Structures of SPOP-Substrate Complexes: Insights into Molecular Architectures of BTB-Cul3 Ubiquitin Ligases

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Items 101–200 of 486

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3. The MATH-BTB BPM3 and BPM5 subunits of Cullin3-RING E3 ubiquitin ligases target PP2CA and other clade A PP2Cs for degradation
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4. SPOP Promotes Nanog Destruction to Suppress Stem Cell Traits and Prostate Cancer Progression
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5. Ubiquitin ligases in cancer: Functions and clinical potentials
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6. Cullin 3-Based Ubiquitin Ligases as Master Regulators of Mammalian Cell Differentiation
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7. The ubiquitin ligase adaptor SPOP in cancer
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8. Crystal Structure of KLHL3 in Complex with Cullin3
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9. Structural Insights into KCTD Protein Assembly and Cullin3 Recognition
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10. Systematic discovery of mutation-directed neo-protein-protein interactions in cancer
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11. Endometrial cancer-associated mutants of SPOP are defective in regulating estrogen receptor-α protein turnover
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12. SPOP E3 Ubiquitin Ligase Adaptor Promotes Cellular Senescence by Degrading the SENP7 deSUMOylase
    Hengrui Zhu, Shancheng Ren, Benjamin Guy Bitler, Katherine M. Aird, Zhigang Tu, Emmanuel Skordalakes, Yasheng Zhu, Jun Yan, Yinghao Sun, Rugang Zhang · 2015 · Cell Reports
13. SPOP and cancer: a systematic review.
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14. SPOP suppresses tumorigenesis by regulating Hedgehog/Gli2 signaling pathway in gastric cancer
    Chunyan Zeng, Yao Wang, Quqin Lu, Jiang Chen, Junyan Zhang, Tao Liu, Nonghua Lv, Shiwen Luo · 2014 · Journal of Experimental & Clinical Cancer Research
15. The E3 ubiquitin ligase SPOP controls resolution of systemic inflammation by triggering MYD88 degradation
    María Guillamot, Dahmane Ouazia, Igor Dolgalev, Stephen T. Yeung, Nikos Kourtis, Yuling Dai, Kate Corrigan, Luna Zea-Redondo, Anita Saraf, Laurence A. Florens et al. · 2019 · Nature Immunology
16. Cullin3-KLHL15 ubiquitin ligase mediates CtIP protein turnover to fine-tune DNA-end resection
    Lorenza P. Ferretti, Sarah-Felicitas Himmels, Anika Trenner, Christina Walker, Christine von Aesch, Aline Eggenschwiler, Olga Murina, Radoslav Ivanov Enchev, Matthias Peter, Raimundo Freire et al. · 2016 · Nature Communications
17. Spop promotes skeletal development and homeostasis by positively regulating Ihh signaling
    Cai, Hongchen, Liu, Aimin · 2016 · Proceedings of the National Academy of Sciences
18. Multiple Weak Linear Motifs Enhance Recruitment and Processivity in SPOP-Mediated Substrate Ubiquitination
    Wendy K. Pierce, Christy R. Grace, Jihun Lee, Amanda Nourse, Melissa R. Marzahn, Edmond R. Watson, Anthony A. High, Junmin Peng, Brenda Arlene Schulman, Tanja Mittag · 2015 · Journal of Molecular Biology
19. Composition, Roles, and Regulation of Cullin-Based Ubiquitin E3 Ligases
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20. Hypertension-causing Mutations in Cullin3 Protein Impair RhoA Protein Ubiquitination and Augment the Association with Substrate Adaptors
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21. Deregulation of SPOP in Cancer
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22. Structural Basis of Selective Ubiquitination of TRF1 by SCFFbx4
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23. Germline-Specific MATH-BTB Substrate Adaptor MAB1 Regulates Spindle Length and Nuclei Identity in Maize
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24. A SPOPL/Cullin-3 ubiquitin ligase complex regulates endocytic trafficking by targeting EPS15 at endosomes
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25. SPOP promotes ATF2 ubiquitination and degradation to suppress prostate cancer progression
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26. Nrf2 in Cancer, Detoxifying Enzymes and Cell Death Programs
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27. SPOP mutations promote tumor immune escape in endometrial cancer via the IRF1–PD-L1 axis
    Kun Gao, Qing Shi, Ye Gu, Wanqi Yang, Yuanlong He, Zeheng Lv, Yan Ding, Wenxin Cao, Chenji Wang, Xiaoping Wan · 2022 · Cell Death and Differentiation
