The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
Oxidative stress and ROS metabolism via down-regulation of sirtuin 3 expression in Cmah-null mice affect hearing loss
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Acaa2, Acad9, and Cyp2u1 function in fatty acid beta-oxidation and lipid metabolism, and increased activity is associated with alteration of mitochondrial architecture, bioenergetics and oxidative stress.
“their functions are reported in fatty acid beta-oxidation and lipid metabolism, with increased activity associated with alteration of mitochondrial architecture, bioenergetics and oxidative stress [38–41].”
From Genetic variation in CCDC93 is associated with elevated central systolic blood pressure, impaired arterial relaxation, and mitochondrial dysfunction (2024) · cites this paper as [39]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
SIRT3 regulates mitochondrial fatty-acid oxidation by reversible enzyme deacetylation
Hirschey, M. D., Shimazu, T., Goetzman, E., Jing, E., Schwer, B., Lombard, D. B., Grueter, C. A., Harris, C., Biddinger, S., Ilkayeva, O. R., et al. (2010) · Nature · doi:10.1038/nature08778 · Cited by 1,687
Calorie restriction reduces oxidative stress by SIRT3-mediated SOD2 activation
Qiu, X., Brown, K., Hirschey, M. D., Verdin, E., & Chen, D. (2010) · Cell Metabolism · doi:10.1016/j.cmet.2010.11.015 · Cited by 1,310
Mammalian sirtuins—emerging roles in physiology, aging, and calorie restriction
Haigis, M. C., & Guarente, L. P. (2006) · Genes & Development · doi:10.1101/gad.1467506 · Cited by 1,295
Tao, R., Coleman, M. C., Pennington, J. D., Ozden, O., Park, S.-H., Jiang, H., Kim, H.-S., Flynn, C. R., Hill, S., Hayes McDonald, W., et al. (2010) · Molecular Cell · doi:10.1016/j.molcel.2010.12.013 · Cited by 899
Shi, T., Wang, F., Stieren, E., & Tong, Q. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m414670200 · Cited by 712
Bell, E. L., Emerling, B. M., Ricoult, S. J. H., & Guarente, L. (2011) · Oncogene · doi:10.1038/onc.2011.37 · Cited by 440
The overexpression of major antioxidant enzymes does not extend the lifespan of mice
Pérez, V. I., Van Remmen, H., Bokov, A., Epstein, C. J., Vijg, J., & Richardson, A. (2009) · Aging Cell · doi:10.1111/j.1474-9726.2008.00449.x · Cited by 353
The sirtuins, oxidative stress and aging: an emerging link
Merksamer, P. I., Liu, Y., He, W., Hirschey, M. D., Chen, D., & Verdin, E. (2013) · Aging · doi:10.18632/aging.100544 · Cited by 275
Flagged first, then by citations
Research works printed but not linked: 41
- Diaz, 1989, Biosynthesis of N-glycolyneuraminic acid. The primary site of hydroxylation of N-acetylneuraminic acid is the cytosolic sugar nucleotide pool, J Biol Chem, 26, 20216
- Suzuki, 1990, Participation of cytochrome b5 in CMP-N-acetylneuraminic acid hydroxylation in mouse liver cytosol, J Biochem, 10, 704
- Suzuki, 1998, The molecular basis for the absence of N-glycolylneuraminic acid in humans, J Biol Chem, 27, 15866
- Takahata, 2001, Alu-mediated inactivation of the human CMP- N-acetylneuraminic acid hydroxylase gene, Proc Natl Acad Sci U S A, 9, 11399
- Varki, 2007, N-glycolylneuraminic acid deficiency in mice: implications for human biology and evolution, Mol Cell Biol, 2, 4340
- Kim, 2014, Gene expression and pathway analysis of effects of the CMAH deactivation on mouse lung, kidney and heart, PLoS One, 9, e107559, 10.1371/journal.pone.0107559 · DOI
- Kim, 2014, MicroRNA dysregulation in liver and pancreas of CMP-Neu5Ac hydroxylase null mice disrupts insulin/PI3K-AKT signaling, Biomed Res Int, 5, 23638
- Wang, 2012, Oxidative stress, inflammation, and autophagic stress as the key mechanisms of premature age-related hearing loss in SAMP8 mouse Cochlea, Antioxid Redox Signal, 1, 263
- Quirk, 2000, Biologic activity of mitochondrial metabolites on aging and age-related hearing loss, Am J Otol, 2, 161
- Wang, 2007, The role of mitochondrial DNA large deletion for the development of presbycusis in Fischer 344 rats, Neurobiol Dis, 2, 370
- Henderson, 2012, Expression pattern of oxidative stress and antioxidant defense-related genes in the aging Fischer 344/NHsd rat cochlea, Neurobiol Aging, 3, e1841
- Kahn, 2011, Sirtuin-3 (Sirt3) regulates skeletal muscle metabolism and insulin signaling via altered mitochondrial oxidation and reactive oxygen species production, Proc Natl Acad Sci U S A, 10, 14608
