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The Noncanonical Role of ULK/ATG1 in ER-to-Golgi Trafficking Is Essential for Cellular Homeostasis
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“Finally, there are several ULK1 substrates that exhibit no, or at least no apparent, function in autophagy, or that have additional cellular functions separate from autophagy.”
From Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition) 1 (2021) · cites this paper as [720]
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Autophagy in the Pathogenesis of Disease
Levine, B., & Kroemer, G. (2008) · Cell · doi:10.1016/j.cell.2007.12.018 · Cited by 7,069
Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice
Hara, T., Nakamura, K., Matsui, M., Yamamoto, A., Nakahara, Y., Suzuki-Migishima, R., Yokoyama, M., Mishima, K., Saito, I., Okano, H., et al. (2006) · Nature · doi:10.1038/nature04724 · Cited by 3,882
The Role of Atg Proteins in Autophagosome Formation
Mizushima, N., Yoshimori, T., & Ohsumi, Y. (2011) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev-cellbio-092910-154005 · Cited by 2,978
The role of autophagy during the early neonatal starvation period
Kuma, A., Hatano, M., Matsui, M., Yamamoto, A., Nakaya, H., Yoshimori, T., Ohsumi, Y., Tokuhisa, T., & Mizushima, N. (2004) · Nature · doi:10.1038/nature03029 · Cited by 2,865
Impairment of starvation-induced and constitutive autophagy in Atg7 -deficient mice
Komatsu, M., Waguri, S., Ueno, T., Iwata, J., Murata, S., Tanida, I., Ezaki, J., Mizushima, N., Ohsumi, Y., Uchiyama, Y., et al. (2005) · The Journal of Cell Biology · doi:10.1083/jcb.200412022 · Cited by 2,331
Nutrient-dependent mTORC1 Association with the ULK1–Atg13–FIP200 Complex Required for Autophagy
Hosokawa, N., Hara, T., Kaizuka, T., Kishi, C., Takamura, A., Miura, Y., Iemura, S.-I., Natsume, T., Takehana, K., Yamada, N., et al. (2009) · Molecular Biology of the Cell · doi:10.1091/mbc.e08-12-1248 · Cited by 2,076
Compromised autophagy and neurodegenerative diseases
Menzies, F. M., Fleming, A., & Rubinsztein, D. C. (2015) · Nature Reviews Neuroscience · doi:10.1038/nrn3961 · Cited by 851
Di Nardo, A., Kramvis, I., Cho, N., Sadowski, A., Meikle, L., Kwiatkowski, D. J., & Sahin, M. (2009) · The Journal of Neuroscience · doi:10.1523/jneurosci.0778-09.2009 · Cited by 165
Kalabis, J., Rosenberg, I., & Podolsky, D. K. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m512905200 · Cited by 55
Flagged first, then by citations
Research works printed but not linked: 41
- Alers, 2011, Atg13 and FIP200 act independently of Ulk1 and Ulk2 in autophagy induction, Autophagy, 7, 1423, 10.4161/auto.7.12.18027 · DOI · Paper page
- Alers, 2012, Role of AMPK-mTOR-Ulk1/2 in the regulation of autophagy: cross talk, shortcuts, and feedbacks, Mol. Cell. Biol., 32, 2, 10.1128/MCB.06159-11 · DOI · Paper page
- Bhattacharyya, 2007, Two mammalian Sec16 homologues have nonredundant functions in endoplasmic reticulum (ER) export and transitional ER organization, Mol. Biol. Cell, 18, 839, 10.1091/mbc.e06-08-0707 · DOI
- Bonnon, 2010, Selective export of human GPI-anchored proteins from the endoplasmic reticulum, J. Cell Sci., 123, 1705, 10.1242/jcs.062950 · DOI
- Cheong, 2011, Ammonia-induced autophagy is independent of ULK1/ULK2 kinases, Proc. Natl. Acad. Sci. USA, 108, 11121, 10.1073/pnas.1107969108 · DOI
- Cheong, 2014, Analysis of a lung defect in autophagy-deficient mouse strains, Autophagy, 10, 45, 10.4161/auto.26505 · DOI
- Egan, 2015, Small Molecule Inhibition of the Autophagy Kinase ULK1 and Identification of ULK1 Substrates, Mol. Cell, 59, 285, 10.1016/j.molcel.2015.05.031 · DOI · Paper page
