Coordination and communication between the p53 and IGF-1–AKT–TOR signal transduction pathways
Open accessAbstract
Over the past 10 years the signal transduction networks for p53, IGF-1-AKT, and TOR pathways have been assembled in worms, flies, and mammals, and their functions elucidated. In the past 1-2 years a number of genes and their proteins have been identified that permit extensive communication and coordination between these pathways. These three pathways are involved in sensing and integrating signals arising from nutrient and growth factor availability, signals from sensory and sexual organs, and intrinsic and extrinsic stress signals. In turn these pathways regulate cell growth, proliferation, and death. These networks are central to our understanding of a variety of physiological and pathological conditions, including cancer, diabetes, and longevity.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
p53 activation is able to inhibit the activity of mTOR through a pathway involving the subsequent activation of TSC1 and TSC2.
“Furthermore, reports showed that p53 activation is able to inhibit the activity of mTOR through a pathway involving the subsequent activation of TSC gene products TSC1 and TSC2, which are tumour suppressors and negative regulators of mTOR [78, 103–105].”
From PKR, the double stranded RNA‐dependent protein kinase as a critical target in Alzheimer's disease (2009) · cites this paper as [104]
Nutrient and energy sensing is an integrated system biology endeavour.
“There is a growing awareness that, as far as the cell is concerned, sensing nutrient availability and energetic status is an integrated and 'system biology' endeavour 101 .”
From The common biology of cancer and ageing (2007) · cites this paper as [101]
Overall lifespan is influenced by many sensors and effectors, indicating an intimate connection between energy sensing and longevity.
“Overall lifespan seems to be influenced by many of these sensors and effectors, indicating that there is an intimate connection between energy sensing and longevity 101 .”
From The common biology of cancer and ageing (2007) · cites this paper as [101]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
p53, the cellular gatekeeper for growth and division
Levine, A. J. (1997) · Cell · doi:10.1016/s0092-8674(00)81871-1 · Cited by 7,693 · see citing works
Self-citationVogelstein, B., Lane, D., & Levine, A. J. (2000) · Nature · doi:10.1038/35042675 · Cited by 6,607 · see citing works
Self-citationAkt Promotes Cell Survival by Phosphorylating and Inhibiting a Forkhead Transcription Factor
Brunet, A., Bonni, A., Zigmond, M. J., Lin, M. Z., Juo, P., Hu, L. S., Anderson, M. J., Arden, K. C., Blenis, J., & Greenberg, M. E. (1999) · Cell · doi:10.1016/s0092-8674(00)80595-4 · Cited by 6,535 · see citing works
Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex
Sarbassov, D. D., Guertin, D. A., Ali, S. M., & Sabatini, D. M. (2005) · Science · doi:10.1126/science.1106148 · Cited by 6,216 · see citing works
Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery
Datta, S. R., Dudek, H., Tao, X., Masters, S., Fu, H., Gotoh, Y., & Greenberg, M. E. (1997) · Cell · doi:10.1016/s0092-8674(00)80405-5 · Cited by 5,689 · see citing works
In Vivo Activation of the p53 Pathway by Small-Molecule Antagonists of MDM2
Vassilev, L. T., Vu, B. T., Graves, B., Carvajal, D., Podlaski, F., Filipovic, Z., Kong, N., Kammlott, U., Lukacs, C., Klein, C., et al. (2004) · Science · doi:10.1126/science.1092472 · Cited by 4,661 · see citing works
Cancer genes and the pathways they control
Vogelstein, B., & Kinzler, K. W. (2004) · Nature Medicine · doi:10.1038/nm1087 · Cited by 4,245 · see citing works
Upstream and downstream of mTOR
Hay, N., & Sonenberg, N. (2004) · Genes & Development · doi:10.1101/gad.1212704 · Cited by 4,181 · see citing works
TSC2 Mediates Cellular Energy Response to Control Cell Growth and Survival
Inoki, K., Zhu, T., & Guan, K.-L. (2003) · Cell · doi:10.1016/s0092-8674(03)00929-2 · Cited by 3,914 · see citing works
Blume-Jensen, P., & Hunter, T. (2001) · Nature · doi:10.1038/35077225 · Cited by 3,738 · see citing works
Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase
Imai, S.-I., Armstrong, C. M., Kaeberlein, M., & Guarente, L. (2000) · Nature · doi:10.1038/35001622 · Cited by 3,510 · see citing works
Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase
Brunet, A., Sweeney, L. B., Sturgill, J. F., Chua, K. F., Greer, P. L., Lin, Y., Tran, H., Ross, S. E., Mostoslavsky, R., Cohen, H. Y., et al. (2004) · Science · doi:10.1126/science.1094637 · Cited by 3,239 · see citing works
Kim, D.-H., Sarbassov, D., Ali, S. M., King, J. E., Latek, R., Erdjument-Bromage, H., Tempst, P., & Sabatini, D. (2002) · Cell · doi:10.1016/s0092-8674(02)00808-5 · Cited by 3,135 · see citing works
TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling
Inoki, K., Li, Y., Zhu, T., Wu, J., & Guan, K.-L. (2002) · Nature Cell Biology · doi:10.1038/ncb839 · Cited by 3,083 · see citing works
Kastan, M. B., Zhan, Q., El-Deiry, W. S., Carrier, F., Jacks, T., Walsh, W. V., Plunkett, B. S., Vogelstein, B., & Fornace, A. J. (1992) · Cell · doi:10.1016/0092-8674(92)90593-2 · Cited by 3,047 · see citing works
p53-dependent apoptosis modulates the cytotoxicity of anticancer agents
Lowe, S. W., Ruley, H. E., Jacks, T., & Housman, D. E. (1993) · Cell · doi:10.1016/0092-8674(93)90719-7 · Cited by 2,911 · see citing works
Sarbassov, D. D., Ali, S. M., Kim, D.-H., Guertin, D. A., Latek, R. R., Erdjument-Bromage, H., Tempst, P., & Sabatini, D. M. (2004) · Current Biology · doi:10.1016/j.cub.2004.06.054 · Cited by 2,665 · see citing works
hSIR2SIRT1 Functions as an NAD-Dependent p53 Deacetylase
Vaziri, H., Dessain, S. K., Eaton, E. N., Imai, S., Frye, R. A., Pandita, T. K., Guarente, L., & Weinberg, R. A. (2001) · Cell · doi:10.1016/s0092-8674(01)00527-x · Cited by 2,653 · see citing works
Autophagy in Health and Disease: A Double-Edged Sword
Shintani, T., & Klionsky, D. J. (2004) · Science · doi:10.1126/science.1099993 · Cited by 2,531 · see citing works
Promotion of tumorigenesis by heterozygous disruption of the beclin 1 autophagy gene
Qu, X., Yu, J., Bhagat, G., Furuya, N., Hibshoosh, H., Troxel, A., Rosen, J., Eskelinen, E.-L., Mizushima, N., Ohsumi, Y., et al. (2003) · Journal of Clinical Investigation · doi:10.1172/jci20039 · Cited by 2,311 · see citing works
Interleukin-3-Induced Phosphorylation of BAD Through the Protein Kinase Akt
del Peso, L., González‐García, M., Page, C., Herrera, R., & Núñez, G. (1997) · Science · doi:10.1126/science.278.5338.687 · Cited by 2,213 · see citing works
Yue, Z., Jin, S., Yang, C., Levine, A. J., & Heintz, N. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2436255100 · Cited by 2,116 · see citing works
Self-citationIGF-1 receptor regulates lifespan and resistance to oxidative stress in mice
Holzenberger, M., Dupont, J., Ducos, B., Leneuve, P., Géloën, A., Even, P. C., Cervera, P., & Le Bouc, Y. (2003) · Nature · doi:10.1038/nature01298 · Cited by 2,109 · see citing works
Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive
Jacinto, E., Loewith, R., Schmidt, A., Lin, S., Rüegg, M. A., Hall, A., & Hall, M. N. (2004) · Nature Cell Biology · doi:10.1038/ncb1183 · Cited by 2,097 · see citing works
Negative Control of p53 by Sir2α Promotes Cell Survival under Stress
Luo, J., Nikolaev, A. Y., Imai, S.-I., Chen, D., Su, F., Shiloh, A., Guarente, L., & Gu, W. (2001) · Cell · doi:10.1016/s0092-8674(01)00524-4 · Cited by 2,081 · see citing works
The p53 pathway: positive and negative feedback loops
Harris, S. L., & Levine, A. J. (2005) · Oncogene · doi:10.1038/sj.onc.1208615 · Cited by 1,967 · see citing works
Self-citationIncreased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans
Tissenbaum, H. A., & Guarente, L. (2001) · Nature · doi:10.1038/35065638 · Cited by 1,918 · see citing works
Raptor, a binding partner of target of rapamycin (TOR), mediates TOR action.
Hara, K., Maruki, Y., Long, S., Yoshino, K., Oshiro, N., Hidayat, S., Tokunaga, C., Avruch, J., & Yonezawa, K. (2002) · Cell · doi:10.1016/s0092-8674(02)00833-4 · Cited by 1,916 · see citing works
Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling
Inoki, K., Li, Y., Xu, T., & Guan, K.-L. (2003) · Genes & Development · doi:10.1101/gad.1110003 · Cited by 1,911 · see citing works
Shaw, R. J., Kosmatka, M., Bardeesy, N., Hurley, R. L., Witters, L. A., DePinho, R. A., & Cantley, L. C. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0308061100 · Cited by 1,797 · see citing works
AMP-activated protein kinase induces a p53-dependent metabolic checkpoint
Jones, R. G., Plas, D. R., Kubek, S., Buzzai, M., Mu, J., Xu, Y., Birnbaum, M. J., & Thompson, C. B. (2005) · Molecular Cell · doi:10.1016/j.molcel.2005.03.027 · Cited by 1,619 · see citing works
Growth factor regulation of autophagy and cell survival in the absence of apoptosis
Lum, J. J., Bauer, D. E., Kong, M., Harris, M. H., Li, C., Lindsten, T., & Thompson, C. B. (2005) · Cell · doi:10.1016/j.cell.2004.11.046 · Cited by 1,487 · see citing works
p53 mutant mice that display early ageing-associated phenotypes
Tyner, S. D., Venkatachalam, S., Choi, J., Jones, S., Ghebranious, N., Igelmann, H., Lu, X., Soron, G., Cooper, B., Brayton, C., et al. (2002) · Nature · doi:10.1038/415045a · Cited by 1,459 · cited 1× · see citing works
“Designing drugs that break the p53–MDM2 com- plexes in cells and activate p53-mediated apoptosis in these cancer cells are awaiting a clinical trial (Vassilev et al. 2004).”
