Alternative molecular formats and therapeutic applications for bispecific antibodies
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- Immunotherapy of cancer: from monoclonal to oligoclonal cocktails of anti‐cancer antibodies: IUPHAR Review 18Sílvia Carvalho, Francesca Levi‐Schaffer, Michael Sela, Yosef Yarden · 2016 · British Journal of Pharmacology
- Insights from native mass spectrometry and ion mobility-mass spectrometry for antibody and antibody-based product characterizationGuillaume Terral, Alain Beck, Sarah Cianférani · 2016 · Journal of Chromatography B
- Nanobodies As Novel Agents for Targeting Angiogenesis in Solid CancersRoghaye Arezumand, Abbas Alibakhshi, Javad Ranjbari, Ali Ramazani, Serge Muyldermans · 2017 · Frontiers in Immunology
- Natural Killer Cell Engagers (NKCEs): a new frontier in cancer immunotherapyMinchuan Zhang, Kong‐Peng Lam, Shengli Xu · 2023 · Frontiers in Immunology
- Computationally Designed Bispecific Antibodies using Negative State RepertoiresAndrew Leaver‐Fay, Karen Froning, S. Atwell, Hector Aldaz, Anna Pustilnik, Frances Lu, Flora Huang, Richard G. Yuan, Saleema Hassanali, Aaron K. Chamberlain et al. · 2016 · Structure
- Augmenting adaptive immunity: progress and challenges in the quantitative engineering and analysis of adaptive immune receptor repertoiresBrown, Alex J., Snapkov, Igor, Akbar, Rahmad, Pavlović, Milena, Miho, Enkelejda, Sandve, Geir K., Greiff, Victor · 2019 · Molecular Systems Design & Engineering
- A Bispecific Molecule Targeting CD40 and Tumor Antigen Mesothelin Enhances Tumor-Specific ImmunityShiming Ye, Diane Dede Cohen, Nicole A. Belmar, Donghee Choi, Siu Sze Tan, Mien Sho, Yoshiko Akamatsu, Han Kim, Ramesh B. Iyer, Jean Cabel et al. · 2019 · Cancer Immunology Research
- Bispecific antibody therapy, its use and risks for infection: Bridging the knowledge gapAnthony Longhitano, Monica A. Slavin, Simon James Harrison, Benjamin W. Teh · 2021 · Blood Reviews
- Monoclonal Antibodies for Bacterial Pathogens: Mechanisms of Action and Engineering Approaches for Enhanced Effector FunctionsFabiola Vacca, Claudia Sala, Rino Rappuoli · 2022 · Biomedicines
- Characterization of the first-in-class T-cell-engaging bispecific single-chain antibody for targeted immunotherapy of solid tumors expressing the oncofetal protein claudin 6Christiane Stadler, Hayat Bähr-Mahmud, Laura M. Plum, Kathrin Schmoldt, Anne C. Kölsch, Özlem Türeci, Uğur Şahin · 2015 · OncoImmunology
- miRNA engineering of CHO cells facilitates production of difficult‐to‐express proteins and increases success in cell line developmentSimon Fischer, Kim Fabiano Marquart, Lisa A. Pieper, Juergen Fieder, Martin Gamer, Ingo H. Gorr, Patrick Schulz, Harald Bradl · 2017 · Biotechnology and Bioengineering
- Engineering bispecific antibodies with defined chain pairingSimon Krah, Carolin Sellmann, Laura Rhiel, Christian J. Schröter, Stephan Dickgießer, Jan Beck, Stefan Zielonka, Lars Toleikis, Björn M Hock, Harald Kolmar et al. · 2017 · New Biotechnology
- Coupling Mixed-Mode Size Exclusion Chromatography with Native Mass Spectrometry for Sensitive Detection and Quantitation of Homodimer Impurities in Bispecific IgGYuetian Yan, Tao Xing, Shunhai Wang, Thomas J. Daly, Ning Li · 2019 · Analytical Chemistry
- Antibody Therapies for Acute Myeloid Leukemia: Unconjugated, Toxin-Conjugated, Radio-Conjugated and Multivalent FormatsBrent A. Williams, Arjun Law, Judit Hunyadkürti, Stéphanie Désilets, Jeffrey Victor Leyton, Armand Keating · 2019 · Journal of Clinical Medicine