28. Molecular genetics of prostate cancer: emerging appreciation of genetic complexity
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29. Breast cancer metastasis suppressor 1 (BRMS1) is destabilized by the Cul3–SPOP E3 ubiquitin ligase complex
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30. BTB domains: A structural view of evolution, multimerization, and protein–protein interactions
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31. SPOP mutation induces DNA methylation via stabilizing GLP/G9a
    Jianong Zhang, Kun Gao, Hongyan Xie, Dejie Wang, Pingzhao Zhang, Ting Wei, Yuqian Yan, Yunqian Pan, Wenbin Ye, Huifen Chen et al. · 2021 · Nature Communications
32. Ubiquitin Ligase Activity of Cul3-KLHL7 Protein Is Attenuated by Autosomal Dominant Retinitis Pigmentosa Causative Mutation
    Yu Kigoshi, Fuminori Tsuruta, Tomoki Chiba · 2011 · Journal of Biological Chemistry
33. Structural and mechanistic insights into the Keap1-Nrf2 system as a route to drug discovery
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34. Structural basis for dimerization quality control
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35. Building ubiquitination machineries: E3 ligase multi-subunit assembly and substrate targeting by PROTACs and molecular glues
    Sarath Ramachandran, Alessio Ciulli · 2020 · Current Opinion in Structural Biology
36. SPOP promotes ubiquitination and degradation of LATS1 to enhance kidney cancer progression
    Lixia Wang, Min Lin, Man Chu, Yi Liu, Jia Ma, Youhua He, Zhiwei Peter Wang · 2020 · EBioMedicine
37. Protein Network Structure Enables Switching between Liquid and Gel States
    Jeremy D. Schmit, Jill J. Bouchard, Erik W. Martin, Tanja Mittag · 2019 · Journal of the American Chemical Society
38. Structural Biology of CRL Ubiquitin Ligases
    Domnița-Valeria Rusnac, Ning Zheng · 2020 · Advances in experimental medicine and biology
39. UM171 glues asymmetric CRL3–HDAC1/2 assembly to degrade CoREST corepressors
    Yeo, Megan J. R., Zhang, Olivia, Xie, Xiaowen, Nam, Eunju, Payne, N. Connor, Gosavi, Pallavi M., Kwok, Hui Si, Iram, Irtiza, Lee, Ceejay, Li, Jiaming et al. · 2025 · Nature
40. CRL3–SPOP ubiquitin ligase complex suppresses the growth of diffuse large B-cell lymphoma by negatively regulating the MyD88/NF-κB signaling
    Xiaofeng Jin, Qing Shi, Qian Li, Linyi Zhou, Jian Wang, Lei Jiang, Xiaying Zhao, Kai Ming Feng, Ting Lin, Zi-Han Lin et al. · 2019 · Leukemia
41. Genome-wide identification and expression analysis of the BTB domain-containing protein gene family in tomato
    Jinhua Li, Xiaoxing Su, Yinlei Wang, Wei Cheng Yang, Yu Pan, Chenggang Su, Xing‐Guo Zhang · 2017 · Genes & Genomics
42. CRL3s: The BTB-CUL3-RING E3 Ubiquitin Ligases
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43. Identification and optimization of piperine analogues as neuroprotective agents for the treatment of Parkinson’s disease via the activation of Nrf2/keap1 pathway
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44. Chromatin-Bound Cullin-Ring Ligases: Regulatory Roles in DNA Replication and Potential Targeting for Cancer Therapy
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45. CSNAP Is a Stoichiometric Subunit of the COP9 Signalosome
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46. Prostate cancer-associated mutation in SPOP impairs its ability to target Cdc20 for poly-ubiquitination and degradation
    Fei Wu, Xiangpeng Dai, Wenjian Gan, Lixin Wan, Min Li, Nicholas Mitsiades, Wenyi Wei, Qiang Ding, Jinfang Zhang · 2016 · Cancer Letters
47. SPOP suppresses prostate cancer through regulation of CYCLIN E1 stability
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48. Dual inhibition of AKT-mTOR and AR signaling by targeting HDAC3 in PTEN- or SPOP-mutated prostate cancer
    Yan, Yuqian, An, Jian, Yang, Yinhui, Wu, Di, Bai, Yang, Cao, William, Ma, Linlin, Chen, Junhui, Yu, Zhendong, He, Yundong et al. · 2018 · EMBO Molecular Medicine
49. SPOP negatively regulates Toll-like receptor-induced inflammation by disrupting MyD88 self-association
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50. ATM-phosphorylated SPOP contributes to 53BP1 exclusion from chromatin during DNA replication
    Dejie Wang, Jian Ma, Maria Victoria Botuyan, Gaofeng Cui, Yuqian Yan, Donglin Ding, Yingke Zhou, Eugene W. Krueger, Jiang Pei, Xiaosheng Wu et al. · 2021 · Science Advances
51. Cullin-RING ubiquitin ligases in salicylic acid-mediated plant immune signaling
