Structural basis for defects of Keap1 activity provoked by its point mutations in lung cancer
Padmanabhan, Balasundaram, Tong, Kit I., Ohta, Tsutomu, Nakamura, Yoshihiro, Scharlock, Maria, Ohtsuji, Makiko, Kang, Moon-Il, Kobayashi, Akira +2 more·2006·Molecular Cell
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- Molecular Mechanism of Cellular Oxidative Stress Sensing by Keap1Takafumi Suzuki, Aki Muramatsu, Ryota Saito, Tatsuro Iso, Takahiro Shibata, Keiko Kuwata, Shin-ichi Kawaguchi, Takao Iwawaki, Saki Adachi, Hiromi Suda et al. · 2019 · Cell Reports
- The emerging family of CULLIN3-RING ubiquitin ligases (CRL3s): cellular functions and disease implicationsGenschik, Pascal, Sumara, Izabela, Lechner, Esther · 2013 · The EMBO Journal
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- NRF2 addiction in cancer cellsHiroshi Kitamura, Hozumi Motohashi · 2018 · Cancer Science
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- Expanding roles of superoxide dismutases in cell regulation and cancerMeixia Che, Ren Wang, Xiaoxing Li, Hui‐Yun Wang, X.F. Steven Zheng · 2015 · Drug Discovery Today
- KEAP1‐NRF2 protein–protein interaction inhibitors: Design, pharmacological properties and therapeutic potentialEnrique Crisman, Pablo Duarte, Esteban Daudén, Antonio Cuadrado, Marı́a Isabel Rodrı́guez-Franco, Manuela G. López, Rafael M. Leon · 2022 · Medicinal Research Reviews
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- Discovery of Potent Keap1–Nrf2 Protein–Protein Interaction Inhibitor Based on Molecular Binding Determinants AnalysisZhengyu Jiang, Mengchen Lu, Lili Xu, Tingting Yang, Meiyang Xi, Xiaoli Xu, Xiaoke Guo, Xiaojin Zhang, Qidong You, Hao-Peng Sun · 2014 · Journal of Medicinal Chemistry
- Update on the Kelch-like (KLHL) gene familyBajinder S Dhanoa, Tiziana Cogliati, Akhila G. Satish, Elspeth A. Bruford, James S. Friedman · 2013 · Human Genomics
- NRF2, a Superstar of FerroptosisRuolan Yan, Bingyi Lin, Wenwei Jin, Ling Tang, Shuming Hu, Rong Cai · 2023 · Antioxidants
- Chronic Obstructive Pulmonary Disease and Lung Cancer: New Molecular InsightsAdcock, Ian M., Caramori, Gaetano, Barnes, Peter J. · 2011 · Respiration
- Human prx1 Gene Is a Target of Nrf2 and Is Up-regulated by Hypoxia/Reoxygenation: Implication to Tumor BiologyYun-Jeong Kim, Jiyeon Ahn, Ping Liang, Clement C.Y. Ip, Yuesheng Zhang, Young-Mee Park · 2007 · Cancer Research
- Review of Molecular Mechanisms Involved in the Activation of the Nrf2-ARE Signaling Pathway by Chemopreventive AgentsAldo Giudice, Claudio Arra, Maria Caterina Turco · 2010 · Methods in molecular biology
- Born to bind: the BTB protein–protein interaction domainR. Pérez-Torrado, D. Yamada, P. Defossez · 2006 · Bioessays
- The clinical impact of artemisinin resistance in Southeast Asia and the potential for future spreadCharles J. Woodrow, Nicholas John White · 2016 · FEMS Microbiology Reviews
- Thirty years of NRF2: advances and therapeutic challenges.Zhang, Donna D. · 2025 · Nature Reviews Drug Discovery