- High-throughput antibody screening from complex matrices using intact protein electrospray mass spectrometrySawyer, William S., Srikumar, Neha, Carver, Joseph, Chu, Phillip Y., Shen, Amy, Xu, Ankai, Williams, Ambrose J., Spiess, Christoph, Wu, Cong, Liu, Yichin et al. · 2020 · Proceedings of the National Academy of Sciences
- A brief introduction of IgG-like bispecific antibody purification: Methods for removing product-related impuritiesYifeng Li · 2018 · Protein Expression and Purification
- Debottlenecking protein secretion and reducing protein aggregation in the cellular hostYizhou Zhou, Ravali Raju, Christina S. Alves, Alan Gilbert · 2018 · Current Opinion in Biotechnology
- Engineering a bispecific antibody with a common light chain: Identification and optimization of an anti-CD3 epsilon and anti-GPC3 bispecific antibody, ERY974Hirotake Shiraiwa, Atsushi Narita, Mika Kamata‐Sakurai, Takahiro Ishiguro, Yuji Sano, Naoka Hironiwa, Takashi Tsushima, Hiroaki Segawa, Toshiaki Tsunenari, Yosuke Ikeda et al. · 2018 · Methods
- Innovation in Chemistry, Manufacturing, and Controls—A Regulatory Perspective From IndustryNina S. Cauchon, Shirley Oghamian, Soraya Hassanpour, Michael J. Abernathy · 2019 · Journal of Pharmaceutical Sciences
- CAR-NK as a Rapidly Developed and Efficient Immunotherapeutic Strategy against CancerMarta Włodarczyk, Beata Pyrzyńska · 2022 · Cancers
- Bispecific antibodies in cancer immunotherapySiqi Chen, Jing Li, Qing Li, Zhong Wang · 2016 · Human Vaccines & Immunotherapeutics
- Immunological and Translational Aspects of NK Cell-Based Antitumor ImmunotherapiesMaxim Alekseevich Shevtsov, Gabriele Multhoff · 2016 · Frontiers in Immunology
- Development of tibulizumab, a tetravalent bispecific antibody targeting BAFF and IL-17A for the treatment of autoimmune diseaseRobert J. Benschop, Chi-Kin Chow, Yu Tian, James Nelson, Barbra Barmettler, S. Atwell, David K. Clawson, Qing Chai, Bryan E. Jones, J.R. Fitchett et al. · 2019 · mAbs
- Unraveling what makes a monoclonal antibody difficult‐to‐express: From intracellular accumulation to incomplete folding and degradation via ERADSven Mathias, Anna Wippermann, Nadja Raab, Nikolas Zeh, René Handrick, Ingo H. Gorr, Patrick Schulz, Simon Fischer, Martin Gamer, Kerstin Otte · 2019 · Biotechnology and Bioengineering
- Dissecting the molecular basis of high viscosity of monospecific and bispecific IgG antibodiesCholpon Tilegenova, Saeed Izadi, Jianping Yin, Christine Huang, Jiansheng Wu, Diego A. Ellerman, S.G. Hymowitz, Benjamin T. Walters, Cleo M. Salisbury, Paul J. Carter · 2019 · mAbs
- Therapeutic bispecific antibody formats: a patent applications review (1994-2017)Marie Godar, Hans de Haard, Christophe Blanchetot, Jacobus Rasser · 2018 · Expert Opinion on Therapeutic Patents
- Aberrant bispecific antibody pharmacokinetics linked to liver sinusoidal endothelium clearance mechanism in cynomolgus monkeysAmita Datta‐Mannan, Johnny E. Croy, Linda Schirtzinger, Stacy Torgerson, Matthew Douglas Breyer, Victor J. Wroblewski · 2016 · mAbs
- Antibody-Based Cancer TherapyDjoke Hendriks, Goda Choi, Marco de Bruyn, Valerie R. Wiersma, Edwin Bremer · 2017 · International review of cytology
