Structural Basis for Defects of Keap1 Activity Provoked by Its Point Mutations in Lung Cancer
Padmanabhan, Balasundaram, Tong, Kit I., Ohta, Tsutomu, Nakamura, Yoshihiro, Scharlock, Maria, Ohtsuji, Makiko, Kang, Moon-Il, Kobayashi, Akira, Yokoyama, Shigeyuki, Yamamoto, Masayuki·2006·Molecular Cell
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- RETRACTED ARTICLE: Wogonin reversed resistant human myelogenous leukemia cells via inhibiting Nrf2 signaling by Stat3/NF-κB inactivationXuefen Xu, Xiaobo Zhang, Yi Zhang, Lin Yang, Yicheng Liu, Shaoliang Huang, Lu Lu, Ling‐Yi Kong, Zhiyu Li, Qinglong Guo et al. · 2017 · Scientific Reports · Retracted
- The multifaceted role of NRF2 in cancer progression and cancer stem cells maintenanceBo-Hyun Choi, Jin Myung Kim, Mi‐Kyoung Kwak · 2021 · Archives of Pharmacal Research
- Computational design of an epitope-specific Keap1 binding antibody using hotspot residues grafting and CDR loop swappingLiu, Xiaofeng, Taylor, Richard D., Griffin, Laura, Coker, Shu-Fen, Adams, Ralph, Ceska, Tom, Shi, Jiye, Lawson, Alastair D. G., Baker, Terry · 2017 · Scientific Reports
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- Hsp90 Interaction with INrf2(Keap1) Mediates Stress-induced Nrf2 ActivationSuryakant K. Niture, Anil K. Jaiswal · 2010 · Journal of Biological Chemistry · Retracted
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- The current status and future prospects for therapeutic targeting of KEAP1-NRF2 and β-TrCP-NRF2 interactions in cancer chemoresistanceRohini Srivastava, Raquel Fernández-Ginés, José Antonio Encinar, Antonio Cuadrado, Geoffrey Wells · 2022 · Free Radical Biology and Medicine
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- Shadows of NRF2 in cancer: Resistance to chemotherapyBo-Hyun Choi, Mi‐Kyoung Kwak · 2016 · Current Opinion in Toxicology
- ERK and PI3K signaling cascades induce Nrf2 activation and regulate cell viability partly through Nrf2 in human glioblastoma cellsZixiang Cong, Handong Wang, Jiawei Wang, Yuan Zhou, Hao Pan, Ding-Ding Zhang, Lin Zhu · 2013 · Oncology Reports
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- The Potential Role of Major Argan Oil Compounds as Nrf2 Regulators and Their Antioxidant EffectsRiad El Kebbaj, Habiba Bouchab, Mounia Tahri-Joutey, Soufiane Rabbaa, Youness Limami, Boubker Nasser, Melford Chuka Egbujor, Paolo Tucci, Pierre Andreoletti, Luciano Saso et al. · 2024 · Antioxidants
- Fuzzy Complex Formation between the Intrinsically Disordered Prothymosin α and the Kelch Domain of Keap1 Involved in the Oxidative Stress ResponseHalema Khan, Elio A. Cino, Anne M. Brickenden, Jing‐Song Fan, Daiwen Yang, Wing‐Yiu Choy · 2013 · Journal of Molecular Biology
- Transcription factor NRF2 uses the Hippo pathway effector TAZ to induce tumorigenesis in glioblastomasMaribel Escoll, Diego Lastra, Marta Pajares, Natalia Robledinos-Antón, Ana Isabel Rojo, Raquel Fernández-Ginés, Marta Mendiola, Virginia Martínez-Marín, I. Esteban, Pilar López‐Larrubia et al. · 2020 · Redox Biology
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- The significance of gene mutations across eight major cancer typesProsenjit Paul, Arup Kumar Malakar, Supriyo Chakraborty · 2019 · Mutation Research/Reviews in Mutation Research