BackgroundBrugarolas, J., Lei, K., Hurley, R. L., Manning, B. D., Reiling, J. H., Hafen, E., Witters, L. A., Ellisen, L. W., & Kaelin, W. G. (2004) · Genes & Development · doi:10.1101/gad.1256804 · Cited by 1,384 · see citing works
Mammalian SIRT1 Represses Forkhead Transcription Factors
Motta, M. C., Divecha, N., Lemieux, M. E., Kamel, C., Chen, D., Gu, W. J., Bultsma, Y., McBurney, M. W., & Guarente, L. (2004) · Cell · doi:10.1016/s0092-8674(04)00126-6 · Cited by 1,351 · see citing works
Genetic pathways that regulate ageing in model organisms
Guarente, L., & Kenyon, C. J. (2000) · Nature · doi:10.1038/35041700 · Cited by 1,337 · see citing works
Tor, a Phosphatidylinositol Kinase Homologue, Controls Autophagy in Yeast
Noda, T., & Ohsumi, Y. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.7.3963 · Cited by 1,308 · see citing works
Post-translational modification of p53 in tumorigenesis
Bode, A. M., & Dong, Z. (2004) · Nature Reviews Cancer · doi:10.1038/nrc1455 · Cited by 1,270 · see citing works
Bond, G. L., Hu, W., Bond, E. E., Robins, H., Lutzker, S. G., Arva, N. C., Bargonetti, J., Bartel, F., Taubert, H., Wuerl, P., et al. (2004) · Cell · doi:10.1016/j.cell.2004.11.022 · Cited by 1,265 · see citing works
Self-citationThe coordinate regulation of the p53 and mTOR pathways in cells
Feng, Z., Zhang, H., Levine, A. J., & Jin, S. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0502857102 · Cited by 1,235 · see citing works
Self-citationLin, K., Hsin, H., Libina, N., & Kenyon, C. J. (2001) · Nature Genetics · doi:10.1038/88850 · Cited by 1,027 · see citing works
Akt regulates growth by directly phosphorylating Tsc2
Potter, C. J., Pedraza, L. G., & Xu, T. (2002) · Nature Cell Biology · doi:10.1038/ncb840 · Cited by 959 · see citing works
Drosophila dFOXO controls lifespan and regulates insulin signalling in brain and fat body
Hwangbo, D., Gersham, B., Tu, M., Palmer, M., & Tatar, M. (2004) · Nature · doi:10.1038/nature02549 · Cited by 954 · see citing works
HER-2/neu induces p53 ubiquitination via Akt-mediated MDM2 phosphorylation
Zhou, B. P., Liao, Y., Xia, W., Zou, Y., Spohn, B., & Hung, M.-C. (2001) · Nature Cell Biology · doi:10.1038/ncb1101-973 · Cited by 951 · see citing works
Rheb is a direct target of the tuberous sclerosis tumour suppressor proteins
Zhang, Y., Gao, X., Saucedo, L. J., Ru, B., Edgar, B. A., & Pan, D. (2003) · Nature Cell Biology · doi:10.1038/ncb999 · Cited by 924 · see citing works
Regulation of PTEN Transcription by p53
Stambolic, V., MacPherson, D. P., Sas, D., Lin, Y., Snow, B., Jang, Y., Benchimol, S., & Mak, T. W. (2001) · Molecular Cell · doi:10.1016/s1097-2765(01)00323-9 · Cited by 913 · see citing works
Self-citationBrunet, A., Park, J., Tran, H., Hu, L. S., Hemmings, B. A., & Greenberg, M. E. (2001) · Molecular and Cellular Biology · doi:10.1128/mcb.21.3.952-965.2001 · Cited by 860 · see citing works
Regulation of p53 activity through lysine methylation
Chuikov, S., Kurash, J. K., Wilson, J. R., Xiao, B., Justin, N., Ivanov, G. S., McKinney, K. M., Tempst, P., Prives, C. L., Gamblin, S. J., et al. (2004) · Nature · doi:10.1038/nature03117 · Cited by 820 · see citing works
Ubiquitination, phosphorylation and acetylation: the molecular basis for p53 regulation
Brooks, C. L., & Gu, W. J. (2003) · Current Opinion in Cell Biology · doi:10.1016/s0955-0674(03)00003-6 · Cited by 742 · see citing works
Modulation of mammalian life span by the short isoform of p53
Maier, B., Gluba, W., Bernier, B., Turner, T., Mohammad, K., Guise, T., Sutherland, A., Thorner, M., & Scrable, H. (2004) · Genes & Development · doi:10.1101/gad.1162404 · Cited by 586 · see citing works
A subset of p53-deficient embryos exhibit exencephaly
Sah, V. P., Attardi, L. D., Mulligan, G., Williams, B. O., Bronson, R. T., & Jacks, T. (1995) · Nature Genetics · doi:10.1038/ng0695-175 · Cited by 579 · see citing works
Long-Lived Drosophila with Overexpressed dFOXO in Adult Fat Body
Giannakou, M. E., Goss, M. W., Jünger, M. A., Hafen, E., Leevers, S. J., & Partridge, L. (2004) · Science · doi:10.1126/science.1098219 · Cited by 577 · see citing works
Corradetti, M. N., Inoki, K., Bardeesy, N. M., DePinho, R. A., & Guan, K. (2004) · Genes & Development · doi:10.1101/gad.1199104 · Cited by 560 · see citing works
Yu, Y., Khan, J. I., Khanna, C., Helman, L. J., Meltzer, P. S., & Merlino, G. T. (2004) · Nature Medicine · doi:10.1038/nm966 · Cited by 525 · see citing works
TSC1 and TSC2 tumor suppressors antagonize insulin signaling in cell growth.Preprint
Gao, X., & Pan, D. (2001) · Genes & Development · doi:10.1101/gad.901101 · Cited by 484 · see citing works
Ellisen, L. W., Ramsayer, K. D., Johannessen, C. M., Yang, A., Beppu, H., Minda, K., Oliner, J. D., McKeon, F., & Haber, D. A. (2002) · Molecular Cell · doi:10.1016/s1097-2765(02)00706-2 · Cited by 474 · see citing works
Cross-talk between Akt, p53 and Mdm2: possible implications for the regulation of apoptosis
Gottlieb, T. M., Martínez-Leal, J. F., Seger, R., Taya, Y., & Oren, M. (2002) · Oncogene · doi:10.1038/sj.onc.1205181 · Cited by 473 · see citing works
Hannan, K., Brandenburger, Y., Jenkins, A., Sharkey, K., Cavanaugh, A., Rothblum, L., Moss, T., Poortinga, G., McArthur, G., Pearson, R., et al. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.23.23.8862-8877.2003 · Cited by 473 · see citing works
High-frequency developmental abnormalities in p53-deficient mice
Armstrong, J. F., Kaufman, M. H., Harrison, D. J., & Clarke, A. R. (1995) · Current Biology · doi:10.1016/s0960-9822(95)00183-7 · Cited by 466 · see citing works