- Guarente, 2004, The Sir2 family of protein deacetylases, Annu Rev Biochem, 7, 417
- Mostoslavsky, 2009, Recent progress in the biology and physiology of sirtuins, Nature, 46, 587
- Guarente, 2010, Aging and disease: connections to sirtuins, Aging Cell, 9, 285, 10.1111/j.1474-9726.2010.00548.x · DOI
- Holbrook, 2000, Oxidants, oxidative stress and the biology of ageing, Nature, 40, 239
- Haigis, 2011, SIRT3 opposes reprogramming of cancer cell metabolism through HIF1alpha destabilization, Cancer Cell, 1, 416
- Finkel, 2008, A role for the mitochondrial deacetylase Sirt3 in regulating energy homeostasis, Proc Natl Acad Sci U S A, 10, 14447
- Prolla, 2010, Mitochondrial oxidative damage and apoptosis in age-related hearing loss, Mech Ageing Dev, 13, 480
- Gupta, 2009, Sirt3 blocks the cardiac hypertrophic response by augmenting Foxo3a-dependent antioxidant defense mechanisms in mice, J Clin Invest, 11, 2758
- Denu, 2011, Sirt3 promotes the urea cycle and fatty acid oxidation during dietary restriction, Mol Cell, 4, 139
- Prolla, 2010, Sirt3 mediates reduction of oxidative damage and prevention of age-related hearing loss under caloric restriction, Cell, 14, 802
- Martin, 2010, A human-specific deletion in mouse Cmah increases disease severity in the mdx model of Duchenne muscular dystrophy, Sci Transl Med, 2, 42ra54
- Pujol, 2012, Oxidative stress underlying axonal degeneration in adrenoleukodystrophy: a paradigm for multifactorial neurodegenerative diseases?, Biochim Biophys Acta, 182, 1475
- Ohlemiller, 2010, Age-related loss of spiral ganglion neurons, Hear Res, 26, 93
- Steinman, 1998, Changes in cochlear antioxidant enzyme activity after sound conditioning and noise exposure in the chinchilla, Hear Res, 11, 31
- Salvi, 1999, Age-related cochlear hair cell loss is enhanced in mice lacking copper/zinc superoxide dismutase, Neurobiol Aging, 2, 1
- Sacchetti, 2004, Paraoxonase and superoxide dismutase gene polymorphisms and noise-induced hearing loss, Clin Chem, 5, 2012
- Sha, 2007, Oxidative imbalance in the aging inner ear, Neurobiol Aging, 2, 1605
- Monga, 2007, WNT/beta-catenin signaling in liver health and disease, Hepatology, 4, 1298
- Monga, 2011, Role of Wnt/beta-catenin signaling in liver metabolism and cancer, Int J Biochem Cell Biol, 4, 1021, 10.1016/j.biocel.2009.09.001 · DOI
- Monga, 2010, Liver-specific beta-catenin knockout mice exhibit defective bile acid and cholesterol homeostasis and increased susceptibility to diet-induced steatohepatitis, Am J Pathol, 17, 744
- Sylvester, 2012, beta-Catenin regulates hepatic mitochondrial function and energy balance in mice, Gastroenterology, 14, 754
- Korswagen, 2005, Functional interaction between beta-catenin and FOXO in oxidative stress signaling, Science, 30, 1181
- Burgering, 2008, Interaction of FOXO with beta-catenin inhibits beta-catenin/T cell factor activity, J Biol Chem, 28, 9224
- Chang, 2010, Sirtuin 3, a new target of PGC-1alpha, plays an important role in the suppression of ROS and mitochondrial biogenesis, PLoS One, 5, e11707, 10.1371/journal.pone.0011707 · DOI · Paper page
- Hakkola, 2012, Metformin reduces hepatic expression of SIRT3, the mitochondrial deacetylase controlling energy metabolism, PLoS One, 7, e49863, 10.1371/journal.pone.0049863 · DOI
- Bellizzi, 2012, SIRT3 gene expression: a link between inherited mitochondrial DNA variants and oxidative stress, Gene, 49, 323
- Someya, 2013, Maintaining good hearing: calorie restriction, Sirt3, and glutathione, Exp Gerontol, 4, 1091
- Lempicki, 2009, Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources, Nat Protoc, 4, 44, 10.1038/nprot.2008.211 · DOI · Paper page
- Goto, 2000, KEGG: kyoto encyclopedia of genes and genomes, Nucleic Acids Res, 2, 27
Cited by
Sorted by citations
Kumar, N., Yang, M.-L., Sun, P., Hunker, K. L., Li, J., Jia, J., Fan, F., Wang, J., Ning, X., Gao, W., et al. (2024) · PLOS Genetics · doi:10.1371/journal.pgen.1011151 · Cited by 1
Metadata
- Authors
- Kwon, D.-N., Park, W.-J., Choi, Y.-J., Gurunathan, S., & Kim, J.-H.
- Affiliations
- Department of Animal Biotechnology, Konkuk University, Seoul 143-701, Republic of Korea
- Venue
- Aging
- Publisher
- Impact Journals, LLC
- Published
- 2015-08-29
- Volume
- 7
- Issue
- 8
- Pages
- 579-594
- ISSN
- 1945-4589
- PMC
- PMC4586103
- Cited by
- 45
- References
- 8
- Language
- en
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review