Sirt3-Mediated Deacetylation of Evolutionarily Conserved Lysine 122 Regulates MnSOD Activity in Response to Stress
Tao, Randa, Coleman, Mitchell C., Pennington, J. Daniel, Ozden, Ozkan, Park, Seong-Hoon, Jiang, Haiyan, Kim, Hyun-Seok, Flynn, Charles Robb, Hill, Salisha, Hayes McDonald, W., Olivier, Alicia K., Spitz, Douglas R., Gius, David·2010·Molecular Cell
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- A Review of the Recent Advances Made with SIRT6 and its Implications on Aging Related Processes, Major Human Diseases, and Possible Therapeutic TargetsRubayat Islam Khan, Saif Shahriar Rahman Nirzhor, Raushanara Akter · 2018 · Biomolecules
- Research progress on the pharmacological effects of berberine targeting mitochondriaXinyi Fang, Haoran Wu, Jiahua Wei, Runyu Miao, Yanjiao Zhang, Jiaxing Tian · 2022 · Frontiers in Endocrinology
- Sirtuin-3 (SIRT3) and the Hallmarks of CancerTurki Y. Alhazzazi, Pachiyappan Kamarajan, Eric M. Verdin, Yvonne Lorraine Kapila · 2013 · Genes & Cancer
- Autophagy and mitochondrial dysfunction in adjuvant-arthritis rats treatment with resveratrolJunqiang Zhang, Xianbin Song, Wei Cao, Jinsen Lu, Xiaoqing Wang, Gaoyuan Wang, Zhicheng Wang, Xiaoyu Chen · 2016 · Scientific Reports
- Regulation of skeletal muscle oxidative capacity and muscle mass by SIRT3Lin, Ligen, Chen, Keyun, Khalek, Waed Abdel, Ward, Jack Lee, Yang, Henry, Chabi, Béatrice, Wrutniak-Cabello, Chantal, Tong, Qiang · 2014 · PLoS ONE
- Natural Antioxidant Control of Neuropathic Pain—Exploring the Role of Mitochondrial SIRT3 PathwaySara Ilari, Luigino Antonio Giancotti, Filomena Lauro, Micaela Gliozzi, Valentina Malafoglia, Ernesto Palma, Marco Tafani, Matteo Antonio Russo, Carlo Tomino, Massimo Fini et al. · 2020 · Antioxidants
- SIRT5 Is a Druggable Metabolic Vulnerability in Acute Myeloid LeukemiaDongqing Yan, Anca Franzini, Anthony D. Pomicter, Brayden J. Halverson, Orlando Antelope, Clinton C. Mason, Jonathan M. Ahmann, Anna V. Senina, Nadeem A. Vellore, Courtney L. Jones et al. · 2021 · Blood Cancer Discovery
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- Post-translational modification of mitochondria as a novel mode of regulationAnnette Hofer, Tina Wenz · 2014 · Experimental Gerontology
- Deletion of Sirt3 does not affect atherosclerosis but accelerates weight gain and impairs rapid metabolic adaptation in LDL receptor knockout mice: implications for cardiovascular risk factor developmentStephan H. Winnik, Daniel S. Gaul, Frédéric Preitner, Christine Lohmann, Julien Weber, Melroy X Miranda, Yilei Liu, Lambertus J. van Tits, José Marı́a Mateos, Chad E. Brokopp et al. · 2013 · Basic Research in Cardiology
- Involvement of free radicals in breast cancerSandra Ríos‐Arrabal, Francisco Artacho‐Cordón, Josefa León, Román-Marinetto Elisa, María del Mar Salinas-Asensio, Irene Calvente, Marı́a Isabel Núñez · 2013 · SpringerPlus
- The Role of SIRT3 in the Brain Under Physiological and Pathological ConditionsElena Sidorova‐Darmos, Rosa Sommer, James H. Eubanks · 2018 · Frontiers in Cellular Neuroscience
- High Sensitivity of SIRT3 Deficient Hearts to Ischemia-Reperfusion Is Associated with Mitochondrial AbnormalitiesRebecca Maria Parodi‐Rullán, Xavier R. Chapa‐Dubocq, Pedro J. Rullán, Sehwan Jang, Sabzali A. Javadov · 2017 · Frontiers in Pharmacology
- Exploring the electrostatic repulsion model in the role of Sirt3 in directing MnSOD acetylation status and enzymatic activityYueming Zhu, Seong‐Hoon Park, Özkan Özden, Hyunseok Kim, Haiyan Jiang, Athanassios Vassilopoulos, Douglas R. Spitz, David R. Gius · 2012 · Free Radical Biology and Medicine
