The DOI matches its Crossref record; 110 of the 110 references it cites were found in a registry or an index.
Regulation of Single-Strand Annealing and its Role in Genome Maintenance
Open accessAbstract
Single Strand Annealing (SSA) is a DNA double strand break (DSB) repair pathway that uses homologous repeats to bridge DSB ends. SSA involving repeats that flank a single DSB causes a deletion rearrangement between the repeats, and hence is relatively mutagenic. Nevertheless, this pathway is conserved, in that SSA events have been found in several organisms. In this review, we describe the mechanism of SSA and its regulation, including the cellular conditions that may favor SSA versus other DSB repair events. We will also evaluate the potential contribution of SSA to cancer-associated genome rearrangements, and to DSB-induced gene targeting.
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Cites
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Cited by
Non-homologous DNA end joining and alternative pathways to double-strand break repair
Chang, H. H. Y., Pannunzio, N. R., Adachi, N., & Lieber, M. R. (2017) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm.2017.48 · Cited by 1,757
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Nonhomologous DNA end-joining for repair of DNA double-strand breaks
Pannunzio, N. R., Watanabe, G., & Lieber, M. R. (2018) · Journal of Biological Chemistry · doi:10.1074/jbc.tm117.000374 · Cited by 489
DNA Repair Pathway Choices in CRISPR-Cas9-Mediated Genome Editing
Xue, C., & Greene, E. C. (2021) · Trends in Genetics · doi:10.1016/j.tig.2021.02.008 · Cited by 431
The molecular basis and disease relevance of non-homologous DNA end joining
Zhao, B., Rothenberg, E., Ramsden, D. A., & Lieber, M. R. (2020) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-020-00297-8 · Cited by 384
Metadata
- Authors
- Bhargava, R., Onyango, D. O., & Stark, J. M.
- Venue
- Trends in Genetics
- Publisher
- Elsevier BV
- Published
- 2016-09
- Volume
- 32
- Issue
- 9
- Pages
- 566-575
- ISSN
- 0168-9525 (ISSN-L)
- OpenAlex
- W2494174731
- Cited by
- 473
- References
- 110
- FWCI
- 2.77
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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