PRAS40 is an insulin-regulated inhibitor of the mTORC1 protein kinase

Cited by (1,000)

Items 701–800 of 1,000

1. Direct imaging of the recruitment and phosphorylation of S6K1 in the mTORC1 pathway in living cells
   Abdullah R. Ahmed, Raymond J. Owens, Christopher D. Stubbs, Anthony William Parker, Richard B. Hitchman, Rahul B. Yadav, Maud Dumoux, Chris R. Hawes, Stanley W. Botchway · 2019 · Scientific Reports
2. Mechanistic target of rapamycin inhibitors: successes and challenges as cancer therapeutics
   Muireann Ní Bhaoighill, Elaine A. Dunlop · 2019 · Cancer Drug Resistance
3. Water Extract of Lotus Leaf Alleviates Dexamethasone-Induced Muscle Atrophy via Regulating Protein Metabolism-Related Pathways in Mice
   Sang Hee Park, Jieun Oh, Minkyeong Jo, Jin Kyeong Kim, Jin Kyeong Kim, Dong Seon Kim, Keejung Yoon, Yoonyong Yang, Jeong-Ho Geum, Jung‐Eun Kim et al. · 2020 · Molecules
4. Organogenesis and tumorigenesis: Insight from the JAK/STAT pathway in the Drosophila eye
   Ying‐Hsuan Wang, Min‐Lang Huang · 2010 · Developmental Dynamics
5. Distinctive Responses to Nitrogen Starvation in the Dominant Active Mutants of the Fission Yeast Rheb GTPase
   Tomoka Murai, Yukiko Nakase, Keiko Fukuda, Yuji Chikashige, Chihiro Tsutsumi, Yasushi Hiraoka, Tomohiro Matsumoto · 2009 · Genetics
6. Knockdown of ubiquitin associated protein 2-like inhibits the growth and migration of prostate cancer cells
   Dong Li, Yiran Huang · 2014 · Oncology Reports
7. Two-Tiered Control of Epithelial Growth and Autophagy by the Insulin Receptor and the Ret-Like Receptor, Stitcher
   Fergal O’Farrell, Shenqiu Wang, Nadja Sandra Katheder, Tor Erik Rusten, Christos Samakovlis · 2013 · PLoS Biology
8. Positive regulation of inositol 1,4,5‐trisphosphate‐induced ca 2+ release by mammalian target of rapamycin (mTOR) in RINm5F cells
   Marc‐Olivier Frégeau, Yannik Régimbald‐Dumas, Gaétan Guillemette · 2010 · Journal of Cellular Biochemistry
9. The mTOR Signaling Pathway in Pediatric Neuroblastoma
   Hong Mei, Ye Wang, Zhenyu Lin, Qiangsong Tong · 2013 · Pediatric Hematology and Oncology
10. A-674563, a putative AKT1 inhibitor that also suppresses CDK2 activity, inhibits human NSCLC cell growth more effectively than the pan-AKT inhibitor, MK-2206
    Paige M. Chorner, Roger A. Moorehead · 2018 · PLoS ONE
11. RETRACTED: Genetically reducing mTOR signaling rescues central insulin dysregulation in a mouse model of Alzheimer's disease
    Antonella Caccamo, Ramona Belfiore, Salvatore Oddo · 2018 · Neurobiology of Aging · Retracted
12. Perspectives of RAS and RHEB GTPase Signaling Pathways in Regenerating Brain Neurons
    Hendrik Schöneborn, Fabian Raudzus, Mathieu Coppey, Sebastian Neumann, Rolf Heumann · 2018 · International Journal of Molecular Sciences
13. mTOR Signaling at the Crossroad between Metazoan Regeneration and Human Diseases
    Yasmine Lund-Ricard, Patrick Cormier, Julia Morales, Agnès Boutet · 2020 · International Journal of Molecular Sciences
14. TGFβ acts through PDGFRβ to activate mTORC1 via the Akt/PRAS40 axis and causes glomerular mesangial cell hypertrophy and matrix protein expression
    Soumya Maity, Falguni Das, Balakuntalam S. Kasinath, Nandini Ghosh‐Choudhury, Goutam Ghosh Choudhury · 2020 · Journal of Biological Chemistry
15. Prolonged deprivation of arginine or leucine induces PI3K/Akt-dependent reactivation of mTORC1
