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MTHFD2 is a metabolic checkpoint controlling effector and regulatory T cell fate and function

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The Role and Therapeutic Perspectives of Sirtuin 3 in Cancer Metabolism Reprogramming, Metastasis, and Chemoresistance

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LECs regulate neutrophil clearance through IL-17RC/CMTM4/NF-κB axis at sites of inflammation or infection

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Mechanical force receptor Piezo1 regulates TH9 cell differentiation

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Up-regulation of MTHFD2 is associated with clinicopathological characteristics and poor survival in ovarian cancer, possibly by regulating MOB1A signaling

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Mitochondrial Sirtuins in Chronic Degenerative Diseases: New Metabolic Targets in Colorectal Cancer

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Knockdown of MTHFD2 inhibits proliferation and migration of nasopharyngeal carcinoma cells through the ERK signaling pathway

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Acetylation of aldehyde dehydrogenase ALDH1L2 regulates cellular redox balance and the chemosensitivity of colorectal cancer to 5-fluorouracil

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In Vitro Cytotoxicity Evaluation of Plastoquinone Analogues against Colorectal and Breast Cancers along with In Silico Insights

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PEGylated Cisplatin Nanoparticles for Treating Colorectal Cancer in a pH-Responsive Manner

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Development of lactate‐related gene signature and prediction of overall survival and chemosensitivity in patients with colorectal cancer

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Induction of MTHFD2 in Macrophages Inhibits Reactive Oxygen Species–mediated NF-κB Activation and Protects against Inflammatory Responses

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SIRT3 Negatively Regulates TFH-Cell Differentiation in Cancer

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Targeting SHMTs and MTHFDs in cancer: attractive opportunity for anti-tumor strategy

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Nuclear localization of MTHFD2 is required for correct mitosis progression

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LncRNA LINC01535 promotes colorectal cancer development and chemoresistance by sponging miR‑761

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Role of SIRT3 in neurological diseases and rehabilitation training

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Interference with MTHFD2 induces ferroptosis in ovarian cancer cells through ERK signaling to suppress tumor malignant progression

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SIRT3/GLUT4 signaling activation by metformin protect against cisplatin-induced ototoxicity in vitro

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The neuroprotective effects of SFGDI on sirtuin 3-related oxidative stress by regulating the Sirt3/SOD/ROS pathway and energy metabolism in BV2 cells

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SIRT3-mediated mitochondrial reprogramming: Emerging therapeutic paradigms in peripheral neuropathy and neuropathic pain

Mishra, Y., & Kumar, A. (2025) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2025.12.035 · Cited by 5 · see citing works

Dynamics of Mitochondrial Proteome and Acetylome in Glioblastoma Cells with Contrasting Metabolic Phenotypes

Fernández-Coto, D. L., Gil, J., Ayala, G., & Encarnación‐Guevara, S. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25063450 · Cited by 5 · see citing works

Sirtuins and tumor immunity: mechanistic insights, immunotherapy prospects, and therapeutic horizons

Gu, J., Liu, S., Xiao, W., & Qu, W. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1700483 · Cited by 4 · see citing works

The Influence of Mitochondrial Energy and 1C Metabolism on the Efficacy of Anticancer Drugs: Exploring Potential Mechanisms of Resistance

Frańczak, M., Toenshoff, I., Jansen, G., Smolenski, R. T., Giovannetti, E., & Peters, G. J. (2022) · Current Medicinal Chemistry · doi:10.2174/0929867329666220401110418 · Cited by 4 · see citing works

Novel nitric oxide-releasing triptolidenol derivatives suppress gastric cancer by targeting the folate one-carbon metabolism pathway and inducing ROS accumulation

Tian, Y., Guan, J., Luo, H., Ning, Q., Yang, X., Ma, J., Zang, Y., Li, C., Lai, F., & Zhang, D. (2026) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2026.118772 · Cited by 3 · see citing works

Non-canonical dihydrolipoyl transacetylase promotes chemotherapy resistance via mitochondrial tetrahydrofolate signaling

Hwang, J. S., Kang, J., Kim, J. H., Eun, K., West, S., Bacho, H. E., Avalos, V., Shuff, S. R., Shin, D. M., Saba, N. F., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-63892-3 · Cited by 4 · see citing works

Metabolomic analysis for diagnosis of oral squamous cell carcinoma using machine learning

Yuan, W., Rao, J., Han, S., Li, S. L., Meng, X., Qin, L., & Huang, X. (2026) · Discover Oncology · doi:10.1007/s12672-026-04988-0 · Cited by 2 · see citing works

Cryptotanshinone, a Potential SIRT3 Inhibitor, Suppresses Colorectal Cancer Proliferation in vitro and in vivo

Song, D., Fang, X., Sun, Z., Qiu, Z., Liu, D., Luo, H., Jin, Y. H., & Wu, D. (2023) · Natural Product Communications · doi:10.1177/1934578x231194808 · Cited by 2 · see citing works

Recent advances in novel targeting mechanisms for colorectal cancer

Li, Z., Wang, H., Liu, Y., Gemingnuer, A., Wang, Y., & Meng, X. (2025) · Clinical & Translational Oncology · doi:10.1007/s12094-025-03990-2 · Cited by 2 · see citing works

