Proteomics Analysis of Cellular Response to Oxidative Stress

Strategies of antioxidant defense

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Thioredoxin-dependent peroxide reductase from yeast.

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Mammalian Peroxiredoxin Isoforms Can Reduce Hydrogen Peroxide Generated in Response to Growth Factors and Tumor Necrosis Factor-α

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The H2O2 Stimulon in Saccharomyces cerevisiae

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Improvement of the solubilization of proteins in two‐dimensional electrophoresis with immobilized pH gradients

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Regulatory Role for a Novel Human Thioredoxin Peroxidase in NF-κB Activation

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Differential regulation of antioxidant enzymes in response to oxidants.

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Cloning and Expression of a Novel Mammalian Thioredoxin

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Crystal structure of a novel human peroxidase enzyme at 2.0 Å resolution

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Thioredoxin Peroxidase Is a Novel Inhibitor of Apoptosis with a Mechanism Distinct from That of Bcl-2

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Sample application by in‐gel rehydration improves the resolution of two‐dimensional electrophoresis with immobilized pH gradients in the first dimension

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Muscle wasting and dedifferentiation induced by oxidative stress in a murine model of cachexia is prevented by inhibitors of nitric oxide synthesis and antioxidants.

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Cloning, sequencing, and mutation of thiol-specific antioxidant gene of Saccharomyces cerevisiae

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Molecular Cloning and Characterization of a Mitochondrial Selenocysteine-containing Thioredoxin Reductase from Rat Liver

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Elimination of point streaking on silver stained two‐dimensional gels by addition of iodoacetamide to the equilibration buffer

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Cloning and Characterization of AOEB166, a Novel Mammalian Antioxidant Enzyme of the Peroxiredoxin Family

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The plant 2‐Cys peroxiredoxin BAS1 is a nuclear‐encoded chloroplast protein: its expressional regulation, phylogenetic origin, and implications for its specific physiological function in plants

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Proteome Research: Two-Dimensional Gel Electrophoresis and Identification Methods

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In Vivo Characterization of a Thioredoxin h Target Protein Defines a New Peroxiredoxin Family

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Antioxidant Defenses in the Lung

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Cloning and characterization of a 23-kDa stress-induced mouse peritoneal macrophage protein.

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A new silver staining apparatus and procedure for matrix-assisted laser desorption/ionization-time of flight analysis of proteins after two-dimensional electrophoresis

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Oxidation of active center cysteine of bovine 1-Cys peroxiredoxin to the cysteine sulfenic acid form by peroxide and peroxynitrite

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Tumor necrosis factor induced oxidative stress in isolated mouse hepatocytes

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Cloning of the peroxiredoxin gene family in rats and characterization of the fourth member

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Antioxidant Function of the Mitochondrial Protein SP-22 in the Cardiovascular System

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Variants of peroxiredoxins expression in response to hydroperoxide stress

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The Non-flavin Redox Center of the Streptococcal NADH Peroxidase

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Mass spectrometry allows direct identification of proteins in large genomes

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Purification and Characterization of a Substrate Protein for Mitochondrial ATP-Dependent Protease in Bovine Adrenal Cortex

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Somatomedin C/insulin-like growth factor 1 as a possible intratesticular regulator of Leydig cell activity

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Inhibition of Metal-Catalyzed Oxidation Systems by a Yeast Protector Protein in the Presence of Thioredoxin

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Search of sequence databases with uninterpreted high-energy collision-induced dissociation spectra of peptides

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Purification and Characterization of Thiol-Specific Antioxidant Protein from Human Red Blood Cell: A New Type of Antioxidant Protein

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Early events in erythroid differentiation: accumulation of the acidic peroxidoxin (PRP/TSA/NKEF-B)

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Characterization of the Murine Gene EncodingAop2(Antioxidant Protein 2) and Identification of Two Highly Related Genes

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Up-regulation of mitochondrial peripheral benzodiazepine receptor expression by tumor necrosis factor alpha in testicular Leydig cells

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ROS as signalling molecules: Mechanisms that generate specificity in ROS homeostasis

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Structure, mechanism and regulation of peroxiredoxins