    Gwen R. Buel, Huy Quang Dang, John M. Asara, John Blenis, Anders Peter Mutvei · 2022 · Journal of Biological Chemistry
16. mTOR in Viral Hepatitis and Hepatocellular Carcinoma: Function and Treatment
    Zhuo Wang, Wei Jin, Hongchuan Jin, Xian Wang · 2014 · BioMed Research International
17. The promise of mTOR inhibitors in the treatment of colorectal cancer
    Dae-Dong Kim, Cathy Eng · 2012 · Expert Opinion on Investigational Drugs
18. Translational responses to growth factors and stress
    Megan Cully, Julian Downward · 2009 · Biochemical Society Transactions
19. The binding of PRAS40 to 14-3-3 proteins is not required for activation of mTORC1 signalling by phorbol esters/ERK
    Bruno D. Fonseca, Vivian H.-Y. Lee, Christopher G. Proud · 2008 · Biochemical Journal
20. Biomolecular condensates: molecular structure, biological functions, diseases, and therapeutic targets
    Sunkyung Choi, Jung-Min Lee, Kee K. Kim · 2025 · Molecular Biomedicine
21. Exendin-4 stimulates islet cell replication via the IGF1 receptor activation of mTORC1/S6K1
    Jianling Xie, Norhan Mohamed El-Sayed, Qi Cheng, Xuechan Zhao, Claire E. Moore, Terence P. Herbert · 2014 · Journal of Molecular Endocrinology
22. Apoptotic Cells Activate AMP-activated Protein Kinase (AMPK) and Inhibit Epithelial Cell Growth without Change in Intracellular Energy Stores
    Vimal A. Patel, Donald Massenburg, Snezana Vujicic, Lanfei Feng, Meiyi Tang, Natalia O. Litbarg, Angelika Antoni, Joyce Rauch, Wilfred Lieberthal, Jerrold S. Levine · 2015 · Journal of Biological Chemistry
23. Protective effect of docosahexaenoic acid on lipotoxicity‐mediated cell death in Schwann cells: Implication of PI3K/AKT and mTORC2 pathways
    Magda Descorbeth, Karen Figueroa Figueroa, Miguel Serrano‐Illán, Marino A. De León · 2018 · Brain and Behavior
24. Sin1/mTORC2 regulate B cell growth and metabolism by activating mTORC1 and Myc
    Man Li, Adam S. Lazorchak, Xinxing Ouyang, Huihui Zhang, Hongzhi Liu, Omotooke Arojo, Lichong Yan, Jingsi Jin, Yuheng Han, Guojun Qu et al. · 2019 · Cellular and Molecular Immunology
25. In Vitro Antitumor Mechanism of (E)-N-(2-methoxy-5-(((2,4,6-trimethoxystyryl)sulfonyl)methyl)pyridin-3-yl)methanesulfonamide
    Tiangong Lu, Charles A. Laughton, Shudong Wang, Tracey Dawn Bradshaw · 2014 · Molecular Pharmacology
26. Upstream signalling of mTORC1 and its hyperactivation in type 2 diabetes (T2D)
    Muhammad Zeeshan Ali, Shazia Anwer Bukhari, Muhammad Zeeshan Ali, Han-Woong Lee · 2017 · BMB Reports
27. Body size regulation by maturation steroid hormones: a Drosophila perspective
    Seogang Hyun · 2018 · Frontiers in Zoology
28. Translating Translation to Mechanisms of Cardiac Hypertrophy
    Michael J. Zeitz, James W. Smyth · 2020 · Journal of Cardiovascular Development and Disease
29. mTORC1 activity as a determinant of cancer risk – Rationalizing the cancer-preventive effects of adiponectin, metformin, rapamycin, and low-protein vegan diets
    Mark Frederick McCarty · 2011 · Medical Hypotheses
30. Targeting PRAS40 for multiple diseases
    Zhao Zhong Chong · 2016 · Drug Discovery Today
31. RAPTOR up-regulation contributes to resistance of renal cancer cells to PI3K-mTOR inhibition
    Philip Earwaker, Caroline J. Anderson, Frances W. Willenbrock, Adrian Llewellyn Harris, Andrew S. Protheroe, Valentine M. Macaulay · 2018 · PLoS ONE