Nuclear MTHFD2 secures mitosis progression by preserving centromere integrityPreprint

Lorente, N. P., Gkanogiannis, A., Cozzuto, L., Zapater, A. G., Espinar, L., García-López, L., Aydin, R. G., Darai, E., Severino, J., Batlle‐Morera, L., et al. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.06.01.543193 · Cited by 2 · see citing works

Research progress on sirtuin family genes in colorectal cancer

Liu, T., Wu, T., Luo, L., Li, W., & Zhang, M. (2025) · Frontiers in Oncology · doi:10.3389/fonc.2025.1570030 · Cited by 2 · see citing works

Methylenetetrahydrofolate dehydrogenase 2 promotes cutaneous squamous cell carcinoma progression by reprogramming metabolism and interacting with fatty acid synthase

Du, W., Liu, X.-Y., He, K., Yin, T., Cheng, B., Gan, X., Liu, M., Zhang, Z., Luo, R., Bai, R., et al. (2026) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2026.150486 · Cited by 1 · see citing works

African swine fever virus DEAD-box helicase D1133L promotes OGG1-driven incision of genomic 8-oxoG via HDAC5 deacetylation

Fan, J., Yang, J., Tian, Z., Zhang, X., Geng, S., Luo, J., Boldogh, I. R., Zeng, Q., Yin, H., Guan, G., et al. (2025) · Journal of Molecular Cell Biology · doi:10.1093/jmcb/mjaf029 · Cited by 1 · see citing works

Exploring novel roles of metabolic enzymes MTHFD2 and PFKFB3 in cancer genome stability and their potential as anticancer therapeutic targets

Villarreal, B., & Nadilly, Y. (2021) · Figshare

Up-Regulation of MTHFD2 is Associated With Clinicopathological Characteistics and Poor Survival in Ovarian Cancer, Possibly By Regulating MOB1A SignalingPreprint

Cui, X., Su, H., Yang, J., Wu, X., Huo, K., Jing, X., & Zhang, S. (2021) · Research Square · doi:10.21203/rs.3.rs-929562/v1

Effects of selective lactate dehydrogenase A inhibitors and their mechanism in neoplastic and non-neoplastic cells

Frańczak, M. (2024) · doi:10.5463/thesis.984

MTHFD2-Mediated Ubiquitination and Degradation of FOXO1 Promote Tongue Squamous Cell Carcinoma Progression

Tuohuti, A., Fang, L., Lin, Z. P., Wu, S., Cai, W., Ming, X., Chen, Z., Xie, Q., Fu, Q., Sun, X., et al. (2025) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-25-0724

Additional file 1 of SGLT2 inhibitor promotes mitochondrial dysfunction and ER-phagy in colorectal cancer cells

Anastasio, C., Donisi, I., Vecchio, V. D., Colloca, A., Mele, L. L., Sardu, C., Marfella, R., BALESTRIERI, M. L., & D’Onofrio, N. (2024) · Figshare · doi:10.6084/m9.figshare.25929059

Nucleotide Metabolism in Health and Disease

Zhao, X., Zeng, Y., Xu, Y., Rao, S., Khouchani, M., Soummane, H., Li, J., & Liu, R. (2026) · MedComm · doi:10.1002/mco2.70900

Deacetylation of MTHFD2 by SIRT4 senses stress signal to inhibit cancer cell growth by remodeling folate metabolism

Zhang, F., Wang, D., Li, J., Su, Y., Liu, S., Lei, Q., & Yin, M. (2022) · Journal of Molecular Cell Biology · doi:10.1093/jmcb/mjac020 · Cited by 24 · see citing works

Modulation of Redox Homeostasis by Inhibition of MTHFD2 in Colorectal Cancer: Mechanisms and Therapeutic Implications

Ju, H., Lu, Y., Chen, D.-L., Zuo, Z.-X., Liu, Z., Wu, Q.-N., Mo, H., Wang, Z., Wang, D., Pu, H., et al. (2018) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djy160 · Cited by 189 · see citing works

Sirtuin 3 silencing improves oxaliplatin efficacy through acetylation of MnSOD in colon cancer

Torrens‐Mas, M., Hernández‐López, R., Oliver, J., Roca, P., & Sastre‐Serra, J. (2018) · Journal of Cellular Physiology · doi:10.1002/jcp.26443 · Cited by 40 · see citing works

The effect of MTHFD2 on the proliferation and migration of colorectal cancer cell lines

Wei, Y., Liu, P., Li, Q., Du, J., Chen, Y., Wang, Y., Shi, H., Wang, Y., Zhang, H., Xue, W., et al. (2019) · OncoTargets and Therapy · doi:10.2147/ott.s210800 · Cited by 47 · see citing works

Abstract 3790: Targeting the one-carbon metabolism protein MTHFD2 for cancer therapy: Exploiting the unique redox status of cancer cells

Glasauer, A., Steckel, M., Haegebarth, A., Bauser, M., & Toschi, L. (2016) · Cancer Research · doi:10.1158/1538-7445.am2016-3790