Caenorhabditis elegans p53: Role in Apoptosis, Meiosis, and Stress Resistance
Derry, W. B., Putzke, A. P., & Rothman, J. H. (2001) · Science · doi:10.1126/science.1065486 · Cited by 464 · see citing works
Genetics and the Specificity of the Aging Process
Hekimi, S., & Guarente, L. (2003) · Science · doi:10.1126/science.1082358 · Cited by 434 · see citing works
Bulavin, D. V., Dudgeon, C., Nannenga, B., Timofeev, O. N., Donehower, L. A., Anderson, C. W., Appella, E., & Fornace, A. J. (2004) · Nature Genetics · doi:10.1038/ng1317 · Cited by 410 · see citing works
Imamura, K., Ogura, T., Kishimoto, A., Kaminishi, M., & Esumi, H. (2001) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2001.5627 · Cited by 345 · see citing works
The Peutz-Jegher Gene Product LKB1 Is a Mediator of p53-Dependent Cell Death
Karuman, P., Gozani, O., Odze, R. D., Zhou, X., Zhu, H., Shaw, R. J., Brien, T. P., Bozzuto, C. D., Ooi, D. L.-Y., Cantley, L. C., et al. (2001) · Molecular Cell · doi:10.1016/s1097-2765(01)00258-1 · Cited by 321 · see citing works
Jin, S. V., & Levine, A. J. (2001) · Journal of Cell Science · doi:10.1242/jcs.114.23.4139 · Cited by 310 · see citing works
Self-citationThe p53MH algorithm and its application in detecting p53-responsive genes
Hoh, J., Jin, S. V., Parrado, T., Edington, J., Levine, A. J., & Ott, J. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.132268899 · Cited by 295 · see citing works
Self-citationGermline p53 Mutations in a Cohort with Childhood Sarcoma: Sex Differences in Cancer Risk
Hwang, S., Lozano, G., Amos, C. I., & Strong, L. C. (2003) · The American Journal of Human Genetics · doi:10.1086/374567 · Cited by 229 · see citing works
Cyclin G Recruits PP2A to Dephosphorylate Mdm2
Okamoto, K., Li, H., Jensen, M. R., Zhang, T., Taya, Y., Thorgeirsson, S. S., & Prives, C. (2002) · Molecular Cell · doi:10.1016/s1097-2765(02)00504-x · Cited by 215 · see citing works
Tumor suppression and normal aging in mice with constitutively high p53 activity
Mendrysa, S. M., O'Leary, K. A., McElwee, M. K., Michalowski, J., Eisenman, R. N., Powell, D. A., & Perry, M. E. (2006) · Genes & Development · doi:10.1101/gad.1378506 · Cited by 210 · see citing works
Damalas, A., Kahan, S., Shtutman, M. S., Ben‐Ze'ev, A., & Oren, M. (2001) · The EMBO Journal · doi:10.1093/emboj/20.17.4912 · Cited by 206 · see citing works
Arf tumor suppressor promoter monitors latent oncogenic signals in vivo
Zindy, F., Williams, R. T., Baudino, T. A., Rehg, J. E., Skapek, S. X., Cleveland, J. L., Roussel, M. F., & Sherr, C. J. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2536808100 · Cited by 150 · see citing works
The PP2A-Associated Protein α4 Is an Essential Inhibitor of Apoptosis
Kong, M., Fox, C. J., Mu, J., Solt, L., Xu, A., Cinalli, R. M., Birnbaum, M. J., Lindsten, T., & Thompson, C. B. (2004) · Science · doi:10.1126/science.1100537 · Cited by 149 · see citing works
p53-dependent inhibition of FKHRL1 in response to DNA damage through protein kinase SGK1
You, H., Jang, Y., You-Ten, A. I., Okada, H., Silvester, J., Wakeham, A. C., Zaugg, K., & Mak, T. W. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0406286101 · Cited by 127 · see citing works
Self-citationLKB1 — A master tumour suppressor of the small intestine and beyond
Yoo, L. I., Chung, D. C., & Yuan, J. (2002) · Nature reviews. Cancer · doi:10.1038/nrc843 · Cited by 120 · see citing works
Unleashing the power of p53: lessons from mice and men: Figure 1.Preprint
Poyurovsky, M. V., & Prives, C. L. (2006) · Genes & Development · doi:10.1101/gad.1397506 · Cited by 96 · see citing works
Mdm2 in the Response to Radiation
Perry, M. E. (2004) · Molecular Cancer Research · doi:10.1158/1541-7786.9.2.1 · Cited by 93 · see citing works
Use of RNA interference libraries to investigate oncogenic signalling in mammalian cells
Downward, J. (2004) · Oncogene · doi:10.1038/sj.onc.1208073 · Cited by 51 · see citing works
Harper, J. W. (2004) · Cell · doi:10.1016/j.cell.2004.06.015 · Cited by 44 · see citing works
Flagged first, then by citations
1 of the 79 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
The LKB1-AMPK pathway: metabolism and growth control in tumour suppression
Shackelford, D. B., & Shaw, R. J. (2009) · Nature Reviews Cancer · doi:10.1038/nrc2676 · Cited by 1,943 · see citing works
p53 Regulates Mitochondrial Respiration
Matoba, S., Kang, J.-G., Patino, W. D., Wragg, A., Boehm, M., Gavrilova, O., Hurley, P. J., Bunz, F., & Hwang, P. M. (2006) · Science · doi:10.1126/science.1126863 · Cited by 1,650 · see citing works
p53 Target Genes Sestrin1 and Sestrin2 Connect Genotoxic Stress and mTOR Signaling
Budanov, A. V., & Karin, M. (2008) · Cell · doi:10.1016/j.cell.2008.06.028 · Cited by 1,326 · see citing works
Belfiore, A., Frasca, F., Pandini, G., Sciacca, L., & Vigneri, R. (2009) · Endocrine Reviews · doi:10.1210/er.2008-0047 · Cited by 1,035 · see citing works
The common biology of cancer and ageing
Finkel, T., Serrano, M., & Blasco, M. A. (2007) · Nature · doi:10.1038/nature05985 · Cited by 988 · see citing works
Vousden, K. H., & Ryan, K. M. (2009) · Nature Reviews Cancer · doi:10.1038/nrc2715 · Cited by 959 · see citing works
Frankel, L. B., Christoffersen, N. R., Jacobsen, A., Lindow, M., Krogh, A., & Lund, A. H. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m707224200 · Cited by 1,141 · see citing works
The P53 pathway: what questions remain to be explored?
