Schulman, Brenda A.

Structure of the Cul1–Rbx1–Skp1–F boxSkp2 SCF ubiquitin ligase complex

Zheng, N., Schulman, B. A., Song, L., Miller, J. J., Jeffrey, P. D., Wang, P., Chu, C., Koepp, D. M., Elledge, S. J., Pagano, M., et al. (2002) · Nature

Ubiquitin and proteasome pathwaysEnzyme Structure and Function

Cited by 1,507

Deletion of IKZF1 and Prognosis in Acute Lymphoblastic Leukemia

Mullighan, C. G., Su, X., Zhang, J., Radtke, I., Phillips, L. A. A., Miller, C. B., Ma, J., Liu, W., Cheng, C., Schulman, B. A., et al. (2009) · New England Journal of Medicine

Acute Lymphoblastic Leukemia researchLymphoma Diagnosis and Treatment

Cited by 1,422

Structural Insights into NEDD8 Activation of Cullin-RING Ligases: Conformational Control of Conjugation

Duda, D. M., Borg, L. A., Scott, D. C., Hunt, H. W., Hammel, M., & Schulman, B. A. (2008) · Cell

Ubiquitin and proteasome pathwaysEnzyme Structure and Function

Cited by 767

Structure of a β-TrCP1-Skp1-β-Catenin Complex

Wu, G., Xu, G., Schulman, B. A., Jeffrey, P. D., Harper, J. W., & Pavletich, N. P. (2003) · Molecular Cell

Ubiquitin and proteasome pathwaysWnt/β-catenin signaling in development and cancer

Cited by 612

Structures of SPOP-Substrate Complexes: Insights into Molecular Architectures of BTB-Cul3 Ubiquitin Ligases

Zhuang, M., Calabrese, M. F., Liu, J., Waddell, M. B., Nourse, A., Hammel, M., Miller, D. J., Walden, H., Duda, D. M., Seyedin, S. N., et al. (2009) · Molecular Cell

Ubiquitin and proteasome pathwaysProtein Degradation and Inhibitors

Cited by 486

Building and remodelling Cullin–RING E3 ubiquitin ligases

Lydeard, J. R., Schulman, B. A., & Harper, J. W. (2013) · The EMBO Reports

Ubiquitin and proteasome pathwaysProtein Degradation and Inhibitors

Cited by 327

Defining roles of PARKIN and ubiquitin phosphorylation by PINK1 in mitochondrial quality control using a ubiquitin replacement strategy

Ordureau, A., Heo, J.-M., Duda, D. M., Paulo, J. A., Olszewski, J. L., Yanishevski, D., Rinehart, J., Schulman, B. A., & Harper, J. W. (2015) · Proceedings of the National Academy of Sciences

Parkinson's Disease Mechanisms and TreatmentsAutophagy in Disease and Therapy

Cited by 310

NEDD8 nucleates a multivalent cullin–RING–UBE2D ubiquitin ligation assembly

Baek, K., Krist, D. T., Prabu, J. R., Hill, S., Klügel, M., Neumaier, L.-M., von Gronau, S., Kleiger, G., & Schulman, B. A. (2020) · Nature

Ubiquitin and proteasome pathwaysNF-κB Signaling Pathways

Cited by 270

Two Distinct Types of E3 Ligases Work in Unison to Regulate Substrate Ubiquitylation

Scott, D. C., Rhee, D. Y., Duda, D. M., Kelsall, I. R., Olszewski, J. L., Paulo, J. A., de Jong, A., Ovaa, H., Alpi, A. F., Harper, J. W., et al. (2016) · Cell

Ubiquitin and proteasome pathwaysProtein Degradation and Inhibitors

Cited by 229

Structural assembly of cullin-RING ubiquitin ligase complexes

Zimmerman, E. S., Schulman, B. A., & Zheng, N. (2010) · Current Opinion in Structural Biology

Ubiquitin and proteasome pathwaysEnzyme Structure and Function

Cited by 227

Mutation in ATG5 reduces autophagy and leads to ataxia with developmental delay

Kim, M., Sandford, E., Gatica, D., Qiu, Y., Liu, X., Zheng, Y., Schulman, B. A., Xu, J., Semple, I., Ro, S.-H., et al. (2016) · eLife

Autophagy in Disease and TherapyGenetic Neurodegenerative Diseases

Cited by 225

Structural regulation of cullin-RING ubiquitin ligase complexes

Duda, D. M., Scott, D. C., Calabrese, M. F., Zimmerman, E. S., Zheng, N., & Schulman, B. A. (2011) · Current Opinion in Structural Biology

