PKBα/Akt1 Acts Downstream of DNA-PK in the DNA Double-Strand Break Response and Promotes Survival

Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex

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ATM and ATR Substrate Analysis Reveals Extensive Protein Networks Responsive to DNA Damage

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Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Bα

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DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis

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DNA double-strand breaks: signaling, repair and the cancer connection

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Activation of the DNA damage checkpoint and genomic instability in human precancerous lesions

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Conserved modes of recruitment of ATM, ATR and DNA-PKcs to sites of DNA damage

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A phosphatidylinositol 3-kinase/Akt pathway promotes translocation of Mdm2 from the cytoplasm to the nucleus

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Mechanism and regulation of human non-homologous DNA end-joining

Lieber, M. R., Ma, Y., Pannicke, U., & Schwarz, K. (2003) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1202 · Cited by 973

Advances in protein kinase B signalling: AKTion on multiple fronts

Brazil, D. P., Yang, Z.-Z., & Hemmings, B. A. (2004) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2004.03.006 · Cited by 830

Interfaces Between the Detection, Signaling, and Repair of DNA Damage

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Spatial organization of the mammalian genome surveillance machinery in response to DNA strand breaks

Bekker-Jensen, S., Lukas, C., Kitagawa, R., Melander, F., Kastan, M. B., Bartek, J., & Lukas, J. (2006) · The Journal of Cell Biology · doi:10.1083/jcb.200510130 · Cited by 625

The role of double-strand break repair — insights from human genetics

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Identification of a PKB/Akt Hydrophobic Motif Ser-473 Kinase as DNA-dependent Protein Kinase

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The role of 3-phosphoinositide-dependent protein kinase 1 in activating AGC kinases defined in embryonic stem cells

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PI 3-kinase related kinases: ‘big’ players in stress-induced signaling pathways

Abraham, R. T. (2004) · DNA Repair · doi:10.1016/j.dnarep.2004.04.002 · Cited by 440

A Targeted DNA-PKcs-Null Mutation Reveals DNA-PK-Independent Functions for KU in V(D)J Recombination

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Molecular Mechanism for the Regulation of Protein Kinase B/Akt by Hydrophobic Motif Phosphorylation

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Autophosphorylation of DNA-PKCS regulates its dynamics at DNA double-strand breaks

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Identification of a highly potent and selective DNA-dependent protein kinase (DNA-PK) inhibitor (NU7441) by screening of chromenone libraries

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Nuclear lipid signalling

Irvine, R. F. (2003) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1100 · Cited by 406

Multiallelic Disruption of the rictor Gene in Mice Reveals that mTOR Complex 2 Is Essential for Fetal Growth and Viability

Shiota, C., Woo, J.-T., Lindner, J., Shelton, K. D., & Magnuson, M. A. (2006) · Developmental Cell · doi:10.1016/j.devcel.2006.08.013 · Cited by 389

Multiple Phosphoinositide 3-Kinase-Dependent Steps in Activation of Protein Kinase B

Scheid, M. P., Marignani, P. A., & Woodgett, J. R. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.17.6247-6260.2002 · Cited by 329

Coordination and communication between the p53 and IGF-1–AKT–TOR signal transduction pathways

Levine, A. J., Feng, Z., Mak, T. W., You, H., & Jin, S. (2006) · Genes & Development · doi:10.1101/gad.1363206 · Cited by 321

Physiological roles of PKB/Akt isoforms in development and disease

Dummler, B., & Hemmings, B. A. (2007) · Biochemical Society Transactions · doi:10.1042/bst0350231 · Cited by 316

Intramolecular and Intermolecular Interactions of Protein Kinase B Define Its Activation In Vivo

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Stabilization of Mdm2 via Decreased Ubiquitination Is Mediated by Protein Kinase B/Akt-dependent Phosphorylation

Feng, J., Tamaskovic, R., Yang, Z., Brazil, D. P., Merlo, A., Hess, D., & Hemmings, B. A. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m404936200 · Cited by 294

Dosage-Dependent Effects of Akt1/Protein Kinase Bα (PKBα) and Akt3/PKBγ on Thymus, Skin, and Cardiovascular and Nervous System Development in Mice

