The EGLN-HIF O 2 -Sensing System: Multiple Inputs and Feedbacks
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Items 101–200 of 273
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- Hypoxia Induces Renal Epithelial Injury and Activates Fibrotic Signaling Through Up-Regulation of Arginase-IIXiujie Liang, Duilio Michele Potenza, Andrea Brenna, Yiqiong Ma, Zhilong Ren, Xin Cheng, Xiu‐Fen Ming, Zhihong Yang · 2021 · Frontiers in Physiology
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- Methyltransferase SMYD3 impairs hypoxia tolerance by augmenting hypoxia signaling independent of its enzymatic activityZixuan Wang, Xiaoyun Chen, Sijia Fan, Chunchun Zhu, Hongyan Deng, Jinhua Tang, Xueyi Sun, Shuke Jia, Qian Liao, Wuhan Xiao et al. · 2022 · Journal of Biological Chemistry
- Regulation of cellular sterol homeostasis by the oxygen responsive noncoding RNA lincNORSXue Wu, Cristina Mariana Niculite, Mihai Bogdan Preda, Annalisa Rossi, Toma Tebaldi, Elena Dragomir Butoi, Mattie K. White, Oana Mihaela Tudoran, Daniela Nicoleta Petrusca, Amber S. Hopf Jannasch et al. · 2020 · Nature Communications
- The non-canonical functions of HIF prolyl hydroxylases and their dual roles in cancerMengchao Yu, Jie Lun, Hongwei Zhang, Lei Zhu, Gang Zhang, Jing Susan Fang · 2021 · The International Journal of Biochemistry & Cell Biology
- Pharmacological HIF‐PHD inhibition reduces renovascular resistance and increases glomerular filtration by stimulating nitric oxide generationMikhail Burmakin, Angelica Fasching, Hanako Kobayashi, Andrés A. Urrutia, Anastasios E. Damdimopoulos, Fredrik Palm, Volker H. Haase · 2021 · Acta Physiologica
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- Transcriptomic Differences in Medullary Thyroid Carcinoma According to GradeIgnacio Ruz‐Caracuel, Tamara Caniego-Casas, Teresa Alonso‐Gordoa, Irene Carretero‐Barrio, Carmen Ariño-Palao, Almudena Santón, Marta Rosas Cancio-Suárez, Héctor Gerardo Pian, Javier Molina‐Cerrillo, Patricia Luengo et al. · 2024 · Endocrine Pathology
- Evolution of Key Oxygen-Sensing Genes Is Associated with Hypoxia Tolerance in FishesCourtney H. Babin, Félix P. Leiva, Wilco C. E. P. Verberk, Bernard B Rees · 2024 · Genome Biology and Evolution
- Quantitative Analyses Reveal How Hypoxia Reconfigures the Proteome of Primary Cytotoxic T LymphocytesSarah H. Ross, Christina M. Rollings, Doreen Ann Cantrell · 2021 · Frontiers in Immunology
- Anti-Hypoxic Molecular Mechanisms of Rhodiola crenulata Extract in Zebrafish as Revealed by MetabonomicsYi Ma, Yi Wu, Zhengchao Xia, Jing Li, Xiaorong Li, Pingxiang Xu, Xuelin Zhou, Ming Xue · 2019 · Frontiers in Pharmacology
- TET is targeted for proteasomal degradation by the PHD-pVHL pathway to reduce DNA hydroxymethylationSijia Fan, Jing Wang, Guangqing Yu, Fangjing Rong, Dawei Zhang, Chenxi Xu, Juan Du, Zhi Li, Gang Ouyang, Wuhan Xiao · 2020 · Journal of Biological Chemistry
- Deciphering ferroptosis in critical care: mechanisms, consequences, and therapeutic opportunitiesRuimin Tan, Ge Chen, Yating Yan, He Guo, Xumin Han, Qiong Zhu, Quansheng Du · 2024 · Frontiers in Immunology
- Recent developments in catalysis and inhibition of the Jumonji histone demethylasesLetitia Sarah, Danica Galonić Fujimori · 2023 · Current Opinion in Structural Biology
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- ER-stress promotes VHL-independent degradation of hypoxia-inducible factors via FBXW1A/βTrCPDaniela Mennerich, Kateryna I. Kubaichuk, Ghulam Shere Raza, Dominik Christian Fuhrmann, Karl‐Heinz Herzig, Bernhard Brüne, Thomas Kietzmann · 2022 · Redox Biology
