The EGLN-HIF O 2 -Sensing System: Multiple Inputs and Feedbacks

Cited by (273)

Items 201–273 of 273

1. ΔNp73 enhances HIF-1α protein stability through repression of the ECV complex
   Marina Stantic, Johanna Wolfsberger, Habib A. M. Sakil, Margareta Wilhelm · 2018 · Oncogene
2. IRF3 attenuates hypoxia signaling by retaining HIF-α in the cytoplasm
   Hongyan Deng, Shuke Jia, Chunchun Zhu, Jiale Hua, Zixuan Wang, Xueyi Sun, Wen Liu, Liyun Shi, Wenhua Li, Jian-Fang Gui et al. · 2026 · Cell Reports
3. Transcriptomic landscapes of the endometrium of dairy cows with clinical or subclinical endometritis
   Lei Xie, Muhammad Hussnain Rashid, Qiang Dong, Alessandro Leonardo Ricci, Geert Opsomer, Osvaldo Bogado Pascottini · 2026 · Journal of Dairy Science
4. Fih attenuates the hypoxic tolerance of Megalobrama amblycephala by inhibiting the activity of hypoxia-inducible factor alpha (hif-α)
   Jun Li, Ziyi Li, Xiaolian Cai, Zhi Li, Yanan Song, Le Yuan, Yanyi Wang, Runkun Yan, Wuhan Xiao, Jing Wang · 2024 · Aquaculture Reports
5. Dysregulation of the sensory and regulatory pathways controlling cellular iron metabolism in unilateral obstructive nephropathy
   James A. Votava, Shannon R. Reese, Kathryn M. Deck, Christopher P. Nizzi, Sheila A. Anderson, Arjang Djamali, Richard S. Eisenstein · 2021 · American Journal of Physiology-Renal Physiology
6. Allantopyrone A interferes with the degradation of hypoxia-inducible factor 1α protein by reducing proteasome activity in human fibrosarcoma HT-1080 cells
   Chiharu Okuda, Yuto Ueda, Makoto Muroi, Emiko Sanada, Hiroyuki Osada, Yoshihito Shiono, Ken‐ichi Kimura, Kenji Takeda, Koichiro Kawaguchi, Takao Kataoka · 2023 · The Journal of Antibiotics
7. Genetic Markers of Postmortem Brain Iron
   Marilyn C. Cornelis, Amir Fazlollahi, David A. Bennett, Julie A. Schneider, Scott Ayton · 2025 · Journal of Neurochemistry
8. A phenopushing platform to identify compounds that alleviate acute hypoxic stress by fast-tracking cellular adaptation
   Li Li, Heinz Hammerlindl, Susan Q. Shen, Feng Bao, Sabrina Hammerlindl, Steven J. Altschuler, Lani F. Wu · 2025 · Nature Communications
9. Effects of PHD and HSP90 on erythropoietin production in yak (Bos grunniens) renal interstitial fibroblast-like cells under hypoxia
   Yan Cui, Hui Li, Sijiu Yu, Seth Yaw Afedo, Xuefeng Bai · 2022 · Journal of Molecular Histology
10. Belzutifan (Welireg™) for von Hippel Lindau disease
    Evan M. McCabe, Soowan Lee, Theodore P. Rasmussen · 2022 · Trends in Pharmacological Sciences
11. Exploiting the circuit breaker cancer evolution model in human clear cell renal cell carcinoma
    James J.-D. Hsieh, Emily H. Y. Cheng · 2020 · Cell Stress
12. A comprehensive landscape of the zinc-regulated human proteome
    Nils Burger, Melanie J. Mittenbühler, Haopeng Xiao, Sang-Hee Shin, Luiz H. M. Bozi, Shelley M Wei, Hans‐Georg Sprenger, Yizhi Sun, Yingde Zhu, Narek Darabedian et al. · 2024 · bioRxiv (Cold Spring Harbor Laboratory)
13. HCMV infection depends on EGLN1-mediated mitochondrial activation to increase dNTP pools for viral DNA replication