Yang, Z.-Z., Tschopp, O., Di-Poï, N., Bruder, E., Baudry, A., Dümmler, B., Wahli, W., & Hemmings, B. A. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.23.10407-10418.2005 · Cited by 220

Chromatin in Need of a Fix: Phosphorylation of H2AX Connects Chromatin to DNA Repair

Thiriet, C., & Hayes, J. J. (2005) · Molecular Cell · doi:10.1016/j.molcel.2005.05.008 · Cited by 205

Insulin-Like Growth Factor-Mediated Muscle Cell Survival: Central Roles for Akt and Cyclin-Dependent Kinase Inhibitor p21

Lawlor, M. A., & Rotwein, P. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.23.8983-8995.2000 · Cited by 184

DNA-dependent protein kinase (Ku protein-p350 complex) assembles on double-stranded DNA.

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Glycogen synthase kinase 3-dependent phosphorylation of Mdm2 regulates p53 abundance

Kulikov, R., Boehme, K. A., & Blattner, C. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.16.7170-7180.2005 · Cited by 132

DNA‐PKcs, but not TLR9, is required for activation of Akt by CpG‐DNA

Dragoi, A., Fu, X., Ivanov, S. S., Zhang, P., Sheng, L., Wu, D., Li, G. C., & Chu, W. (2005) · The EMBO Journal · doi:10.1038/sj.emboj.7600539 · Cited by 111

Phosphoinositide-Dependent Phosphorylation of PDK1 Regulates Nuclear Translocation

Scheid, M. P., Parsons, M., & Woodgett, J. R. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.6.2347-2363.2005 · Cited by 89

Novel Localization of the DNA-PK Complex in Lipid Rafts

Lucero, H. A., Gae, D., & Taccioli, G. E. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m301579200 · Cited by 84

DNA-dependent Protein Kinase-independent Activation of p53 in Response to DNA Damage

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Irradiation of mitochondria initiates apoptosis in a cell free system

Taneja, N., Tjalkens, R. B., Philbert, M. A., & Rehemtulla, A. (2001) · Oncogene · doi:10.1038/sj.onc.1204054 · Cited by 66

The Ability of p53 to Activate Downstream Genes p21 and MDM2, and Cell Cycle Arrest following DNA Damage Is Delayed and Attenuated in scid Cells Deficient in the DNA-dependent Protein Kinase

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Roles of oxidative stress and Akt signaling in doxorubicin cardiotoxicity

Ichihara, S., Yamada, Y., Kawai, Y., Osawa, T., Furuhashi, K., Duan, Z., & Ichihara, G. (2007) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2007.05.027 · Cited by 58

Growth factor-independent activation of protein kinase B contributes to the inherent resistance of vascular endothelium to radiation-induced apoptotic response.

Tan, J., & Hallahan, D. E. (2003) · PubMed · Cited by 50

Analysis of Protein Kinase B/Akt

Hill, M. M. C., & Hemmings, B. A. (2002) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(02)45037-9 · Cited by 17

AKT/PKB Signaling: Navigating the Network

Manning, B. D., & Toker, A. (2017) · Cell · doi:10.1016/j.cell.2017.04.001 · Cited by 3,772

Akt signalling in health and disease

Hers, I., Vincent, E. E., & Tavaré, J. M. (2011) · Cellular Signalling · doi:10.1016/j.cellsig.2011.05.004 · Cited by 1,239

Active-Site Inhibitors of mTOR Target Rapamycin-Resistant Outputs of mTORC1 and mTORC2

Feldman, M. E., Apsel, B., Uotila, A., Loewith, R., Knight, Z. A., Ruggero, D., & Shokat, K. M. (2009) · PLoS Biology · doi:10.1371/journal.pbio.1000038 · Cited by 1,082

Development of PI3K inhibitors: lessons learned from early clinical trials

Rodon, J., Dienstmann, R., Serra, V., & Tabernero, J. (2013) · Nature Reviews Clinical Oncology · doi:10.1038/nrclinonc.2013.10 · Cited by 766

FoxO transcription factors; Regulation by AKT and 14-3-3 proteins

Tzivion, G., Dobson, M., & Ramakrishnan, G. (2011) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2011.06.002 · Cited by 728