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52. Reshaping of the androgen-driven chromatin landscape in normal prostate cells by early cancer drivers and effect on therapeutic sensitivity
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53. RING-finger E3 ligases regulatory network in PI3K/AKT-mediated glucose metabolism
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54. Natural products in attenuating renal inflammation via inhibiting the NLRP3 inflammasome in diabetic kidney disease
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55. The E3 Ligase CUL3/RDX Controls Centromere Maintenance by Ubiquitylating and Stabilizing CENP-A in a CAL1-Dependent Manner
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56. Speckle-type POZ protein, SPOP, is involved in the DNA damage response
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57. Protein Interaction Screening for the Ankyrin Repeats and Suppressor of Cytokine Signaling (SOCS) Box (ASB) Family Identify Asb11 as a Novel Endoplasmic Reticulum Resident Ubiquitin Ligase
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58. GCL and CUL3 Control the Switch between Cell Lineages by Mediating Localized Degradation of an RTK
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59. ACE2 in chronic disease and COVID-19: gene regulation and post-translational modification
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60. Zinc-binding triggers a conformational-switch in the cullin-3 substrate adaptor protein KEAP1 that controls transcription factor NRF2
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61. Ubiquitin-dependent remodeling of the actin cytoskeleton drives cell fusion
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62. The molecular biology and therapeutic potential of Nrf2 in leukemia
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63. Twists and turns in ubiquitin‐like protein conjugation cascades
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64. Tumor suppressor SPOP ubiquitinates and degrades EglN2 to compromise growth of prostate cancer cells
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65. E3 Ubiquitin Ligases in Neurological Diseases: Focus on Gigaxonin and Autophagy
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66. Higher-order SPOP assembly reveals a basis for cancer mutant dysregulation
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67. Quality control of protein complex composition
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68. Hypomorph mutation-directed small-molecule protein-protein interaction inducers to restore mutant SMAD4-suppressed TGF-β signaling
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69. Beta turn propensity and a model polymer scaling exponent identify intrinsically disordered phase-separating proteins
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70. MYB106 is a negative regulator and a substrate for CRL3 BPM E3 ligase in regulating flowering time in Arabidopsis thaliana
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71. Molecular Mechanisms of Prostate Cancer Development in the Precision Medicine Era: A Comprehensive Review
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72. Single-particle EM reveals extensive conformational variability of the Ltn1 E3 ligase
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73. Hedgehog-induced phosphorylation by CK1 sustains the activity of Ci/Gli activator
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74. Genomic Evaluation of Multiparametric Magnetic Resonance Imaging-visible and -nonvisible Lesions in Clinically Localised Prostate Cancer
    Marina Parry, Shambhavi Srivastava, Adnan Ali, Alessio Cannistraci, Jenny Antonello, João Diogo Barros-Silva, Valentina Ubertini, Vijay Ramani, Maurice Lau, Jonathan H. Shanks et al. · 2018 · European Urology Oncology
75. Structural basis of high-order oligomerization of the cullin-3 adaptor SPOP
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76. KLHL39 suppresses colon cancer metastasis by blocking KLHL20-mediated PML and DAPK ubiquitination
    Chen, H Y, Hu, J Y, Chen, T H, Lin, Y C, Liu, X, Lin, M Y, Lang, Y D, Yen, Y, Chen, R H · 2015 · Oncogene
77. Conserved properties of Drosophila Insomniac link sleep regulation and synaptic function
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78. Destruction of DDIT3/CHOP Protein by Wild-Type SPOP but Not Prostate Cancer-Associated Mutants
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79. Cullin 3SPOP ubiquitin E3 ligase promotes the poly-ubiquitination and degradation of HDAC6