    Lucas A Simpson, Diana M. Dunn, Wyatt Fales, Zachary J Moore, Jessica H. Ciesla, Nicole C. Waild, Matthew H. Raymonda, Isaac S. Harris, Joshua C. Munger · 2026 · Cell Reports
14. Mechanisms underlying tolerance of severe hypoxia in sulfide spring fish
    Bethany L. Williams, Ethan Christopher, Casey Ernest, Isabel Kline, Owen W. Moosman, Kegan B. Morrow, Madison Nobrega, Nathan Surendran, Nick Barts, Lenin Arias-Rodriguez et al. · 2026 · Comparative Biochemistry and Physiology Part A Molecular & Integrative Physiology
15. Identification of Target Genes Associated with Vitamin C Treatment in Renal Cell Carcinoma
    Gözde Öztan · 2024 · International Journal of Pharmacology
16. MiR-155 deficiency and hypoxia results in metabolism switch in the leukemic B-cells
    Elena Golovina, Tomáš Heizer, Lenka Daumová, Martin Báječný, Simona Fontana, Valentina Griggio, Rebecca Jones, Marta Coscia, Chiara Riganti, Karina Vargová · 2024 · Cancer Cell International
17. Crosstalk of fibroblast growth factor 23 and anemia‑related factors during the development and progression of CKD (Review)
    Rui Zhang, Song-Yan Wang, Fan Yang, Shuang Ma, Lu Xu, Chao Kan, Jing-Bin Zhang · 2021 · Experimental and Therapeutic Medicine
18. Identification of appropriate housekeeping genes for gene expression studies in human renal cell carcinoma under hypoxic conditions
    Luiz Felipe S. Teixeira, Rodrigo Giglioti, Luana da Silva Ferreira, Maria Helena Bellini · 2022 · Molecular Biology Reports
19. Chromatin oxygen sensing by histone H3 prolyl hydroxylation
    James A. Nathan · 2022 · Nature Genetics
20. Non-canonical Function of Prolyl Hydroxylase Domain 2 in Breast Cancer Cell Growth and Progression: Role of Peptidyl-prolyl Cis-trans Isomerase NIMA-interacting 1
    Yanymee N. Guillen Quispe, Su‐Jung Kim, Soma Saeidi, Gyo-Jin Choi, Chaithanya Chelakkot, Tianchi Zhou, Sang-Beom Bang, Tae-Won Kim, Young Kee Shin, Young‐Joon Surh · 2024 · Journal of Cancer Prevention
21. Hypoxia-inducible factor-1 alpha modulates muscle growth and the molting process through its regulation of glycolysis in Neocaridina davidi
    Ran Li, Lezhen Hu, Runlin Zhou, Jialu Zhou, Jiale Yang, Moran Wang, Jinsheng Sun · 2025 · Journal of Biological Chemistry
22. Discovery of DS79540454 via fragment-based drug discovery strategy: New scaffolds of hypoxia-inducible factor prolyl hydroxylase inhibitor
    Takeshi Fukuda, Tatsuya Nishi, Takashi Ishiyama, Riko Kitazawa, Ken J. Ishii, Shinichi Takahashi, Yuki Kawabata, Kyoji Yamaguchi, Daichi Baba, Shuichiro Ito et al. · 2025 · Bioorganic & Medicinal Chemistry Letters
23. EGLN1 (PHD2) role in tumor microenvironment: insights for therapeutic targeting
    Giulio Verna, Valentina Fantini, A Grieco, Alessia Ciarrocchi, Valentina Sancisi · 2025 · Experimental & Molecular Medicine
24. Projected Warming of the Southern Ocean Disrupts Embryonic Development and Hatch Timing in Antarctic Fish
    Margaret A. Streeter, Nathalie Rose Le François, Thomas Desvignes, Jacob Grondin, John H. Postlethwait, H. William Detrich, Jacob M. Daane · 2026 · Global Change Biology Communications
25. Parkin-mediated ubiquitination of hif-α modulates hypoxia signaling in Megalobrama amblycephala