- Fang, 2015, COPII-Dependent ER Export: A Critical Component of Insulin Biogenesis and β-Cell ER Homeostasis, Mol. Endocrinol., 29, 1156, 10.1210/me.2015-1012 · DOI
- Ge, 2013, The ER-Golgi intermediate compartment is a key membrane source for the LC3 lipidation step of autophagosome biogenesis, eLife, 2, e00947, 10.7554/eLife.00947 · DOI
- Ge, 2014, Phosphatidylinositol 3-kinase and COPII generate LC3 lipidation vesicles from the ER-Golgi intermediate compartment, eLife, 3, e04135, 10.7554/eLife.04135 · DOI
- Graef, 2013, ER exit sites are physical and functional core autophagosome biogenesis components, Mol. Biol. Cell, 24, 2918, 10.1091/mbc.e13-07-0381 · DOI
- Hieke, 2015, Expression of a ULK1/2 binding-deficient ATG13 variant can partially restore autophagic activity in ATG13-deficient cells, Autophagy, 11, 1471, 10.1080/15548627.2015.1068488 · DOI
- Huang, 2014, Bacteria-autophagy interplay: a battle for survival, Nat. Rev. Microbiol., 12, 101, 10.1038/nrmicro3160 · DOI
- Ichimura, 2010, Selective degradation of p62 by autophagy, Semin. Immunopathol., 32, 431, 10.1007/s00281-010-0220-1 · DOI
- Iinuma, 2007, Mammalian Sec16/p250 plays a role in membrane traffic from the endoplasmic reticulum, J. Biol. Chem., 282, 17632, 10.1074/jbc.M611237200 · DOI
- Ishihara, 2001, Autophagosome requires specific early Sec proteins for its formation and NSF/SNARE for vacuolar fusion, Mol. Biol. Cell, 12, 3690, 10.1091/mbc.12.11.3690 · DOI
- Jafari, 2011, Regulation of extrasynaptic 5-HT by serotonin reuptake transporter function in 5-HT-absorbing neurons underscores adaptation behavior in Caenorhabditis elegans, J. Neurosci., 31, 8948, 10.1523/JNEUROSCI.1692-11.2011 · DOI
- Joo, 2011, Hsp90-Cdc37 chaperone complex regulates Ulk1- and Atg13-mediated mitophagy, Mol. Cell, 43, 572, 10.1016/j.molcel.2011.06.018 · DOI · Paper page
- Komatsu, 2006, Loss of autophagy in the central nervous system causes neurodegeneration in mice, Nature, 441, 880, 10.1038/nature04723 · DOI · Paper page
- Kundu, 2008, Ulk1 plays a critical role in the autophagic clearance of mitochondria and ribosomes during reticulocyte maturation, Blood, 112, 1493, 10.1182/blood-2008-02-137398 · DOI
- Liang, 2010, Neural-specific deletion of FIP200 leads to cerebellar degeneration caused by increased neuronal death and axon degeneration, J. Biol. Chem., 285, 3499, 10.1074/jbc.M109.072389 · DOI
- Liang, 2012, The C. elegans ATG101 homolog EPG-9 directly interacts with EPG-1/Atg13 and is essential for autophagy, Autophagy, 8, 1426, 10.4161/auto.21163 · DOI
- Lim, 2015, Proteotoxic stress induces phosphorylation of p62/SQSTM1 by ULK1 to regulate selective autophagic clearance of protein aggregates, PLoS Genet., 11, e1004987, 10.1371/journal.pgen.1004987 · DOI
- Mercado, 2010, Molecular mechanisms of SERT in platelets: regulation of plasma serotonin levels, Mol. Interv., 10, 231, 10.1124/mi.10.4.6 · DOI
- Miller, 2010, Regulation of coat assembly--sorting things out at the ER, Curr. Opin. Cell Biol., 22, 447, 10.1016/j.ceb.2010.04.003 · DOI
- Montgomery, 2014, Axonal targeting of the serotonin transporter in cultured rat dorsal raphe neurons is specified by SEC24C-dependent export from the endoplasmic reticulum, J. Neurosci., 34, 6344, 10.1523/JNEUROSCI.2991-13.2014 · DOI
- Nixon, 2013, The role of autophagy in neurodegenerative disease, Nat. Med., 19, 983, 10.1038/nm.3232 · DOI · Paper page
- Noda, 2015, Atg1 family kinases in autophagy initiation, Cell. Mol. Life Sci., 72, 3083, 10.1007/s00018-015-1917-z · DOI
- Ogura, 2006, The autophagy-related kinase UNC-51 and its binding partner UNC-14 regulate the subcellular localization of the Netrin receptor UNC-5 in Caenorhabditis elegans, Development, 133, 3441, 10.1242/dev.02503 · DOI
