The DOI matches its Crossref record; 105 of the 105 references it cites were found in a registry or an index.
Ferroptosis at the intersection of lipid metabolism and cellular signaling
Open accessAbstract
SUMMARY Ferroptosis, a newly emerged form of regulated necrotic cell death, has been demonstrated to play an important role in multiple diseases including cancer, neurodegeneration, and ischemic organ injury. Mounting evidence also suggests its potential physiological function in tumor suppression and immunity. Execution of ferroptosis is driven by iron-dependent phospholipid peroxidation. As such, metabolism of biological lipids regulates ferroptosis via controlling phospholipid peroxidation, as well as various other cellular processes relevant to phospholipid peroxidation. In this review, we will provide a comprehensive analysis by focusing on how lipid metabolism impacts the initiation, propagation, and termination of phospholipid peroxidation, how multiple signal transduction pathways communicate with ferroptosis via modulating lipid metabolism, and how such intimate crosstalk of ferroptosis with lipid metabolism and related signaling pathways can be exploited for the development of rational therapeutic strategies.
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Ferroptosis: mechanisms, biology and role in disease
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Self-citationACSL4 dictates ferroptosis sensitivity by shaping cellular lipid composition
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The CoQ oxidoreductase FSP1 acts parallel to GPX4 to inhibit ferroptosis
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Cited by
The Cell Biology of Ferroptosis
Dixon, S. J., & Olzmann, J. A. (2024) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-024-00703-5 · Cited by 1,596
Iron Homeostasis and Ferroptosis in Human Diseases: Mechanisms and Therapeutic Prospects
Ru, Q., Li, Y., Chen, L., Wu, Y., Min, J., & Wang, F. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-01969-z · Cited by 724
Ferroptosis surveillance independent of GPX4 and differentially regulated by sex hormones
Liang, D., Feng, Y., Zandkarimi, F., Wang, H., Zhang, Z., Kim, J., Cai, Y., Gu, W., Stockwell, B. R., & Jiang, X. (2023) · Cell · doi:10.1016/j.cell.2023.05.003 · Cited by 722
Self-citationLei, G., Zhuang, L., & Gan, B. (2024) · Cancer Cell · doi:10.1016/j.ccell.2024.03.011 · Cited by 586
Cell-cell communication: New insights and clinical implications
Su, J., Song, Y., Zhu, Z., Huang, X., Fan, J., Qiao, J., & Mao, F. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-01888-z · Cited by 433
Metadata
- Authors
- Liang, D., Minikes, A. M., & Jiang, X.
- Venue
- Molecular Cell
- Publisher
- Elsevier BV
- Published
- 2022-06
- Volume
- 82
- Issue
- 12
- Pages
- 2215-2227
- ISSN
- 1097-2765 (ISSN-L)
- OpenAlex
- W4226367800
- Cited by
- 1,345
- References
- 105
- FWCI
- 142.07
- Type
- journal article
- Language
- en
- Open access
- bronze
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