    Zhi Li, Xiaoqian Leng, Runkun Yan, Jing Wang, J Du · 2026 · BMC Genomics
26. Els mites de Muret i Montsegur
    Xavier Escura i Dalmau · 2003 · Dialnet (Universidad de la Rioja)
27. Holothuria tubulosa Extract Represses Proliferation and HIF‐α Activity by Inhibiting Erk1/2 Phosphorylation in Liver Cancer Cell Line under Hypoxia
    Christina D. Befani, Persephoni Giannouli, Aikaterini Diseri, Anastasia Bari, Chrysoula Apostologamvrou, Chryssanthi Antoniadou, Panagiotis Liakos, Dimitris Vafidis · 2024 · Journal of Food Biochemistry
28. Neuronal Polarity Pathways as Central Integrators of Cell-Extrinsic Information During Interactions of Neural Progenitors With Germinal Niches
    David J. Solecki · 2022 · Frontiers in Molecular Neuroscience
29. Deep Proteome Profiling Enabled Functional Annotation and Data-Independent Quantification of Proline Hydroxylation Targets
    Yao Gong, Gaurav K. Behera, Luke N. Erber, Ang Luo, Yue Chen · 2022 · bioRxiv (Cold Spring Harbor Laboratory)
30. Hypoxic memory of tumor intrinsic type I interferon suppression promotes breast cancer metastasis
    Oihana Iriondo, Desirea Mecenas, Yilin Li, Christopher R. Chin, Amal Thomas, Yonatan Amzaleg, Aidan Moriarty, Veronica Ortiz, Matthew J. MacKay, Amber Dickerson et al. · 2022 · bioRxiv (Cold Spring Harbor Laboratory)
31. BMAL1-HIF2α heterodimers contribute to ccRCC
    Rebecca M. Mello, Diego Gomez Ceballos, Colby R. Sandate, Daniel Agudelo, Céline Jouffe, N. Henriette Uhlenhaut, Nicolas H. Thomä, Marie Celeste Simon, Katja A Lamia · 2024 · bioRxiv (Cold Spring Harbor Laboratory)
32. Wie wird die Bildung von Erythropoietin gesteuert?
    Joachim Fandrey · 2018 · Der Nephrologe
33. Modeling Impaired Coaptation Effects on Mitral Leaflet Homeostasis Using a Flow-Culture Bioreactor
    Katsuhide Maeda, Xiaoyuan Ma, Frank Louis Hanley, Robert Kirk Riemer · 2018 · The Annals of Thoracic Surgery
34. Oxygen-Tension and the VHL-Hif1α Pathway Comprise a Developmental Switch Controlling the Onset of Neuronal Polarization and Germinal Zone Exit
    Jan A. Kullmann, Niraj Trivedi, Danielle Howell, Christophe Laumonnerie, Vien Nguyen, Shalini S. Banerjee, Daniel R. Stabley, Abbas Shirinifard, David H. Rowitch, David J. Solecki · 2018 · SSRN Electronic Journal
35. C allele of rs479200 of the host EGLN1 gene - a risk factor for severe COVID-19 (pilot study)
    Renuka Harit, Sajal De, Piyoosh Kumar Singh, Deepika Kashyap, Manish Kumar, Dibakar Sahu, Chander Prakash Yadav, Mradul Mohan, Vineeta Singh, Ram Singh Tomar et al. · 2022 · medRxiv
36. Invited Commentary: Prolyl Hydroxylase Inhibitors for Cardioprotection: A Cautiously Optimistic Outlook
    Guangming Cheng, Buddhadeb Dawn · 2022 · Journal of the American College of Surgeons
37. Regulation of Hypoxia Inducible Factors HIF-1 and HIF-2 by Calcidiol in Hepatocellular Carcinoma Cells Under Normoxia and Hypoxia
    Ioanna‐Maria Gkotinakou, Eleni Kechagia, Kalliopi Pazaitou‐Panayiotou, Panagiotis Liakos, Ilias Mylonis, Andreas K. Tsakalof · 2022 · SSRN Electronic Journal
38. Tumor hypoxia promotes MAPK signaling by inhibiting prolyl hydroxylation of SOS1