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- Nrf2 protects against airway disordersHye‐Youn Cho, Steven R. Kleeberger · 2009 · Toxicology and Applied Pharmacology
- Molecular mechanisms of natural products in chemoprevention: Induction of cytoprotective enzymes by Nrf2Aimee L. Eggler, Kelly A. Gay, Andrew D. Mesecar · 2008 · Molecular Nutrition & Food Research
- Keap1 is a forked-stem dimer structure with two large spheres enclosing the intervening, double glycine repeat, and C-terminal domainsToshihiko Ogura, Kit I. Tong, Kazuhiro Mio, Yuusuke Maruyama, Hirofumi Kurokawa, Chikara Sato, Masayuki P. Yamamoto · 2010 · Proceedings of the National Academy of Sciences
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- The Keap1-Nrf2 system and diabetes mellitusUruno, Akira, Yagishita, Yoko, Yamamoto, Masayuki · 2015 · Archives of Biochemistry and Biophysics
- Arsenic Inhibits Autophagic Flux, Activating the Nrf2-Keap1 Pathway in a p62-Dependent MannerAlexandria Lau, Yi Zheng, Shasha Tao, Huihui Wang, Samantha A. Whitman, Eileen White, Donna D. Zhang · 2013 · Molecular and Cellular Biology
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- Genetic Analysis of Cytoprotective Functions Supported by Graded Expression of Keap1Keiko Taguchi, Jonathan M. Maher, Takafumi Suzuki, Yukie Kawatani, Hozumi Motohashi, Masayuki P. Yamamoto · 2010 · Molecular and Cellular Biology
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- The CUL3–KLHL3 E3 ligase complex mutated in Gordon's hypertension syndrome interacts with and ubiquitylates WNK isoforms: disease-causing mutations in KLHL3 and WNK4 disrupt interactionAkihito Ohta, Frances‐Rose Schumacher, Youcef Mehellou, Clare Johnson, Axel Knebel, Thomas Macartney, Nicola T. Wood, Dario R. Alessi, Thimo Kurz · 2013 · Biochemical Journal
- Suppression of NF-κB signaling by KEAP1 regulation of IKKβ activity through autophagic degradation and inhibition of phosphorylationJeong-eun Kim, Dong‐Joo You, Cheolju Lee, Curie Ahn, Jae Young Seong, Jong‐Ik Hwang · 2010 · Cellular Signalling
- Nrf2-induced antiapoptotic Bcl-xL protein enhances cell survival and drug resistanceSuryakant K. Niture, Anil K. Jaiswal · 2012 · Free Radical Biology and Medicine
- Regulatory crosstalk between the oxidative stress-related transcription factor Nfe2l2/Nrf2 and mitochondriaIn-geun Ryoo, Mi‐Kyoung Kwak · 2018 · Toxicology and Applied Pharmacology
- Somatic mutations of the KEAP1 gene in common solid cancersNam Jin Yoo, Hyung Ran Kim, Yoo Ri Kim, Chang Hyeok An, Sug Hyung Lee · 2012 · Histopathology
- Adaptation to Oxidative Stress, Chemoresistance, and Cell SurvivalMatteo Landriscina, Francesca Maddalena, Gabriella Laudiero, Franca Esposito · 2009 · Antioxidants and Redox Signaling
- NRF2 activation promotes the recurrence of dormant tumour cells through regulation of redox and nucleotide metabolismDouglas B. Fox, Nina Marie G. Garcia, Brock J. McKinney, Ryan Lupo, Laura C. Noteware, Rachel Newcomb, Juan Liu, Jason W. Locasale, Matthew D. Hirschey, James V. Alvarez · 2020 · Nature Metabolism
- A mutation of Keap1 found in breast cancer impairs its ability to repress Nrf2 activityNioi, Paul, Nguyen, Truyen · 2007 · Biochemical and Biophysical Research Communications
