The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Transcription-Coupled Nucleotide Excision Repair Factors Promote R-Loop-Induced Genome Instability
Open accessAbstract
Summary R-loops, consisting of an RNA-DNA hybrid and displaced single-stranded DNA, are physiological structures that regulate various cellular processes occurring on chromatin. Intriguingly, changes in R-loop dynamics have also been associated with DNA damage accumulation and genome instability, however the mechanisms underlying R-loop induced DNA damage remain unknown. Here we demonstrate in human cells that R-loops induced by the absence of diverse RNA processing factors, including the RNA/DNA helicases Aquarius (AQR) and Senataxin (SETX), or by the inhibition of topoisomerase I, are actively processed into DNA double-strand breaks (DSBs) by the nucleotide excision repair endonucleases XPF and XPG. Surprisingly, DSB formation requires the transcription-coupled nucleotide excision repair (TC-NER) factor Cockayne syndrome group B (CSB), but not the global genome repair protein XPC. These findings reveal an unexpected and potentially deleterious role for TC-NER factors in driving R-loop-induced DNA damage and genome instability.
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1 retracted
Fousteri, M., Vermeulen, W., van Zeeland, A. A., & Mullenders, L. H. F. (2006) · Molecular Cell · doi:10.1016/j.molcel.2006.06.029 · Cited by 387
RetractedInstability and decay of the primary structure of DNA
Lindahl, T. (1993) · Nature · doi:10.1038/362709a0 · Cited by 5,679
C9orf72 nucleotide repeat structures initiate molecular cascades of disease
Haeusler, A. R., Donnelly, C. J., Periz, G., Simko, E. A. J., Shaw, P. G., Kim, M.-S., Maragakis, N. J., Troncoso, J. C., Pandey, A., Sattler, R., et al. (2014) · Nature · doi:10.1038/nature13124 · Cited by 978
Sugasawa, K., Ng, J. M. Y., Masutani, C., Iwai, S., van der Spek, P. J., Eker, A. P. M., Hanaoka, F., Bootsma, D., & Hoeijmakers, J. H. J. (1998) · Molecular Cell · doi:10.1016/s1097-2765(00)80132-x · Cited by 899
Mechanisms of transcription-coupled DNA repair
Svejstrup, J. Q. (2002) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm703 · Cited by 380
Cited by
R-Loops as Cellular Regulators and Genomic Threats
Crossley, M. P., Bocek, M., & Cimprich, K. A. (2019) · Molecular Cell · doi:10.1016/j.molcel.2019.01.024 · Cited by 746
Self-citationR Loops: From Physiological to Pathological Roles
García-Muse, T., & Aguilera, A. (2019) · Cell · doi:10.1016/j.cell.2019.08.055 · Cited by 697
Self-citationRegulation of Single-Strand Annealing and its Role in Genome Maintenance
Bhargava, R., Onyango, D. O., & Stark, J. M. (2016) · Trends in Genetics · doi:10.1016/j.tig.2016.06.007 · Cited by 473
Mechanisms of Oncogene-Induced Replication Stress: Jigsaw Falling into Place
Kotsantis, P., Petermann, E., & Boulton, S. J. (2018) · Cancer Discovery · doi:10.1158/2159-8290.cd-17-1461 · Cited by 416
The Fanconi Anemia Pathway Maintains Genome Stability by Coordinating Replication and Transcription
Schwab, R. A., Nieminuszczy, J., Shah, F., Langton, J., Lopez Martinez, D., Liang, C.-C., Cohn, M. A., Gibbons, R. J., Deans, A. J., & Niedzwiedz, W. (2015) · Molecular Cell · doi:10.1016/j.molcel.2015.09.012 · Cited by 361
Metadata
- Authors
- Sollier, J., Stork, C. T., García-Rubio, M. L., Paulsen, R. D., Aguilera, A., & Cimprich, K. A.
- Venue
- Molecular Cell
- Publisher
- Elsevier BV
- Published
- 2014-12
- Volume
- 56
- Issue
- 6
- Pages
- 777-785
- ISSN
- 1097-2765 (ISSN-L)
- OpenAlex
- W2107455041
- Cited by
- 595
- References
- 5
- FWCI
- 14.36
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Sollier, J., Stork, C. T., García-Rubio, M. L., Paulsen, R. D., Aguilera, A., & Cimprich, K. A. (2014). Transcription-Coupled Nucleotide Excision Repair Factors Promote R-Loop-Induced Genome Instability. Molecular Cell. https://doi.org/10.1016/j.molcel.2014.10.020
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
