Interleukin-1β Induces mtDNA Release to Activate Innate Immune Signaling via cGAS-STING

Integrating single-cell transcriptomic data across different conditions, technologies, and species

Butler, A., Hoffman, P., Smibert, P., Papalexi, E., & Satija, R. (2018) · Nature Biotechnology · doi:10.1038/nbt.4096 · Cited by 13,174

Pattern Recognition Receptors and Inflammation

Takeuchi, O., & Akira, S. (2010) · Cell · doi:10.1016/j.cell.2010.01.022 · Cited by 8,895

Causal analysis approaches in Ingenuity Pathway Analysis

Krämer, A., Green, J., Pollard, J., & Tugendreich, S. (2014) · Bioinformatics · doi:10.1093/bioinformatics/btt703 · Cited by 5,724

Cyclic GMP-AMP Synthase Is a Cytosolic DNA Sensor That Activates the Type I Interferon Pathway

Sun, L., Wu, J., Du, F., Chen, X., & Chen, Z. J. (2013) · Science · doi:10.1126/science.1232458 · Cited by 4,996

Dissecting the multicellular ecosystem of metastatic melanoma by single-cell RNA-seq

Tirosh, I., Izar, B., Prakadan, S. M., Wadsworth, M. H., Treacy, D., Trombetta, J. J., Rotem, A., Rodman, C., Lian, C., Murphy, G., et al. (2016) · Science · doi:10.1126/science.aad0501 · Cited by 4,944

Immunological and inflammatory functions of the interleukin-1 family

Dinarello, C. A. (2009) · Annual Review of Immunology · doi:10.1146/annurev.immunol.021908.132612 · Cited by 3,466

NF-kappaB antiapoptosis: induction of TRAF1 and TRAF2 and c-IAP1 and c-IAP2 to suppress caspase-8 activation.

Wang, C.-Y., Mayo, M., Korneluk, R., Goeddel, D., & Baldwin, A. (1998) · Science · doi:10.1126/science.281.5383.1680 · Cited by 2,950

STING regulates intracellular DNA-mediated, type I interferon-dependent innate immunity

Ishikawa, H., Ma, Z., & Barber, G. N. (2009) · Nature · doi:10.1038/nature08476 · Cited by 2,759

IKKε and TBK1 are essential components of the IRF3 signaling pathway

Fitzgerald, K. A., McWhirter, S. M., Faia, K. L., Rowe, D. C., Latz, E., Golenbock, D. T., Coyle, A. J., Liao, S.-M., & Maniatis, T. (2003) · Nature Immunology · doi:10.1038/ni921 · Cited by 2,680

Mitochondrial DNA stress primes the antiviral innate immune response

West, A. P., Khoury-Hanold, W., Staron, M., Tal, M. C., Pineda, C. M., Lang, S. M., Bestwick, M., Duguay, B. A., Raimundo, N., MacDuff, D. A., et al. (2015) · Nature · doi:10.1038/nature14156 · Cited by 1,975

Regulation of Mitochondria-Derived Immune Activation by ‘Antiviral’ TRIM Proteins

Oh, S., & Mandell, M. A. (2024) · Viruses · doi:10.3390/v16071161 · Cited by 10

The cGAS-STING signaling pathway in the regulation of pulmonary infections: a systematic review

Xu, Q., & Zhu, J. (2025) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2025.1628481 · Cited by 11

Cardiomyocytic cyclic GMP-AMP synthase is critical for the induction of experimental cardiac graft rejection

Wu, Z., Miao, X., Jiang, Y., Kong, D., Liu, H., Xie, W., Shi, B., & Gong, W. (2023) · Journal of Thoracic and Cardiovascular Surgery · doi:10.1016/j.jtcvs.2023.03.005 · Cited by 10

Stimulator of interferon genes from Asian swamp eel (MaSTING) is involved in host defense against bacterial infection

Meng, F., Liu, R., Song, M., Wei, J., Li, H., An, L., Yang, G., & Shan, S. (2023) · Fish & Shellfish Immunology · doi:10.1016/j.fsi.2023.108788 · Cited by 12

Immunoenhancement effect of cinobufagin on macrophages and the cyclophosphamide-induced immunosuppression mouse model

Zhao, Y.-Z., Wang, Y., & Yu, Y. (2024) · International Immunopharmacology · doi:10.1016/j.intimp.2024.111885 · Cited by 10

Through DNA sensors and hidden mitochondrial effects of SARS-CoV-2

Targhetta, V. P., do Amaral, M. A., & Câmara, N. O. S. (2021) · The Journal of venomous animals and toxins including tropical diseases · doi:10.1590/1678-9199-jvatitd-2020-0183 · Cited by 10