- Gain of Nrf2 Function in Non-Small-Cell Lung Cancer Cells Confers RadioresistanceAnju Singh, Manish Bodas, Nobunao Wakabayashi, Fred Bunz, Shyam S. Biswal · 2010 · Antioxidants and Redox Signaling
- An Auto-regulatory Loop between Stress Sensors INrf2 and Nrf2 Controls Their Cellular AbundanceOk-Hee Lee, Abhinav K. Jain, Victor Z. Papusha, Anil K. Jaiswal · 2007 · Journal of Biological Chemistry
- Oncogenic functions of the transcription factor Nrf2Irene Gañán‐Gómez, Yue Wei, Hui Yang, M. C. Boyano-Adánez, Guillermo Garcia‐Manero · 2013 · Free Radical Biology and Medicine
- PGAM5, a Bcl-XL-interacting protein, is a novel substrate for the redox-regulated Keap1-dependent ubiquitin ligase complexLo, Shih-Ching, Hannink, Mark · 2006 · Journal of Biological Chemistry
- Nrf2-deficiency creates a responsive microenvironment for metastasis to the lungHironori Satoh, Takashi Moriguchi, Keiko Taguchi, Jun Takai, Jonathan M. Maher, Takafumi Suzuki, Paul T. Winnard, Venu Raman, Masahito Ebina, Toshihiro Nukiwa et al. · 2010 · Carcinogenesis
- The KEAP1–NRF2 System as a Molecular Target of Cancer TreatmentTaguchi, Keiko, Yamamoto, Masayuki · 2020 · Cancers
- Molecular basis for the disruption of Keap1–Nrf2 interaction via Hinge & Latch mechanismYuta Horie, Takafumi Suzuki, Jin Inoue, Tatsuro Iso, Geoffrey Wells, Terry W. Moore, Tsunehiro Mizushima, Albena T. Dinkova‐Kostova, Takuma Kasai, Takashi Kamei et al. · 2021 · Communications Biology
- Expression of ABCG2 (BCRP) Is Regulated by Nrf2 in Cancer Cells That Confers Side Population and Chemoresistance PhenotypeAnju Singh, Hailong Wu, Ping Zhang, Christine Happel, Jinfang Ma, Shyam S. Biswal · 2010 · Molecular Cancer Therapeutics
- PALB2 Interacts with KEAP1 To Promote NRF2 Nuclear Accumulation and FunctionJianglin Ma, Hong Cai, Tongde Wu, Bijan Sobhian, Yanying Huo, Allen L. Alcivar, Monal Mehta, Ka Lung Cheung, Shridar Ganesan, Ah‐Ng Tony Kong et al. · 2012 · Molecular and Cellular Biology
- Antioxidant-induced modification of INrf2 cysteine 151 and PKC-δ-mediated phosphorylation of Nrf2 serine 40 are both required for stabilization and nuclear translocation of Nrf2 and increased drug resistanceSuryakant K. Niture, Abhinav K. Jain, Anil K. Jaiswal · 2009 · Journal of Cell Science · Retracted
- Methylation of the KEAP1 gene promoter region in human colorectal cancerNaoyuki Hanada, Takenori Takahata, Qiliang Zhou, Xulu Ye, Ruowen Sun, Jugoh Itoh, Atsushi Ishiguro, Hiroshi Kijima, Junsei Mimura, Ken Itoh et al. · 2012 · BMC Cancer
- The Nrf2 Pathway in Liver DiseasesJiaming Zhou, Qiuxian Zheng, Zhi Chen · 2022 · Frontiers in Cell and Developmental Biology
- The Keap1–Nrf2 system as an in vivo sensor for electrophilesAkira Uruno, Hozumi Motohashi · 2011 · Nitric Oxide
- NRF2 Activation in Cancer: From DNA to ProteinErica W. Cloer, Dennis Goldfarb, Travis Parke Schrank, Bernard E. Weissman, Michael B. Major · 2019 · Cancer Research