    Lin Yuan, Guoqing Lv, Hebing Chen, Caixia Ren, Qiao Ye, Hao Li, Xiangzhen Kong, Xi Li, Xiaolong Cao, Jinlu Zhang et al. · 2023 · Research Square
39. Hypoxia-induced factor-1α and markers of inflammation in patients with ischemic stroke
    Lyudmila P. Pivovarova, Igor A. Voznyuk, I. V. Osipova, Olga B. Ariskina, Ekaterina A. Gogoleva, Mariia V. Prokhorova, N. G. Karpova · 2023 · Medical Immunology (Russia)
40. GOT1 primes the cellular response to hypoxia by supporting glycolysis and HIF1α stabilisation
    Fiona Grimm, Agustín Asuaje, Aakriti Jain, Mariana Silva dos Santos, Jens Kleinjung, Patrícia M. Nunes, Stefanie M. Gehrig, Louise Fets, James I. MacRae, Dimitrios Anastasiou · 2023 · bioRxiv (Cold Spring Harbor Laboratory)
41. Deubiquitinating enzyme mutagenesis screens identify a USP43 driven HIF-1 transcriptional response
    Tekle Pauzaite, Niek Wit, Rachel Seear, James A. Nathan · 2024 · bioRxiv (Cold Spring Harbor Laboratory)
42. Changes in RNA dynamics in the course of hypoxia in myeloid cells
    Rebekka Bauer · 2024 · Publication Server of Goethe University Frankfurt am Main (Goethe University Frankfurt)
43. Branched chain α-ketoacids aerobically activate HIF1α signaling in vascular cells
    Wusheng Xiao, Nishith M. Shrimali, William M. Oldham, Clary B. Clish, Huamei He, Samantha J. Wong, Bradley M. Wertheim, Elena Arons, Marcia C. Haigis, Jane A. Leopold et al. · 2024 · bioRxiv (Cold Spring Harbor Laboratory)
44. A Small‐Molecule Inhibitor of Factor Inhibiting HIF Binding to a Tyrosine‐Flip Pocket for the Treatment of Obesity
    Yue Wu, Yafen Chen, Thomas P. Corner, Yu Nakashima, E. Salah, Zhihong Li, Linjian Zhang, Le Yang, Anthony Tumber, Zhuoli Sun et al. · 2024 · Angewandte Chemie
45. Oxygenator assisted dynamic microphysiological culture elucidates the impact of hypoxia on valvular interstitial cell calcification
    Claudia Dittfeld, Florian Schmieder, Stephan Behrens, Anett Jannasch, Klaus Matschke, Frank Sonntag, Sems‐Malte Tugtekin · 2024 · Journal of Biological Engineering
46. Protective role of hypoxia-induced factor-1α and HIF-1A gene polymorphism in the development of acute pancreatitis
    Л. П. Пивоварова, Olga B. Ariskina, I. V. Osipova, Andrey Evgenievich Demko, A. A. Ryseva, V. M. Malkova · 2024 · Russian Journal of Immunology
47. Mechanism Analysis of Zuogui and Yougui Pills on Diabetic Nephropathy Through Transcriptional Regulatory Networks of HIF1A and PPARA
    Liansheng Qiao, Xiaopeng Zhao, Anlei Yuan, Chaoqun Liu, Zewen Wang, Xiaoqian Huo, Shijie Bi, Jiaye Tian, Bin Yu, Zhaozhou Lin et al. · 2025 · Food Science & Nutrition
48. Projected warming disrupts embryonic development and hatch timing in Antarctic fish
    Margaret Streeter, Nathalie Rose Le François, Thomas Desvignes, Jacob Grondin, John H. Postlethwait, H. William Detrich, Jacob M. Daane · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
49. Prolyl hydroxylase-2 (EGLN1) mediates TGF-β1 pathway regulated epithelial–mesenchymal transition in yak kidneys
    Xuefeng Bai, Hongqin Lu, Zhe Lü, Sijiu Yu, Rui Ma, Junfeng He, Yan Cui · 2025 · International Journal of Biological Macromolecules