A Highly Charged Positive Cage Causes Simultaneous Enhancement of Type‐II and O2‐Independent‐Type‐I Photodynamic Therapy via One‐/Two‐Photon Stimulation and Tumor Immunotherapy via PANoptosis and Ferroptosis

Zhang, X., Yu, H., Guan, S., Lu, Y., Zhang, Y., Huang, Y., Wang, Y., Liu, C., Cao, Z., Qin, Y., et al. (2024) · Small Science · doi:10.1002/smsc.202400220 · Cited by 9

BLOC1S1 Control of Vacuolar Organelle Fidelity Modulates Murine T H 2 Cell Immunity and Allergy Susceptibility

Sharma, R., Wu, K., Han, K., Russo, A. C., Dagur, P. K., Combs, C. A., Yao, X., Levine, S. J., & Sack, M. N. (2024) · Allergy · doi:10.1111/all.16461 · Cited by 9

Co-option of mitochondrial nucleic acid–sensing pathways by HSV-1 UL12.5 for reactivation from latent infection

Krakowiak, P. A., Flores, M., Cuddy, S. R., Whitford, A. L., Dochnal, S. A., Babnis, A. W., Miyake, T., Tigano, M., Engel, D. A., & Cliffe, A. R. (2025) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2413965122 · Cited by 9

Mitochondrial DNA damage in HIV infection: a mechanistic driver of immunometabolic dysfunction and chronic inflammation

Ma, L., Wang, X., & XU, H. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1722463 · Cited by 11

Complex regulation of mitochondrial signaling by human adenovirus minor capsid protein VI

Schubert, E., Mun, K., Larsson, M., Panagiotou, S., Idevall‐Hagren, O., Svensson, C., & Punga, T. (2024) · Journal of Virology · doi:10.1128/jvi.00356-24 · Cited by 11

STING in tumors: a focus on non-innate immune pathways

Yang, J., Yang, M., Wang, Y., Sun, J., Liu, Y., Zhang, L., & Guo, B. (2023) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2023.1278461 · Cited by 11

STING Contributes to Pulmonary Hypertension by Targeting IFN and BMPR2 Signaling through Regulating of F2RL3

Deng, L., Cao, C., Cai, Z., Wang, Z., Leng, B., Chen, Z., Kong, F., Zhou, Z., He, J., Nie, X., et al. (2024) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2023-0308oc · Cited by 8

Mechanisms and effects of activation of innate immunity by mitochondrial nucleic acids

Rai, P., & Fessler, M. B. (2024) · International Immunology · doi:10.1093/intimm/dxae052 · Cited by 11

HIV-1 Vpu and SARS-CoV-2 ORF3a proteins disrupt STING-mediated activation of antiviral NF-κB signaling

Rui, Y., Shen, S., Wang, Y., Cheng, L., Chen, S., Hu, Y., Cai, Y., Wei, W., Su, J., & Yu, X. (2025) · Science Signaling · doi:10.1126/scisignal.add6593 · Cited by 8

Viruses - a major cause of amyloid deposition in the brain

Fülöp, T., Ramassamy, C., Lévesque, S., Frost, E. H., Laurent, B., Lacombe, G., Khalil, A., Larbi, A., Hirokawa, K., Desroches, M., et al. (2023) · Expert Review of Neurotherapeutics · doi:10.1080/14737175.2023.2244162 · Cited by 8

Characterization of STING from common carp (Cyprinus carpio L.) involved in spring viremia of carp virus infection

Liu, R., Meng, F., Li, X., Li, H., Yang, G., & Shan, S. (2023) · Fish & Shellfish Immunology · doi:10.1016/j.fsi.2023.109164 · Cited by 9

Crosstalk between myocardial autophagy and sterile inflammation in the development of heart failure

Tang, J., Tam, E., Song, E., Xu, A., & Sweeney, G. (2024) · Autophagy Reports · doi:10.1080/27694127.2024.2320605 · Cited by 7

Pre-validation of a novel reconstructed skin equivalent model for skin irritation and nanoparticle risk assessment

Sanches, P. L., Carias, R. B. V., Alves, G. G., Catarino, C. M., Bosquetti, B., Costa, M. C. D. C., Canavez, A. D. P. M., Schuck, D. C., Granjeiro, J. M., & Ribeiro, A. R. (2025) · Nanoscale Advances · doi:10.1039/d4na00804a · Cited by 7

Cytopathic bovine viral diarrhea virus-induced NLRP3 inflammasome activation triggers GSDMD-mediated pyroptosis, amplifying the inflammatory response.

