Cytosolic sensing of immuno-stimulatory DNA, the enemy within

Cyclic GMP-AMP Synthase Is a Cytosolic DNA Sensor That Activates the Type I Interferon Pathway

Sun, L., Wu, J., Du, F., Chen, X., & Chen, Z. J. (2013) · Science · doi:10.1126/science.1232458 · Cited by 4,996 · see citing works

HOW CELLS RESPOND TO INTERFERONS

Stark, G. R., Kerr, I. M., Williams, B. R. G., Silverman, R. H., & Schreiber, R. D. (1998) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.67.1.227 · Cited by 3,932 · see citing works

Regulation and function of the cGAS–STING pathway of cytosolic DNA sensing

Chen, Q., Sun, L., & Chen, Z. J. (2016) · Nature Immunology · doi:10.1038/ni.3558 · Cited by 2,333 · see citing works

STING-Dependent Cytosolic DNA Sensing Promotes Radiation-Induced Type I Interferon-Dependent Antitumor Immunity in Immunogenic Tumors

Deng, L., Liang, H., Xu, M., Yang, X., Burnette, B., Arina, A., Li, X.-D., Mauceri, H., Beckett, M., Darga, T., et al. (2014) · Immunity · doi:10.1016/j.immuni.2014.10.019 · Cited by 2,182 · see citing works

Mitochondrial DNA stress primes the antiviral innate immune response

West, A. P., Khoury-Hanold, W., Staron, M., Tal, M. C., Pineda, C. M., Lang, S. M., Bestwick, M., Duguay, B. A., Raimundo, N., MacDuff, D. A., et al. (2015) · Nature · doi:10.1038/nature14156 · Cited by 1,975 · see citing works

STING-Dependent Cytosolic DNA Sensing Mediates Innate Immune Recognition of Immunogenic Tumors

Woo, S.-R., Fuertes, M. B., Corrales, L., Spranger, S., Furdyna, M. J., Leung, M. Y. K., Duggan, R., Wang, Y., Barber, G. N., Fitzgerald, K. A., et al. (2014) · Immunity · doi:10.1016/j.immuni.2014.10.017 · Cited by 1,917 · see citing works

DNA exonuclease Trex1 regulates radiotherapy-induced tumour immunogenicity

Vanpouille-Box, C., Alard, A., Aryankalayil, M. J., Sarfraz, Y., Diamond, J. M., Schneider, R. J., Inghirami, G., Coleman, C. N., Formenti, S. C., & Demaria, S. (2017) · Nature Communications · doi:10.1038/ncomms15618 · Cited by 1,834 · see citing works

cGAS surveillance of micronuclei links genome instability to innate immunity

Mackenzie, K. J., Carroll, P., Martin, C.-A., Murina, O., Fluteau, A., Simpson, D. J., Olova, N., Sutcliffe, H., Rainger, J. K., Leitch, A., et al. (2017) · Nature · doi:10.1038/nature23449 · Cited by 1,752 · see citing works

Direct Activation of STING in the Tumor Microenvironment Leads to Potent and Systemic Tumor Regression and Immunity

Corrales, L., Glickman, L. H., McWhirter, S. M., Kanne, D. B., Sivick, K. E., Katibah, G. E., Woo, S.-R., Lemmens, E., Banda, T., Leong, J. J., et al. (2015) · Cell Reports · doi:10.1016/j.celrep.2015.04.031 · Cited by 1,560 · see citing works

Mitotic progression following DNA damage enables pattern recognition within micronuclei

Harding, S. M., Benci, J. L., Irianto, J., Discher, D. E., Minn, A. J., & Greenberg, R. A. (2017) · Nature · doi:10.1038/nature23470 · Cited by 1,508 · see citing works

Cytoplasmic chromatin triggers inflammation in senescence and cancer

Dou, Z., Ghosh, K., Vizioli, M. G., Zhu, J., Sen, P., Wangensteen, K. J., Simithy, J., Lan, Y., Lin, Y., Zhou, Z., et al. (2017) · Nature · doi:10.1038/nature24050 · Cited by 1,335 · see citing works

Trex1 prevents cell-intrinsic initiation of autoimmunity

Stetson, D. B., Ko, J. S., Heidmann, T., & Medzhitov, R. (2008) · Cell · doi:10.1016/j.cell.2008.06.032 · Cited by 1,280 · see citing works

Innate immune sensing of cytosolic chromatin fragments through cGAS promotes senescence

Glück, S., Guey, B., Gulen, M. F., Wolter, K., Kang, T.-W., Schmacke, N. A., Bridgeman, A., Rehwinkel, J., Zender, L., & Ablasser, A. (2017) · Nature Cell Biology · doi:10.1038/ncb3586 · Cited by 1,196 · see citing works

Host type I IFN signals are required for antitumor CD8+ T cell responses through CD8α+ dendritic cells

Fuertes, M. B., Kacha, A. K., Kline, J., Woo, S.-R., Kranz, D. M., Murphy, K. M., & Gajewski, T. F. (2011) · Journal of Experimental Medicine · doi:10.1084/jem.20101159 · Cited by 1,192 · see citing works

Cyclic [G(2′,5′)pA(3′,5′)p] is the metazoan second messenger produced by DNA-activated cyclic GMP-AMP synthase.

Gao, P., Ascano, M., Wu, Y., Barchet, W., Gaffney, B. L., Zillinger, T., Serganov, A. A., Liu, Y., Jones, R. A., Hartmann, G., et al. (2013) · Cell · doi:10.1016/j.cell.2013.04.046 · Cited by 1,101 · see citing works

Pivotal Roles of cGAS-cGAMP Signaling in Antiviral Defense and Immune Adjuvant Effects

Li, X.-D., Wu, J., Gao, D., Wang, H., Sun, L., & Chen, Z. J. (2013) · Science · doi:10.1126/science.1244040 · Cited by 1,097 · see citing works

Type I interferon is selectively required by dendritic cells for immune rejection of tumors

Diamond, M. S., Kinder, M., Matsushita, H., Mashayekhi, M., Dunn, G. P., Archambault, J. M., Lee, H., Arthur, C. D., White, J. M., Kalinke, U., et al. (2011) · Journal of Experimental Medicine · doi:10.1084/jem.20101158 · Cited by 1,081 · see citing works

cGAS is essential for cellular senescence

Yang, H., Wang, H., Ren, J., Chen, Q., & Chen, Z. J. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1705499114 · Cited by 1,009 · see citing works

The cGAS-cGAMP-STING Pathway of Cytosolic DNA Sensing and Signaling

Cai, X., Chiu, Y., & Chen, Z. J. (2014) · Molecular Cell · doi:10.1016/j.molcel.2014.03.040 · Cited by 995 · see citing works