Levine, A. J., Hu, W., & Feng, Z. (2006) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4401910 · Cited by 654 · see citing works
Self-citationLKB1 and AMP-activated protein kinase control of mTOR signalling and growth
Shaw, R. J. (2009) · Acta Physiologica · doi:10.1111/j.1748-1716.2009.01972.x · Cited by 644 · see citing works
Feng, Z., Hu, W., de Stanchina, E., Teresky, A. K., Jin, S., Lowe, S., & Levine, A. J. (2007) · Cancer Research · doi:10.1158/0008-5472.can-06-4149 · Cited by 633 · see citing works
Self-citationAMP-activated Protein Kinase and the Regulation of Autophagic Proteolysis
Meley, D., Bauvy, C., Houben-Weerts, J. H. P. M., Dubbelhuis, P. F., Helmond, M. T. J., Codogno, P., & Meijer, A. J. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m605488200 · Cited by 461 · see citing works
PKBα/Akt1 Acts Downstream of DNA-PK in the DNA Double-Strand Break Response and Promotes Survival
Bozulic, L., Sürücü, B., Hynx, D., & Hemmings, B. A. (2008) · Molecular Cell · doi:10.1016/j.molcel.2008.02.024 · Cited by 386 · see citing works
Oxygen, a source of life and stress
Brahimi-Horn, M. C., & Pouysségur, J. (2007) · FEBS Letters · doi:10.1016/j.febslet.2007.06.018 · Cited by 383 · see citing works
The proliferating role of insulin and insulin-like growth factors in cancer
Gallagher, E. J., & LeRoith, D. (2010) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2010.06.007 · Cited by 391 · see citing works
Shaping Genetic Alterations in Human Cancer: The p53 Mutation Paradigm
Soussi, T., & Wiman, K. G. (2007) · Cancer Cell · doi:10.1016/j.ccr.2007.10.001 · Cited by 366 · see citing works
The regulation of energy metabolism and the IGF-1/mTOR pathways by the p53 protein
Feng, Z., & Levine, A. J. (2010) · Trends in Cell Biology · doi:10.1016/j.tcb.2010.03.004 · Cited by 359 · see citing works
Self-citationMinireview: IGF, Insulin, and Cancer
Gallagher, E. J., & LeRoith, D. (2011) · Endocrinology · doi:10.1210/en.2011-0231 · Cited by 347 · see citing works
Targeting cellular pathways in glioblastoma multiforme
Pearson, J. R. D., & Regad, T. (2017) · Signal Transduction and Targeted Therapy · doi:10.1038/sigtrans.2017.40 · Cited by 343 · see citing works
Ribosome biogenesis surveillance: probing the ribosomal protein-Mdm2-p53 pathway
Deisenroth, C., & Zhang, Y. (2010) · Oncogene · doi:10.1038/onc.2010.189 · Cited by 303 · see citing works
Obesity, type 2 diabetes, and cancer: the insulin and IGF connection
Cohen, D., & LeRoith, D. (2012) · Endocrine Related Cancer · doi:10.1530/erc-11-0374 · Cited by 303 · see citing works
Tumor suppressor p53 and metabolism
Liu, J., Zhang, C., Hu, W., & Feng, Z. (2018) · Journal of Molecular Cell Biology · doi:10.1093/jmcb/mjy070 · Cited by 298 · see citing works
Self-citationThe Origins and Evolution of the p53 Family of GenesPreprint
Белый, В. А., Ak, P., Markert, E. K., Wang, H., Hu, W., Puzio‐Kuter, A. M., & Levine, A. J. (2009) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a001198 · Cited by 293 · see citing works
Self-citationParadoxical suppression of cellular senescence by p53
Demidenko, Z. N., Korotchkina, L. G., Gudkov, A. V., & Blagosklonny, M. V. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1002298107 · Cited by 273 · see citing works
Feng, Z., Hu, W., Teresky, A. K., Hernando, E., Cordon-Cardo, C., & Levine, A. J. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0708043104 · Cited by 264 · see citing works
Self-citationEid, A. A., Ford, B. M., Block, K. L., Kasinath, B. S., Gorin, Y. C., Ghosh-Choudhury, G., Barnes, J. L., & Abboud, H. E. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.136796 · Cited by 255 · see citing works
Combinatorial patterns of somatic gene mutations in cancer
Yeang, C.-H., McCormick, F., & Levine, A. (2008) · The FASEB Journal · doi:10.1096/fj.08-108985 · Cited by 251 · see citing works
Self-citationBlagosklonny, M. V. (2012) · Aging · doi:10.18632/aging.100443 · Cited by 251 · see citing works
Signalling and autophagy regulation in health, aging and disease
Meijer, A. J., & Codogno, P. (2006) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2006.08.002 · Cited by 244 · see citing works
A systematic review of p53 regulation of oxidative stress in skeletal muscle
Beyfuss, K. A., & Hood, D. A. (2018) · Redox Report · doi:10.1080/13510002.2017.1416773 · Cited by 239 · see citing works
Healthful aging mediated by inhibition of oxidative stress
Vatner, S. F., Zhang, J., Oydanich, M. K., Berkman, T., Naftalovich, R., & Vatner, D. E. (2020) · Ageing Research Reviews · doi:10.1016/j.arr.2020.101194 · Cited by 239 · see citing works
p53 Regulation of the IGF-1/AKT/mTOR Pathways and the Endosomal CompartmentPreprint
Feng, Z. (2009) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a001057 · Cited by 237 · see citing works