Yao, X., Li, Y., Wang, J., Liu, Z.-Y., Chen, J.-R., Feng, Z.-X., Wang, Z., Xiang, J., Xu, R., Jia, S., et al. (2025) · Veterinary Microbiology · doi:10.1016/j.vetmic.2025.110736 · Cited by 7

Interleukin-1β suppresses rabies virus infection by activating cGAS-STING pathway and compromising the blood-brain barrier integrity in mice

Wu, D., Wang, J., Huang, C., Zhao, J., Fu, Z. F., Zhao, L., & Zhou, M. (2023) · Veterinary Microbiology · doi:10.1016/j.vetmic.2023.109708 · Cited by 7

Interleukin-1β promotes human metapneumovirus replication via activating the cGAS-STING pathway

Wu, G., Zhang, Y., Niu, L., Hu, Y., Yang, Y., & Zhao, Y. (2024) · Virus Research · doi:10.1016/j.virusres.2024.199344 · Cited by 7

IFNγ at the early stage induced after cryo-thermal therapy maintains CD4+ Th1-prone differentiation, leading to long-term antitumor immunity

Wang, J., Lou, Y., Wang, S., Zhang, Z., You, J., Zhu, Y., Yao, Y., Hao, Y., Liu, P., & Xu, L. X. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1345046 · Cited by 7

Bystander monocytic cells drive infection-independent NLRP3 inflammasome response to SARS-CoV-2

Hsieh, L. L., Looney, M. M., Figueroa, A., Massaccesi, G., Stavrakis, G., Anaya, E. U., D’Alessio, F. R., Ordoñez, A. A., Pekosz, A. S., DeFilippis, V. R., et al. (2024) · mBio · doi:10.1128/mbio.00810-24 · Cited by 8

B Cell Intrinsic STING Signaling Is Not Required for Autoreactive Germinal Center Participation

Green, K., Wittenborn, T. R., Hagert, C., Terczyńska‐Dyla, E., van Campen, N., Jensen, L., Reinert, L. S., Hartmann, R., Paludan, S. R., & Degn, S. E. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.782558 · Cited by 8

The role and research progress of macrophages after heart transplantation

Chen, Y., Wang, J., An, C., Bao, S., & Zhang, C. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e33844 · Cited by 7

Neutrophil Airfreighter Efficiently Delivers siRNA‐Loaded Nanocomplex to Mononuclear Phagocytes for Inhibition of mtDNA‐Induced Inflammation

Ren, M., He, P., Liu, F., Li, Y., Li, M., Xiang, K., Zhang, Y., Li, X., Wu, T., Yang, S. L., et al. (2025) · Advanced Functional Materials · doi:10.1002/adfm.202416336 · Cited by 6

CpG-mediated TLR9 signaling pathway enhances the efficacy of the OprF/PcrV DNA vaccine with cGAS-STING-activating properties

Tian, L., He, H., Liu, H., Zhang, Y., & Yu, X. (2025) · Life Sciences · doi:10.1016/j.lfs.2025.123930 · Cited by 6

M1-like macrophages regulate T cell infiltration in colorectal cancer through P2X4 receptor

Zhou, K., Zhang, X., Yu, L., Yao, H., Hou, Y., Zhang, X., Du, L., Wang, W., Wang, J., & Meng, X. (2025) · iScience · doi:10.1016/j.isci.2025.113517 · Cited by 6

MAVS signaling exacerbates chondrocytes extracellular matrix degradation in osteoarthritis

Guo, H., Sun, M., Tao, M., Zhu, J., Song, Y., Chen, S., Guo, Z., ZHANG, X., Hou, F., Sun, C., et al. (2026) · Cell Reports · doi:10.1016/j.celrep.2025.116778 · Cited by 6

Structural characteristics, bioactivities, and structure-activity relationships of polysaccharides from three pharmacopeial Polygonatum species using ultrasound-assisted enzymatic extraction

Zhang, W., Yang, N., Ma, S., Xue, S., Sun, X., Wu, M., Cui, Y., & Chen, S. (2026) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2026.150703 · Cited by 6

Mitochondrial DNA as a driver of inflammation via the cGAS-STING pathway

Wen, X., Yang, F., Zhang, L., & Huang, D. (2026) · Inflammation Research · doi:10.1007/s00011-026-02231-8 · Cited by 6

Aggravating mechanisms from COVID-19

Lee, J., Sergi, C. M., Kast, R. E., Kanwar, B. A., Altschuler, E. L., Bourbeau, J., Sohn, M.-G., Sohn, M.-G., Lee, K. H., & Coleman, M. D. (2024) · Virology Journal · doi:10.1186/s12985-024-02506-8 · Cited by 6