Ubiquitin and proteasome pathwaysProtein Degradation and Inhibitors

Cited by 205

Structure of a RING E3 Trapped in Action Reveals Ligation Mechanism for the Ubiquitin-like Protein NEDD8

Scott, D. C., Sviderskiy, V. O., Monda, J. K., Lydeard, J. R., Cho, S. E., Harper, J. W., & Schulman, B. A. (2014) · Cell

Ubiquitin and proteasome pathwaysProtein Degradation and Inhibitors

Cited by 201

Identification and Characterization of the First Small Molecule Inhibitor of MDMX

Reed, D., Shen, Y., Shelat, A. A., Arnold, L. A., Ferreira, A. M., Zhu, F., Mills, N., Smithson, D. C., Regni, C. A., Bashford, D., et al. (2010) · Journal of Biological Chemistry

Cancer-related Molecular PathwaysHeat shock proteins research

Cited by 198

Ubiquitin ligation to F-box protein targets by SCF–RBR E3–E3 super-assembly

Horn-Ghetko, D., Krist, D. T., Prabu, J. R., Baek, K., Mulder, M. P. C., Klügel, M., Scott, D. C., Ovaa, H., Kleiger, G., & Schulman, B. A. (2021) · Nature

Ubiquitin and proteasome pathwaysProtein Degradation and Inhibitors

Cited by 187

System-Wide Modulation of HECT E3 Ligases with Selective Ubiquitin Variant Probes

Zhang, W., Wu, K.-P., Sartori, M. A., Kamadurai, H. B., Ordureau, A., Jiang, C., Mercredi, P. Y., Murchie, R., Hu, J., Persaud, A., et al. (2016) · Molecular Cell

Ubiquitin and proteasome pathwaysProtein Degradation and Inhibitors

Cited by 168

Mechanism of ubiquitin ligation and lysine prioritization by a HECT E3

Kamadurai, H. B., Qiu, Y., Deng, A., Harrison, J. S., MacDonald, C., Actis, M., Rodrigues, P., Miller, D. J., Souphron, J., Lewis, S. M., et al. (2013) · eLife

Ubiquitin and proteasome pathwaysEnzyme Structure and Function

Cited by 165

NEDD8 and ubiquitin ligation by cullin-RING E3 ligases

Baek, K., Scott, D. C., & Schulman, B. A. (2021) · Current Opinion in Structural Biology

Ubiquitin and proteasome pathwaysEnzyme Structure and Function

Cited by 152

Structural and mechanistic basis of the EMC-dependent biogenesis of distinct transmembrane clients

Miller-Vedam, L. E., Bräuning, B., Popova, K. D., Schirle Oakdale, N. T., Bonnar, J. L., Prabu, J. R., Boydston, E. A., Sevillano, N., Shurtleff, M. J., Stroud, R. M., et al. (2020) · eLife

Cellular transport and secretionEndoplasmic Reticulum Stress and Disease

Cited by 87

Structural and mechanistic basis of the EMC-dependent biogenesis of distinct transmembrane clients

Miller-Vedam, L. E., Bräuning, B., Popova, K. D., Oakdale, N. T. S., Bonnar, J. L., Prabu, J. R., Boydston, E. A., Sevillano, N., Shurtleff, M. J., Stroud, R. M., et al. (2020) · eLife

Cellular transport and secretionEndoplasmic Reticulum Stress and Disease

Cited by 86

Structural Studies of HHARI/UbcH7∼Ub Reveal Unique E2∼Ub Conformational Restriction by RBR RING1

Dove, K. K., Olszewski, J. L., Martino, L., Duda, D. M., Wu, X. S., Miller, D. J., Reiter, K. H., Rittinger, K., Schulman, B. A., & Klevit, R. E. (2017) · Structure

Ubiquitin and proteasome pathwaysEnzyme Structure and Function

Cited by 52

Visualizing chaperone-mediated multistep assembly of the human 20S proteasome

Adolf, F., Du, J., Goodall, E. A., Walsh, R. M., Rawson, S., von Gronau, S., Harper, J. W., Hanna, J., & Schulman, B. A. (2024) · Nature Structural & Molecular Biology

Ubiquitin and proteasome pathwaysHeat shock proteins research

Cited by 33

Visualizing chaperone-mediated multistep assembly of the human 20S proteasome

Adolf, F., Du, J., Goodall, E. A., Walsh, R. M., Rawson, S., von Gronau, S., Harper, J. W., Hanna, J., & Schulman, B. A. (2024) · Nature Structural & Molecular Biology

Ubiquitin and proteasome pathwaysHeat shock proteins research

Cited by 33