Apoptotic Caspases Suppress mtDNA-Induced STING-Mediated Type I IFN Production

White, M. J., McArthur, K., Metcalf, D., Lane, R. M., Cambier, J. C., Herold, M. J., van Delft, M. F., Bedoui, S., Lessene, G., Ritchie, M. E., et al. (2014) · Cell · doi:10.1016/j.cell.2014.11.036 · Cited by 983 · see citing works

Mutations in the gene encoding the 3′-5′ DNA exonuclease TREX1 cause Aicardi-Goutières syndrome at the AGS1 locus

Crow, Y. J., Hayward, B. E., Parmar, R., Robins, P., Leitch, A., Ali, M., Black, D. N., van Bokhoven, H., Brunner, H. G., Hamel, B. C. J., et al. (2006) · Nature Genetics · doi:10.1038/ng1845 · Cited by 906 · see citing works

Pan-viral specificity of IFN-induced genes reveals new roles for cGAS in innate immunity

Schoggins, J. W., MacDuff, D. A., Imanaka, N., Gainey, M. D., Shrestha, B., Eitson, J. L., Mar, K. B., Richardson, R. B., Ratushny, A. V., Litvak, V., et al. (2014) · Nature · doi:10.1038/nature12862 · Cited by 896 · see citing works

Structural mechanism of cytosolic DNA sensing by cGAS

Çivril, F., Deimling, T., Mann, C. C. D. O., Ablasser, A., Moldt, M., Witte, G., Hornung, V., & Hopfner, K. (2013) · Nature · doi:10.1038/nature12305 · Cited by 888 · see citing works

Apoptotic Caspases Prevent the Induction of Type I Interferons by Mitochondrial DNA

Rongvaux, A., Jackson, R., Harman, C. C. D., Li, T., West, A. P., de Zoete, M. R., Wu, Y., Yordy, B., Lakhani, S. A., Kuan, C.-Y., et al. (2014) · Cell · doi:10.1016/j.cell.2014.11.037 · Cited by 847 · see citing works

CD47 blockade triggers T cell–mediated destruction of immunogenic tumors

Liu, X., Pu, Y., Cron, K. R., Deng, L., Kline, J. P., Frazier, W. A., Xu, H., Peng, H., Fu, Y., & Xu, M. M. (2015) · Nature Medicine · doi:10.1038/nm.3931 · Cited by 770 · see citing works

STING agonist formulated cancer vaccines can cure established tumors resistant to PD-1 blockade

Fu, J., Kanne, D. B., Leong, M., Glickman, L. H., McWhirter, S. M., Lemmens, E., Mechette, K., Leong, J. J., Lauer, P., Liu, W., et al. (2015) · Science Translational Medicine · doi:10.1126/scitranslmed.aaa4306 · Cited by 720 · see citing works

Activation of cyclic GMP-AMP synthase by self-DNA causes autoimmune diseases

Gao, D., Li, T., Li, X.-D., Chen, X., Li, Q., Wight‐Carter, M., & Chen, Z. J. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1516465112 · Cited by 685 · see citing works

Mutations in genes encoding ribonuclease H2 subunits cause Aicardi-Goutières syndrome and mimic congenital viral brain infection

Crow, Y. J., Leitch, A., Hayward, B. E., Garner, A., Parmar, R., Griffith, E., Ali, M., Semple, C. A. M., Aicardi, J. F., Babul‐Hirji, R., et al. (2006) · Nature Genetics · doi:10.1038/ng1842 · Cited by 670 · see citing works

Cyclic GMP-AMP Synthase Is Activated by Double-Stranded DNA-Induced Oligomerization

Li, X., Shu, C., Yi, G., Chaton, C. T., Shelton, C. L., Diao, J., Zuo, X., Kao, C. C., Herr, A. B., & Li, P. (2013) · Immunity · doi:10.1016/j.immuni.2013.10.019 · Cited by 655 · see citing works

Cell intrinsic immunity spreads to bystander cells via the intercellular transfer of cGAMP

Ablasser, A., Schmid-Burgk, J. L., Hemmerling, I., Horvath, G. L., Schmidt, T., Latz, E., & Hornung, V. (2013) · Nature · doi:10.1038/nature12640 · Cited by 649 · see citing works

A critical function for type I interferons in cancer immunoediting

Dunn, G. P., Bruce, A. T., Sheehan, K. C. F., Shankaran, V., Uppaluri, R., Bui, J. D., Diamond, M. S., Koebel, C. M., Arthur, C. D., White, J. M., et al. (2005) · Nature Immunology · doi:10.1038/ni1213 · Cited by 611 · see citing works

The Vaccine Adjuvant Chitosan Promotes Cellular Immunity via DNA Sensor cGAS-STING-Dependent Induction of Type I Interferons

Carroll, E. C., Jin, L., Mori, A., Muñoz‐Wolf, N., Oleszycka, E., Moran, H. B. T., Mansouri, S., McEntee, C. P., Lambe, E. M., Agger, E. M., et al. (2016) · Immunity · doi:10.1016/j.immuni.2016.02.004 · Cited by 599 · see citing works

STING activation of tumor endothelial cells initiates spontaneous and therapeutic antitumor immunity

Demaria, O., Gassart, A. D., Coso, S., Gestermann, N., Domizio, J. D., Flatz, L., Gaide, O., Michielin, O. A., Hwu, P., Petrova, T. V., et al. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1512832112 · Cited by 574 · see citing works

IRF3 and type I interferons fuel a fatal response to myocardial infarction

King, K. R., Aguirre, A. D., Ye, Y., Sun, Y., Roh, J. D., Ng, R. P., Köhler, R. H., Arlauckas, S. P., Iwamoto, Y., Savol, A. J., et al. (2017) · Nature Medicine · doi:10.1038/nm.4428 · Cited by 571 · see citing works

cGAS is essential for the antitumor effect of immune checkpoint blockade

Wang, H., Hu, S., Chen, X., Shi, H., Chen, C., Sun, L., & Chen, Z. J. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1621363114 · Cited by 563 · see citing works

cGAS senses long and HMGB/TFAM-bound U-turn DNA by forming protein-DNA ladders

Andreeva, L., Hiller, B., Kostrewa, D., Lässig, C., de Oliveira Mann, C. C., Jan Drexler, D., Maiser, A., Gaidt, M., Leonhardt, H., Hornung, V., et al. (2017) · Nature · doi:10.1038/nature23890 · Cited by 511 · see citing works

The Cytosolic DNA Sensor cGAS Forms an Oligomeric Complex with DNA and Undergoes Switch-like Conformational Changes in the Activation Loop

Zhang, X., Wu, J., Du, F., Xu, H., Sun, L., Chen, Z., Brautigam, C. A., Zhang, X., & Chen, Z. J. (2014) · Cell Reports · doi:10.1016/j.celrep.2014.01.003 · Cited by 505 · see citing works

Signalling strength determines proapoptotic functions of STING

Gulen, M. F., Koch, U., Haag, S. M., Schuler, F., Apetoh, L., Villunger, A., Radtke, F., & Ablasser, A. (2017) · Nature Communications · doi:10.1038/s41467-017-00573-w · Cited by 505 · see citing works