The mtDNA-STING pathway plays an important role in both navitoclax- and S63845-induced autophagy and enhances cell death

Jia, J., Li, M., Li, Y., Xiao, J., & Dai, H. (2023) · Cell Biology and Toxicology · doi:10.1007/s10565-023-09804-x · Cited by 7

Molecular Function of cGAS‐STING in SARS‐CoV‐2: A Novel Approach to COVID‐19 Treatment

Moossavi, M., Rastegar, M., Moossavi, S. Z., & Khorasani, M. (2022) · BioMed Research International · doi:10.1155/2022/6189254 · Cited by 6

Alternative oxidase causes cell type- and tissue-specific responses in mutator mice

Ikonen, L., Pirnes-Karhu, S., Pradhan, S., Jacobs, H. T., Szibor, M., & Suomalainen, A. (2023) · Life Science Alliance · doi:10.26508/lsa.202302036 · Cited by 6

Mitochondrial dysfunction in immune cells during the perioperative period: mechanisms, emerging therapeutic strategies, and implications for multi-organ protection

Wang, Z., Wang, L. E., Ji, M., 娄杰, Yuan, Y., Cui, Y., Xiang, G., & Zhou, X. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1734880 · Cited by 5

Mitigating aberrant Cdk5 activation alleviates mitochondrial defects and motor neuron disease symptoms in spinal muscular atrophy

Miller, N., Xu, Z., Quinlan, K. A., Ji, A., McGivern, J. V., Feng, Z., Shi, H., Ko, C., Tsai, L., Heckman, C. J., et al. (2023) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2300308120 · Cited by 5

IL-1β-Mediated Immunometabolic Adaptation in Corneal Epithelial Cells

Sanches, J. M., Ramachandran, R. A., Mussi, N., Baniasadi, H. R., & Robertson, D. M. (2025) · Journal of Inflammation Research · doi:10.2147/jir.s495323 · Cited by 5

Ingenol mebutate inhibits the growth of pancreatic cancer cells in vitro via STING with an efficacy comparable to that of clinically used anticancer agents

Kikuyama, F., Suzuki, S., Jibiki, A., Yokoyama, Y., Kawazoe, H., Kitanaka, S., & Nakamura, T. (2023) · Journal of Natural Medicines · doi:10.1007/s11418-023-01682-1 · Cited by 5

STING1 deficiency ameliorates immune‐mediated crescentic glomerulonephritis in mice

García‐Giménez, J., Córdoba‐David, G., Rayego‐Mateos, S., Cannata‐Ortiz, P., Carrasco, S., Ruiz‐Ortega, M., Fernández‐Fernández, B., Ortíz, A., & Ramos, A. M. (2023) · The Journal of Pathology · doi:10.1002/path.6177 · Cited by 5

A cryptic homotypic interaction motif of insect STING is required for its antiviral signaling

Wang, X., Wei, D., Pan, Y., Liu, J., Xiao, X., Xia, Q., & Wang, F. (2024) · Developmental & Comparative Immunology · doi:10.1016/j.dci.2024.105224 · Cited by 5

Immune gene features and prognosis in colorectal cancer: insights from ssGSEA typing

Huang, A., Wu, J., Wang, J., Jiao, C., Yang, Y., Xiao, H., & Li, Y. (2025) · Discover Oncology · doi:10.1007/s12672-025-01928-2 · Cited by 4

Colorectal cancer cell‐derived extracellular vesicles trigger macrophage production of IL6 through activating STING signaling to drive metastasis

Hu, F., Gong, W., Song, B., & Zhang, S. (2025) · The FASEB Journal · doi:10.1096/fj.202402757rr · Cited by 4

Cortistatin antagonizes Piezo1-STING axis and facilitates mitochondrial homeostasis of keratinocytes by attenuating AGEs accumulation in diabetic ulcers

Ma, G., Yuan, Q., Li, Y., Liu, B., Bi, J., Lv, M., Li, H., Huang, T., Yin, K., Zhao, W., et al. (2026) · Cell Death and Differentiation · doi:10.1038/s41418-026-01699-5 · Cited by 5

Cellular response against cytosolic leakage of mitochondrial DNA: insights into the pathology of Parkinson’s disease

Matsui, H., & Sakai, A. (2022) · Neural Regeneration Research · doi:10.4103/1673-5374.335816 · Cited by 4

