The DOI matches its Crossref record; 62 of the 62 references it cites were found in a registry or an index.
Oncogenic B-RAF Negatively Regulates the Tumor Suppressor LKB1 to Promote Melanoma Cell Proliferation
Open accessAbstract
Summary The LKB1 – AMPK signaling pathway serves as a critical cellular sensor coupling energy homeostasis to cell growth, proliferation and survival. However, how tumor cells suppress this signaling pathway to gain growth advantage under conditions of energy stress is largely unknown. Here, we show that AMPK activation is suppressed in melanoma cells with the B-RAF V600E mutation and that down-regulation of B-RAF signaling activates AMPK. We find that in these cells LKB1 is phosphorylated by ERK and Rsk, two kinases downstream of B-RAF, and that this phosphorylation compromises the ability of LKB1 to bind and activate AMPK. Furthermore, expression of a phosphorylation-deficient mutant of LKB1 allows activation of AMPK and inhibits melanoma cell proliferation and anchorage-independent cell growth. Our findings provide a molecular linkage between the LKB1-AMPK and the RAF-MEK-ERK pathways and suggest that suppression of LKB1 function by B-RAF V600E plays an important role in B-RAF V600E-driven tumorigenesis.
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Cites
Mutations of the BRAF gene in human cancer
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Cited by
Activation and function of the MAPKs and their substrates, the MAPK-activated protein kinases
Cargnello, M., & Roux, P. P. (2011) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.00031-10 · Cited by 3,274
The LKB1-AMPK pathway: metabolism and growth control in tumour suppression
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AMP-activated protein kinase: an energy sensor that regulates all aspects of cell function
Hardie, D. G. (2011) · Genes & Development · doi:10.1101/gad.17420111 · Cited by 1,638
ERK signalling: A master regulator of cell behaviour, life and fate
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AMPK Is a Negative Regulator of the Warburg Effect and Suppresses Tumor Growth In Vivo
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Metadata
- Authors
- Zheng, B., Jeong, J. H., Asara, J. M., Yuan, Y.-Y., Granter, S. R., Chin, L., & Cantley, L. C.
- Venue
- Molecular Cell
- Publisher
- Elsevier BV
- Published
- 2009-01
- Volume
- 33
- Issue
- 2
- Pages
- 237-247
- ISSN
- 1097-2765 (ISSN-L)
- OpenAlex
- W2165002727
- Cited by
- 359
- References
- 62
- FWCI
- 12.36
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: Oncogenic B-RAF Negatively Regulates the Tumor Suppressor LKB1 to Promote Melanoma Cell Proliferation. https://app.cochat.ai/papers/10.1016/j.molcel.2008.12.026
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- Zheng, B., Jeong, J. H., Asara, J. M., Yuan, Y.-Y., Granter, S. R., Chin, L., & Cantley, L. C. (2009). Oncogenic B-RAF Negatively Regulates the Tumor Suppressor LKB1 to Promote Melanoma Cell Proliferation. Molecular Cell. https://doi.org/10.1016/j.molcel.2008.12.026
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