- The Bioreductive Prodrug PR-104A Is Activated under Aerobic Conditions by Human Aldo-Keto Reductase 1C3Christopher P. Guise, Maria Rosaria Abbattista, Rachelle S. Singleton, Samuel D. Holford, Joanna Connolly, Gabi U. Dachs, Stephen B. Fox, Robert Pollock, Justin Harvey, Parry Guilford et al. · 2010 · Cancer Research
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- The transcription factor NF‐E2‐related Factor 2 (Nrf2): a protooncogene?Phillip M. Shelton, Anil K. Jaiswal · 2012 · The FASEB Journal
- Arsenic-induced malignant transformation of human keratinocytes: Involvement of Nrf2Jingbo Pi, Bhalchandra A. Diwan, Yang Sun, Jie Liu, Wei Qu, Yu‐Ying He, Miroslav Stýblo, Michael P. Waalkes · 2008 · Free Radical Biology and Medicine
- Potential Applications of NRF2 Inhibitors in Cancer TherapyEmiliano Panieri, Luciano Saso · 2019 · Oxidative Medicine and Cellular Longevity
- Redox Potential of Antioxidants in Cancer Progression and PreventionSajan George, Heidi Abrahamse · 2020 · Antioxidants
- The Nrf2-Keap1-ARE Signaling Pathway: The Regulation and Dual Function of Nrf2 in CancerDonna D. Zhang · 2010 · Antioxidants and Redox Signaling
- p62 at the Interface of Autophagy, Oxidative Stress Signaling, and CancerIoannis P. Nezis, Harald Stenmark · 2011 · Antioxidants and Redox Signaling
- Ferroptosis in Cancer Treatment: Another Way to RomeYinan Wu, Chengcheng Yu, Meng Luo, Cen Chen, Jili Qiu, Suzhan Zhang, Kaimin Hu · 2020 · Frontiers in Oncology
- The Keap1–Nrf2 Cell Defense Pathway – A Promising Therapeutic Target?Ian M. Copple · 2012 · Advances in pharmacology
- SIRT5 facilitates cancer cell growth and drug resistance in non-small cell lung cancerWei‐Dong Lü, Yun Zuo, Yufang Feng, Min Zhang · 2014 · Tumor Biology
- Keap Calm, and Carry on CovalentlyWilson, Anthony J., Kerns, Jeffrey K., Callahan, James F., Moody, Christopher J. · 2013 · Journal of Medicinal Chemistry
- Molecular mechanisms of Nrf2 regulation and how these influence chemical modulation for disease interventionBryan G. Harder, Tao Jiang, Tongde Wu, Shasha Tao, Montserrat Rojo de la Vega, Wang Tian, Eli Chapman, Donna D. Zhang · 2015 · Biochemical Society Transactions
- Metabolic rewiring in melanomaBoris I. Ratnikov, David A. Scott, Andrei L. Osterman, Jeffrey W. Smith, Ze’ev A. Ronai · 2016 · Oncogene
- Regulation of the Keap1–Nrf2 pathway by p62/SQSTM1Y. Katsuragi, Y. Ichimura, M. Komatsu · 2016 · Current Opinion in Toxicology
- Conservation of the Keap1-Nrf2 System: An Evolutionary Journey through Stressful Space and TimeYuji Fuse, Makoto Kobayashi · 2017 · Molecules
- State-of-the-art strategies for targeting protein–protein interactions by small-molecule inhibitorsSheng, Chunquan, Dong, Guoqiang, Miao, Zhenyuan, Zhang, Wannian, Wang, Wei · 2015 · Chemical Society Reviews
- Role of the Nrf2-antioxidant system in cytotoxicity mediated by anticancer cisplatin: Implication to cancer cell resistanceJeong‐Min Cho, Sarala Manandhar, Hyang‐Rim Lee, Hyun-Min Park, Mi‐Kyoung Kwak · 2007 · Cancer Letters
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- Roles of reactive oxygen species in inflammation and cancerYunfei Yu, Shengzhuo Liu, Luchen Yang, Pan Song, Zhenghuan Liu, Xiaoyang Liu, Xin Yan, Qiang Dong · 2024 · MedComm