Dengue virus NS2B protein targets cGAS for degradation and prevents mitochondrial DNA sensing during infection

Aguirre, S., Luthra, P., Sánchez-Aparicio, M. T., Maestre, A. M., Patel, J. R., Lamothe, F., Fredericks, A. C., Tripathi, S., Zhu, T., Silva, J. P., et al. (2017) · Nature Microbiology · doi:10.1038/nmicrobiol.2017.37 · Cited by 393 · see citing works

Cutting Edge: cGAS Is Required for Lethal Autoimmune Disease in the Trex1-Deficient Mouse Model of Aicardi–Goutières Syndrome

Gray, E. E., Treuting, P. M., Woodward, J. J., & Stetson, D. B. (2015) · The Journal of Immunology · doi:10.4049/jimmunol.1500969 · Cited by 384 · see citing works

Cytosolic RNA:DNA hybrids activate the cGAS–STING axis

Mankan, A. K., Schmidt, T., Chauhan, D., Goldeck, M., Höning, K., Gaidt, M. M., Kubarenko, A. V., Andreeva, L., Hopfner, K., & Hornung, V. (2014) · The EMBO Journal · doi:10.15252/embj.201488726 · Cited by 359 · see citing works

Type I IFN Contributes to NK Cell Homeostasis, Activation, and Antitumor Function

Swann, J. B., Hayakawa, Y., Zerafa, N., Sheehan, K. C. F., Scott, B., Schreiber, R. D., Hertzog, P. J., & Smyth, M. J. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.178.12.7540 · Cited by 340 · see citing works

Agonist-Mediated Activation of STING Induces Apoptosis in Malignant B Cells

Tang, C.-H. A., Zundell, J. A., Ranatunga, S., Lin, C., Nefedova, Y., Valle, J. R. D., & Hu, C. A. (2016) · Cancer Research · doi:10.1158/0008-5472.can-15-1885 · Cited by 318 · see citing works

DsbA-L prevents obesity-induced inflammation and insulin resistance by suppressing the mtDNA release-activated cGAS-cGAMP-STING pathway

Bai, J., Cervantes, C., Liu, J., He, S., Zhou, H., Zhang, B., Cai, H., Yin, D., Hu, D., Li, Z., et al. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1708744114 · Cited by 313 · see citing works

DNA damage-induced type I interferon promotes senescence and inhibits stem cell function

Yu, Q., Katlinskaya, Y. V., Carbone, C. J., Zhao, B., Katlinski, K. V., Zheng, H., Guha, M., Li, N., Chen, Q., Yang, T., et al. (2015) · Cell Reports · doi:10.1016/j.celrep.2015.03.069 · Cited by 260 · see citing works

Sequence-specific activation of the DNA sensor cGAS by Y-form DNA structures as found in primary HIV-1 cDNA

Herzner, A., Hagmann, C. A., Goldeck, M., Wolter, S., Kübler, K., Wittmann, S., Gramberg, T., Andreeva, L., Hopfner, K., Mertens, C., et al. (2015) · Nature Immunology · doi:10.1038/ni.3267 · Cited by 255 · see citing works

Ribonuclease H2 mutations induce a cGAS/STING‐dependent innate immune response

Mackenzie, K. J., Carroll, P., Lettice, L., Tarnauskaitė, Ž., Reddy, K., Dix, F., Revuelta, A., Abbondati, E., Rigby, R. E., Rabe, B., et al. (2016) · The EMBO Journal · doi:10.15252/embj.201593339 · Cited by 248 · see citing works

RNase H2 catalytic core Aicardi-Goutières syndrome–related mutant invokes cGAS–STING innate immune-sensing pathway in mice

Pokatayev, V., Hasin, N., Chon, H., Cerritelli, S. M., Sakhuja, K., Ward, J. M., Morris, H. D., Yan, N., & Crouch, R. J. (2016) · Journal of Experimental Medicine · doi:10.1084/jem.20151464 · Cited by 245 · see citing works

STING Ligand c-di-GMP Improves Cancer Vaccination against Metastatic Breast Cancer

Chandra, D., Quispe‐Tintaya, W., Jahangir, A., Asafu-Adjei, D. A., Ramos, I., Sintim, H. O., Zhou, J., Hayakawa, Y., Karaolis, D. K. R., & Gravekamp, C. (2014) · Cancer Immunology Research · doi:10.1158/2326-6066.cir-13-0123 · Cited by 234 · see citing works

The DNA Damage Response Induces IFN

Racine‐Brzostek, S., Gordon, C. R., Scoy, S. V., & Reich, N. C. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1100040 · Cited by 232 · see citing works

Influenza A virus targets a cGAS-independent STING pathway that controls enveloped RNA viruses

Holm, C. K., Rahbek, S. H., Gad, H. H., Bak, R. O., Jakobsen, M. R., Jiang, Z., Hansen, A. L., Jensen, S. K., Sun, C., Thomsen, M. K., et al. (2016) · Nature Communications · doi:10.1038/ncomms10680 · Cited by 232 · see citing works

Dengue virus activates cGAS through the release of mitochondrial DNA

Sun, B., Sundström, K. B., Chew, J. J., Bist, P., Gan, E. S., Tan, H. C., Goh, K. C., Chawla, T., Tang, C. K., & Ooi, E. E. (2017) · Scientific Reports · doi:10.1038/s41598-017-03932-1 · Cited by 225 · see citing works

STING-Mediated DNA Sensing Promotes Antitumor and Autoimmune Responses to Dying Cells

Klarquist, J. S., Hennies, C. M., Lehn, M. A., Reboulet, R. A., Feau, S., & Janssen, E. M. (2014) · The Journal of Immunology · doi:10.4049/jimmunol.1401869 · Cited by 211 · see citing works

The DNA Structure-Specific Endonuclease MUS81 Mediates DNA Sensor STING-Dependent Host Rejection of Prostate Cancer Cells

Ho, S. S. W., Zhang, W. Y. L., Tan, N. Y., Khatoo, M., Suter, M. A., Tripathi, S., Cheung, F. S. G., Lim, W. K., Tan, P. H., Ngeow, J. Y. Y., et al. (2016) · Immunity · doi:10.1016/j.immuni.2016.04.010 · Cited by 206 · see citing works

Type I interferonopathies: Mendelian type I interferon up-regulation

Crow, Y. J. (2014) · Current Opinion in Immunology · doi:10.1016/j.coi.2014.10.005 · Cited by 189 · see citing works

How cells respond to interferons revisited: From early history to current complexity

Stark, G. R. (2007) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2007.06.013 · Cited by 182 · see citing works

Extrachromosomal telomere repeat DNA is linked to ALT development via cGAS-STING DNA sensing pathway