- Protective Role of Sirtuin3 (SIRT3) in Oxidative Stress Mediated by Hepatitis B Virus X Protein ExpressionJi‐Hua Ren, Xiang 'Anthony' Chen, Li Zhou, Na‐Na Tao, Hongzhong Zhou, Bo Liu, Wanyu Li, Ailong Huang, Juan Chen · 2016 · PLoS ONE
- Antidepressant activity of crocin-I is associated with amelioration of neuroinflammation and attenuates oxidative damage induced by corticosterone in miceQingfeng Xiao, Ze Xiong, Chunan Yu, Jiafeng Zhou, Qichen Shen, Liangliang Wang, Xiaoxian Xie, Zhengwei Fu · 2019 · Physiology & Behavior
- The role of SIRT3 in mitochondrial homeostasis and cardiac adaptation to hypertrophy and agingMichael N. Sack · 2011 · Journal of Molecular and Cellular Cardiology
- Myc-mediated SDHA acetylation triggers epigenetic regulation of gene expression and tumorigenesisShiting Li, De Huang, Shengqi Shen, Yongping Cai, Songge Xing, Gongwei Wu, Zetan Jiang, Yijie Hao, Mengqiu Yuan, Nana Wang et al. · 2020 · Nature Metabolism
- LncDACH1 promotes mitochondrial oxidative stress of cardiomyocytes by interacting with sirtuin3 and aggravates diabetic cardiomyopathyQi Zhang, Danyang Li, Xue Dong, Xiaowen Zhang, Junwu Liu, Li-Li Peng, Bo Meng, Qi Hua, Xinyu Pei, Lu Zhao et al. · 2021 · Science China Life Sciences
- Mitochondrial Quality Control via Mitochondrial Unfolded Protein Response (mtUPR) in Ageing and Neurodegenerative DiseasesPaula Cilleros-Holgado, David Gómez-Fernández, Rocío Piñero-Pérez, José Manuel Romero-Domínguez, Diana Reche-López, Alejandra López-Cabrera, Mónica Álvarez-Córdoba, Manuel Munuera-Cabeza, Marta Talaverón-Rey, Alejandra Suárez-Carrillo et al. · 2023 · Biomolecules
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- Vitamin D3 ameliorates nitrogen mustard‐induced cutaneous inflammation by inactivating the NLRP3 inflammasome through the SIRT3–SOD2–mtROS signaling pathwayXunhu Dong, Ying He, Ye Feng, Yuanpeng Zhao, Jin Shiung Cheng, Jingsong Xiao, Wenpei Yu, Jiqing Zhao, Yan Sai, Guorong Dan et al. · 2021 · Clinical and Translational Medicine
- Major Oxidative and Antioxidant Mechanisms During Heat Stress-Induced Oxidative Stress in ChickensBikash Aryal, Josephine Kwakye, Oluwatomide W. Ariyo, Ahmed F. A. Ghareeb, Marie C. Milfort, Alberta Lorraine Fuller, Saroj Khatiwada, Romdhane Rekaya, Samuel E. Aggrey · 2025 · Antioxidants
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- Emerging characterization of the role of SIRT3-mediated mitochondrial protein deacetylation in the heartMichael N. Sack · 2011 · American Journal of Physiology-Heart and Circulatory Physiology
- Decreased Mitochondrial Pyruvate Transport Activity in the Diabetic HeartShraddha S. Vadvalkar, Satoshi Matsuzaki, Craig A. Eyster, Jennifer R. Giorgione, Lee Broderick Bockus, Caroline S. Kinter, Michael T Kinter, Kenneth Michael Humphries · 2017 · Journal of Biological Chemistry
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- Role of SIRT3 in mitochondrial biology and its therapeutic implications in neurodegenerative disordersYogesh Mishra, Ravinder Kumar Kaundal · 2023 · Drug Discovery Today
- SOD1 is essential for oncogene-driven mammary tumor formation but dispensable for normal development and proliferationMaria Gomez-Jenkins, Nagma Shah, Timothy C. Kenny, Edmund Charles Jenkins, Doris Germain · 2019 · Oncogene
- Mitochondrial Superoxide Dismutase in Cisplatin-Induced Kidney InjuryKranti A. Mapuskar, Emily J. Steinbach, Amira Zaher, Dennis P. Riley, Robert Alan Beardsley, Jeffery L. Keene, Jon Holmlund, Carryn M. Anderson, Diana Zepeda‐Orozco, John Michael Buatti et al. · 2021 · Antioxidants
- A Novel Sirtuin-3 Inhibitor, LC-0296, Inhibits Cell Survival and Proliferation, and Promotes Apoptosis of Head and Neck Cancer Cells.Turki Y. Alhazzazi, Pachiyappan Kamarajan, Yanli Xu, Teng Ai, Liqiang Chen, Eric M. Verdin, Yvonne Lorraine Kapila · 2016 · PubMed