- <i>CUL3</i>
and
<i>NRF2</i>
Mutations Confer an NRF2 Activation Phenotype in a Sporadic Form of Papillary Renal Cell CarcinomaOoi, Aikseng, Dykema, Karl, Ansari, Asif, Petillo, David, Snider, John, Kahnoski, Richard, Anema, John, Craig, David, Carpten, John, Teh, Bin-Tean et al. · 2013 · Cancer Research
- Emerging role of NRF2 in chemoresistance by regulating drug-metabolizing enzymes and efflux transportersXupeng Bai, Yibei Chen, Xiangyu Hou, Min Huang, Jing Jin · 2016 · Drug Metabolism Reviews
- Role of the Keap1–Nrf2 Pathway in CancerHanna M. Leinonen, Emilia Kansanen, Petri Pölönen, Merja Heinäniemi, Anna–Liisa Levonen · 2014 · Advances in cancer research
- Luteolin inhibits the Nrf2 signaling pathway and tumor growth in vivoSong Chian, Ruby Thapa, Zhexu Chi, Xiu Jun Wang, Xiuwen Tang · 2014 · Biochemical and Biophysical Research Communications
- Redox regulation of neuronal survival mediated by electrophilic compoundsTakumi Satoh, Stuart A. Lipton · 2006 · Trends in Neurosciences
- Drugging the addict: non‐oncogene addiction as a target for cancer therapyRemco Nagel, Ekaterina A Semenova, Anton J. M. Berns · 2016 · EMBO Reports
- The Critical Role of Nitric Oxide Signaling, via Protein S-Guanylation and Nitrated Cyclic GMP, in the Antioxidant Adaptive ResponseShigemoto Fujii, Tomohiro Sawa, Hideshi Ihara, Kit I. Tong, Tomoaki Ida, Tatsuya Okamoto, Khandaker Ahtesham Ahmed, Yu Ishima, Hozumi Motohashi, Masayuki P. Yamamoto et al. · 2010 · Journal of Biological Chemistry
- KEAP1-NRF2 complex in ischemia-induced hepatocellular damage of mouse liver transplantsBibo Ke, Xiu‐Da Shen, Yu Long Zhang, Haofeng Ji, Feng Gao, Shi Yue, Naoko Kamo, Yuan Zhai, Masayuki P. Yamamoto, Ronald W. Busuttil et al. · 2013 · Journal of Hepatology
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- A catalogue of somatic NRF2 gain-of-function mutations in cancerKerins, Michael John, Ooi, Aikseng · 2018 · Scientific Reports
- Nrf-2 overexpression in mesenchymal stem cells reduces oxidative stress-induced apoptosis and cytotoxicityMohammad Mohammadzadeh-Vardin, Raheleh Halabian, Ahmad Gharehbaghian, Naser Amirizadeh, Ali Jahanian‐Najafabadi, Amaneh Mohammadi Roushandeh, Mehryar Habibi Roudkenar · 2012 · Cell Stress and Chaperones
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- Sustained Activation of Nuclear Erythroid 2-Related Factor 2/Antioxidant Response Element Signaling Promotes Reductive Stress in the Human Mutant Protein Aggregation Cardiomyopathy in MiceNamakkal Soorappan Rajasekaran, Saradhadevi Varadharaj, Gayatri Deepti Khanderao, Christopher J. Davidson, Sankaranarayanan Kannan, Matthew A. Firpo, Jay Louis Zweier, Ivor J. Benjamin · 2010 · Antioxidants and Redox Signaling
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- Arsenic‐Mediated Activation of the Nrf2‐Keap1 Antioxidant PathwayAlexandria Lau, Samantha A. Whitman, Melba C. Jaramillo, Donna D. Zhang · 2012 · Journal of Biochemical and Molecular Toxicology
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