Chen, Y., Shen, Y., Hsia, H.-Y., Tiang, Y. P., Sung, T.-L., & Chen, L. (2017) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.3498 · Cited by 158 · see citing works

cGAS-STING Signaling Regulates Initial Innate Control of Cytomegalovirus Infection

Lio, C. J., McDonald, B., Takahashi, M., Dhanwani, R., Sharma, N., Huang, J., Pham, E., Benedict, C. A., & Sharma, S. (2016) · Journal of Virology · doi:10.1128/jvi.01040-16 · Cited by 130 · see citing works

Growing tumors induce a local STING dependent Type I IFN response in dendritic cells

Andzinski, L., Spanier, J., Kasnitz, N., Kröger, A., Jin, L., Brinkmann, M. M., Kalinke, U., Weiß, S., Jabłońska, J., & Lienenklaus, S. (2016) · International Journal of Cancer · doi:10.1002/ijc.30159 · Cited by 65 · see citing works

Pattern Recognition Theory and the Launch of Modern Innate Immunity

Medzhitov, R. M. (2013) · The Journal of Immunology · doi:10.4049/jimmunol.1302427 · Cited by 64 · see citing works

Genetic syndromes mimic congenital infections

Sanchís, A., Cerveró, L., Bataller, A., Tortajada, J. L., Huguet, J., Crow, Y. J., Ali, M., Higuet, L. J., & Martínez‐Frías, M. L. (2005) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2005.01.033 · Cited by 58 · see citing works

Hepatic DsbA‐L protects mice from diet‐induced hepatosteatosis and insulin resistance

Chen, H., Bai, J., Dong, F., Fang, H., Zhang, Y., Meng, W., Liu, B., Luo, Y., Liu, M., Bai, Y., et al. (2017) · The FASEB Journal · doi:10.1096/fj.201600985r · Cited by 27 · see citing works

L1 drives IFN in senescent cells and promotes age-associated inflammation

De Cecco, M., Ito, T., Petrashen, A. P., Elias, A. E., Skvir, N. J., Criscione, S. W., Caligiana, A., Brocculi, G., Adney, E. M., Boeke, J. D., et al. (2019) · Nature · doi:10.1038/s41586-018-0784-9 · Cited by 1,255 · see citing works

cGAS-STING, an important pathway in cancer immunotherapy

Jiang, M., Chen, P., Wang, L., Li, W., Chen, B., Liu, Y., Wang, H., Zhao, S., Ye, L., He, Y., et al. (2020) · Journal of Hematology & Oncology · doi:10.1186/s13045-020-00916-z · Cited by 647 · see citing works

Non-canonical activation of the DNA sensing adaptor STING by ATM and IFI16 mediates NF-κB signaling after nuclear DNA damage

Dunphy, G., Flannery, S. M., Almine, J. F., Connolly, D. J., Paulus, C., Jønsson, K. L., Jakobsen, M. R., Nevels, M. M., Bowie, A. G., & Unterholzner, L. (2018) · Molecular Cell · doi:10.1016/j.molcel.2018.07.034 · Cited by 648 · see citing works

A Genetic Map of the Response to DNA Damage in Human Cells

Olivieri, M., Cho, T., Álvarez-Quilón, A., Li, K., Schellenberg, M. J., Zimmermann, M., Hustedt, N., Rossi, S. E., Adam, S., Melo, H., et al. (2020) · Cell · doi:10.1016/j.cell.2020.05.040 · Cited by 551 · see citing works

Biomolecular Condensates and Cancer

Boija, A., Klein, I. A., & Young, R. A. (2021) · Cancer Cell · doi:10.1016/j.ccell.2020.12.003 · Cited by 320 · see citing works

Type I Interferons in Autoimmune Disease

Crow, M. K., Olferiev, M., & Kirou, K. A. (2018) · Annual Review of Pathology Mechanisms of Disease · doi:10.1146/annurev-pathol-020117-043952 · Cited by 297 · see citing works

Macrophage-specific inhibition of the histone demethylase JMJD3 decreases STING and pathologic inflammation in diabetic wound repair

Audu, C. O., Melvin, W. J., Joshi, A., Wolf, S., Moon, J. Y., Davis, F. M., Barrett, E. C., Mangum, K. D., Deng, H., Xing, X., et al. (2022) · Cellular and Molecular Immunology · doi:10.1038/s41423-022-00919-5 · Cited by 159 · see citing works

Emerging Role of Mitochondrial DNA as a Major Driver of Inflammation and Disease Progression

Zhong, F., Liang, S., & Zhong, Z. (2019) · Trends in Immunology · doi:10.1016/j.it.2019.10.008 · Cited by 133 · see citing works

Role of microglia in stroke

Planas, A. M. (2024) · Glia · doi:10.1002/glia.24501 · Cited by 133 · see citing works

DNA damage-triggered activation of cGAS-STING pathway induces apoptosis in human keratinocyte HaCaT cells

Li, C., Liu, W., Wang, F., Hayashi, T., Mizuno, K., Hattori, S., Fujisaki, H., & Ikejima, T. (2021) · Molecular Immunology · doi:10.1016/j.molimm.2020.12.037 · Cited by 104 · see citing works

Crosstalk of pyroptosis and cytokine in the tumor microenvironment: from mechanisms to clinical implication

Wang, H., Wang, T., Yan, S., Tang, J., Zhang, Y., Wang, L., Xu, H., & Tu, C. (2024) · Molecular Cancer · doi:10.1186/s12943-024-02183-9 · Cited by 113 · see citing works

African swine fever virus I267L acts as an important virulence factor by inhibiting RNA polymerase III-RIG-I-mediated innate immunity

Ran, Y., Li, D., Xiong, M.-G., Liu, H., Feng, T., Shi, Z., Li, Y., Wu, H.-N., Wang, S., Zheng, H., et al. (2022) · PLoS Pathogens · doi:10.1371/journal.ppat.1010270 · Cited by 91 · see citing works

Aging Biomarkers: From Functional Tests to Multi‐Omics Approaches

Kudryashova, K. S., Burka, K., Kulaga, A. Y., Vorobyeva, N. S., & Kennedy, B. K. (2020) · PROTEOMICS · doi:10.1002/pmic.201900408 · Cited by 86 · see citing works

Astrocytes: Heterogeneous and Dynamic Phenotypes in Neurodegeneration and Innate Immunity

Cunningham, C. M., Dunne, A., & López-Rodríguez, A. B. (2018) · The Neuroscientist · doi:10.1177/1073858418809941 · Cited by 78 · see citing works

Function and Molecular Mechanism of the DNA Damage Response in Immunity and Cancer Immunotherapy

Ye, Z., Shi, Y., Lees-Miller, S. P., & Tainer, J. A. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.797880 · Cited by 78 · see citing works

Roles for the IKK-Related Kinases TBK1 and IKKε in Cancer

Durand, J. K., Zhang, Q. H., & Baldwin, A. S. (2018) · Cells · doi:10.3390/cells7090139 · Cited by 73 · see citing works