- Structural Basis for Recruitment of DAPK1 to the KLHL20 E3 LigaseChen, Zhuoyao, Picaud, Sarah, Filippakopoulos, Panagis, D'Angiolella, Vincenzo, Bullock, Alex N. · 2019 · Structure
- A NRF2 inhibitor selectively sensitizes KEAP1 mutant tumor cells to cisplatin and gefitinib by restoring NRF2-inhibitory function of KEAP1 mutantsTahar Aboulkassim, Xiaohong Tian, Qiang Liu, Dinghong Qiu, Mark A. Hancock, Jian Hui Wu, Gerald Batist · 2023 · Cell Reports
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- The KEAP1/NRF2 Signaling Pathway in KeratinizationYosuke Ishitsuka, Tatsuya Ogawa, Dennis R. Roop · 2020 · Antioxidants
- Oxidative Stress-Induced Misfolding and Inclusion Formation of Nrf2 and Keap1Vy Ngo, Nadun C. Karunatilleke, Anne M. Brickenden, Wing‐Yiu Choy, Martin L. Duennwald · 2022 · Antioxidants
- Multiple binding modes of a small molecule to human Keap1 revealed by X‐ray crystallography and molecular dynamics simulationMikiya Satoh, Hajime Saburi, Tomoyuki U Tanaka, Yoshinori Matsuura, Hisashi Naitow, Rieko Shimozono, Naoyoshi Yamamoto, Hideki Inoue, Noriko Nakamura, Yoshitaka Yoshizawa et al. · 2015 · FEBS Open Bio
- Structural basis of tRNA modification with CO2 fixation and methylation by wybutosine synthesizing enzyme TYW4†Yoko Suzuki, Akiko Noma, Tsutomu Suzuki, Ryuichiro Ishitani, Osamu Nureki · 2009 · Nucleic Acids Research
- Genetic deletion of Nrf2 promotes immortalization and decreases life span of murine embryonic fibroblastsJodar, L., Mercken, E. M., Ariza, J., Younts, C., Gonzalez-Reyes, J. A., Alcain, F. J., Buron, I., de Cabo, R., Villalba, J. M. · 2011 · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences
- A systematic molecular dynamics approach to the study of peptide Keap1–Nrf2 protein–protein interaction inhibitors and its application to p62 peptidesMengchen Lu, Zhenwei Yuan, Yong-Lin Jiang, Zhiyun Chen, Qidong You, Zhengyu Jiang · 2016 · Molecular BioSystems
- Characterization of a small molecule inhibitor of disulfide reductases that induces oxidative stress and lethality in lung cancer cellsFraser D. Johnson, John R. Ferrarone, Alvin Liu, Christina Brandstädter, Ravi S. N. Munuganti, Dylan Farnsworth, Daniel Lu, Jennifer Luu, Tianna S. Sihota, Sophie Jansen et al. · 2022 · Cell Reports
- Phylogenetic, Structural and Functional Relationships between WD- and Kelch-Repeat ProteinsAndrew M. Hudson, Lynn Cooley · 2008 · Sub-cellular biochemistry/Subcellular biochemistry
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- The instability of the BTB-KELCH protein Gigaxonin causes Giant Axonal Neuropathy and constitutes a new penetrant and specific diagnostic testAlexia Boizot, Yasmina Talmat-Amar, Deborah Morrogh, Nancy L. Kuntz, Cecile Halbert, B. Chabrol, Henry Houlden, Tanya Stojkovic, Brenda Arlene Schulman, Bernd W. Rautenstrauss et al. · 2014 · Acta Neuropathologica Communications
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- Nrf2 expression in endometrial serous carcinomas and its precancers.Ning Chen, Xiaofang Yi, Nisreen Abushahin, Shujie Pang, Donna Zhang, Beihua Kong, Wenxin Zheng · 2010 · PubMed Central
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