- CD38-Specific Biparatopic Heavy Chain Antibodies Display Potent Complement-Dependent Cytotoxicity Against Multiple Myeloma CellsKerstin Schütze, Katharina Petry, Julia Hambach, Niklas Schuster, William Fumey, Levin Schriewer, Jana Larissa Röckendorf, Stephan Menzel, Birte Albrecht, Friedrich Haag et al. · 2018 · Frontiers in Immunology
- Characterization of Chain Pairing Variants of Bispecific IgG Expressed in a Single Host Cell by High-Resolution Native and Denaturing Mass SpectrometryLuis F. Schachner, Guanghui Han, Michael A. Dillon, Jianhui Zhou, Luke McCarty, Diego A. Ellerman, Yiyuan Yin, Christoph Spiess, Jennie Rebecca Lill, Paul J. Carter et al. · 2016 · Analytical Chemistry
- Bispecific antibodies: The next generation of targeted inflammatory bowel disease therapiesLaurent Peyrin‐Biroulet, Stephen J. Demarest, Ajay Nirula · 2018 · Autoimmunity Reviews
- A Single-Agent Dual-Specificity Targeting of FOLR1 and DR5 as an Effective Strategy for Ovarian CancerGururaj Shivange, Karol Urbanek, Piotr Przanowski, Justin S. A. Perry, James O. Jones, Robert Haggart, Christina Kostka, Tejal Patki, Edward B. Stelow, Yuliya I. Petrova et al. · 2018 · Cancer Cell
- Toward generalizable prediction of antibody thermostability using machine learning on sequence and structure featuresAmeya Harmalkar, Roshan Rao, Yuxuan Richard Xie, Jonas Honer, Wibke Deisting, Jonas Anlahr, Anja Hoenig, Julia Czwikla, Eva Sienz-Widmann, Doris Rau et al. · 2023 · mAbs
- Optimizing antibody expression: The nuts and boltsB. Vijayalakshmi Ayyar, Sushrut Arora, Shiva Shankar Ravi · 2017 · Methods
- Renaissance of armored immune effector cells, CAR-NK cells, brings the higher hope for successful cancer therapyFaroogh Marofi, Heshu Sulaiman Rahman, Lakshmi Prasanth Thangavelu, Aleksei Evgenievich Dorofeev, Favián Bayas-Morejón, Naghmeh Shirafkan, Navid Shomali, Max Stanley Chartrand, Mostafa Jarahian, Ghasem Vahedi et al. · 2021 · Stem Cell Research & Therapy
- Summary of a workshop on preclinical and translational safety assessment of CD3 bispecificsCris Kamperschroer, Jacintha M. Shenton, Herve N. Lebrec, John K. Leighton, Paul A. Moore, Oliver Thomas · 2020 · Journal of Immunotoxicology
- Recent Advances in LC–MS Based Characterization of Protein‐Based Bio‐Therapeutics—Mastering Analytical Challenges Posed by the Increasing Format ComplexityGraf, Tobias, Heinrich, Katrin, Grunert, Ingrid, Wegele, Harald, Haberger, Markus, Bulau, Patrick, Leiss, Michael · 2020 · Journal of Pharmaceutical and Biomedical Analysis
- Recent Advances in the Molecular Design and Applications of Multispecific BiotherapeuticsXiaotian Zhong, Aaron M. D’Antona · 2021 · Antibodies
- Bispecific Antibody Conjugated Manganese-Based Magnetic Engineered Iron Oxide for Imaging of HER2/neu- and EGFR-Expressing TumorsShou-Cheng Wu, Yu-Jen Chen, Hsiang-Ching Wang, Min-Yuan Chou, Teng‐Yuan Chang, Shyng‐Shiou F. Yuan, Chiao-Yun Chen, Ming‐Feng Hou, John T.-A. Hsu, Yun‐Ming Wang · 2015 · Theranostics
- Fv-clasp: An Artificially Designed Small Antibody Fragment with Improved Production Compatibility, Stability, and CrystallizabilityTakao Arimori, Yu Kitago, Masataka Umitsu, Yuki Fujii, Ryoko Asaki, Keiko Tamura‐Kawakami, Junichi Takagi · 2017 · Structure
- Acute myeloid leukemia targets for bispecific antibodiesSayed Shahabuddin Hoseini, Nai‐Kong V. Cheung · 2017 · Blood Cancer Journal
- Productive common light chain libraries yield diverse panels of high affinity bispecific antibodiesThomas J. Van Blarcom, Kevin C. Lindquist, Zea Melton, Wai Ling Cheung‐Lee, Chris Wagstrom, Dan McDonough, Cendy A. Valle Oseguera, Sheng Ding, Andrea Rossi, Shobha Potluri et al. · 2017 · mAbs