PARP inhibition and immune modulation: scientific rationale and perspectives for the treatment of gynecologic cancers

Lee, E. K., & Konstantinopoulos, P. A. (2020) · Therapeutic Advances in Medical Oncology · doi:10.1177/1758835920944116 · Cited by 71 · see citing works

Molecular and physiological consequences of faulty eukaryotic ribonucleotide excision repair

Kellner, V., & Luke, B. (2019) · The EMBO Journal · doi:10.15252/embj.2019102309 · Cited by 65 · see citing works

SAMHD1 and the innate immune response to cytosolic DNA during DNA replication

Coquel, F., Neumayer, C., Lin, Y., & Pasero, P. (2018) · Current Opinion in Immunology · doi:10.1016/j.coi.2018.09.017 · Cited by 57 · see citing works

Stalled replication fork protection limits cGAS–STING and P-body-dependent innate immune signalling

Emam, A., Wu, X. Y., Xu, S., Wang, L., Liu, S., & Wang, B. (2022) · Nature Cell Biology · doi:10.1038/s41556-022-00950-8 · Cited by 55 · see citing works

Cellular sensing of extracellular purine nucleosides triggers an innate IFN-β response

Dhanwani, R., Takahashi, M., Mathews, I. T., Lenzi, C., Romanov, A., Watrous, J. D., Pieters, B. C. H., Hedrick, C. C., Benedict, C. A., Linden, J. M., et al. (2020) · Science Advances · doi:10.1126/sciadv.aba3688 · Cited by 48 · see citing works

Centromere defects, chromosome instability, and cGAS-STING activation in systemic sclerosis

Paul, S., Kaplan, M. H., Khanna, D., McCourt, P. M., Saha, A. K., Tsou, P., Anand, M., Radecki, A. A., Mourad, M., Sawalha, A. H., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-34775-8 · Cited by 47 · see citing works

Poor mitochondrial health and systemic inflammation? Test of a classic hypothesis in the Baltimore Longitudinal Study of Aging

Zampino, M., Brennan, N. A., Kuo, P.-L., Spencer, R. G., Fishbein, K. W., Simonsick, E. M., & Ferrucci, L. (2020) · GeroScience · doi:10.1007/s11357-020-00208-x · Cited by 43 · see citing works

The activation of the adaptor protein STING depends on its interactions with the phospholipid PI4P

Luteijn, R. D., van Terwisga, S. R., Eecke, J. E. V., Onia, L., Zaver, S. A., Woodward, J. J., Wubbolts, R., Raulet, D. H., & van Kuppeveld, F. J. M. (2024) · Science Signaling · doi:10.1126/scisignal.ade3643 · Cited by 41 · see citing works

MUC1-C Dictates PBRM1-Mediated Chronic Induction of Interferon Signaling, DNA Damage Resistance, and Immunosuppression in Triple-Negative Breast Cancer

Yamashita, N., Morimoto, Y., Fushimi, A., Ahmad, R., Bhattacharya, A., Daimon, T., Haratake, N., Inoue, Y., Ishikawa, S., Yamamoto, M., et al. (2022) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-22-0772 · Cited by 39 · see citing works

The Interplay between Dengue Virus and the Human Innate Immune System: A Game of Hide and Seek

Tremblay, N., Freppel, W., Sow, A. A., & Chatel‐Chaix, L. (2019) · Vaccines · doi:10.3390/vaccines7040145 · Cited by 41 · see citing works

Mitochondrial Dysfunction-Associated Mechanisms in the Development of Chronic Liver Diseases

Arumugam, M. K., Gopal, T., Kandy, R. R. K., Boopathy, L. K., Perumal, S. K., Ganesan, M., Rasineni, K., Donohue, T. M., Osna, N. A., & Kharbanda, K. K. (2023) · Biology · doi:10.3390/biology12101311 · Cited by 38 · see citing works

Mitochondria: Powering the Innate Immune Response to Mycobacterium tuberculosis Infection

Patrick, K. L., & Watson, R. O. (2021) · Infection and Immunity · doi:10.1128/iai.00687-20 · Cited by 36 · see citing works

Macrophage phagocytosis of SARS-CoV-2-infected cells mediates potent plasmacytoid dendritic cell activation

García-Nicolás, O., Godel, A., Zimmer, G., & Summerfield, A. (2023) · Cellular and Molecular Immunology · doi:10.1038/s41423-023-01039-4 · Cited by 35 · see citing works

Nucleic Acid Sensing in Mammals and Plants: Facts and Caveats

Heil, M., & Vega-Muñoz, I. (2018) · International review of cytology · doi:10.1016/bs.ircmb.2018.10.003 · Cited by 35 · see citing works

Cationic Nanostructures for Vaccines Design

Carmona‐Ribeiro, A. M., & Pérez-Betancourt, Y. (2020) · Biomimetics · doi:10.3390/biomimetics5030032 · Cited by 33 · see citing works

Activation of Innate Immunity by Therapeutic Nucleic Acids

Bishani, A., & Chernolovskaya, E. L. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222413360 · Cited by 34 · see citing works

Mitochondrial Contribution to Inflammation in Diabetic Kidney Disease

Mitrofanova, A. V., Fontanella, A. M., Burke, G. W., Merscher, S., & Fornoni, A. (2022) · Cells · doi:10.3390/cells11223635 · Cited by 35 · see citing works

A dual role for SAMHD1 in regulating HBV cccDNA and RT-dependent particle genesis

Wing, P. A. C., Davenne, T., Wettengel, J. M., Lai, A. G., Zhuang, X. A., Chakraborty, A., D’Arienzo, V., Kramer, C., Ko, C., Harris, J. M., et al. (2019) · Life Science Alliance · doi:10.26508/lsa.201900355 · Cited by 30 · see citing works

Targeting activation of cGAS-STING signaling pathway by engineered biomaterials for enhancing cancer immunotherapy

Liang, J., Jin, X., Deng, X., Huang, Q., Zhang, S., Chen, W., & Zhang, X. (2024) · Materials Today · doi:10.1016/j.mattod.2024.07.004 · Cited by 30 · see citing works

Consequences of Genomic Diversification Induced by Segregation Errors

Soto, M., Raaijmakers, J. A., & Medema, R. H. (2019) · Trends in Genetics · doi:10.1016/j.tig.2019.01.003 · Cited by 26 · see citing works

Guardians of the Cell: Effector-Triggered Immunity Steers Mammalian Immune Defense

Kufer, T. A., Creagh, E. M., & Bryant, C. E. (2019) · Trends in Immunology · doi:10.1016/j.it.2019.08.001 · Cited by 27 · see citing works

DNA‐Based Biomaterials for Immunoengineering

Maeda, M., Kojima, T., Song, Y., & Takayama, S. (2018) · Advanced Healthcare Materials · doi:10.1002/adhm.201801243 · Cited by 27 · see citing works

