PreprintCited by 321PI3K/AKT/mTOR signaling in cancerCancer-related Molecular PathwaysMetabolism, Diabetes, and Cancer

Coordination and communication between the p53 and IGF-1–AKT–TOR signal transduction pathways

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Levine, Arnold J., Feng, Zhaohui, Mak, Tak W., You, Han, Jin, Shengkan·2006·Genes & Development

Abstract

Over the past 10 years the signal transduction networks for p53, IGF-1-AKT, and TOR pathways have been assembled in worms, flies, and mammals, and their functions elucidated. In the past 1-2 years a number of genes and their proteins have been identified that permit extensive communication and coordination between these pathways. These three pathways are involved in sensing and integrating signals arising from nutrient and growth factor availability, signals from sensory and sexual organs, and intrinsic and extrinsic stress signals. In turn these pathways regulate cell growth, proliferation, and death. These networks are central to our understanding of a variety of physiological and pathological conditions, including cancer, diabetes, and longevity.

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Crossref · 10.1101/gad.1363206

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  • p53 activation is able to inhibit the activity of mTOR through a pathway involving the subsequent activation of TSC1 and TSC2.

    “Furthermore, reports showed that p53 activation is able to inhibit the activity of mTOR through a pathway involving the subsequent activation of TSC gene products TSC1 and TSC2, which are tumour suppressors and negative regulators of mTOR [78, 103–105].”
  • Nutrient and energy sensing is an integrated system biology endeavour.

    “There is a growing awareness that, as far as the cell is concerned, sensing nutrient availability and energetic status is an integrated and 'system biology' endeavour 101 .”

    From The common biology of cancer and ageing (2007) · cites this paper as [101]

  • Overall lifespan is influenced by many sensors and effectors, indicating an intimate connection between energy sensing and longevity.

    “Overall lifespan seems to be influenced by many of these sensors and effectors, indicating that there is an intimate connection between energy sensing and longevity 101 .”

    From The common biology of cancer and ageing (2007) · cites this paper as [101]

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Authors
Levine, A. J., Feng, Z., Mak, T. W., You, H., & Jin, S.
Affiliations
University of Toronto (CA)
Venue
Genes & Development
Published
2006-02-01
Volume
20
Issue
3
Pages
267-275
ISSN
  • 0890-9369 (ISSN-L)
  • 1549-5477
OpenAlex
W2136212424
Cited by
321
References
79
Citations by year
2025: 3 · 2024: 5 · 2023: 2 · 2022: 9 · 2021: 6 · 2020: 9 · 2019: 14 · 2018: 6 · 2017: 14 · 2016: 11 · 2015: 13 · 2014: 23 · 2013: 18 · 2012: 33
Type
posted content
Language
en
Open access
Locations
  • Genes & Development (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › PI3K/AKT/mTOR signaling in cancer
  • Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
Keywords
p53 pathway, TOR signaling, signaling pathways, pathway integration, nutrient sensing, growth factor signaling, stress signaling, cell growth and proliferation, apoptosis, cancer, diabetes mellitus, longevity
MeSH terms
Animals, Enzyme Activation, Humans, Insulin-Like Growth Factor I, Models, Biological, Multienzyme Complexes, Protein Kinases, Signal Transduction, Tumor Suppressor Protein p53, Oncogene Protein v-akt, Forkhead Transcription Factors, TOR Serine-Threonine Kinases

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