Mechanistic insights into aniline-induced liver injury: Role of the mmu_circ_26984/Myh9/NLRP3 axis and modulation by N-acetylcysteine

Fu, X., Li, S., Chen, L., Jin, S., Duan, Z., Zhang, B., Xing, Y., & Wang, Y. (2023) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2023.115826 · Cited by 4

Frame-shifted APOBEC3A encodes two alternative proapoptotic proteins that target the mitochondrial network

Caval, V., Suspène, R., Khalfi, P., Burlaud‐Gaillard, J., Caignard, G., Vitour, D., Roingeard, P., Vartanian, J., & Wain–Hobson, S. (2021) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2021.101081 · Cited by 4

Effects of Bacillus subtilis Natto Strains on Antiviral Responses in Resiquimod-Stimulated Human M1-Phenotype Macrophages

Fujii, K., Kubo, Y., Noguchi, T., & Tobita, K. (2023) · Foods · doi:10.3390/foods12020313 · Cited by 4

Treatment mechanism of immune triad from the repurposing drug against COVID-19

Lee, J. (2023) · Translational Medicine of Aging · doi:10.1016/j.tma.2023.06.005 · Cited by 6

Inhibiting the cGAS‐STING pathway in myeloid cells effectively improves myocardial healing related to TET2 deficiency‐induced DNA damage response

Dou, Y., Zhang, Y., Rivera, L., Hong, T., Fang, S., Tran, T. T. T., Zhou, Y., Martin, J. F., & Huang, Y. (2024) · Clinical and Translational Medicine · doi:10.1002/ctm2.1741 · Cited by 3

The cGAS-STING pathway in fibroblast microenvironment: from molecular mechanisms to targeted therapies

Zhang, Z., Deng, H., Zhang, X., Li, J., Zhao, J., Liu, J., Deng, C., Yang, Y., & Liang, Z. (2026) · APOPTOSIS · doi:10.1007/s10495-026-02268-4 · Cited by 3

Innate immune signalling in the adipocyte

Dumesic, P. A. (2026) · The Journal of Biochemistry · doi:10.1093/jb/mvag017 · Cited by 3

ROS-responsive nanodiscs for STING-NF-κB pathway inhibition and glycosaminoglycan layer restoration in interstitial cystitis/bladder pain syndrome therapy

Zhang, P., Tan, R., Huang, C., Guan, W., Jiang, G., Liang, C., Jiang, C., Zhang, J., Xu, Y., & Zhang, L. (2026) · Journal of Controlled Release · doi:10.1016/j.jconrel.2026.114907 · Cited by 3

Cytosolic mtDNA released from pneumolysin-damaged mitochondria triggers IFN-β production in epithelial cells

Fang, Y., Zhang, X., Lu, C., Yin, Y., Hu, X., Xu, W., Liu, Y., & Zhang, H. (2020) · Canadian Journal of Microbiology · doi:10.1139/cjm-2019-0481 · Cited by 3

mtDNA amplifies beryllium sulfate‐induced inflammatory responses via the cGAS‐STING pathway in 16HBE cells

Liu, X., Jiang, T., Jin, H., Yan, C., Tong, Y., Ding, J., Li, Y., Huang, L., & Zhang, Z. (2024) · Journal of Applied Toxicology · doi:10.1002/jat.4631 · Cited by 4

Exploring therapeutic potential of claudin in Flavivirus infection: A review on current advances and future perspectives

Meena, K., Babu, R., Pancholi, B., & Garabadu, D. (2025) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2025.142936 · Cited by 3

T cell-extrinsic IL-1 signaling controls long-term gammaherpesvirus infection by suppressing viral reactivation

Sylvester, P. A., Corbett, J. A., & Tarakanova, V. L. (2022) · Virology · doi:10.1016/j.virol.2022.09.006 · Cited by 3

NEGATIVE MODULATORS OF THE CGAS-STING PATHWAY

Pike, K. A., Beveridge, R. E., Cyr, P., Skeldon, A. M., Wang, L., & Burch, J. D. (2022) · Medicinal chemistry reviews · doi:10.1021/mc-2022-vol57.ch07 · Cited by 3

Biomarkers to Predict Multiorgan Distress Syndrome and Acute Kidney Injury in Critically Ill Surgical Patients

Shin, I. S., Kim, D. K., An, S., Gong, S. C., Kim, M. H., Rahman, M. H., Kim, C.-S., Sohn, J. H., Kim, K., & Ryu, H. (2023) · Medicina · doi:10.3390/medicina59122054 · Cited by 3