50. Seasonal dynamics of Galaxea fascicularis holobiont from physiological to transcriptional responses and implications for natural resilience
    Yushan Li, Jingzhao Ke, Haiyan Yang, Xiangbo Liu, Junling Zhang, Mingce Huangfu, Jinling Liu, Wentao Zhu, Aimin Wang, Rou-Wen Chen et al. · 2025 · Frontiers in Microbiology
51. Additional file 3 of MiR-155 deficiency and hypoxia results in metabolism switch in the leukemic B-cells
    Golovina, Elena, Tomáš Heizer, Lenka Daumová, Martin Báječný, S Fontana, Valentina Griggio, Rebecca Jones, Coscia, Marta, Chiara Riganti, Karina Vargová · 2024 · Figshare
52. Additional file 1 of Oxygenator assisted dynamic microphysiological culture elucidates the impact of hypoxia on valvular interstitial cell calcification
    Claudia Dittfeld, Florian Schmieder, Stephan Behrens, Jannasch, Anett, Matschke, Klaus, Sonntag, Frank, Tugtekin, Sems-Malte · 2024 · Figshare
53. Additional file 2 of MiR-155 deficiency and hypoxia results in metabolism switch in the leukemic B-cells
    Golovina, Elena, Tomáš Heizer, Lenka Daumová, Martin Báječný, S Fontana, Valentina Griggio, Rebecca Jones, Coscia, Marta, Chiara Riganti, Karina Vargová · 2024 · Figshare
54. Additional file 1 of MiR-155 deficiency and hypoxia results in metabolism switch in the leukemic B-cells
    Golovina, Elena, Tomáš Heizer, Lenka Daumová, Martin Báječný, S Fontana, Valentina Griggio, Rebecca Jones, Coscia, Marta, Chiara Riganti, Karina Vargová · 2024 · Figshare
55. Additional file 4 of MiR-155 deficiency and hypoxia results in metabolism switch in the leukemic B-cells
    Golovina, Elena, Tomáš Heizer, Lenka Daumová, Martin Báječný, S Fontana, Valentina Griggio, Rebecca Jones, Coscia, Marta, Chiara Riganti, Karina Vargová · 2024 · Figshare
56. Étude du rôle de LRRFIP2 au cours de la cardiogenèse
    Laura Ben Driss · 2021
57. Genomics Insights into the Demographic History and Introgression of Tibetan Pigs
    Peng-Xiang Xue, Cheng-Wan Zha, Ya-Biao Luo, N. Huang, Nian Liu, Hao Wang, Mei-Ying Fang · 2026 · Animals
58. cGAS attenuates hypoxia-inducible factor signaling via chaperone-mediated autophagic degradation of HIFα
    Xiong Li, Rui Wang, Xiaolian Cai, Gang Ouyang, Jun Li, Ziyi Li, Jing Wang, Xing Liu, Jian-Fang Gui, Wuhan Xiao · 2026 · Cell Reports
59. Plasticity of hepatic metabolism in Arctic char (Salvelinus alpinus) in response to cyclic hypoxia
    Loïck Ducros, Nicolas Pichaud, Simon G. Lamarre · 2026 · Comparative Biochemistry and Physiology Part D Genomics and Proteomics
60. Dynamic responses in the human methylome to exertional heat exhaustion, heat injury, and heat stroke
    Brandon M. Roberts, Ruoting Yang, Kari C. Goodwin, Aarti Gautam, Stacy Miller, Ida Nela Crespo Rosales, David W. DeGroot, Rasha Hammamieh, Nisha Charkoudian · 2026 · Human Genomics
61. Allantopyrone A promotes cross-linking of ubiquitin-specific protease 5 (USP5) and inhibits its deubiquitinase activity by targeting distinct domains
    Chiharu Okuda, Seito Tokumori, Nhat Thi Vu, Makoto Muroi, Emiko Sanada, Takehiro Suzuki, Naoshi Dohmae, Hiroyuki Osada, Yoshihito Shiono, Ken‐ichi Kimura et al. · 2026 · The Journal of Antibiotics