- T cell-redirecting bispecific antibodies in cancer immunotherapy: recent advancesYu Lin, Jianhua Wang · 2019 · Journal of Cancer Research and Clinical Oncology
- Successful engineering of a highly potent single-chain variable-fragment (scFv) bispecific antibody to target disialoganglioside (GD2) positive tumorsMing Huei Cheng, Brian H. Santich, Hong Xu, Mahiuddin Ahmed, Morgan Huse, Nai‐Kong V. Cheung · 2016 · OncoImmunology
- Building blocks for bispecific and trispecific antibodiesXiufeng Wu, Stephen J. Demarest · 2018 · Methods
- Improving product quality and productivity of bispecific molecules through the application of continuous perfusion principlesNatalia V. Gomez, Jonathan Lull, Xiaorui Yang, Yan Wang, Xin Zhang, Agatha Wieczorek, John Harrahy, Mike Pritchard, Diandra Martinez‐Cano, Michael Shearer et al. · 2020 · Biotechnology Progress
- Co-Stimulatory Bispecific Antibodies Induce Enhanced T Cell Activation and Tumor Cell Killing in Breast Cancer ModelsKarsten Michael Warwas, Marten Meyer, Márcia Gonçalves, Gerhard Moldenhauer, Nadja Bulbuc, Susanne Knabe, Claudia Luckner‐Minden, Claudia Ziegelmeier, Claus Peter Heußel, Inka Zörnig et al. · 2021 · Frontiers in Immunology
- Efficient Generation of Bispecific Murine Antibodies for Pre-Clinical Investigations in Syngeneic Rodent ModelsAran F. Labrijn, Joyce I. Meesters, Matthew W. Bunce, Anthony A. Armstrong, Sandeep Somani, Tom Nesspor, Mark L. Chiu, Işıl Altıntaş, Sandra A.B.W. Verploegen, Janine Schuurman et al. · 2017 · Scientific Reports
- Pharmacokinetics of Bispecific AntibodyYang Chen, Yan Chun Xu · 2017 · Current Pharmacology Reports
- Fabs-in-tandem immunoglobulin is a novel and versatile bispecific design for engaging multiple therapeutic targetsShiyong Gong, Fang Ren, Danqing Wu, Xuan Wu, Chengbin Wu · 2017 · mAbs
- Targeting ligand–receptor interactions for development of cancer therapeuticsJun W. Kim, Jennifer R. Cochran · 2017 · Current Opinion in Chemical Biology
- Antibody-Based Strategies to Prevent and Treat InfluenzaZachary H. Shriver, José Trevejo, Ram Sasisekharan · 2015 · Frontiers in Immunology
- CD89-mediated recruitment of macrophages via a bispecific antibody enhances anti-tumor efficacyBingyu Li, Lijun Xu, Chenyu Pi, Yanxin Yin, Kun Xie, Fei Tao, Renhao Li, Hua Gu, Jianmin Fang · 2017 · OncoImmunology
- In vivo Phage Display: A promising selection strategy for the improvement of antibody targeting and drug delivery propertiesA André, Isa Moutinho, Joana Dias, Frederico Aires‐da‐Silva · 2022 · Frontiers in Microbiology
- Bispecific Antibody Affords Complete Post-Exposure Protection of Mice from Both Ebola (Zaire) and Sudan VirusesJulia Carina Frei, Elisabeth K. Nyakatura, Samantha E. Zak, Russell R. Bakken, Kartik Chandran, John M. Dye, Jonathan R. Lai · 2016 · Scientific Reports
- Next-generation flexible formats of VNAR domains expand the drug platform's utility and developabilityObinna C. Ubah, Magdalena J. Buschhaus, Laura Ferguson, Marina Kovaleva, John Steven, A.J. Porter, Caroline Jane Barelle · 2018 · Biochemical Society Transactions
- Perfusion reduces bispecific antibody aggregation via mitigating mitochondrial dysfunction-induced glutathione oxidation and ER stress in CHO cellsPritam Sinharoy, Aaron H. Aziz, Natalia I. Majewska, Sanjeev Ahuja, Michael W. Handlogten · 2020 · Scientific Reports
