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The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.

Structure of the Human mTOR Complex I and Its Implications for Rapamycin Inhibition

Yip, Calvin K., Murata, Kazuyoshi, Walz, Thomas, Sabatini, David M., Kang, Seong A.·2010·Molecular Cell
DOI 10.1016/j.molcel.2010.05.017PMC PMC2887672
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Crossref · 10.1016/j.molcel.2010.05.017

Cites

4 of 4 references verified0 citation errors · 0 not checkable

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  • The difference in rapamycin sensitivity between mTORC1 and mTORC2 is structural; RICTOR in mTORC2 masks the rapamycin-interacting domain of mTOR.

    “The reasons for this difference in rapamycin sensitivity is structural; the mTOR interacting protein RICTOR, which is present in mTORC2 but not mTORC1, masks the rapamycin-interacting domain of mTOR29–31.”

    From Targeting the biology of aging with mTOR inhibitors (2023) · cites this paper as [31]

    The Introduction identifies rictor as a component of mTORC2 but not mTORC1. The Results and Discussion section on FKBP12-rapamycin describes binding to mTOR’s FRB domain in mTORC1, but does not show that rictor masks that domain in mTORC2 or establish this as the reason for their different rapamycin sensitivity. No page numbers are available in our copy. (LLM, conf=0.86)

    Experimental — accuracy not yet measured

  • In yeast, dephosphorylation of Atg13 is associated with activation/assembly of the core complex that reflects the reduction of TORC1 and PKA activities.

    “In yeast, dephosphorylation of Atg13 is associated with activation/assembly of the core complex that reflects the reduction of TORC1 and PKA activities.”

    From Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition) 1 (2021) · cites this paper as [739]

    The Introduction discusses mTORC1 and autophagy, while Results and Discussion discusses the structure of human mTORC1 and briefly compares it with yeast TORC1; no page numbers are available in our copy. Searches for Atg13 dephosphorylation, PKA, and activation or assembly of the claimed yeast core complex found no passage addressing their proposed relationship. (LLM, conf=0.73)

    Experimental — accuracy not yet measured

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Citations

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Research works printed but not linked: 28

