, Molly C. Kottemann, Lynn Cooley · 2018 · Development
- Chlorhexidine as a Keap1-Nrf2 inhibitor: a new target for an old drug for Parkinson's disease therapySruthi Unni, Prashant H. Deshmukh, Gopinatha Krishnappa, M. M. Srinivas Bharath, Balasundaram Padmanabhan · 2022 · Journal of Biomolecular Structure and Dynamics
- Forensic significance of intracardiac expressions of Nrf2 in acute myocardial ischemiaShion Hiyamizu, Yuko Ishida, Haruki Yasuda, Yumi Kuninaka, Mizuho Nosaka, Akiko Ishigami, Emi Shimada, Akihiko Kimura, Hiroki Yamamoto, Miyu Osako et al. · 2024 · Scientific Reports
- Cardamonin anticancer effects through the modulation of the tumor immune microenvironment in triple-negative breast cancer cellsPatricia Mendonca · 2024 · American Journal of Cancer Research
- Structural mimicry of UM171 and neomorphic cancer mutants co-opts E3 ligase KBTBD4 for HDAC1/2 recruitmentChen, Zhuoyao, Chi, Gamma, Balo, Timea, Chen, Xiangrong, Montes, Beatriz Ralsi, Clifford, Steven C., D’Angiolella, Vincenzo, Szabo, Timea, Kiss, Arpad, Novak, Tibor et al. · 2025 · Nature Communications
- CACUL1/CAC1 Regulates the Antioxidant Response by Stabilizing Nrf2Yu Kigoshi, Tomomi Fukuda, Tomoyuki Endo, Nami Hayasaka, Shun‐ichiro Iemura, Tohru Natsume, Fuminori Tsuruta, Tomoki Chiba · 2015 · Scientific Reports
- Structural basis of Nrf2 activation by flavonolignans from silymarinMartiniano Bello · 2022 · Journal of Molecular Graphics and Modelling
- Discovery of polypodiside as a Keap1-dependent Nrf2 activator attenuating oxidative stress and accumulation of extracellular matrix in glomerular mesangial cells under high glucoseHuankai Yao, Nan Zhang, Wenting Zhang, Jindong Li, Huilian Hua, Yan Li · 2020 · Bioorganic & Medicinal Chemistry
- Traumatic brain injury induces the activation of the Nrf2-ARE pathway in the lung in ratsWei Xing Yan, Handong Wang, Lin Zhu, Xiaomei Feng, Liang Qiao, Wei Jin, Ke Tang · 2008 · Brain Injury
- In silico and in vivo analysis of the relationship between ADHD and social isolation in pups rat model: Implication of redox mechanisms, and the neuroprotective impact of PunicalaginKarema Abu‐Elfotuh, Alshaymaa Darwish, Heba M. A. Elsanhory, Hamzah Hussain Alharthi, Ahmed M. Hamdan, Amira M. Hamdan, Rehab Ali Elsayed Masoud, Rana H. Abd El‐Rhman, Enji Reda · 2023 · Life Sciences
- Nrf2, A Target for Precision Oncology in Cancer Prognosis and TreatmentHoang Kieu Chi Ngo, Hoang Le, Young‐Joon Surh · 2023 · Journal of Cancer Prevention
- Mechanisms of Cyanotoxin Toxicity—Carcinogenicity, Anticancer Potential, and Clinical ToxicologyDeyana Georgieva Vankova, Milena Gincheva Pasheva, Yoana Dimitrova Kiselova-Kaneva, Dobri Lazarov Ivanov, Diana Georgieva Ivanova · 2019 · IntechOpen eBooks
- Recombinant adenovirus Ad-RUNrf2 reduces paraquat-induced A549 injuryQ Cai, Zhongqiu Lu, Guangliang Hong, Xin Jiang, Z Wu, Jianjian Zheng, Qingliang Song, Z Chang · 2012 · Human & Experimental Toxicology
- The Emerging Roles of Hydrogen Sulfide in FerroptosisYiwen Zhu, Zi-Tao Liu, Ao-Qi Tang, Xiaoyi Liang, Yan Wang, Yafang Liu, Yuqing Jin, Wei Gao, Hang Yuan, Dayong Wang et al. · 2024 · Antioxidants and Redox Signaling
- Design, synthesis, and anti-inflammatory activity of 2H-1,4-benzoxazin-3(4H)-one derivatives modified with 1,2,3-triazole in LPS-induced BV-2 cellsXixi Hou, Longfei Mao, Huibin Zhang, Lan Wang, Baoyu He, Jingjing Guo, Jianji Wang · 2025 · Frontiers in Pharmacology
- Screening and characterization of antioxidant peptides from Ganoderma lucidum: Virtual prediction, experimental validation, and mechanistic insightsMinghao Liu, Yan Zhang, Jiuliang Yang, Xue Zhou, Wannan Li, Weiwei Han · 2025 · Food Bioscience
- A novel β-TrCP1/NRF2 interaction inhibitor for effective anti-inflammatory therapyÁngel J. García‐Yagüe, Lucía Cañizares-Moscato, José Antonio Encinar, Eduardo Cazalla, Raquel Fernández-Ginés, Maribel Escoll, Ana Isabel Rojo, Antonio Cuadrado · 2025 · Journal of Biomedical Science
- New insights into the mechanism of Keap1-Nrf2 interaction based on cancer-associated mutationsLiangkai Cheng, Huihui Wang, Shehan Li, Zhongqiu Liu, Caiyan Wang · 2021 · Life Sciences
- Engineering New Protein–Protein Interactions on the β‐Propeller Fold by Yeast Cell Surface DisplayKeya Zhang, Heng Li, Karan Bhuripanyo, Bo Zhao, Tiffany F. Chen, Ning Zheng, Jun Yin · 2013 · ChemBioChem