- Exosome-based strategies for diagnosis and therapy of glioma cancerMohsen Karami Fath, Jalil Azami, Alireza Masoudi, Reza Mosaddeghi-Heris, Elnaz Rahmani, Fatemeh Alavi, Armina Alagheband Bahrami, Zahra Payandeh, Bahman Khalesi, Masoomeh Dadkhah et al. · 2022 · Cancer Cell International
- Precise quantification of mixtures of bispecific IgG produced in single host cells by liquid chromatography-Orbitrap high-resolution mass spectrometryYiyuan Yin, Guanghui Han, Jianhui Zhou, Michael A. Dillon, Luke McCarty, Lou Gavino, Diego A. Ellerman, Christoph Spiess, Wendy N. Sandoval, Paul J. Carter · 2016 · mAbs
- Erratum: Acute myeloid leukemia targets for bispecific antibodiesSayed Shahabuddin Hoseini, Nai‐Kong V. Cheung · 2017 · Blood Cancer Journal
- Purification of common light chain IgG-like bispecific antibodies using highly linear pH gradientsBeth Sharkey, Sarat Pudi, Ian Wallace Moyer, Lihui Zhong, Bianka Prinz, Hemanta Baruah, Heather Lynaugh, Sampath Kumar, Karl Dane Wittrup, Juergen H. Nett · 2016 · mAbs
- Novel agents for pancreatic ductal adenocarcinoma: emerging therapeutics and future directionsYiyin Zhang, Chao Yang, He Cheng, Zhiyao Fan, Qiuyi Huang, Lu Yu, Kun Fan, Guopei Luo, Kaizhou Jin, Zhengshi Wang et al. · 2018 · Journal of Hematology & Oncology
- The biodistribution of therapeutic proteins: Mechanism, implications for pharmacokinetics, and methods of evaluationKip P. Conner, Siva Charan Devanaboyina, Veena A. Thomas, Dan A. Rock · 2020 · Pharmacology & Therapeutics
- Development of bispecific antibodies in China: overview and prospectsJing Zhang, Jizu Yi, Pengfei Zhou · 2020 · Antibody Therapeutics
- Biophysical differences in IgG1 Fc-based therapeutics relate to their cellular handling, interaction with FcRn and plasma half-lifeTorleif Tollefsrud Gjølberg, Rahel Frick, Simone Mester, Stian Foss, Algirdas Grevys, Lene Støkken Høydahl, Øystein Kalsnes Jørstad, Tilman Schlothauer, Inger Sandlie, Morten C. Moe et al. · 2022 · Communications Biology
- Current status of novel biologics and small molecule drugs in the individualized treatment of inflammatory bowel diseaseYihan Xu, Weiming Zhu, Zhen Guo · 2022 · World Journal of Gastroenterology
- Structural and Functional Characterization of a Hole–Hole Homodimer Variant in a “Knob-Into-Hole” Bispecific AntibodyHui‐Min Zhang, Charlene Li, Ming Lei, Victor Lundin, Ho‐Young Lee, Milady R. Niñonuevo, Kevin Lin, Guanghui Han, Wendy N. Sandoval, Dongsheng Lei et al. · 2017 · Analytical Chemistry
- MAPPs for the identification of immunogenic hotspots of biotherapeutics; an overview of the technology and its application to the biopharmaceutical arenaValerie E. Quarmby, Qui T. Phung, Jennie Rebecca Lill · 2018 · Expert Review of Proteomics
- Potential Role of CD47-Directed Bispecific Antibodies in Cancer ImmunotherapyYan Yang, Zheng Yang, Yun Yang · 2021 · Frontiers in Immunology
- Design and Validation of a Novel Generic Platform for the Production of Tetravalent IgG1-like Bispecific AntibodiesJosée Golay, Sylvie Choblet, Justyna Iwaszkiewicz, Pierre Cérutti, Annick Ozil, Séverine Loisel, Martine Pugnière, Greta Ubiali, Vincent Zoete, Olivier Alain Michielin et al. · 2016 · The Journal of Immunology
- Bispecific T-cell engagers for the recruitment of T cells in solid tumors: a literature reviewLaura Dewaele, Ricardo A. Fernandes · 2024 · Immunotherapy Advances
- T-Cell Engagers—The Structure and Functional Principle and Application in Hematological MalignanciesPaweł Cech, Katarzyna Skórka, Laura Dziki, Krzysztof Giannopoulos · 2024 · Cancers