Cyclic GMP-AMP synthase is essential for cytosolic double-stranded DNA and fowl adenovirus serotype 4 triggered innate immune responses in chickens

Wang, J., Ba, G., Han, Y.-Q., Ming, S., Wang, M.-D., Fu, P.-F., Zhao, Q., Zhang, S., Wu, Y., Yang, G., et al. (2020) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2020.01.015 · Cited by 26 · see citing works

The Mystery of Cancer Resistance: A Revelation Within Nature

Trivedi, D. D., Dalai, S. K., & Bakshi, S. R. (2023) · Journal of Molecular Evolution · doi:10.1007/s00239-023-10092-6 · Cited by 26 · see citing works

Retroelement-derived RNA and its role in the brain

Evans, T. A., & Erwin, J. A. (2020) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2020.11.001 · Cited by 25 · see citing works

Targeting MUC1-C Suppresses Chronic Activation of Cytosolic Nucleotide Receptors and STING in Triple-Negative Breast Cancer

Yamashita, N., Fushimi, A., Morimoto, Y., Bhattacharya, A., Hagiwara, M., Yamamoto, M., Hata, T., Shapiro, G. I., Long, M. D., Liu, S., et al. (2022) · Cancers · doi:10.3390/cancers14112580 · Cited by 24 · see citing works

Advancing Cancer Immunotherapy: The Potential of mRNA Vaccines As a Promising Therapeutic Approach

Goyal, F., Chattopadhyay, A., Navik, U., Jain, A., Reddy, P. H., Bhatti, G. K., & Bhatti, J. S. (2023) · Advanced Therapeutics · doi:10.1002/adtp.202300255 · Cited by 24 · see citing works

Cytosolic DNA Sensors and CNS Responses to Viral Pathogens

Jeffries, A. M., & Marriott, I. (2020) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2020.576263 · Cited by 22 · see citing works

Mitochondrial nucleoid in cardiac homeostasis: bidirectional signaling of mitochondria and nucleus in cardiac diseases

Feng, Y., Huang, W. C., Paul, C., Liu, X., Sadayappan, S., Wang, Y., & Pauklin, S. (2021) · Basic Research in Cardiology · doi:10.1007/s00395-021-00889-1 · Cited by 22 · see citing works

Brief report: STING expressed in tumor and non-tumor compartments has distinct roles in regulating anti-tumor immunity

Kim, J. C., Liu, X., Fitzgerald, K., Eng, J. S., Orf, J., O’Brien, S. A., Belmontes, B., Casbon, A.-J., Novitskiy, S. V., Tarbell, K. V., et al. (2023) · Cancer Immunology, Immunotherapy · doi:10.1007/s00262-022-03327-w · Cited by 22 · see citing works

Host-pathogen protein-nucleic acid interactions: A comprehensive review

Jain, A., Mittal, S., Tripathi, L. P., Nussinov, R., & Ahmad, S. (2022) · Computational and Structural Biotechnology Journal · doi:10.1016/j.csbj.2022.08.001 · Cited by 21 · see citing works

Significance of base excision repair to human health

Zhao, S., Tadesse, S., & Kidane, D. (2021) · International review of cytology · doi:10.1016/bs.ircmb.2021.05.002 · Cited by 20 · see citing works

The importance of type I interferon in orchestrating the cytotoxic T-cell response to cancer

Busselaar, J., Sijbranda, M., & Borst, J. G. (2024) · Immunology Letters · doi:10.1016/j.imlet.2024.106938 · Cited by 20 · see citing works

The cGAS-STING pathway promotes endometriosis by up-regulating autophagy

Zhu, S., Chen, Q., Sun, J., Du, W., Chen, Z., Yu, M., Tao, J., Zhou, Y., Zhao, Y., & Zhang, Q. (2023) · International Immunopharmacology · doi:10.1016/j.intimp.2022.109644 · Cited by 19 · see citing works

Innate Immune DNA Sensing of Flaviviruses

Zhu, T., & Fernández-Sesma, A. (2020) · Viruses · doi:10.3390/v12090979 · Cited by 19 · see citing works

A Link between Replicative Stress, Lamin Proteins, and Inflammation

Willaume, S., Rass, E., Fontanilla-Ramirez, P., Moussa, A., Wanschoor, P., & Bertrand, P. (2021) · Genes · doi:10.3390/genes12040552 · Cited by 19 · see citing works

Inflammatory cytokine storms severity may be fueled by interactions of micronuclei and RNA viruses such as COVID-19 virus SARS-CoV-2. A hypothesis

Kirsch‐Volders, M., & Fenech, M. F. (2021) · Mutation Research/Reviews in Mutation Research · doi:10.1016/j.mrrev.2021.108395 · Cited by 19 · see citing works

Knockdown of CENPM activates cGAS-STING pathway to inhibit ovarian cancer by promoting pyroptosis

Xie, W., Zhang, L., Shen, J., Lai, F., Han, W., & Liu, X. (2024) · BMC Cancer · doi:10.1186/s12885-024-12296-5 · Cited by 17 · see citing works

Immune Checkpoint Inhibitors, Small-Molecule Immunotherapies and the Emerging Role of Neutrophil Extracellular Traps in Therapeutic Strategies for Head and Neck Cancer

O’Meara, C. H., Jafri, Z., & Khachigian, L. M. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241411695 · Cited by 17 · see citing works

Self-DNA Sensing Fuels HIV-1-Associated Inflammation

Heil, M., & Brockmeyer, N. H. (2019) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2019.06.004 · Cited by 16 · see citing works

Grouper cGAS is a negative regulator of STING-mediated interferon response

Zhang, L., Zhang, X., Liao, J., Xu, L., Kang, S., Chen, H., Sun, M., Wu, S., Xu, Z., Wei, S., et al. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1092824 · Cited by 16 · see citing works

Operation of mitochondrial machinery in viral infection-induced immune responses

Lai, J., Luo, S., & Ho, L. (2018) · Biochemical Pharmacology · doi:10.1016/j.bcp.2018.08.044 · Cited by 15 · see citing works

G3BP1 enhances cytoplasmic DNA pattern recognition

Wiser, C. L., Kim, B., & Ascano, M. (2018) · Nature Immunology · doi:10.1038/s41590-018-0279-8 · Cited by 15 · see citing works

Mechanisms by Which Genotoxins Cause Micronuclei and Other Nuclear Anomalies

Fenech, M. F. (2019) · Royal Society of Chemistry eBooks · doi:10.1039/9781788013604-00008 · Cited by 15 · see citing works

Role of Base Excision Repair in Innate Immune Cells and Its Relevance for Cancer Therapy

Zhao, S., Habib, S. L., Senejani, A. G., Sebastian, M. M., & Kidane, D. (2022) · Biomedicines · doi:10.3390/biomedicines10030557 · Cited by 14 · see citing works