32. Targeting translation regulators improves cancer therapy.
    Shi-Long Jiang, Jun-Luan Mo, Ji Peng, L. Lei, Ji-Ye Yin, Hong-Hao Zhou, W. Hong, Zhao-Qian Liu · 2020 · Genomics
33. Amino Acid Trafficking and Skeletal Muscle Protein Synthesis: A Case of Supply and Demand
    James P. White · 2021 · Frontiers in Cell and Developmental Biology
34. Protein kinase C and P2Y12 take center stage in thrombin‐mediated activation of mammalian target of rapamycin complex 1 in human platelets
    Samantha Moore, Roger W. Hunter, Ingeborg Hers · 2014 · Journal of Thrombosis and Haemostasis
35. Genetic ablation of PRAS40 improves glucose homeostasis via linking the AKT and mTOR pathways
    Ritu Malla, Yu Wang, William K. Chan, Amit Kumar Tiwari, Jesika S. Faridi · 2015 · Biochemical Pharmacology
36. Akt and mTORC1 signaling as predictive biomarkers for the EGFR antibody nimotuzumab in glioblastoma
    Michael W. Ronellenfitsch, Pia Susann Zeiner, Michel Guy André Mittelbronn, Hans Urban, Torsten Pietsch, Dirk Reuter, Christian Senft, Joachim Peter Steinbach, Manfred Westphal, Patrick N. Harter · 2018 · Acta Neuropathologica Communications
37. Marmoset as a Model to Study Kidney Changes Associated With Aging
    Hak Joo Lee, Olga González, Edward J. Dick, Andrew Donati, Denis Féliers, Goutam Ghosh Choudhury, Corinna N. Ross, Manjeri A. Venkatachalam, Suzette D. Tardif, Balakuntalam S. Kasinath · 2018 · The Journals of Gerontology Series A
38. Central Suppression of the GH/IGF Axis and Abrogation of Exercise-Related mTORC1/2 Activation in the Muscle of Phenotype-Selected Male Marathon Mice (DUhTP)
    Julia Brenmoehl, Christina Walz, Caroline Caffier, Elli Brosig, Michael Walz, Daniela Ohde, Nares Trakooljul, Martina Langhammer, Siriluck Ponsuksili, Klaus Wimmers et al. · 2021 · Cells
39. Bisleuconothine A Induces Autophagosome Formation by Interfering with AKT-mTOR Signaling Pathway
    Chin Piow Wong, Ari Seki, Kaori Horiguchi, Tomokazu Shoji, Takashi Arai, Alfarius Eko Nugroho, Yusuke Hirasawa, Fumiaki Sato, Toshio Kaneda, Hiroshi Morita · 2015 · Journal of Natural Products
40. Nanoscale Mapping and Affinity Constant Measurement of Signal-Transducing Proteins by Atomic Force Microscopy
    Il Hong Kim, Mi Nam Lee, Sung Ho Ryu, Joon Won Park · 2011 · Analytical Chemistry
41. Sustained activation of mTORC1 in macrophages increases AMPKα-dependent autophagy to maintain cellular homeostasis
    Hongjie Pan, Xiao‐Ping Zhong, Sunhee Lee · 2016 · BMC Biochemistry
42. PDGF receptor-β uses Akt/mTORC1 signaling node to promote high glucose-induced renal proximal tubular cell collagen I (α2) expression
    Falguni Das, Nandini Ghosh‐Choudhury, Balachandar A. Venkatesan, Balakuntalam S. Kasinath, Goutam Ghosh Choudhury · 2017 · American Journal of Physiology-Renal Physiology
43. Cross Talk Networks of Mammalian Target of Rapamycin Signaling With the Ubiquitin Proteasome System and Their Clinical Implications in Multiple Myeloma
    Ruth Eichner, Vanesa Fernández‐Sáiz, Bianca‐Sabrina Targosz, Florian C. Bassermann · 2018 · International review of cytology
44. Amino acids enhance polyubiquitination of Rheb and its binding to mTORC1 by blocking lysosomal ATXN3 deubiquitinase activity
