The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.
2-Cys peroxiredoxin function in intracellular signal transduction: therapeutic implications
Open accessAbstract
H2O2 is a reactive oxygen species that has drawn much interest because of its role as a second messenger in receptor-mediated signaling. Mammalian 2-Cys peroxiredoxins have been shown to eliminate efficiently the H2O2 generated in response to receptor stimulation. 2-Cys peroxiredoxins are members of a novel peroxidase family that catalyze the H2O2 reduction reaction in the presence of thioredoxin, thioredoxin reductase and NADPH. Several lines of evidence suggest that 2-Cys peroxiredoxins have dual roles as regulators of the H2O2 signal and as defenders of oxidative stress. In particular, 2-Cys peroxiredoxin appears to provide selective, specific and localized control of receptor-mediated signal transduction. Thus, the therapeutic potential of 2-Cys peroxiredoxins is clear for diseases, such as cancer and cardiovascular diseases, that involve reactive oxygen species.
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Cites
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Self-citationProteomics Analysis of Cellular Response to Oxidative Stress
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Metadata
- Authors
- Kang, S. W., Rhee, S. G., Chang, T.-S., Jeong, W., & Choi, M. H.
- Venue
- Trends in Molecular Medicine
- Publisher
- Elsevier BV
- Published
- 2005-12
- Volume
- 11
- Issue
- 12
- Pages
- 571-578
- ISSN
- 1471-4914 (ISSN-L)
- OpenAlex
- W2032635496
- Cited by
- 323
- References
- 10
- FWCI
- 6.68
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Kang, S. W., Rhee, S. G., Chang, T.-S., Jeong, W., & Choi, M. H. (2005). 2-Cys peroxiredoxin function in intracellular signal transduction: therapeutic implications. Trends in Molecular Medicine. https://doi.org/10.1016/j.molmed.2005.10.006
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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