- Insights into the role of NRF2 in cancer provided by cancer genomicsPetri Pölönen, Anna–Liisa Levonen · 2016 · Current Opinion in Toxicology
- Clinical significance of SQSTM1/P62 and nuclear factor-κB expression in pancreatic carcinomaZhao-Yang Zhang, Sen Guo, Rui Zhao, Zhipeng Ji, Zhuonan Zhuang · 2020 · World Journal of Gastrointestinal Oncology
- Combating Oxidative/Nitrosative Stress with Electrophilic Counterattack StrategiesTakumi Satoh, Mohd Waseem Akhtar, Stuart A. Lipton · 2013 · Springer eBooks
- Molecular effects of cancer-associated somatic mutations on the structural and target recognition properties of Keap1Halema Khan, Ryan C. Killoran, Anne M. Brickenden, Jing‐Song Fan, Daiwen Yang, Wing‐Yiu Choy · 2015 · Biochemical Journal
- Whole-exome mutational landscape of metastasis in patient-derived hepatocellular carcinoma cellsQian Zhou, Zuli Li, Linlan Song, Di Mu, Jin Wang, Li Tian, Yong Liao · 2020 · Genes & Diseases
- Structural and Dynamic Characterization of Mutated Keap1 for Varied Affinity toward Nrf2: A Molecular Dynamics Simulation StudyI-Chung Cheng, Ya‐Jyun Chen, Chia‐Wei Ku, Yu-Wen Huang, Chia‐Ning Yang · 2015 · Journal of Chemical Information and Modeling
- Oncogene PKCε controls INrf2:Nrf2 interaction in normal and cancer cells through INrf2 phosphorylationSuryakant K. Niture, Averell L. Gnatt, Anil K. Jaiswal · 2013 · Journal of Cell Science · Retracted
- Accurate Description of Solvent-Exposed Salt Bridges with a Non-polarizable Force Field Incorporating Solvent EffectsHan Liu, Haohao Fu, Christophe J. Chipot, Xueguang Shao, Wensheng Cai · 2022 · Journal of Chemical Information and Modeling
- Ascorbic acid attenuates cadmium-induced myocardial hypertrophy and cardiomyocyte injury through Nrf2 signaling pathways comparable to resveratrolSundaresan Sasikumar, Subramani Yuvraj, Pattapulavar Veilumuthu, John Godwin Christopher, Anand Kumar Purushothaman, Tamilmaran Nagarajan, Sureshkumar Selvaraj, Govindan Sadasivam Selvam · 2023 · 3 Biotech
- Mononuclear and binuclear dioxidomolybdenum(VI) chelates derived from a tridentate ONO donor aroylhydrazone: Spectral, structural, DFT and in silico biological investigationsA. Ambili Aravindakshan, Nithya Mohan, M.R. Prathapachandra Kurup, Sultan Erkan, Savaş Kaya, E. Manoj · 2024 · Polyhedron
- Cruciferous Vegetables, Isothiocyanates, Indoles, and Cancer PreventionCynthia A. Thomson, Sally E. Dickinson, G. Tim Bowden · 2010 · Humana Press eBooks
- Possible involvement of granulocyte oxidative burst in Nrf2 signaling in cancer.Morana Jaganjac · 2010 · PubMed
- The Nrf2-Keap1 signalling pathway: Mechanisms of ARE transcription regulation in antioxidant cellular defenceAhmed Atia, Azman Abdullah · 2014 · International Journal of PharmTech Research
- Nrf2-Mediated Antioxidant Response and Drug Efflux Transporters Upregulation as Possible Mechanisms of Resistance in Photodynamic Therapy of CancersOlawale Razaq Ajuwon, Fleury Augustin Nsole Biteghe, Jean De La Croix Ndong, Lester M. Davids, Basiru Olaitan Ajiboye, Bartholomew I. C. Brai, Fisayo Abraham Bamisaye, John Adeolu Falode, Ikenna Maximillian Odoh, Kabirat Adegbite et al. · 2024 · OncoTargets and Therapy
- Development of Keap1‐Nrf2 Protein–Protein Interaction Inhibitor Activating Intracellular Nrf2 Based on the Naphthalene‐2‐acetamide Scaffold, and its Anti‐Inflammatory EffectsDaisuke Yasuda, Kai Toyoshima, Koujin Kojima, Hanako Ishida, Kazuma Kaitoh, Riyo Maruki Imamura, Kayoko Kanamitsu, Hirotatsu Kojima, Megumi Funakoshi‐Tago, Masanori Osawa et al. · 2025 · ChemMedChem
- NRF2 activation in cancer cells suppresses immune infiltration into the tumor microenvironmentHuaichun Wen, Takafumi Suzuki, Anqi Zhang, Miu Sato, Mahiro Matsumoto, Yuka Takahashi, Yushi Takahashi, Masayuki P. Yamamoto · 2025 · iScience
- Flavonoids Regulate Redox-Responsive Transcription Factors in Glioblastoma and MicrogliaNatali Joma, Issan Zhang, Germanna Lima Righetto, Laura McKay, Evan Rizzel Gran, Ashok K. Kakkar, Dušica Maysinger · 2023 · Cells
- Acute accumulation of PIM2 and NRF2 and recovery of β5 subunit activity mitigate multiple myeloma cell susceptibility to proteasome inhibitorsKimiko Sogabe, Shingen Nakamura, Yoshiki Higa, Hirokazu Miki, Asuka Oda, Tomoko Maruhashi, Ryohei Sumitani, Masahiro Oura, Mamiko Takahashi, Masafumi Nakamura et al. · 2024 · International Journal of Hematology