    Yao Yao, Sungki Hong, T. Ikeda, Hiroyuki Mori, O. MacDougald, S. Nada, M. Okada, K. Inoki · 2020 · Molecules and Cells
45. Pib2 as an Emerging Master Regulator of Yeast TORC1
    Riko Hatakeyama · 2021 · Biomolecules
46. Targeting mTOR Signaling in Type 2 Diabetes Mellitus and Diabetes Complications
    Lin Yang, Zhixin Zhang, Doudou Wang, Yu Jiang, Ying Liu · 2022 · Current Drug Targets
47. Reduction of Lobe leads to TORC1 hypoactivation that induces ectopic Jak/STAT signaling to impair Drosophila eye development
    Ying‐Hsuan Wang, Min‐Lang Huang · 2009 · Mechanisms of Development
48. Targeting the Mammalian Target of Rapamycin in Lung Cancer
    Glenn W. Vicary, Jesse Roman · 2016 · The American Journal of the Medical Sciences
49. Alcohol-Induced Modulation of Rictor and mTORC2 Activity in C2C12 Myoblasts
    Ly Q. Hong‐Brown, C. Randell Brown, Maithili Navaratnarajah, Danuta S. Huber, Charles H. Lang · 2011 · Alcoholism Clinical and Experimental Research
50. mTOR kinase-dependent, but raptor-independent regulation of downstream signaling is important for cell cycle exit and myogenic differentiation
    Hilary J. Pollard, Mark Willett, Simon Morley · 2014 · Cell Cycle
51. Sin1-mediated mTOR signaling in cell growth, metabolism and immune response
    Chun-Hong Ruan, Xin-Xing Ouyang, Hong-Zhi Liu, Song Li, Jing-Si Jin, Wen-Ting Tang, Yu-Jia Xia, Bing Su · 2019 · National Science Review
52. Low FoxO expression in Drosophila somatosensory neurons protects dendrite growth under nutrient restriction
    Amy R. Poe, Yineng Xu, Christine Zhang, Joyce Lei, Kailyn Li, David Labib, Chun Han · 2020 · eLife
53. Phenotypic Screen with TSC-Deficient Neurons Reveals Heat-Shock Machinery as a Druggable Pathway for mTORC1 and Reduced Cilia
    Alessia Di Nardo, Isadora Lenoël, Kellen Diamond Winden, Alina Rühmkorf, Meera E. Modi, Lee B Barrett, Ebru Ercan-Herbst, Pooja Venugopal, Robert Behne, Carla A.M. Lopes et al. · 2020 · Cell Reports
54. eIF3a regulation of mTOR signaling and translational control via HuR in cellular response to DNA damage
    Shijie Ma, Zizheng Dong, Yanfei Huang, Jingyuan Liu, Jian‐Ting Zhang · 2022 · Oncogene
55. REPTOR and CREBRF encode key regulators of muscle energy metabolism
    Pedro Saavedra, Phillip A. Dumesic, Yanhui Hu, Elizabeth Filine, Patrick Jouandin, Richard C. Binari, Sarah E. Wilensky, Jonathan Rodiger, Haiyun Wang, Weihang Chen et al. · 2023 · Nature Communications
56. Amino acid sensing and regulation of mTORC1
    Lijun Yan, Richard F. Lamb · 2012 · Seminars in Cell and Developmental Biology
57. Insulin Signaling in Insulin Resistance States and Cancer: A Modeling Analysis
    ALESSANDRO BERTUZZI, Federica Conte, Geltrude Mingrone, Federico Papa, Serenella Salinari, Carmela Sinisgalli · 2016 · PLoS ONE
58. Current Targeted Therapies in HER2-Positive Gastric Adenocarcinoma
    Fabiana Curea, Mohamed Hebbar, Silvia Mihaela Ilie, Xenia Elena Bacinschi, Oana Gabriela Trifanescu, Inga Botnariuc, Rodica Maricela Anghel · 2017 · Cancer Biotherapy and Radiopharmaceuticals
59. Hypoxia‐induced regulation of mTOR signaling by miR‐7 targeting REDD1
    Minhyeong Seong, Jihui Lee, Hara Kang · 2018 · Journal of Cellular Biochemistry
60. Rapamycin inhibits mSin1 phosphorylation independently of mTORC1 and mTORC2