62. CRISPR/Cas9-mediated egln1a deficiency enhances hypoxia tolerance in Megalobrama amblycephala through gill remodeling and transcriptomic reprogramming
    Songlin Chen, Zuyi Du, Xinyu Meng, Qianqian Qin, Yahui Feng, Jie chen, Guodong Zheng, Shuming Zou · 2026 · Aquaculture
63. Association between lactic dehydrogenase-to-albumin ratio and all-cause mortality in critical obstructive sleep apnea patients: a retrospective cohort study from the MIMIC-IV database
    Enhui Zhou, Fan Song, Xinyi Li, Jingyu Zhang, Tianjiao Zhou, Weijun Huang, Hongliang Yi · 2026 · BMC Pulmonary Medicine
64. Elephant seal cells export iron and form lipid droplets to evade lipid peroxidation
    Kaitlin N. Allen, Elizabeth R. Piotrowski, Diana D. Moreno-Santillán, Alexander L. Li, Diamond Luong, Violet Foley, Caroline T. del Real, José Pablo Vázquez‐Medina · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
65. KDM6A loss enhances oxidative phosphorylation uncovering tissue-level convergent evolution
    Antonino Alex Cartalemi, Dalia Rosano, Camilla Ferrari, Gemma Crupi, Laura Cassina, Guido Gatti, Federica Corigliano, Simona Punzi, ILARIA VILLANTI, Daphné Dupéré-Richer et al. · 2026 · The EMBO Journal
66. MAVS undergoes aggregation under hypoxia to enhance the hypoxia signaling pathway by promoting the generation of mitochondrial ROS
    Xueyi Sun, Chunchun Zhu, Wen Liu, Zixuan Wang, Hongyan Deng, Shuke Jia, Shuai Shi, Yuhan Xiang, Yiman Luo, Jian‐Fang Gui et al. · 2026 · Proceedings of the National Academy of Sciences
67. DEPP1 connects nutrient and oxygen availability to maintenance of muscle mass
    Shariq Qayyum, Christopher Lavallee, Madhu Singh, Gregory A. Wyant · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
68. Ether glycerophospholipid control of peroxisome degradation confers protection from ischemia
    Madhu Singh, Shariq Qayyum, Giovanny Godoy, Jenane Benhalima, Olivia Seidel, Nina Mädl, Katrin Watschinger, Amy Deik, Hasmik Keshishian, Clary B. Clish et al. · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
69. Development of A10P3C, an isoform-selective inhibitor of EGLN2, for targeting breast cancer
    Qian Liang, Huimin Zhu, Ban-Chieh Huang, Tzu-Kuan Lin, Yayoi Adachi, Ying Xue, Chengheng Liao, Xiaodong Lv, Xufen Yu, Lee‐Wei Yang et al. · 2026 · Proceedings of the National Academy of Sciences
70. HIF-2α in Lung Biology and Disease: From Adaptation and Repair to Therapeutic Modulation
    H. S. Jeffrey Man, Aninda D. Saha, Licun Wu, Marc E. de Perrot · 2026 · Biology
71. BindingDB Entry 50017968: Inhibition of the Oxygen-Sensing Asparaginyl Hydroxylase Factor Inhibiting Hypoxia-Inducible Factor: A Potential Hypoxia Response Modulating Strategy.
    BindingDB · 2023 · UC San Diego
72. BindingDB Entry 50022875: Discovery of ZG-2305, an Orally Bioavailable Factor Inhibiting HIF Inhibitor for the Treatment of Obesity and Fatty Liver Disease.
    BindingDB · 2026 · UC San Diego
73. BindingDB Entry 50021856: Discovery of DS44470011: An oral hypoxia-inducible factor prolyl hydroxylase inhibitor for the treatment of renal anemia.
    BindingDB · 2025 · UC San Diego