Self-citationZhu, W., Soonpaa, M. H., Chen, H., Shen, W., Payne, R. M., Liechty, E. A., Caldwell, R. L., Shou, W., & Field, L. J. (2008) · Circulation · doi:10.1161/circulationaha.108.799700 · Cited by 229 · see citing works
PI3K/Akt-mediated regulation of p53 in cancer
Abraham, A., & O’Neill, E. (2014) · Biochemical Society Transactions · doi:10.1042/bst20140070 · Cited by 219 · see citing works
Sanli, T., Steinberg, G. R., Singh, G., & Tsakiridis, T. (2014) · Cancer Biology & Therapy · doi:10.4161/cbt.26726 · Cited by 220 · see citing works
Wan, G., Zhaorigetu, S., Liu, Z., Kaini, R. R., Jiang, Z., & Hu, C. A. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m800214200 · Cited by 218 · see citing works
Small Is Beautiful: Insulin-Like Growth Factors and Their Role in Growth, Development, and Cancer
Maki, R. G. (2010) · Journal of Clinical Oncology · doi:10.1200/jco.2009.27.5040 · Cited by 217 · see citing works
Diabetes, cancer, and metformin: connections of metabolism and cell proliferation
Gallagher, E. J., & LeRoith, D. (2011) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2011.06285.x · Cited by 205 · see citing works
Mechanisms of Obesity-Induced Gastrointestinal Neoplasia
Alemán, J. O., Eusebi, L. H., Ricciardiello, L., Patidar, K. R., Sanyal, A. J., & Holt, P. R. (2013) · Gastroenterology · doi:10.1053/j.gastro.2013.11.051 · Cited by 200 · see citing works
Autophagy: Regulation and role in disease
Meijer, A. J., & Codogno, P. (2009) · Critical Reviews in Clinical Laboratory Sciences · doi:10.1080/10408360903044068 · Cited by 199 · see citing works
She, Q., Gruvberger-Saal, S. K., Maurer, M. S., Chen, Y., Jumppanen, M., Su, T., Dendy, M., Lau, Y.-K. I., Memeo, L., Horlings, H. M., et al. (2016) · BMC Cancer · doi:10.1186/s12885-016-2609-2 · Cited by 193 · see citing works
Regulation of survivin expression by IGF-1/mTOR signaling
Vaira, V., Lee, C. W., Goel, H. L., Bòsari, S., Languino, L. R., & Altieri, D. C. (2006) · Oncogene · doi:10.1038/sj.onc.1210094 · Cited by 180 · see citing works
p53 isoforms regulate astrocyte-mediated neuroprotection and neurodegeneration
Turnquist, C., Horikawa, I., Foran, E., Major, E. O., Vojtěšek, B., Lane, D. P., Lü, X., Harris, B. T., & Harris, C. C. (2016) · Cell Death and Differentiation · doi:10.1038/cdd.2016.37 · Cited by 177 · see citing works
Macronutrient balance and lifespan
Simpson, S. J., & Raubenheimer, D. (2009) · Aging · doi:10.18632/aging.100098 · Cited by 172 · see citing works
Hypoxia suppresses conversion from proliferative arrest to cellular senescence
Leontieva, O. V., Natarajan, V., Demidenko, Z. N., Burdelya, L. G., Gudkov, A. V., & Blagosklonny, M. V. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1205690109 · Cited by 169 · see citing works
Lifelong accumulation of bone in mice lacking Pten in osteoblasts
Liu, X., Bruxvoort, K. J., Diegel, C. R., Liu, J., Cichowski, R., Monier‐Faugere, M., Bouxsein, M., Wan, C., Williams, B. O., & Clemens, T. L. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0604153104 · Cited by 173 · see citing works
Interleukin-1 stimulates catabolism in C2C12 myotubes
Li, W. S., Moylan, J. S., Chambers, M. A., Smith, J. D., & Reid, M. B. (2009) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00626.2008 · Cited by 164 · see citing works
LPCAT1 promotes brain metastasis of lung adenocarcinoma by up-regulating PI3K/AKT/MYC pathway
Wei, C., Dong, X., Lü, H., Tong, F., Chen, L., Zhang, R., Dong, J., Wu, G., Wu, G., & Dong, X. (2019) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-019-1092-4 · Cited by 163 · see citing works
Lee, C., Inoki, K., Karbowniczek, M., Petroulakis, E., Sonenberg, N., Henske, E. P., & Guan, K. (2007) · The EMBO Journal · doi:10.1038/sj.emboj.7601900 · Cited by 160 · see citing works
Rieker, C., Engblom, D., Kreiner, G., Domanskyi, A., Schober, A., Stotz, S., Neumann, M., Yuan, X., Grummt, I., Schütz, G., et al. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.0590-10.2011 · Cited by 162 · see citing works
The IGF Axis and Placental Function
Forbes, K. A., & Westwood, M. (2008) · Hormone Research in Paediatrics · doi:10.1159/000112585 · Cited by 164 · see citing works
Insulin‐like growth factor‐1 regulates the <scp>SIRT</scp> 1‐p53 pathway in cellular senescence
Tran, D., Bergholz, J., Zhang, H., He, H., Wang, Y., Zhang, Y., Li, Q., Kirkland, J. L., & Xiao, Z. (2014) · Aging Cell · doi:10.1111/acel.12219 · Cited by 161 · see citing works
“These data suggest that IGF-1 activates p53 in serum-starved cells through the PI3kinase cascade, in line with previous observations that IGF-1 modulates p53 protein levels and activities via several different mechanisms (Levine et al., 2006).”