    Yan Luo, Lei Liu, Yang Wu, Karnika Singh, Bing Su, Nan Zhang, Xiaowei Liu, Yangmei Shen, Shile Huang · 2015 · Oncotarget
61. Nutri-stress, mitochondrial dysfunction, and insulin resistance—role of heat shock proteins
    Kuppuswami Jayashree, Gandhipuram Periyasamy Senthilkumar · 2022 · Cell Stress and Chaperones
62. Role of mammalian target of rapamycin (mTOR) signalling in oncogenesis
    Mohamed El‐Tanani, Hamdi Nsairat, Alaa A. A. Aljabali, Ángel Serrano‐Aroca, Vijay Kumar Mishra, Yachana Mishra, Gowhar A. Naikoo, Walhan Alshaer, Murtaza M. Tambuwala · 2023 · Life Sciences
63. Investigation of POPX2 phosphatase functions by comparative phosphoproteomic analysis
    Pritpal Singh, Chee Sian Gan, Tiannan Guo, Hui‐Qun Phang, Siu Kwan Sze, Cheng-Gee Koh · 2011 · PROTEOMICS
64. Recent advances in targeting mTOR signaling pathway using small molecule inhibitors
    A. Roohi, M. Hojjat-Farsangi · 2017 · Journal of drug targeting (Print)
65. In Vitro and In Vivo Synergistic Antitumor Activity of the Combination of BKM120 and Erlotinib in Head and Neck Cancer: Mechanism of Apoptosis and Resistance
    Abu Syed Md Anisuzzaman, Abedul Haque, Dongsheng Wang, Mohammad Aminur Rahman, Chao Zhang, Zhengjia Chen, Zhuo Georgia Chen, Dong Moon Shin, A.R.M. Ruhul Amin · 2017 · Molecular Cancer Therapeutics
66. Disruption of the vacuolar-type H+-ATPase complex in liver causes MTORC1-independent accumulation of autophagic vacuoles and lysosomes
    Sandra Kissing, Sönke Rudnik, Markus Daμμe, Renate Lüllmann‐Rauch, Atsuhiro Ichihara, Uwe Kornak, Eeva‐Liisa Eskelinen, Sabrina Jabs, Jörg Heeren, Jef K. De Brabander et al. · 2017 · Autophagy
67. The mTOR pathway in Gliomas: From molecular insights to targeted therapies
    Safura Pournajaf, Mohammad H. Pourgholami · 2025 · Biomedicine & Pharmacotherapy
68. AMPK Control of mTOR Signaling and Growth
    Dana M. Gwinn, Reuben J. Shaw · 2010 · The Enzymes
69. Phosphoinositides in cell proliferation and metabolism.
    E. Hirsch, F. Gulluni, M. Martini · 2020 · Advances in Biological Regulation
70. Dual Specificity Kinase DYRK3 Promotes Aggressiveness of Glioblastoma by Altering Mitochondrial Morphology and Function
    Kyeong‐Min Kim, Sungmin Lee, Hyunkoo Kang, Eunguk Shin, Hae Yu Kim, HyeSook Youn, BuHyun Youn · 2021 · International Journal of Molecular Sciences
71. Loss of RanGAP1 drives chromosome instability and rapid tumorigenesis of osteosarcoma
    Yan Gong, Shitian Zou, Daizhao Deng, Liang Wang, Hongling Hu, Zeyou Qiu, Tiantian Wei, Panpan Yang, Jielong Zhou, Yu Zhang et al. · 2023 · Developmental Cell
72. Unacylated ghrelin restores insulin and autophagic signaling in skeletal muscle of diabetic mice
    Bjorn T. Tam, Xiao Meng Pei, Benjamin Yat‐Ming Yung, Shea Ping Yip, Lawrence Chan, Sze Chuen Cesar Wong, Parco M. Siu · 2015 · Pflügers Archiv - European Journal of Physiology
73. Pleiotropic roles of mTOR complexes in haemato-lymphopoiesis and leukemogenesis
    Takayuki Hoshii, S. Matsuda, Atsushi Hirao · 2014 · The Journal of Biochemistry
74. Mammalian Target of Rapamycin at the Crossroad Between Alzheimer’s Disease and Diabetes
    Hanyu Liang, Jia Nie, Candice E. Van Skike, Joseph M. Valentine, Miranda E. Orr · 2019 · Advances in experimental medicine and biology