  1. Adami, 2007, Structure of TOR and its complex with KOG1, Mol. Cell, 27, 509, 10.1016/j.molcel.2007.05.040 · DOI
  2. Chen, 1995, Identification of an 11-kDa FKBP12-rapamycin-binding domain within the 289-kDa FKBP12-rapamycin-associated protein and characterization of a critical serine residue, Proc. Natl. Acad. Sci. USA, 92, 4947, 10.1073/pnas.92.11.4947 · DOI · Paper page
  3. Choi, 1996, Structure of the FKBP12-rapamycin complex interacting with the binding domain of human FRAP, Science, 273, 239, 10.1126/science.273.5272.239 · DOI
  4. Choo, 2008, Rapamycin differentially inhibits S6Ks and 4E-BP1 to mediate cell-type-specific repression of mRNA translation, Proc. Natl. Acad. Sci. USA, 105, 17414, 10.1073/pnas.0809136105 · DOI
  5. Feldman, 2009, Active-site inhibitors of mTOR target rapamycin-resistant outputs of mTORC1 and mTORC2, PLoS Biol., 7, e38, 10.1371/journal.pbio.1000038 · DOI
  6. Gingras, 1999, Regulation of 4E-BP1 phosphorylation: a novel two-step mechanism, Genes Dev., 13, 1422, 10.1101/gad.13.11.1422 · DOI
  7. Gottlieb, 1993, The DNA-dependent protein kinase: requirement for DNA ends and association with Ku antigen, Cell, 72, 131, 10.1016/0092-8674(93)90057-W · DOI
  8. Guertin, 2007, Defining the role of mTOR in cancer, Cancer Cell, 12, 9, 10.1016/j.ccr.2007.05.008 · DOI · Paper page
  9. Guertin, 2006, Ablation in mice of the mTORC components raptor, rictor, or mLST8 reveals that mTORC2 is required for signaling to Akt-FOXO and PKCalpha, but not S6K1, Dev. Cell, 11, 859, 10.1016/j.devcel.2006.10.007 · DOI
  10. Hara, 2002, Raptor, a binding partner of target of rapamycin (TOR), mediates TOR action, Cell, 110, 177, 10.1016/S0092-8674(02)00833-4 · DOI
  11. Keith, 1995, PIK-related kinases: DNA repair, recombination, and cell cycle checkpoints, Science, 270, 50, 10.1126/science.270.5233.50 · DOI
  12. Kim, 2002, mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery, Cell, 110, 163, 10.1016/S0092-8674(02)00808-5 · DOI
  13. Kim, 2003, GbetaL, a positive regulator of the rapamycin-sensitive pathway required for the nutrient-sensitive interaction between raptor and mTOR, Mol. Cell, 11, 895, 10.1016/S1097-2765(03)00114-X · DOI
  14. Long, 2005, Rheb binds and regulates the mTOR kinase, Curr. Biol., 15, 702, 10.1016/j.cub.2005.02.053 · DOI · Paper page
  15. Ma, 2009, Molecular mechanisms of mTOR-mediated translational control, Nat. Rev. Mol. Cell Biol., 10, 307, 10.1038/nrm2672 · DOI · Paper page
  16. Ohi, 2004, Negative Staining and Image Classification - Powerful Tools in Modern Electron Microscopy, Biol. Proced. Online, 6, 23, 10.1251/bpo70 · DOI
  17. Richter, 2005, Regulation of cap-dependent translation by eIF4E inhibitory proteins, Nature, 433, 477, 10.1038/nature03205 · DOI
  18. Sabatini, 1994, RAFT1: a mammalian protein that binds to FKBP12 in a rapamycin-dependent fashion and is homologous to yeast TORs, Cell, 78, 35, 10.1016/0092-8674(94)90570-3 · DOI · Paper page
  19. Sancak, 2008, The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1, Science, 320, 1496, 10.1126/science.1157535 · DOI · Paper page
  20. Sarbassov, 2005, Growing roles for the mTOR pathway, Curr. Opin. Cell Biol., 17, 596, 10.1016/j.ceb.2005.09.009 · DOI
  21. Sibanda, 2010, Crystal structure of DNA-PKcs reveals a large open-ring cradle comprised of HEAT repeats, Nature, 463, 118, 10.1038/nature08648 · DOI
  22. Spagnolo, 2006, Three-dimensional structure of the human DNA-PKcs/Ku70/Ku80 complex assembled on DNA and its implications for DNA DSB repair, Mol. Cell, 22, 511, 10.1016/j.molcel.2006.04.013 · DOI
  23. Takahara, 2006, Nutrient-dependent multimerization of the mammalian target of rapamycin through the N-terminal HEAT repeat region, J. Biol. Chem., 281, 28605, 10.1074/jbc.M606087200 · DOI
  24. Urano, 2007, Point mutations in TOR confer Rheb-independent growth in fission yeast and nutrient-independent mammalian TOR signaling in mammalian cells, Proc. Natl. Acad. Sci. USA, 104, 3514, 10.1073/pnas.0608510104 · DOI
  25. Vander Haar, 2007, Insulin signalling to mTOR mediated by the Akt/PKB substrate PRAS40, Nat. Cell Biol., 9, 316, 10.1038/ncb1547 · DOI
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Metadata

Authors
Yip, C. K., Murata, K., Walz, T., Sabatini, D. M., & Kang, S. A.
Venue
Molecular Cell
Publisher
Elsevier BV
Published
2010-06
Volume
38
Issue
5
Pages
768-774
ISSN
1097-2765
DOI
10.1016/j.molcel.2010.05.017
PMC
PMC2887672
Cited by
372
References
4
Language
en
Licence

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