ZFAND6 promotes TRAF2-dependent mitophagy to restrain cGAS-STING signaling

Shaikh, K., Bowman, M., McCormick, S. M., Gao, L., Zhang, J., Tawil, J., Kapoor, A., Arav‐Boger, R., Choi, Y. B., Pekosz, A. S., et al. (2024) · iScience · doi:10.1016/j.isci.2024.111544 · Cited by 5

Role of Mitochondrial DNA in Inflammatory Airway Diseases

Snyder, R. J., & Kleeberger, S. R. (2021) · Comprehensive physiology · doi:10.1002/cphy.c200010 · Cited by 5

Mitochondrial genes affect the immune response against bacterial infection (Duck Pasteurellosis) through a cascade of mechanisms mediated by nuclear immune genes-a cross talk with nuclear and mitochondrial genePreprint

Chakraborty, A., Pal, A., Debnath, M., Sahu, J., Chatterjee, P. N., Pal, A., Mukherjee, J., & Samanta, R. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.08.30.555483 · Cited by 3

Role of Mitochondrial DNA in Inflammatory Airway Diseases

Snyder, R. J., & Kleeberger, S. R. (2021) · Comprehensive physiology · doi:10.1002/j.2040-4603.2021.tb00159.x · Cited by 2

Integrated bioinformatics and network pharmacology analysis to reveal the therapeutic targets and potential molecular mechanism of Traditional Chinese Medicine Lianhua-Qingwen capsule on children's influenza

Fang, L., Li, C., Ding, H., & Tao, J. (2025) · Phytomedicine Plus · doi:10.1016/j.phyplu.2025.100807 · Cited by 2

Antiviral effects of mogroside V against porcine reproductive and respiratory syndrome virus in vitro

Liang, L., Huang, X., Qin, G., Ma, X., He, R., Dai, H., Zhang, Z., Yang, X., & Liang, X. (2025) · Frontiers in Microbiology · doi:10.3389/fmicb.2025.1611600 · Cited by 2

Effects of Wuzi Yanzong Pill on Mitochondrial Homeostasis and the cGAS‐STING Signaling Pathway in Rats Under Testicular Heat Stress

Liu, C., Zeng, Z., Wang, X., Wang, Y., Deng, D., & Guo, J. (2025) · Andrologia · doi:10.1155/and/1637113 · Cited by 2

Context-dependent roles of palmitoylation in acute respiratory distress syndrome: integrating inflammation, cell death and repair

Ma, Q., Wang, Y., & Zhu, F. (2025) · European Respiratory Review · doi:10.1183/16000617.0086-2025 · Cited by 2

Targeting immunometabolism in cancer through pharmacological and lifestyle interventions

Tan, R. J. Y., Liu, Y., Chen, W., Liang, Y., & Ling, G. S. (2026) · PLoS Biology · doi:10.1371/journal.pbio.3003617 · Cited by 2

The Immune Enhancement Effect of Pinus densiflora Pollen Extract in Splenocytes and Peritoneal Macrophages Derived from Naïve BALB/c Mice

Kim, J. Y., Kim, S., Kim, S. J., Jang, S., Yoon, S. R., Ryu, J. A., Park, J. M., Son, J. E., & Jung, S. K. (2024) · Journal of the Korean Society of Food Science and Nutrition · doi:10.3746/jkfn.2024.53.6.539 · Cited by 2

Potential role of AIM2 inflammasome in SARS‐CoV ‐2 infection

Uresti‐Rivera, E. E., & García-Hernández, M. H. (2022) · Scandinavian Journal of Immunology · doi:10.1111/sji.13239 · Cited by 2

cGAS, a DNA Sensor, Promotes Inflammatory Responses in Huntington DiseasePreprint

Sharma, M., Rajendrarao, S., Shahani, N., Ramírez-Jarquín, U. N., & Subramaniam, S. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.01.08.898718 · Cited by 2

Neuronal hyperexcitability is a DLK-dependent trigger of HSV-1 reactivation that can be induced by IL-1Preprint

Cuddy, S. R., Schinlever, A. R., Dochnal, S. A., Suzich, J. B., Kundu, P., Downs, T. K., Farah, M., Desai, B. N., Boutell, C., & Cliffe, A. R. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.04.16.044875 · Cited by 2

Macrophage activation of cGAS and TRIM5 distinguish pandemic and non-pandemic HIVPreprint

Zuliani‐Alvarez, L., Govasli, M. L., Rasaiyaah, J., Monit, C., Perry, S. O., Sumner, R. P., McAlpine-Scott, S., Dickson, C. F., Faysal, K. M. R., Hilditch, L., et al. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.01.21.477263 · Cited by 2

