The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
RETRACTED: The Noncoding RNA Mistral Activates Hoxa6 and Hoxa7 Expression and Stem Cell Differentiation by Recruiting MLL1 to Chromatin
Open accessAbstract
SUMMARY The epigenetic activator Mixed lineage leukemia 1 (Mll1) is paramount for embryonic development and hematopoiesis. Here we demonstrate that the long, non-coding RNA (lncRNA) Mistral (Mira) activates transcription of the homeotic genes Hoxa6 and Hoxa7 in mouse embryonic stem cells (mESC) by recruiting Mll1 to chromatin. The Mira gene is located in the spacer DNA region (SDR) separating Hoxa6 and Hoxa7, transcriptionally silent in mESCs, and activated by retinoic acid. Mira-mediated recruitment of Mll1 to the Mira gene triggers dynamic changes in chromosome conformation, culminating in activation of Hoxa6 and Hoxa7 transcription. Hoxa6 and Hoxa7 activate the expression of genes involved in germ layer specification during mESC differentiation in a cooperative and redundant fashion. Our results connect the lncRNA Mira with the recruitment of Mll1 to target genes and implicate lncRNAs in epigenetic activation of gene expression during vertebrate cell fate determination.
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Cites
The Polycomb complex PRC2 and its mark in life
Margueron, R., & Reinberg, D. (2011) · Nature · doi:10.1038/nature09784 · Cited by 3,347
Long Noncoding RNA as Modular Scaffold of Histone Modification Complexes
Tsai, M.-C., Manor, O., Wan, Y., Mosammaparast, N., Wang, J. K., Lan, F., Shi, Y., Segal, E., & Chang, H. Y. (2010) · Science · doi:10.1126/science.1192002 · Cited by 3,290 · cited 2×
“LncRNAs have been associated with gene silencing, imprinting, and gene-dosage compensation by guiding enzymes involved in chromatin remodeling and posttranslational modification of histones to target genes (Khalil et al., 2009; Tsai et al., 2010).”
Khalil, A. M., Guttman, M., Huarte, M., Garber, M., Raj, A., Rivea Morales, D., Thomas, K., Presser, A., Bernstein, B. E., van Oudenaarden, A., et al. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0904715106 · Cited by 2,872
Long Noncoding RNAs with Enhancer-like Function in Human Cells
Ørom, U. A., Derrien, T., Beringer, M., Gumireddy, K., Gardini, A., Bussotti, G., Lai, F., Zytnicki, M., Notredame, C., Huang, Q., et al. (2010) · Cell · doi:10.1016/j.cell.2010.09.001 · Cited by 1,721
Quantitative analysis of chromosome conformation capture assays (3C-qPCR)
Hagège, H., Klous, P., Braem, C., Splinter, E., Dekker, J., Cathala, G., de Laat, W., & Forné, T. (2007) · Nature Protocols · doi:10.1038/nprot.2007.243 · Cited by 720 · cited 2×
“Chromosome Conformation Capture (3C) Assays The 3C assay was performed as described (Hagège et al., 2007) (see Supplemental Experimental Procedures for details).”
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Cited by
Long non-coding RNAs: new players in cell differentiation and development
Fatica, A., & Bozzoni, I. (2014) · Nature Reviews Genetics · doi:10.1038/nrg3606 · Cited by 2,980
Long Noncoding RNAs: Cellular Address Codes in Development and Disease
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Long noncoding RNAs: past, present, and future
Kung, J. T. Y., Colognori, D., & Lee, J. T. (2013) · Genetics · doi:10.1534/genetics.112.146704 · Cited by 1,874
The Adult Ventricular–Subventricular Zone (V-SVZ) and Olfactory Bulb (OB) Neurogenesis
Lim, D. A., & Alvarez-Buylla, A. (2016) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a018820 · Cited by 571
SET for life: biochemical activities and biological functions of SET domain-containing proteins
Herz, H.-M., Garruss, A., & Shilatifard, A. (2013) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2013.09.004 · Cited by 314
Metadata
- Authors
- Bertani, S., Sauer, S., Bolotin, E., & Sauer, F.
- Venue
- Molecular Cell
- Publisher
- Elsevier BV
- Published
- 2011-09
- Volume
- 43
- Issue
- 6
- Pages
- 1040-1046
- ISSN
- 1097-2765 (ISSN-L)
- OpenAlex
- W1974690690
- Cited by
- 220
- References
- 5
- FWCI
- 12.86
- Type
- journal article
- Language
- en
- Status
- Retracted
- Open access
- bronze
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- CoChat. (2026). Citation check: RETRACTED: The Noncoding RNA Mistral Activates Hoxa6 and Hoxa7 Expression and Stem Cell Differentiation by Recruiting MLL1 to Chromatin. https://app.cochat.ai/papers/10.1016/j.molcel.2011.08.019
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- Bertani, S., Sauer, S., Bolotin, E., & Sauer, F. (2011). RETRACTED: The Noncoding RNA Mistral Activates Hoxa6 and Hoxa7 Expression and Stem Cell Differentiation by Recruiting MLL1 to Chromatin. Molecular Cell. https://doi.org/10.1016/j.molcel.2011.08.019
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