ResultThe role of mTOR in the management of solid tumors: An overview
Strimpakos, A. S., Karapanagiotou, E. M., Saif, M. W., & Syrigos, K. (2008) · Cancer Treatment Reviews · doi:10.1016/j.ctrv.2008.09.006 · Cited by 160 · see citing works
The role of tumor suppressor p53 in the antioxidant defense and metabolism
Budanov, A. V. (2014) · Subcellular Biochemistry · doi:10.1007/978-94-017-9211-0_18 · Cited by 157 · see citing works
Diet, Autophagy, and Cancer: A Review
Singletary, K. W., & Milner, J. (2008) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.epi-07-2917 · Cited by 157 · see citing works
Leontieva, O. V., Demidenko, Z. N., & Blagosklonny, M. V. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1405723111 · Cited by 150 · see citing works
The regulation of cellular metabolism by tumor suppressor p53
Liang, Y., Liu, J., & Feng, Z. (2013) · Cell & Bioscience · doi:10.1186/2045-3701-3-9 · Cited by 147 · see citing works
Self-citationSIRT6 in DNA repair, metabolism and ageing
Lombard, D. B., Schwer, B., Alt, F. W., & Mostoslavsky, R. (2008) · Journal of Internal Medicine · doi:10.1111/j.1365-2796.2007.01902.x · Cited by 146 · see citing works
Rapamycin extends lifespan and delays tumorigenesis in heterozygous p53+/− mice
Komarova, E. A., Antoch, M. P., Novototskaya, L. R., Chernova, O. B., Paszkiewicz, G., Leontieva, O. V., Blagosklonny, M. V., & Gudkov, A. V. (2012) · Aging · doi:10.18632/aging.100498 · Cited by 145 · see citing works
Tăcutu, R., Budovsky, A., Yanai, H., & Fraifeld, V. E. (2011) · Aging · doi:10.18632/aging.100413 · Cited by 143 · see citing works
Maternal growth factor regulation of human placental development and fetal growth
Forbes, K. A., & Westwood, M. (2010) · Journal of Endocrinology · doi:10.1677/joe-10-0174 · Cited by 144 · see citing works
ER Stress Inhibits mTORC2 and Akt Signaling Through GSK-3β–Mediated Phosphorylation of Rictor
Chen, C.-H., Shaiken, T. E., Peterson, T. R., Aimbetov, R., Bissenbaev, A. K., Lee, S.-W., Wu, J., Lin, H., & Sarbassov, D. D. (2011) · Science Signaling · doi:10.1126/scisignal.2001731 · Cited by 139 · see citing works
Geroconversion: irreversible step to cellular senescence
Blagosklonny, M. V. (2014) · Cell Cycle · doi:10.4161/15384101.2014.985507 · Cited by 140 · see citing works
Amin, A. R. M. R., Karpowicz, P. A., Carey, T. E., Arbiser, J. L., Nahta, R., Chen, Z. G., Dong, J., Küçük, Ö., Khan, G. N., Huang, G. S., et al. (2015) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2015.02.005 · Cited by 136 · see citing works
Qiu, W., Leibowitz, B. J., Zhang, L., & Yu, J. (2009) · Oncogene · doi:10.1038/onc.2009.451 · Cited by 136 · see citing works
Regulation of Protein Synthesis by Ionizing Radiation
Braunstein, S. E., Badura, M. L., Xi, Q., Formenti, S. C., & Schneider, R. J. (2009) · Molecular and Cellular Biology · doi:10.1128/mcb.00711-09 · Cited by 138 · see citing works
Diabetes and cancer: Associations, mechanisms, and implications for medical practice
Xu, C. (2014) · World Journal of Diabetes · doi:10.4239/wjd.v5.i3.372 · Cited by 135 · see citing works
IGF and Insulin Receptor Signaling in Breast Cancer
Belfiore, A., & Frasca, F. (2008) · Journal of Mammary Gland Biology and Neoplasia · doi:10.1007/s10911-008-9099-z · Cited by 134 · see citing works
Sami, A., & Karsy, M. J. (2013) · Tumor Biology · doi:10.1007/s13277-013-0800-5 · Cited by 134 · see citing works
The mammalian target of rapamycin-signaling pathway in regulating metabolism and growth1,2
Yang, X., Yang, C. B., Farberman, A., Rideout, T. C., de Lange, C. F. M., France, J., & Fan, M. Z. (2007) · Journal of Animal Science · doi:10.2527/jas.2007-0567 · Cited by 128 · see citing works
The regulation of the endosomal compartment by p53 the tumor suppressor gene
Yu, X., Riley, T., & Levine, A. J. (2009) · FEBS Journal · doi:10.1111/j.1742-4658.2009.06949.x · Cited by 130 · see citing works
Self-citationRegulation of nucleotide metabolism by mutant p53 contributes to its gain-of-function activities
Kollareddy, M., Dimitrova, E., Vallabhaneni, K. C., Chan, A., Le, T., Chauhan, K. M., Carrero, Z. I., Ramakrishnan, G., Watabe, K., Haupt, Y., et al. (2015) · Nature Communications · doi:10.1038/ncomms8389 · Cited by 127 · see citing works
Cell Cycle Regulation by the Nutrient-Sensing Mammalian Target of Rapamycin (mTOR) Pathway
Cuyàs, E., Corominas-Faja, B., Joven, J., & Menéndez, J. A. (2014) · Methods in molecular biology · doi:10.1007/978-1-4939-0888-2_7 · Cited by 126 · see citing works
Werner, H. (2011) · Oncogene · doi:10.1038/onc.2011.447 · Cited by 127 · see citing works
Hasskarl, J. (2018) · Recent results in cancer research/Recent Results in Cancer Research · doi:10.1007/978-3-319-91442-8_8 · Cited by 124 · see citing works
Diabetes mellitus and increased risk of cholangiocarcinoma
Jing, W., Jin, G., Zhou, X., Zhou, Y., Zhang, Y., Shao, C., Liu, R., & Hu, X. (2011) · European Journal of Cancer Prevention · doi:10.1097/cej.0b013e3283481d89 · Cited by 121 · see citing works
Hu, W., Feng, Z., Modica, I., Klimstra, D. S., Song, L., Allen, P. J., Brennan, M. F., Levine, A. J., & Tang, L. H. (2010) · Genes & Cancer · doi:10.1177/1947601910371979 · Cited by 116 · see citing works
Self-citation9-Aminoacridine-based anticancer drugs target the PI3K/AKT/mTOR, NF-κB and p53 pathways
Guo, C., Gasparian, A. V., Zhuang, Z., Bosykh, D. A., Komar, A. A., Gudkov, A. V., & Gurova, K. V. (2009) · Oncogene · doi:10.1038/onc.2008.460 · Cited by 116 · see citing works
Therapeutic targeting of the mTOR ‐signalling pathway in cancer: benefits and limitations