- A novel mechanism for inhibiting proliferation of rheumatoid arthritis fibroblast-like synoviocytes: geniposide suppresses HIF-1α accumulation in the hypoxic microenvironment of synoviumPeirong Gan, Minghui Sun, Hong Wu, Jiang-Tao Ke, Xin-Tong Dong, Fangyuan Chen · 2022 · Inflammation Research
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- Hypoxia and Tissue Regeneration: Adaptive Mechanisms and Therapeutic OpportunitiesIsabel Cristina Vásquez Vélez, Carlos Mario Charris Domínguez, M. J. Fernández Sánchez, Z. V. Garavito-Aguilar · 2025 · International Journal of Molecular Sciences
- The bioinformatics and metabolomics research on anti-hypoxic molecular mechanisms of Salidroside via regulating the PTEN mediated PI3K/Akt/NF-κB signaling pathwayYi Wu, Yi Ma, Jing Li, Xue-Lin ZHOU, Lei Li, Pingxiang Xu, Xiaorong Li, Ming Xue · 2021 · Chinese Journal of Natural Medicines
- Associations between HIFs and tumor immune checkpoints: mechanism and therapyLiu, Jiayu, Jiang, Ying, Chen, Lingyan, Qian, Zhiwen, Zhang, Yan · 2024 · Discover Oncology
- HIF-2α Preserves Mitochondrial Activity and Glucose Sensing in Compensating β-Cells in ObesityMoon, Jae-Su, Riopel, Matthew, Seo, Jong Bae, Herrero-Aguayo, Vicente, Isaac, Roi, Lee, Yun Sok · 2022 · Diabetes
- miR-451 protects against ischemic stroke by targeting Phd3Mengmeng Wang, Ying Bai, Haitao Chi, Ping Lin, Yu Wu, Jiahui Cui, Yi Wang, Jing Sun, Ming‐Fei Lang · 2021 · Experimental Neurology
- Detailed survey of an in vitro intestinal epithelium model by single-cell transcriptomicsRan Ran, Javier Muñoz Briones, Smrutiti Jena, Nicole L. Anderson, Matthew Richard Olson, Leopold N. Green, Douglas K. Brubaker · 2024 · iScience
- Metabolic priming by multiple enzyme systems supports glycolysis, HIF1α stabilisation, and human cancer cell survival in early hypoxiaFiona Grimm, Agustín Asuaje, Aakriti Jain, Mariana Silva dos Santos, Jens Kleinjung, Patrícia M. Nunes, Stefanie M. Gehrig, Louise Fets, Salihanur Darici, James I. MacRae et al. · 2024 · The EMBO Journal
- Epigenetic Regulation of the N-Terminal Truncated Isoform of Matrix Metalloproteinase-2 (NTT-MMP-2) and Its Presence in Renal and Cardiac DiseasesJuliana de Oliveira Cruz, Alessandra Oliveira Silva, Jéssyca Milene Ribeiro, Marcelo R. Luizon, Carla S. Ceron · 2021 · Frontiers in Genetics
- Unique expression of the atypical mitochondrial subunit NDUFA4L2 in cerebral pericytes fine tunes HIF activity in response to hypoxiaClaudia Mesa‐Ciller, Guillermo Turiel, Andrea Guajardo-Grence, Ana Belén López-Rodríguez, Javier Egea, Katrien De Bock, Julián Aragonés, Andrés A. Urrutia · 2022 · Journal of Cerebral Blood Flow & Metabolism
- ROS elevate HIF-1α phosphorylation for insect lifespan through the CK2-MKP3-p38 pathwayXiaolong Su, Zhiren Su, Wei‐Hua Xu · 2022 · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research
- Targeting EGLN2/PHD1 protects motor neurons and normalizes the astrocytic interferon responseChristine Germeys, Tijs Vandoorne, Kristofer Davie, Suresh Kumar Poovathingal, Kara Heeren, Wendy Vermeire, Fatemeharefeh Nami, Matthieu Moisse, Annelies Quaegebeur, Annerieke S. R. Sierksma et al. · 2024 · Cell Reports
- PHD3 mediates denervation skeletal muscle atrophy through Nf‐κB signal pathwayFan Li, Cong Yin, Zewei Ma, Kelin Yang, Lijuan Sun, Chen Duan, Tao Wang, Abdelaziz Hussein, Lina Wang, Xiaotong Zhu et al. · 2021 · The FASEB Journal