STING contributes to pulmonary hypertension by targeting the interferon and BMPR2 signaling through targeting F2RL3Preprint

Deng, L., Cao, C., Cai, Z., Wang, Z., Leng, B., Chen, Z., Kong, F., Zhou, Z., He, J., Nie, X., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.02.20.578386 · Cited by 2

Sirtuins and mitochondrial dysfunction

He, J., Wang, T.-S., & Wang, Y.-P. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-822467-0.00007-3 · Cited by 2

Mitochondrial Dysfunction-Triggered Innate Immune Response and Its Therapeutic Implications

He, Y., Shen, B., & Zhou, X. (2024) · IntechOpen eBooks · doi:10.5772/intechopen.1007130 · Cited by 2

cGAS-STING pathway-mediated inflammatory response and its role in corneal fibrosis mechanisms

Liu, M., Lin, Y., & Wu, H. (2025) · Molecular Biology Reports · doi:10.1007/s11033-025-11148-0 · Cited by 1

Proposed unified model of late-onset Alzheimer's disease: Chronic astrocytic and neuronal bioenergetic failure

Garrahy, J. P. (2025) · Journal of Alzheimer s Disease · doi:10.1177/13872877251404970 · Cited by 1

Black Phosphorus Nanomaterials and the Senescent Osteoimmune Microenvironment: Mechanisms, Opportunities, Challenges, and Future Outlook

Wang, J., Xun, J.-J., & Zhao, F.-F. (2026) · International Journal of Nanomedicine · doi:10.2147/ijn.s576356 · Cited by 1

Grass carp NLRP12-like 2 facilitates GCRV replication by disrupting the NLRP3-ASC inflammasome axis

Zhang, L. Q., Wu, X. M., Liu, L. Y., & Chang, M. X. (2026) · Fish & Shellfish Immunology · doi:10.1016/j.fsi.2026.111229 · Cited by 1

Defective RNA Polymerase III sensing of mitochondrial DNA in pulmonary epithelial cells impairs type I IFN immunity to SARS-CoV-2

Møhlenberg, M., Jørgensen, S. E., van der Sluis, R. M., Zillinger, T., Hinke, D. M., Hollensen, A. K., Hansen, A. L., Effort, C. H. G., COVID-19 DNABR Group, French COVID Cohort Study Group, et al. (2026) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2522111123 · Cited by 1

Mitochondrial kinase CMPK2 in immune homeostasis and disease: from metabolic regulation to inflammatory signaling

Yao, J., Shi, M., Chen, S., Zhang, H., Lin, Y., Hua, C., & Gao, S. (2026) · International Immunopharmacology · doi:10.1016/j.intimp.2026.116582 · Cited by 1

Targeting the cGAS–STING pathway mitigates Huntington disease pathogenesis in a knock-in mouse model

Kesharwani, A., Dagar, S., Zuniga, I., Monet, M. C., Halade, G. V., Upadhyay, G., Ramírez-Jarquín, U. N., López-Huerta, V. G., Mirza, E., Quan, N., et al. (2026) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2535879123 · Cited by 1

HTLV-1 Tax induces PINK1-PRKN/parkin-dependent mitophagy to mitigate activation of the CGAS-STING1 pathway

Mohanty, S., Suklabaidya, S., Mnatsakanyan, N., Jacobson, S., & Harhaj, E. W. (2026) · Autophagy · doi:10.1080/15548627.2026.2707897 · Cited by 2

BLOC1S1 control of vacuolar organelle fidelity modulates T H 2 cell immunity and allergy susceptibilityPreprint

Sharma, R., Wu, K., Han, K., Russo, A. C., Dagur, P. K., Combs, C. A., & Sack, M. N. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.03.21.586144 · Cited by 1

ZFAND6 is a subunit of a TRAF2-cIAP E3 ubiquitin ligase complex essential for mitophagyPreprint

Shaikh, K., Bowman, M., McCormick, S. M., Gao, L., Zhang, J., Tawil, J., Kapoor, A., Arav‐Boger, R., Choi, Y. B., Pekosz, A. S., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.03.27.586763 · Cited by 1

HTLV-1 Tax induces PINK1-Parkin-dependent mitophagy to mitigate activation of the cGAS-STING1 pathwayPreprint

Mohanty, S., Suklabaidya, S., Mnatsakanyan, N., Jacobson, S., & Harhaj, E. W. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.03.15.643451 · Cited by 1

The contribution of Sting and Nlrp3 activation to anti-tumour immunity in microsatellite instable colorectal cancer

Mowat, C. (2019) · ERA: Education and Research Archive (University of Alberta) · doi:10.7939/r3-jywj-nr54