Cell type- and region-specific translatomes in an MPTP mouse model of Parkinson's disease

Huang, Q., Chen, C., Chen, W., Cai, C., Xing, H., Li, J., Li, M., & Ma, S. (2023) · Neurobiology of Disease · doi:10.1016/j.nbd.2023.106105 · Cited by 14 · see citing works

Micronuclei and Their Association with Infertility, Pregnancy Complications, Developmental Defects, Anaemias, Inflammation, Diabetes, Chronic Kidney Disease, Obesity, Cardiovascular Disease, Neurodegenerative Diseases and Cancer

Bonassi, S., & Fenech, M. F. (2019) · Royal Society of Chemistry eBooks · doi:10.1039/9781788013604-00038 · Cited by 14 · see citing works

cGAS-dependent proinflammatory and immune homeostatic effects of the microtubule-targeting agent paclitaxel

Serpico, A. F., Pisauro, C., & Grieco, D. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1127623 · Cited by 13 · see citing works

Role of the Innate Immune Response in Glomerular Disease Pathogenesis: Focus on Podocytes

Issa, W., Njeim, R., Carrazco, A., Burke, G. W., & Mitrofanova, A. V. (2024) · Cells · doi:10.3390/cells13131157 · Cited by 12 · see citing works

Aneuploidy, inflammation and diseases

Kirsch‐Volders, M., & Fenech, M. F. (2022) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/j.mrfmmm.2022.111777 · Cited by 12 · see citing works

Centrosome Dynamics and Its Role in Inflammatory Response and Metastatic Process

Pancione, M., Cerulo, L., Remo, A., Giordano, G., Gutiérrez-Uzquiza, Á., Bragado, P., & Porrás, A. (2021) · Biomolecules · doi:10.3390/biom11050629 · Cited by 12 · see citing works

The role of the adaptor molecule STING during Schistosoma mansoni infection

Souza, C. D. L. R., Sanches, R. C. O., Assis, N. R. G., Marinho, F. V., Mambelli, F., Morais, S. B., Gimenez, E. G. T., Guimarães, E. S., Castro, T. B. R., & Oliveira, S. C. (2020) · Scientific Reports · doi:10.1038/s41598-020-64788-6 · Cited by 11 · see citing works

Restoration of Proteostasis in the Endoplasmic Reticulum Reverses an Inflammation-Like Response to Cytoplasmic DNA in <i>Caenorhabditis elegans</i>

Williams, A. B., Heider, F., Messling, J.-E., Rieckher, M., Bloch, W., & Schumacher, B. (2019) · Genetics · doi:10.1534/genetics.119.302422 · Cited by 10 · see citing works

LC3B labeling of the parasitophorous vacuole membrane of Plasmodium berghei liver stage parasites depends on the V‐ATPase and ATG16L1

Bindschedler, A., Schmuckli‐Maurer, J., Buchser, S., Fischer, T. D., Wacker, R., Davalan, T., Brunner, J., & Heussler, V. T. (2024) · Molecular Microbiology · doi:10.1111/mmi.15259 · Cited by 9 · see citing works

TBK1 is paradoxical in tumor development: a focus on the pathway mediating IFN-I expression

Wang, B., Zhang, F., Wu, X., & Ji, M. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1433321 · Cited by 9 · see citing works

Inhibiting DNA Sensing Pathway Controls Steroid Hyporesponsive Lung Inflammation

Mdkhana, B., Sharif‐Askari, N. S., Cagliani, R., Al-Sheakly, B. K. S., Ramakrishnan, R. K., Sharif‐Askari, F. S., Hachim, I. Y., Hamid, Q. A., Rawas‐Qalaji, M., & Halwani, R. (2024) · Advanced Biology · doi:10.1002/adbi.202400230 · Cited by 9 · see citing works

Like a Rolling Stone: Sting-Cgas Pathway and Cell-Free DNA as Biomarkers for Combinatorial Immunotherapy

Sicard, G., Fina, F., Fanciullino, R., Barlési, F., & Ciccolini, J. (2020) · Pharmaceutics · doi:10.3390/pharmaceutics12080758 · Cited by 10 · see citing works

Development of a risk model to predict prognosis in breast cancer based on cGAS-STING-related genes

Chen, C., Wang, J., Dong, C., LIM, D. J., & Feng, Z. (2023) · Frontiers in Genetics · doi:10.3389/fgene.2023.1121018 · Cited by 8 · see citing works

Activation of APOBEC3 cytidine deaminases and endogenous retroviruses is integrated by MUC1-C in NSCLC cells

Haratake, N., Takamori, S., Isozaki, H., Shigeta, K., Kikutake, C., Ozawa, H., Bhattacharya, A., Nakashoji, A., Suyama, M., Takenaka, T., et al. (2025) · Cell Death Discovery · doi:10.1038/s41420-025-02673-9 · Cited by 7 · see citing works

GNB4 Silencing Promotes Pyroptosis to Inhibit the Development of Glioma by Activating cGAS–STING Pathway

Gao, Z., & Yang, J. (2024) · Molecular Biotechnology · doi:10.1007/s12033-024-01194-7 · Cited by 7 · see citing works

Emerging areas for therapeutic discovery in SLE

Maria, N. I., & Davidson, A. (2018) · Current Opinion in Immunology · doi:10.1016/j.coi.2018.09.004 · Cited by 7 · see citing works

Selective Inhibition of Cysteine-Dependent Enzymes by Bioorthogonal Tethering

Spear, L. A., Huang, Y., Chen, J., Nödling, A. R., Virdee, S., & Tsai, Y. (2022) · Journal of Molecular Biology · doi:10.1016/j.jmb.2022.167524 · Cited by 7 · see citing works

Age‐Dependent Pathogenesis of Influenza A Virus H7N9 Mediated Through PB1‐F2‐Induced Mitochondrial DNA Release and Activation of cGAS‐STING‐NF‐κB Signaling

Cheung, P. H., Yuen, T., Tang, T., Leung, H., Lee, T. T., Chan, P., Cheng, Y., Fung, S., Ye, Z., Chan, C., et al. (2024) · Journal of Medical Virology · doi:10.1002/jmv.70062 · Cited by 6 · see citing works

The STING-IRF3 pathway contributes to paraquat-induced acute lung injury

Wang, N., Wang, X., Li, Y., Shen, H., Liu, Z., Ma, Z., Li, Q., & Zhao, M. (2021) · Toxicology Mechanisms and Methods · doi:10.1080/15376516.2021.1974133 · Cited by 6 · see citing works

LINE-1 retrotransposon activation drives age-associated inflammation via cytoplasmic cDNA-STING/type I interferon signalling: therapeutic potential of reverse transcriptase inhibition

Mehmood, A., Xue, Y., Yassin, H. M., Zubair, M. A., Rahmat, S. A., & Ahmad, A. (2025) · Współczesna Onkologia · doi:10.5114/wo.2025.152369 · Cited by 5 · see citing works