- A Small‐Molecule Inhibitor of Factor Inhibiting HIF Binding to a Tyrosine‐Flip Pocket for the Treatment of ObesityYue Wu, Yafen Chen, Thomas P. Corner, Yu Nakashima, E. Salah, Zhihong Li, Linjian Zhang, Le Yang, Anthony Tumber, Zhuoli Sun et al. · 2024 · Angewandte Chemie International Edition
- Structural optimization of adaptaquin, a HIF prolyl hydroxylase inhibitorAndrey A. Poloznikov, Anna Yu. Khristichenko, N. A. Smirnova, Dmitry M. Hushpulian, Irina N. Gaisina, Andrey I. Osipyants, Vladimir I. Tishkov, Irina G. Gazaryan · 2019 · Russian Chemical Bulletin
- Disturbance of Hypoxia Response and Its Implications in Kidney DiseasesZuo‐Lin Li, Bin Wang, Yi Wen, Qiuli Wu, Lin‐Li Lv, Bi‐Cheng Liu · 2022 · Antioxidants and Redox Signaling
- USP38 promotes deubiquitination of K11-linked polyubiquitination of HIF1α at Lys769 to enhance hypoxia signalingRui Wang, Xiaolian Cai, Xiong Li, Jun Li, Xing Liu, Jing Wang, Wuhan Xiao · 2023 · Journal of Biological Chemistry
- Transmembrane Prolyl 4-Hydroxylase is a Novel Regulator of Calcium Signaling in AstrocytesNadiya Byts, Subodh Sharma, Jenny Laurila, Prodeep Paudel, Ilkka Miinalainen, Veli‐Pekka Ronkainen, Reetta Hinttala, Kid Törnquist, Peppi Koivunen, Johanna Myllyharju · 2020 · eNeuro
- Role of Arginase-II in Podocyte Injury under Hypoxic ConditionsZhilong Ren, Duilio Michele Potenza, Yiqiong Ma, Guillaume Ajalbert, David Hoogewijs, Xiu‐Fen Ming, Zhihong Yang · 2022 · Biomolecules
- Hypoxia-Inducible Factor 1α Stabilization Restores Epigenetic Control of Nitric Oxide Synthase 1 Expression and Reverses Gastroparesis in Female Diabetic MiceFei Gao, Yujiro Hayashi, Siva Arumugam Saravanaperumal, Gabriella Bedekovicsne Gajdos, Sabriya A. Syed, Aditya Vijay Bhagwate, Zhenqing Ye, Jian Zhong, Yuebo Zhang, Egan L. Choi et al. · 2023 · Gastroenterology
- The protease Lon prolongs insect lifespan by responding to reactive oxygen species and degrading mitochondrial transcription factor AXiao-Long Su, Zhiren Su, Wei‐Hua Xu · 2023 · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research
- Zebrafish mutants in egln1 display a hypoxic response and develop polycythemiaXuehan Dou, Zhongyuan Chen, Yunzhang Liu, Yun Li, Junli Ye, Ling Lü · 2024 · Life Sciences
- Deubiquitinating enzyme mutagenesis screens identify a USP43-dependent HIF-1 transcriptional responseTekle Pauzaite, Niek Wit, Rachel Seear, James A. Nathan · 2024 · The EMBO Journal
- Enzyme–substrate reporters for evaluation of substrate specificity of HIF prolyl hydroxylase isoformsAndrey I. Osipyants, N. A. Smirnova, Anna Yu. Khristichenko, Dmitry M. Hushpulian, Sergey V. Nikulin, Tatiana A. Chubar, A. A. Zakhariants, Vladimir I. Tishkov, Irina G. Gazaryan, Andrey A. Poloznikov · 2017 · Biochemistry (Moscow)
- Combinatorial regulation by ERK1/2 and CK1δ protein kinases leads to HIF-1α association with microtubules and facilitates its symmetrical distribution during mitosisChristina Arseni, Martina K. Samiotaki, George Panayotou, George Simos, Ilias Mylonis · 2024 · Cellular and Molecular Life Sciences
- Label-Free Interactome Analysis Revealed an Essential Role of CUL3-KEAP1 Complex in Mediating the Ubiquitination and Degradation of PHD2Ang Luo, Yue Chen · 2019 · Journal of Proteome Research
- General principles of developing novel radioprotective agents for nuclear emergencyJicong Du, Pei Zhang, Ying Cheng, Ruling Liu, Hu Liu, 高福, Chunmeng Shi, Cong Liu · 2020 · Radiation Medicine and Protection