- Context-dependent activation of SIRT3 is necessary for anchorage-independent survival and metastasis of ovarian cancer cellsYeon Soo Kim, Piyushi Gupta Vallur, Victoria M. Jones, Beth L. Worley, Sara Shimko, Dong‐Hui Shin, LaTaijah C. Crawford, Chi‐Wei Chen, Katherine M. Aird, Thomas Abraham et al. · 2019 · Oncogene
- Cisplatin inhibits SIRT3-deacetylation MTHFD2 to disturb cellular redox balance in colorectal cancer cellWan, Xingyou, Wang, Chao, Huang, Zhenyu, Zhou, Dejian, Xiang, Sheng, Qi, Qian, Chen, Xinyuan, Arbely, Eyal, Liu, Chen-Ying, Du, Peng et al. · 2020 · Cell Death & Disease
- Sirtuin 3 interacts with Lon protease and regulates its acetylation statusLara Gibellini, Marcello Pinti, Francesca Beretti, Ciro Leonardo Pierri, Angelo Onofrio, Massimo Riccio, Gianluca Carnevale, Sara De Biasi, Milena Nasi, Francesca Torelli et al. · 2014 · Mitochondrion
- Oral Supplementation of Melatonin Protects against Fibromyalgia-Related Skeletal Muscle Alterations in Reserpine-Induced Myalgia RatsGaia Favero, Valentina Trapletti, Francesca Bonomini, Alessandra Stacchiotti, Antonio Lavazza, Luigi Fabrizio Rodella, Rita Rezzani · 2017 · International Journal of Molecular Sciences
- Low-Level Saturated Fatty Acid Palmitate Benefits Liver Cells by Boosting Mitochondrial Metabolism via CDK1-SIRT3-CPT2 CascadeLin Liu, Bowen Xie, Ming Fan, Demet Candas, Joy X. Jiang, Ryan Wei, Yinsheng Wang, Hong-Wu Chen, Yiyang Hu, Jian Jian Li · 2019 · Developmental Cell
- Retuning Mitochondrial Apoptosis/Mitophagy Balance via SIRT3‐Energized and Microenvironment‐Modulated Hydrogel Microspheres to Impede OsteoarthritisXiaowei Xia, Yang Liu, Yingjie Lu, Junlin Liu, Yaoge Deng, Yubin Wu, Mingzhuang Hou, Fan He, Huilin Yang, Yong X. Xu et al. · 2023 · Advanced Healthcare Materials
- SIRT3 Activation a Promise in Drug Development? New Insights into SIRT3 Biology and Its Implications on the Drug Discovery ProcessChiara Lambona, Clemens Zwergel, Sérgio Valente, Antonello Mai · 2024 · Journal of Medicinal Chemistry
- Metabolic inflexibility and protein lysine acetylation in heart mitochondria of a chronic model of Type 1 diabetesShraddha S. Vadvalkar, C. Nathan Baily, Satoshi Matsuzaki, Melinda S. West, Yasvir A. Tesiram, Kenneth M. Humphries · 2012 · Biochemical Journal
- Polydatin ameliorates injury to the small intestine induced by hemorrhagic shock via SIRT3 activation-mediated mitochondrial protectionZhenhua Zeng, Yating Yang, Xingui Dai, Siqi Xu, Tao Li, Qin Zhang, Ke‐seng Zhao, Zhongqing Chen · 2016 · Expert Opinion on Therapeutic Targets
- Resveratrol attenuates oxidative stress in mitochondrial Complex I deficiency: Involvement of SIRT3Lise Mathieu, Alexandra Lopes Costa, Carole Le Bachelier, Abdelhamid Slama, Anne-Sophie Lèbre, Robert William Taylor, Jean Bastin, Fatima Djouadi · 2016 · Free Radical Biology and Medicine
- Dysregulation of mitochondrial function and biogenesis modulators in adipose tissue of obese childrenRubén G. Zamora-Mendoza, Haydeé Rosas‐Vargas, María Teresa Ramos-Cervantes, Pedro Alberto García-Zúñiga, Héctor Pérez-Lorenzana, Patricia Mendoza‐Lorenzo, Andric Christopher Perez-Ortiz, Francisco Javier Estrada-Mena, Ángel Miliar-García, Eleazar Lara‐Padilla et al. · 2017 · International Journal of Obesity
- Manganese Superoxide Dismutase: Structure, Function, and Implications in Human DiseaseJovan Grujičić, Antiño R. Allen · 2025 · Antioxidants
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- The pyruvate carboxylase-pyruvate dehydrogenase axis in islet pyruvate metabolism: Going round in circles?Mary C. Sugden, Mark J. Holness · 2011 · Islets
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