- Presley, 1997, ER-to-Golgi transport visualized in living cells, Nature, 389, 81, 10.1038/38001 · DOI
- Preston, 2009, Reduced endoplasmic reticulum (ER)-to-Golgi protein trafficking contributes to ER stress in lipotoxic mouse beta cells by promoting protein overload, Diabetologia, 52, 2369, 10.1007/s00125-009-1506-5 · DOI
- Russell, 2013, ULK1 induces autophagy by phosphorylating Beclin-1 and activating VPS34 lipid kinase, Nat. Cell Biol., 15, 741, 10.1038/ncb2757 · DOI · Paper page
- Schuck, 2009, Membrane expansion alleviates endoplasmic reticulum stress independently of the unfolded protein response, J. Cell Biol., 187, 525, 10.1083/jcb.200907074 · DOI
- Sucic, 2011, The serotonin transporter is an exclusive client of the coat protein complex II (COPII) component SEC24C, J. Biol. Chem., 286, 16482, 10.1074/jbc.M111.230037 · DOI
- Suzuki, 2013, Fine mapping of autophagy-related proteins during autophagosome formation in Saccharomyces cerevisiae, J. Cell Sci., 126, 2534
- Tian, 2009, epg-1 functions in autophagy-regulated processes and may encode a highly divergent Atg13 homolog in C. elegans, Autophagy, 5, 608, 10.4161/auto.5.5.8624 · DOI
- Walter, 2011, The unfolded protein response: from stress pathway to homeostatic regulation, Science, 334, 1081, 10.1126/science.1209038 · DOI
- Watson, 2006, Sec16 defines endoplasmic reticulum exit sites and is required for secretory cargo export in mammalian cells, Traffic, 7, 1678, 10.1111/j.1600-0854.2006.00493.x · DOI · Paper page
- Yubero-Lahoz, 2013, Platelet SERT as a peripheral biomarker of serotonergic neurotransmission in the central nervous system, Curr. Med. Chem., 20, 1382, 10.2174/0929867311320110003 · DOI
- Zanetti, 2011, COPII and the regulation of protein sorting in mammals, Nat. Cell Biol., 14, 20, 10.1038/ncb2390 · DOI
- Zoppino, 2010, Autophagosome formation depends on the small GTPase Rab1 and functional ER exit sites, Traffic, 11, 1246, 10.1111/j.1600-0854.2010.01086.x · DOI
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Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition) 1
Klionsky, D. J., Abdel-Aziz, A. K., Abdelfatah, S., Abdellatif, M., Abdoli, A., Abel, S., Abeliovich, H., Abildgaard, M. H., Abudu, Y. P., Acevedo-Arozena, A., et al. (2021) · Autophagy · doi:10.1080/15548627.2020.1797280 · Cited by 2,897
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Autophagy-Independent Functions of the Autophagy Machinery
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“Indeed, Ulk1 / Ulk2 / neurons do not exhibit accumulation of autophagic substrates such as sequestosome 1 (SQSTM1, best known as p62) but manifest signs of the unfolded protein response (Joo et al., 2016; Wang et al., 2018), an intracellular pathway of adaptation to accumulation of unfolded polypeptides in the ER lume…”
BackgroundInfluentialSelf-citationExercise-stimulated glucose uptake — regulation and implications for glycaemic control
Sylow, L., Kleinert, M., Richter, E. A., & Jensen, T. E. (2017) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2016.162 · Cited by 498
Autophagy and the cell biology of age-related disease
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Metadata
- Authors
- Joo, J. H., Wang, B., Frankel, E., Ge, L., Xu, L., Iyengar, R., Li-Harms, X., Wright, C., Shaw, T. I., Lindsten, T., Green, D. R., Peng, J., Hendershot, L. M., Kilic, F., Sze, J. Y., Audhya, A., & Kundu, M.
- Venue
- Molecular Cell
- Publisher
- Elsevier BV
- Published
- 2016-05
- Volume
- 62
- Issue
- 4
- Pages
- 491-506
- ISSN
- 1097-2765
- PMC
- PMC4993601
- Cited by
- 158
- References
- 9
- Language
- en
- Update notices
- erratum (2016-06-16)
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