Mitochondrial DNA may act as a biomarker to predict donor‐kidney quality

Hao, C., Zhang, J., Zhang, F., Wu, J., Cao, H., & Wang, W. (2021) · Clinical Transplantation · doi:10.1111/ctr.14469 · Cited by 5 · see citing works

The immunostimulator Victrio activates chicken toll-like receptor 21

Ilg, T. (2019) · Veterinary Immunology and Immunopathology · doi:10.1016/j.vetimm.2019.109977 · Cited by 5 · see citing works

Single cell transcriptomics of bone marrow derived macrophages reveals Ccl5 as a biomarker of direct IFNAR-independent responses to DNA sensing

McCarty, E., Yu, J. D., Ninh, V. K., Calcagno, D. M., Lee, J., & King, K. R. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1199730 · Cited by 4 · see citing works

Modulation of Immune Reaction in Hydrodynamic Gene Therapy for Hemophilia A

Zhao, M., Sun, Y., Yin, M., Zhao, J.-J., Li, S.-A., Li, G., Zhang, F., Xu, J., Meng, F., Zhang, B., et al. (2021) · Human Gene Therapy · doi:10.1089/hum.2021.145 · Cited by 4 · see citing works

The Third Man: DNA sensing as espionage in pulmonary vascular health and disease

Bryant, A. J., Pham, A. T., Gogoi, H., Mitchell, C. R., Pais, F. M., & Jin, L. (2021) · Pulmonary Circulation · doi:10.1177/2045894021996574 · Cited by 4 · see citing works

The Fate of Micronuclei and Micronucleated Cells

Stopper, H., & Hintzsche, H. (2019) · Royal Society of Chemistry eBooks · doi:10.1039/9781788013604-00024 · Cited by 4 · see citing works

Non‐canonical PKG1 regulation in cardiovascular health and disease

Su, J., & Burgoyne, J. R. (2025) · British Journal of Pharmacology · doi:10.1111/bph.70148 · Cited by 3 · see citing works

Cytosolic DNA in radiotherapy: relevance, mechanisms, and detection

Poulton, E., Desjardins, A., Harding, S. M., Malbeteau, L., & Koritzinsky, M. (2025) · Radiotherapy and Oncology · doi:10.1016/j.radonc.2025.111220 · Cited by 3 · see citing works

Human functional genomics reveals toxicological mechanism underlying genotoxicants-induced inflammatory responses under low doses exposure

Tian, M., Xia, P., Yan, L., Gou, X., Yu, H., & Zhang, X. (2022) · Chemosphere · doi:10.1016/j.chemosphere.2022.137658 · Cited by 3 · see citing works

Gene therapy enhances deoxyribonuclease I treatment in antimyeloperoxidase glomerulonephritis

Le, A. C., Oudin, V., Dick, J., Alikhan, M. A., Gottschalk, T. A., Lu, L., Lawlor, K. E., Cheong, D. K. Y., Mandwie, M., Alexander, I. E., et al. (2025) · JCI Insight · doi:10.1172/jci.insight.188951 · Cited by 3 · see citing works

Hepatit B Virüsüne (HBV) Karşı Doğal Bağışık, Kronik HBV Enfeksiyonu Olan ve HBV ile Karşılaşmamış Bireylerdeki “Stimulator of Interferon Genes (STING)” mRNA Düzeylerinin Karşılaştırılması

Kasap, B., Buruk, C. K., Kaklıkkaya, N., Özkaya, E., Kasap, Z. A., & Aydın, F. (2020) · Mikrobiyoloji Bulteni · doi:10.5578/mb.68787 · Cited by 3 · see citing works

Overcoming photodynamic therapy resistance via DNA repair inhibitors: Advanced review

Moloudi, K., Abrahamse, H., & George, B. P. A. (2025) · Photodiagnosis and Photodynamic Therapy · doi:10.1016/j.pdpdt.2025.104724 · Cited by 2 · see citing works

Selective Inhibition of Kinase Activity in Mammalian Cells by Bioorthogonal Ligand Tethering

Chen, J., Huang, Y., Gan, W., & Tsai, Y. (2023) · Methods in molecular biology · doi:10.1007/978-1-0716-3251-2_16 · Cited by 2 · see citing works

Alternative splicing of IRF3 plays an important role in the development of hepatocarcinoma

Lv, Z., Gao, W., Du, Z., Zheng, Y., Liu, T., Hao, C., & Xue, D. (2023) · Epigenetics · doi:10.1080/15592294.2023.2276371 · Cited by 2 · see citing works

Ataxia Telengectesia Protein Influences Bleomycin-Induced DNA Damage in Human Fibroblast Cells

Gnanasekaran, T. S., & Venkatachalam, P. (2024) · Cell Biochemistry and Biophysics · doi:10.1007/s12013-024-01275-z · Cited by 2 · see citing works

Unexpected link between mitochondrial DNA and T cell help in systemic lupus erythematosus

Pisetsky, D. S. (2019) · Annals of the Rheumatic Diseases · doi:10.1136/annrheumdis-2019-215597 · Cited by 2 · see citing works

ISG15 fast-tracks DNA replication

Meroni, A., & Vindigni, A. (2020) · The Journal of Cell Biology · doi:10.1083/jcb.202007028 · Cited by 2 · see citing works

Pathophysiology of glomerulonephritis in autoimmune diseases

Maeda, K. (2025) · Current Opinion in Rheumatology · doi:10.1097/bor.0000000000001134 · Cited by 1 · see citing works

Deoxyguanosine Kinase Deficiency Couples Purine Metabolism to Innate Immune Activation and Lipid Accumulation in Hepatocytes 2309176

Corey, M., Rayadurgam, M., Vatanmakanian, M., Gibbons, A., Altbaum, C., Jung, J., Reddy, N., Saminathan, P., Kakugawa, K., & Sharma, S. (2026) · The Journal of Immunology · doi:10.1093/jimmun/vkag141.1506 · Cited by 1 · see citing works

Multifunction of Cytosolic DNA Sensor - cGAS

Gao, Y., & Liu, L. (2019) · Journal of Advances in Health · doi:10.3724/sp.j.2640-8686.2019.0030

Enemy Within ‐ Immune and Autoimmune Responses to Cytosolic DNA and RNA

Chen, Z. J. (2015) · The FASEB Journal · doi:10.1096/fasebj.29.1_supplement.217.1

S-8

Chen, Z. J. (2014) · Cytokine · doi:10.1016/j.cyto.2014.07.228

Cytosolic DNA sensing via cGAS: long, U-shaped and other DNA ligands and cellular co-factors

Andreeva, L. (2018) · doi:10.5282/edoc.22177

cGAS-STING: The Novel Mechanism of Cytosolic DNA Sensing Pathways

Ding, L. (2014) · PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS · Cited by 1 · see citing works