Moschetta, M., Reale, A., Marasco, C., Vacca, A., & Carratù, M. R. (2014) · British Journal of Pharmacology · doi:10.1111/bph.12749 · Cited by 116 · see citing works
Kang, C., & Avery, L. (2008) · Autophagy · doi:10.4161/auto.5154 · Cited by 124 · see citing works
Hypoxia in cancer cell metabolism and pH regulation
Brahimi-Horn, M. C., & Pouysségur, J. (2007) · Essays in Biochemistry · doi:10.1042/bse0430165 · Cited by 113 · see citing works
Seeliger, H., Guba, M. O., Kleespies, A., Jauch, K., & Bruns, C. J. (2007) · Cancer and Metastasis Reviews · doi:10.1007/s10555-007-9077-8 · Cited by 113 · see citing works
Lee, S. M., Kim, J., Cho, E., & Youn, H. (2009) · Cell Death and Differentiation · doi:10.1038/cdd.2009.5 · Cited by 104 · see citing works
Cevenini, A., Orrù, S., Mancini, A., Alfieri, A., Buono, P., & Imperlini, E. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19082411 · Cited by 96 · see citing works
Bartella, V., Marco, P. D., Malaguarnera, R., Belfiore, A., & Maggiolini, M. (2012) · Cellular Signalling · doi:10.1016/j.cellsig.2012.03.012 · Cited by 92 · see citing works
Rasul, A., Ding, C., Li, X., Khan, M., Yi, F., Ali, M. A., & Ma, T. (2012) · APOPTOSIS · doi:10.1007/s10495-012-0742-1 · Cited by 90 · see citing works
Targeting the insulin growth factor receptor 1
Arnaldez, F. I., & Helman, L. J. (2012) · Hematology/Oncology Clinics of North America · doi:10.1016/j.hoc.2012.01.004 · Cited by 88 · see citing works
Diabetes and cancer II: role of diabetes medications and influence of shared risk factors
Onitilo, A. A., Engel, J. M., Glurich, I., Stankowski, R. V., Williams, G. M., & Doi, S. A. R. (2012) · Cancer Causes & Control · doi:10.1007/s10552-012-9971-4 · Cited by 89 · see citing works
Long-lived C. elegans Mitochondrial mutants as a model for human mitochondrial-associated diseases
Ventura, N., Rea, S. L., & Testi, R. (2006) · Experimental Gerontology · doi:10.1016/j.exger.2006.06.060 · Cited by 89 · see citing works
Molecular damage in cancer: an argument for mTOR-driven aging
Blagosklonny, M. V. (2011) · Aging · doi:10.18632/aging.100422 · Cited by 87 · see citing works
The impact of hyperglycemia on the corneal epithelium: Molecular mechanisms and insight
Zhu, L., Titone, R., & Robertson, D. M. (2019) · The Ocular Surface · doi:10.1016/j.jtos.2019.06.007 · Cited by 84 · see citing works
Mitochondria and Energetic Depression in Cell Pathophysiology
Seppet, E. K., Puurand, M., Peetsalu, A., Gizatullina, Z. Z., Nguyen, H. P., Vielhaber, S., Wussling, M. H. P., Trumbeckaitė, S., Arandarčikaitė, O., Jerzembek, D., et al. (2009) · International Journal of Molecular Sciences · doi:10.3390/ijms10052252 · Cited by 83 · see citing works
Versatile functions of p53 protein in multicellular organisms
Chumakov, P. M. (2007) · Biochemistry (Moscow) · doi:10.1134/s0006297907130019 · Cited by 84 · see citing works
Blagosklonny, M. V. (2012) · Cancer Biology & Therapy · doi:10.4161/cbt.22859 · Cited by 82 · see citing works
Adaptive Response, Evidence of Cross-Resistance and Its Potential Clinical Use
Milisav, I., Poljšak, B., & Šuput, D. (2012) · International Journal of Molecular Sciences · doi:10.3390/ijms130910771 · Cited by 81 · see citing works
Hormesis does not make sense except in the light of TOR-driven aging
Blagosklonny, M. V. (2011) · Aging · doi:10.18632/aging.100411 · Cited by 79 · see citing works
Campa, D., Hüsing, A., Stein, A., Dostal, L., Boeing, H., Pischon, T., Tjønneland, A. M., Roswall, N., Overvad, K., Østergaard, J. N., et al. (2011) · PLoS ONE · doi:10.1371/journal.pone.0016914 · Cited by 78 · see citing works
Insulin-like Growth Factor: Current Concepts and New Developments in Cancer Therapy
King, E. R., & Wong, K. (2011) · Recent Patents on Anti-Cancer Drug Discovery · doi:10.2174/157489212798357930 · Cited by 77 · see citing works
Oldham, S. (2011) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2010.11.002 · Cited by 75 · see citing works
Insulin, Insulin Resistance, Obesity, and Cancer
Gallagher, E. J., & LeRoith, D. (2010) · Current Diabetes Reports · doi:10.1007/s11892-010-0101-y · Cited by 75 · see citing works
Reddy, D., Kumavath, R., Tan, T. Z., Ampasala, D. R., & Kumar, A. P. (2019) · Life Sciences · doi:10.1016/j.lfs.2019.117147 · Cited by 74 · see citing works
- Authors
- Levine, A. J., Feng, Z., Mak, T. W., You, H., & Jin, S.
- Affiliations
- University of Toronto (CA)
- Venue
- Genes & Development
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2006-02-01
- Volume
- 20
- Issue
- 3
- Pages
- 267-275
- ISSN
- 0890-9369 (ISSN-L)
- 1549-5477
- OpenAlex
- W2136212424
- Cited by
- 321
- References
- 79
- Citations by year
- 2025: 3 · 2024: 5 · 2023: 2 · 2022: 9 · 2021: 6 · 2020: 9 · 2019: 14 · 2018: 6 · 2017: 14 · 2016: 11 · 2015: 13 · 2014: 23 · 2013: 18 · 2012: 33
- Type
- posted content
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Genes & Development (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › PI3K/AKT/mTOR signaling in cancer
- Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
- Keywords
- p53 pathway, TOR signaling, signaling pathways, pathway integration, nutrient sensing, growth factor signaling, stress signaling, cell growth and proliferation, apoptosis, cancer, diabetes mellitus, longevity
- MeSH terms
- Animals, Enzyme Activation, Humans, Insulin-Like Growth Factor I, Models, Biological, Multienzyme Complexes, Protein Kinases, Signal Transduction, Tumor Suppressor Protein p53, Oncogene Protein v-akt, Forkhead Transcription Factors, TOR Serine-Threonine Kinases
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review