    Yuyong Tan, Yanpeng Ci, Xiangpeng Dai, Fei Wu, Jianping Guo, Deliang Liu, Brian J. North, Jirong Huo, Jinfang Zhang · 2017 · Oncotarget
80. Intrinsic Disorder in Plant Transcription Factor Systems: Functional Implications
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81. Mutated SPOP E3 Ligase Promotes 17βHSD4 Protein Degradation to Drive Androgenesis and Prostate Cancer Progression
    Lei Shi, Yuqian Yan, Yundong He, Binyuan Yan, Yunqian Pan, Jacob J. Orme, Jun Zhang, Wanhai Xu, Jun Pang, Haojie Huang · 2021 · Cancer Research
82. Structural Basis for Recruitment of DAPK1 to the KLHL20 E3 Ligase
    Chen, Zhuoyao, Picaud, Sarah, Filippakopoulos, Panagis, D'Angiolella, Vincenzo, Bullock, Alex N. · 2019 · Structure
83. Prostate cancer-associated SPOP mutations lead to genomic instability through disruption of the SPOP–HIPK2 axis
    Xiaofeng Jin, Shi Qing, Qian Li, Hui Zhuang, Liliang Shen, Jinhui Li, Honggang Qi, Ting Lin, Zi-Han Lin, Jian Wang et al. · 2021 · Nucleic Acids Research
84. Silencing speckle-type POZ protein by promoter hypermethylation decreases cell apoptosis through upregulating Hedgehog signaling pathway in colorectal cancer
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85. Molecular Architecture of the Ankyrin SOCS Box Family of Cul5-Dependent E3 Ubiquitin Ligases
    Muniz, João R.C., Guo, Kunde, Kershaw, Nadia J., Ayinampudi, Vikram, von Delft, Frank, Babon, Jeffrey J., Bullock, Alex N. · 2013 · Journal of Molecular Biology
86. SPOP mutation induces replication over-firing by impairing Geminin ubiquitination and triggers replication catastrophe upon ATR inhibition
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87. BCLAF1 binds SPOP to stabilize PD-L1 and promotes the development and immune escape of hepatocellular carcinoma
    Zongdong Yu, Xiang Wu, Jie Zhu, Huan Yan, Yuxuan Li, Hui Zhang, Yeling Zhong, Man Lin, Ganghui Ye, Xinming Li et al. · 2024 · Cellular and Molecular Life Sciences
88. Molecular Basis of Prostate Cancer and Natural Products as Potential Chemotherapeutic and Chemopreventive Agents
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89. G3BP1 inhibits Cul3SPOP to amplify AR signaling and promote prostate cancer
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90. Properties and Clinical Relevance of Speckle-Type POZ Protein in Human Colorectal Cancer
    Junfei Xu, Feiran Wang, Haiyan Jiang, Yasu Jiang, Jinpeng Chen, Jun Qin · 2015 · Journal of Gastrointestinal Surgery
91. The E3 ligase adaptor molecule SPOP regulates fetal hemoglobin levels in adult erythroid cells
    Xianjiang Lan, Eugene Khandros, Peng Huang, Scott A. Peslak, Saurabh K. Bhardwaj, Jeremy D. Grevet, Osheiza Y. Abdulmalik, Hongxin Wang, Cheryl A. Keller, Belinda M. Giardine et al. · 2019 · Blood Advances
92. SPOP suppresses pancreatic cancer progression by promoting the degradation of NANOG
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93. Structure–Activity Relationship of SPOP Inhibitors against Kidney Cancer
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94. Characterization of Arabidopsis thaliana R2R3 S23 MYB Transcription Factors as Novel Targets of the Ubiquitin Proteasome-Pathway and Regulators of Salt Stress and Abscisic Acid Response
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95. The instability of the BTB-KELCH protein Gigaxonin causes Giant Axonal Neuropathy and constitutes a new penetrant and specific diagnostic test
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96. Multisite dependency of an E3 ligase controls monoubiquitylation-dependent cell fate decisions
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97. Structural and biochemical characterization establishes a detailed understanding of KEAP1-CUL3 complex assembly
    R.J. Adamson, N. Connor Payne, Sergio G. Bartual, Ralph Mazitschek, Alex N. Bullock · 2023 · Free Radical Biology and Medicine
98. Speckle-type POZ protein is negatively associated with malignancies and inhibits cell proliferation and migration in liver cancer
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99. Multimeric Complexes among Ankyrin-Repeat and SOCS-box Protein 9 (ASB9), ElonginBC, and Cullin 5: Insights into the Structure and Assembly of ECS-type Cullin-RING E3 Ubiquitin Ligases
    Jemima C. Thomas, Dijana Matak‐Vinković, Inge Van Molle, Alessio Ciulli · 2013 · Biochemistry
100. Functional roles of Speckle-Type Poz (SPOP) Protein in Genomic stability
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