- Highly Specific and Effective Targeting of EGFRvIII-Positive Tumors with TandAb AntibodiesKristina Ellwanger, Uwe Reusch, Ivica Fucek, Stefan H.J. Knackmuss, Michael Weichel, Thorsten Gantke, Vera Molkenthin, Eugene A. Zhukovsky, Michael Tesar, Martin Treder · 2017 · Frontiers in Oncology
- Fcab-HER2 Interaction: a Ménage à Trois. Lessons from X-Ray and Solution StudiesElisabeth Laurent, Anne-Sophie Humm, Kathrin Göritzer, Georg Mlynek, Martin Gerald Puchinger, Christoph Hasenhindl, Florian Rüker, Michael W. Traxlmayr, Kristina Djinović‐Carugo, Christian Obinger · 2017 · Structure
- Multivalent protein-drug conjugates – An emerging strategy for the upgraded precision and efficiency of drug delivery to cancer cellsNatalia Porębska, Krzysztof Ciura, Aleksandra Chorążewska, Małgorzata Zakrzewska, Jacek Otlewski, Łukasz Opaliński · 2023 · Biotechnology Advances
- Heavy and light chain pairing of bivalent quadroma and knobs-into-holes antibodies analyzed by UHR-ESI-QTOF mass spectrometryWolfgang M. Schäfer, Hans Rainer Völger, Stefan H. Lorenz, Sabine Imhof-Jung, Jörg T. Regula, Christian Klein, Michael Mølhøj · 2015 · mAbs
- A Novel Affibody-Auristatin E Conjugate With a Potent and Selective Activity Against HER2+ Cell LinesAlicja M. Sochaj-Gregorczyk, Anna Maria Serwotka-Suszczak, Jacek Otlewski · 2016 · Journal of Immunotherapy
- T Cell Bispecific Antibodies: An Antibody-Based Delivery System for Inducing Antitumor ImmunityDaisuke Kamakura, Ryutaro Asano, Masahiro Yasunaga · 2021 · Pharmaceuticals
- Characterization and analysis of scFv-IgG bispecific antibody size variantsMingyan Cao, Chunlei Wang, Wai Keen Chung, Dana Motabar, Jihong Wang, Elizabeth A. Christian, Shi‐Hua Lin, Alan K. Hunter, Xiangyang Wang, Dengfeng Liu · 2018 · mAbs
- Microfluidic methods for cell separation and subsequent analysisTianyou Chen, Chunxia Huang, Yanran Wang, Jing Wu · 2021 · Chinese Chemical Letters
- An Integrated Approach to Aggregate Control for Therapeutic Bispecific Antibodies Using an Improved Three Column Mab Platform‐Like Purification ProcessCassia Andrade, Lindsay Arnold, Dana Motabar, Matthew T. Aspelund, Alison Tang, Alan K. Hunter, Wai Keen Chung · 2018 · Biotechnology Progress
- Visualisation of intracellular production bottlenecks in suspension-adapted CHO cells producing complex biopharmaceuticals using fluorescence microscopySven Mathias, Simon Fischer, René Handrick, Jürgen Fieder, Patrick Schulz, Harald Bradl, Ingo H. Gorr, Martin Gamer, Kerstin Otte · 2018 · Journal of Biotechnology
- A biparatopic agonistic antibody that mimics fibroblast growth factor 21 ligand activitySally Yu Shi, Ya‐Wen Lu, Zhi Liu, Jennitte L. Stevens, Christopher M. Murawsky, Vicki Wilson, Zhonghua Hu, William G. Richards, Mark Leo Michaels, Jun Zhang et al. · 2018 · Journal of Biological Chemistry
- Advances in molecular mechanisms of drugs affecting abnormal glycosylation and metastasis of breast cancerHuimin Liu, Lele Ma, Junzhi Lin, Bo Cao, Duan Qu, Chuanhong Luo, Wei Huang, Li Han, Hong Xu, Zhenfeng Wu et al. · 2020 · Pharmacological Research
- Tailoring translational strength using Kozak sequence variants improves bispecific antibody assembly and reduces product‐related impurities in CHO cellsNoelia Blanco, Ambrose J. Williams, Danming Tang, Dejin Zhan, Shahram Misaghi, Robert F. Kelley, Laura C. Simmons · 2020 · Biotechnology and Bioengineering