75. AKT signaling promotes DNA damage accumulation and proliferation in polycystic kidney disease
    Sarah E. Conduit, Elizabeth M. Davies, Lisa M. Ooms, Rajendra Gurung, Meagan J. McGrath, Sandra Hakim, Denny L. Cottle, Ian Smyth, Jennifer M. Dyson, Christina Anne Mitchell · 2019 · Human Molecular Genetics
76. mTOR Regulation of Metabolism in Hematologic Malignancies
    Simone Mirabilii, Maria Rosaria Ricciardi, Agostino Tafuri · 2020 · Cells
77. Over-expression of PRAS40 enhances insulin sensitivity in skeletal muscle
    Claudia Wiza, Alexandra Chadt, Marcel Blumensatt, Timo Kanzleiter, Daniella Herzfeld de Wiza, Angelika Horrighs, Heidi Mueller, Emmani B. M. Nascimento, Annette Schürmann, Hadi Al‐Hasani et al. · 2014 · Archives of Physiology and Biochemistry
78. Activation of 5′ Adenosine Monophosphate-Activated Protein Kinase Blocks Cumulus Cell Expansion Through Inhibition of Protein Synthesis During In Vitro Maturation in Swine1
    Nicolas William Santiquet, Maxime Sasseville, Martin F. Laforest, Christine Guillemette, Robert Bruce Gilchrist, François J. Richard · 2014 · Biology of Reproduction
79. Leonurine improves atherosclerosis by activating foam cell autophagy and metabolic remodeling via METTL3-mediated AKT1S1 mRNA stability modulation
    Xinyuan Yu, Yaoyuan Zhang, Juan Wang, Xiaodan Wang, Xu Chen, Kai Yin, Xiao Zhu · 2024 · Phytomedicine
80. Tetrahydroquinoline: An Efficient Scaffold As mTOR Inhibitor for the Treatment of Lung Cancer
    Udit Chaube, Rajdeep Dey, Suman K. Shaw, Bhumika Patel, Hardik Bhatt · 2022 · Future Medicinal Chemistry
81. (−)-Guaiol regulates autophagic cell death depending on mTOR signaling in NSCLC
    Xiaohui Yang, Jiabei Zhu, Jianchun Wu, Nan Jing Huang, Zhongqi Cui, Yingbin Luo, Fenyong Sun, Qiuhui Pan, Yan Li, Qingyuan Yang · 2018 · Cancer Biology & Therapy
82. Curcumin represses mTORC1 signaling in Caco-2 cells by a two-sided mechanism involving the loss of IRS-1 and activation of AMPK
    Harleen Kaur, Régis F. Moreau · 2020 · Cellular Signalling
83. Protein Phosphorylation as a Key Mechanism of mTORC1/2 Signaling Pathways
    Elena M. Tchevkina, Andrei V. Komelkov · 2012 · InTech eBooks
84. mTOR Signaling in Lymphangioleiomyomatosis
    Arnold S. Kristof · 2010 · Lymphatic Research and Biology
85. Activation of AMPK/TSC2/PLD by Alcohol Regulates mTORC1 and mTORC2 Assembly in C2C12 Myocytes
    Ly Q. Hong‐Brown, C. Randell Brown, Maithili Navaratnarajah, Charles H. Lang · 2013 · Alcoholism Clinical and Experimental Research
86. Role of the Mammalian Target of Rapamycin (mTOR) Complexes in Pancreatic β-Cell Mass Regulation
    Alberto Bartolomé, Carlos Guillén · 2014 · Vitamins and hormones
87. A first-in-class selective inhibitor of EGFR and PI3K offers a single-molecule approach to targeting adaptive resistance
    Christopher E. Whitehead, Elizabeth K. Ziemke, Christy L. Frankowski-McGregor, Rachel A. Mumby, June Chung, Jinju Li, Nathaniel Osher, Oluwadara Coker, Veerabhadran Baladandayuthapani, Scott Kopetz et al. · 2024 · Nature Cancer
88. Adipocyte JAK2 Regulates Hepatic Insulin Sensitivity Independently of Body Composition, Liver Lipid Content, and Hepatic Insulin Signaling
    Kevin C. Corbit, João Paulo Camporez, Lia R. Edmunds, Jennifer L. Tran, Nicholas B. Vera, Derek M. Erion, Rahul C. Deo, Rachel J. Perry, Gerald I. Shulman, Michael J. Jurczak et al. · 2017 · Diabetes