- Inactivation of HIF‐prolyl 4‐hydroxylases 1, 2 and 3 in NG2‐expressing cells induces HIF2‐mediated neurovascular expansion independent of erythropoietinAndrés A. Urrutia, Nan Guan, Claudia Mesa‐Ciller, Aqeela Afzal, Olena Davidoff, Volker H. Haase · 2020 · Acta Physiologica
- rs1769793 variant reduces EGLN1 expression in skeletal muscle and hippocampus and contributes to high aerobic capacity in hypoxiaGuiyou Liu, Wenbo Zhao, Haihua Zhang, Tao Wang, Zhifa Han, Xunming Ji · 2020 · Proceedings of the National Academy of Sciences
- α-Ketoglutarate-dependent Enzymes in Breast Cancer and Therapeutic ImplicationsJingjing Xiong, Chaojun Yan, Qing Hua Zhang, Jing Zhang · 2023 · Endocrinology
- Expression of prolyl hydroxylase domains, the upstream regulators of HIF, in the brain of the anoxia-tolerant crucian carp during anoxia-reoxygenationLucie Gerber, Julien Rességuier, Tellef Helle-Valle, Elie Farhat, Göran Nilsson, Sjannie Lefevre · 2023 · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology
- Knockout of the fih gene by CRISPR/Cas9 enhances the hypoxia tolerance in grass carp (Ctenopharyngodon idella)Huimei Zhang, Ziquan Yang, Jianjun Fu, Ziming Yuan, Jie Chen, Rengao Shen, Guo-Dong Zheng, Shuming Zou, Zaijie Dong · 2025 · Aquaculture
- Rhythms of risk: the intersection of clocks, cancer, and chronotherapyRebecca M. Mello, Selma Masri, Katja A Lamia · 2026 · Journal of Clinical Investigation
- Integrated systems biology approach identifies gene targets for endothelial dysfunctionIguaracy Pinheiro‐de‐Sousa, Miriam Helena Fonseca‐Alaniz, Girolamo Giudice, Iuri Cordeiro Valadão, Silvestre Massimo Modestia, Sarah Viana-Mattioli, Ricardo De la Rosa, Lykourgos‐Panagiotis Zalmas, Yun Hua Fang, Evangelia Petsalaki et al. · 2023 · Molecular Systems Biology
- HIF2 ODD-luciferase reporter: the most sensitive assay for HIF prolyl hydroxylase inhibitorsN. A. Smirnova, Andrey I. Osipyants, Anna Yu. Khristichenko, Dmitry M. Hushpulian, Sergey V. Nikulin, Tatiana A. Chubar, A. A. Zakhariants, Vladimir I. Tishkov, Irina G. Gazaryan, Andrey A. Poloznikov · 2018 · Russian Chemical Bulletin
- A PHD in immunosuppression: oxygen-sensing pathways regulate immunosuppressive TregsWeiping Zou, Yatrik Madhukar Shah · 2019 · Journal of Clinical Investigation
- Novel HIF-2α interaction with Reptin52 impairs HIF-2 transcriptional activity and EPO secretionIoanna‐Maria Gkotinakou, Christina D. Befani, Martina K. Samiotaki, George Panayotou, Panagiotis Liakos · 2021 · Biochemical and Biophysical Research Communications
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- Increased epithelial mTORC1 activity in chronic rhinosinusitis with nasal polypsGeorge X. Huang, Nils R. Hallen, Minkyu Lee, Kelly Zheng, Xin Wang, Michael V Mandanas, Sarah Djeddi, Daniela Fernandez, Jonathan Hacker, Tessa Ryan et al. · 2023 · bioRxiv (Cold Spring Harbor Laboratory)
- Transcriptional responses indicate acclimation to prolonged deoxygenation in the coral Stylophora pistillataHagit Kvitt, Assaf Malik, Smadar Ben‐Tabou de‐Leon, Eli Shemesh, Maya Lalzar, David F. Gruber, Hanna Rosenfeld, Tuo Shi, Tali Mass, Dan Tchernov · 2022 · Frontiers in Marine Science
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- The dynamic transcriptomic response of the goldfish brain under chronic hypoxiaSergio Alberto Cortés-Ramírez, Elie Farhat, Giancarlo G. M. Talarico, Jan Alexander Mennigen · 2024 · Comparative Biochemistry and Physiology Part D Genomics and Proteomics
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