- Bioassay Development for Bispecific Antibodies—Challenges and OpportunitiesAmes C. Register, Somayeh Samadzadeh Tarighat, Ho‐Young Lee · 2021 · International Journal of Molecular Sciences
- For whom the T cells troll? Bispecific T-cell engagers in glioblastomaKirit Singh, Kelly M. Hotchkiss, Aditya A Mohan, Jessica L. Reedy, John Howard Sampson, Mustafa Khasraw · 2021 · Journal for ImmunoTherapy of Cancer
- Current Mass Spectrometric Tools for the Bioanalyses of Therapeutic Monoclonal Antibodies and Antibody-Drug ConjugatesKenichiro Todoroki, Tomohiro Yamada, Hajime Mizuno, Toshimasa Toyo’oka · 2018 · Analytical Sciences
- Modulating binding affinity, specificity, and configurations by multivalent interactionsYunxin Deng, Artem K. Efremov, Jie Yan · 2022 · Biophysical Journal
- Synthetic Modular Antibody Construction by Using the SpyTag/SpyCatcher Protein‐Ligase SystemMd. Kausar Alam, Carolina Gonzalez, Wayne Hill, Ayman El‐Sayed, Humphrey Fonge, Kris Barreto, Clarence Ronald Geyer · 2017 · ChemBioChem
- Development of a novel affinity chromatography resin for platform purification of bispecific antibodies with modified protein a binding avidityAndrew D. Tustian, Linus Laurin, Henrik R. Ihre, Travis Tran, Robert Stairs, Hanne Bak · 2018 · Biotechnology Progress
- Generation of Fcabs targeting human and murine LAG-3 as building blocks for novel bispecific antibody therapeuticsKaty L. Everett, Matthew Kraman, Francisca Wollerton, Carlo Zimarino, Katarzyna Kmiecik, Miguel A. Gaspar, Sarka Pechouckova, Natalie L. Allen, Jacqueline F. Doody, Mihriban Tuna · 2018 · Methods
- Antibody and antibody derivatives as cancer therapeuticsKeith J. Arlotta, Shawn C. Owen · 2019 · Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology
- The manufacturing considerations of bispecific antibodiesDennis J. Underwood, Jeffrey Bettencourt, Zahra Jawad · 2022 · Expert Opinion on Biological Therapy
- LC–MS Challenges in Characterizing and Quantifying Monoclonal Antibodies (mAb) and Antibody-Drug Conjugates (ADC) in Biological SamplesCong Wei, Dian Su, Jian Wang, Wenying Jian, Donglu Zhang · 2018 · Current Pharmacology Reports
- Variable heavy–variable light domain and Fab-arm CrossMabs with charged residue exchanges to enforce correct light chain assemblyJörg T. Regula, Sabine Imhof-Jung, Michael Mølhøj, Joerg Benz, A. Ehler, Alexander Bujotzek, Wolfgang M. Schäfer, Christian Klein · 2018 · Protein Engineering Design and Selection
- Computational design of a specific heavy chain/κ light chain interface for expressing fully IgG bispecific antibodiesKaren Froning, Andrew Leaver‐Fay, Xiufeng Wu, S. Phan, Ling Gao, F. Huang, Anna Pustilnik, Michael Bacica, Kevin Houlihan, Qing Chai et al. · 2017 · Protein Science
- Immunotherapy Strategy for Systemic Autoimmune Diseases: Betting on CAR-T Cells and AntibodiesVitaly V. Chasov, Ekaterina Zmievskaya, Irina Ganeeva, Elvina Gilyazova, Damir Davletshin, Marat Khaliulin, Emmanuel Kabwe, Yuriy N. Davidyuk, Aygul Valiullina, Albert Anatolyevich Rizvanov et al. · 2024 · Antibodies
- Integrating Computational Design and Experimental Approaches for Next-Generation BiologicsSon, Ahrum, Park, Jongham, Kim, Woojin, Lee, Wonseok, Yoon, Yoonki, Ji, Jaeho, Kim, Hyunsoo · 2024 · Biomolecules
- CHO Cell Line Development and Engineering via Site-specific Integration: Challenges and OpportunitiesSung Wook Shin, Jae Seong Lee · 2020 · Biotechnology and Bioprocess Engineering