Extracellular release of mitochondrial DNA is triggered by cigarette smoke and is detected in COPDPreprint

Giordano, L., Gregory, A. D., Pérez-Verdaguer, M., Ware, S. A., Harvey, H., DeVallance, E., Brzóska, T., Sundd, P., Zhang, Y., Sciurba, F. C., et al. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.10.04.462069

Origin, evolution, and pathogenesis of coronaviruses

Rathod, S. (2022) · Elsevier eBooks · doi:10.1016/b978-0-323-99596-2.00005-4

Les virus à ARN Nipah et de la rougeole activent une voie alternative de signalisation : cGAS-STING

Chemarin, M., Chenel, A., & Knoche, A. (2023) · médecine/sciences · doi:10.1051/medsci/2023047

Induction of antiviral Interferon-Stimulated Genes (ISGs) by neuronal STING promotes the resolution of painPreprint

Defaye, M., Bradaïa, A., Abdullah, N. S., Agosti, F., Iftinca, M., Soubeyre, V., Svendsen, K., Gill, G., Cuménal, M., Ghéziel, N., et al. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.08.04.551993

Is the Cell-Free Circulating Mitochondrial DNA a Potential Biomarker for Atrial Fibrillation?

Rahmanian, M., Khaheshi, I., Khani, M. M., Bayati, R., Ataee, M., & Sohrabifar, N. (2023) · International Journal of Cardiovascular Practice · doi:10.5812/intjcardiovascpract-141066

Ferroptosis activates retinoic acid inflammation and ignites the development of SilicosisPreprint

Li, X., Tan, J., Wu, R., & Zhang, Z. (2023) · Research Square · doi:10.21203/rs.3.rs-3578592/v1

Sustainable Nanomaterials and Diagnosis for Arboviral Infections

Mariappan, V., Srinivasan, R., Surendra, M. P., & Pillai, A. B. (2024) · Royal Society of Chemistry eBooks · doi:10.1039/bk9781837672813-00349

Recognition of protein with nucleic acid

Li, G. (2024) · Elsevier eBooks · doi:10.1016/b978-0-323-95917-9.00015-8

Co-option of mitochondrial nucleic acid sensing pathways by HSV-1 UL12.5 for reactivation from latent InfectionPreprint

Cuddy, S. R., Flores, M. E., Krakowiak, P. A., Whitford, A., Dochnal, S. A., Babnis, A. W., Miyake, T., Tigano, M., Engel, D. A., & Cliffe, A. R. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.07.06.601241

Mitochondrial dysfunction induced by trichloroethylene in Parkinson’s disease

Ilieva, N. M., Adamson, A. B., Ghalib, M., Walters, T., & Miranda, B. R. D. (2024) · Advances in neurotoxicology · doi:10.1016/bs.ant.2024.09.003

ZNFX1 is a Novel Master Regulator in Epigenetically-induced Pathogen Mimicry and Inflammasome Signaling in CancerPreprint

Stojanovic, L., Abbotts, R., Tripathi, K. K., Coon, C. M., Rajendran, S., Farid, E. A., Hostetter, G. H., Guarnieri, J. W., Wallace, D. C., Liu, S., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.10.18.618659

Identification and characterization of a novel transcript isoform of STING that suppresses innate immune response

Wang, P. (2015) · doi:10.5353/th_b5689283

Activation of the cGAS‐STING‐IRF3 Axis by Type I and II Interferons Contributes to Host Defense

Tong, Z., Zou, J., Wang, S., Luo, W., & Wang, Y. (2024) · Advanced Science · doi:10.1002/advs.202308890 · Cited by 43

Cytosolic sensing of immuno-stimulatory DNA, the enemy within

Dhanwani, R., Takahashi, M., & Sharma, S. (2018) · Current Opinion in Immunology · doi:10.1016/j.coi.2017.11.004 · Cited by 123

Cyclic GMP-AMP Is an Endogenous Second Messenger in Innate Immune Signaling by Cytosolic DNA

Wu, J., Sun, L., Chen, X., Du, F., Shi, H., Chen, C., & Chen, Z. J. (2012) · Science · doi:10.1126/science.1229963 · Cited by 2,628

A novel transcript isoform of STING that sequesters cGAMP and dominantly inhibits innate nucleic acid sensing

Wang, P., Fung, S., Gao, W., Deng, J., Cheng, Y., Chaudhary, V., Yuen, K., Ho, T., Chan, C.-P., Zhang, Y., et al. (2018) · Nucleic Acids Research · doi:10.1093/nar/gky186 · Cited by 70