89. Semaphorin 3F and Netrin-1: The Novel Function as a Regulator of Tumor Microenvironment
    Hironao Nakayama, Chiaki Kusumoto, Masako Nakahara, Akira Fujiwara, Shigeki Higashiyama · 2018 · Frontiers in Physiology
90. Graphene quantum dot antioxidant and proautophagic actions protect SH-SY5Y neuroblastoma cells from oxidative stress-mediated apoptotic death
    Matija Krunić, Biljana Z. Ristic, Mihajlo Bošnjak, Verica Paunović, Gordana Tovilović-Kovačević, Nevena S. Zogovic, Aleksandar Mirčić, Zoran M Marković, Biljana M. Todorović Marković, Svetlana Jovanović et al. · 2021 · Free Radical Biology and Medicine
91. MNK, mTOR or eIF4E-selecting the best anti-tumor target for blocking translation initiation
    Shuo Li, Jia‐Shu Chen, Xiangqian Li, Xiaoyi bai, Dayong Shi · 2023 · European Journal of Medicinal Chemistry
92. Regulation of cardiac autophagy by insulin‐like growth factor 1
    Rodrigo Troncoso, Jessica Díaz‐Elizondo, Sandra P. Espinoza, Mario Navarro-Márquez, Alejandra P. Oyarzún, Jaime A. Riquelme, Ivonne García‐Carvajal, Guillermo Dı́az-Araya, Lorena Garcı́a, Joseph A. Hill et al. · 2013 · IUBMB Life
93. Calcineurin Inhibitor-Induced and Ras-Mediated Overexpression of VEGF in Renal Cancer Cells Involves mTOR through the Regulation of PRAS40
    Aninda Basu, Pallavi Banerjee, Alan G. Contreras, Evelyn A. Flynn, Soumitro Pal · 2011 · PLoS ONE
94. Platelet-Derived Growth Factor/Vascular Endothelial Growth Factor Receptor Inactivation by Sunitinib Results in Tsc1/Tsc2-Dependent Inhibition of TORC1
    Tram Anh T. Tran, Lisa N. Kinch, Samuel Peña‐Llopis, Lutz Kockel, Nick V. Grishin, Huaqi Jiang, James Brugarolas · 2013 · Molecular and Cellular Biology
95. Diminished DYRK2 sensitizes hormone receptor-positive breast cancer to everolimus by the escape from degrading mTOR
    Rei Mimoto, Naoe Taira Nihira, Shinichi Hirooka, Hiroshi Takeyama, Kiyotsugu Yoshida · 2016 · Cancer Letters
96. New Insights into mTOR Signal Pathways in Ovarian-Related Diseases: Polycystic Ovary Syndrome and Ovarian Cancer
    Ai Ling Liu, Hongqing Liao, Zhi Liang Li, Jun Liu, Cui Lan Zhou, Zi Fen Guo, Hong Yan Xie, Cui Ying Peng · 2016 · Europe PMC (PubMed Central)
97. UCHL1 regulates muscle fibers and mTORC1 activity in skeletal muscle
    Hongbo Gao, Jessica Freeling, Penglong Wu, Ashley Paula Liang, Xuejun Wang, Yifan Li · 2019 · Life Sciences
98. MELK is Upregulated in Advanced Clear Cell Renal Cell Carcinoma and Promotes Disease Progression by Phosphorylating PRAS40
    Han Zhang, Pengtao Wei, Wenwei Lv, Xingtao Han, Jinhui Yang, Shuaifeng Qin, Yue Zhang · 2019 · Cell Transplantation
99. A Genome-scale CRISPR Screen Identifies the ERBB and mTOR Signaling Networks as Key Determinants of Response to PI3K Inhibition in Pancreatic Cancer
    Charlotte K. Milton, Annette J. Self, Paul Andrew Clarke, Udai Banerji, Federica Piccioni, David E. Root, Steven R. Whittaker · 2020 · Molecular Cancer Therapeutics
100. P2 × 7 Receptor Inhibits Astroglial Autophagy via Regulating FAK- and PHLPP1/2-Mediated AKT-S473 Phosphorylation Following Kainic Acid-Induced Seizures
     Duk-Shin Lee, Ji-Eun Kim · 2020 · International Journal of Molecular Sciences