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Hydrogen peroxide sensing and signaling

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Peroxiredoxins: A historical overview and speculative preview of novel mechanisms and emerging concepts in cell signaling

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Oxidant signals and oxidative stress

Finkel, T. (2003) · Current Opinion in Cell Biology · doi:10.1016/s0955-0674(03)00002-4 · Cited by 1,393 · see citing works

Peroxiredoxin Evolution and the Regulation of Hydrogen Peroxide Signaling

Wood, Z. A., Poole, L. B., & Karplus, P. A. (2003) · Science · doi:10.1126/science.1080405 · Cited by 1,369 · see citing works

Thiol chemistry and specificity in redox signaling

Winterbourn, C. C., & Hampton, M. B. (2008) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2008.05.004 · Cited by 1,226 · see citing works

ATP-dependent reduction of cysteine–sulphinic acid by S. cerevisiae sulphiredoxin

Biteau, B., Labarre, J., & Tolédano, M. B. (2003) · Nature · doi:10.1038/nature02075 · Cited by 970 · see citing works

Effects of Ionizing Radiation on Biological Molecules—Mechanisms of Damage and Emerging Methods of Detection

Reisz, J. A., Bansal, N., Qian, J. X., Zhao, W., & Furdui, C. M. (2014) · Antioxidants and Redox Signaling · doi:10.1089/ars.2013.5489 · Cited by 838 · see citing works

Regeneration of peroxiredoxins by p53-regulated sestrins, homologs of bacterial AhpD

Budanov, A. V., Sablina, A. A., Feinstein, E., Koonin, E. V., & Chumakov, P. M. (2004) · Science · doi:10.1126/science.1095569 · Cited by 731 · see citing works

Intracellular messenger function of hydrogen peroxide and its regulation by peroxiredoxins

Rhee, S. G., Kang, S. W., Jeong, W., Chang, T.-S., Yang, K., & Woo, H. A. (2005) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2005.02.004 · Cited by 709 · see citing works

Peroxiredoxin functions as a peroxidase and a regulator and sensor of local peroxides

Rhee, S. G., Woo, H. A., Kil, I. S., & Bae, S. H. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.r111.283432 · Cited by 603 · see citing works

Redox regulation of mitochondrial function

Handy, D. E., & Loscalzo, J. (2012) · Antioxidants & Redox Signaling · doi:10.1089/ars.2011.4123 · Cited by 588 · see citing works

Protein Sulfenic Acids in Redox Signaling

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Reversing the Inactivation of Peroxiredoxins Caused by Cysteine Sulfinic Acid Formation

Woo, H. A., Chae, H. Z., Hwang, S. C., Yang, K., Kang, S. W., Kim, K., & Rhee, S. G. (2003) · Science · doi:10.1126/science.1080273 · Cited by 558 · see citing works

Mitochondrial peroxiredoxin involvement in antioxidant defence and redox signalling

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Typical 2‐Cys peroxiredoxins – structures, mechanisms and functions

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Inactivation of Human Peroxiredoxin I during Catalysis as the Result of the Oxidation of the Catalytic Site Cysteine to Cysteine-sulfinic Acid

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Proteins as biomarkers of oxidative/nitrosative stress in diseases: The contribution of redox proteomics

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Use of proteomics to demonstrate a hierarchical oxidative stress response to diesel exhaust particle chemicals in a macrophage cell line

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The proteasomal system

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Characterization of Mammalian Sulfiredoxin and Its Reactivation of Hyperoxidized Peroxiredoxin through Reduction of Cysteine Sulfinic Acid in the Active Site to Cysteine

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Discovering mechanisms of signaling-mediated cysteine oxidation

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Controlled Elimination of Intracellular H ₂ O2: Regulation of Peroxiredoxin, Catalase, and Glutathione Peroxidase via Post-translational Modification

Rhee, S. G., Yang, K.-S., Kang, S. W., Woo, H. A., & Chang, T.-S. (2005) · Antioxidants & Redox Signaling · doi:10.1089/ars.2005.7.619 · Cited by 376 · see citing works

Cysteine-106 of DJ-1 is the most sensitive cysteine residue to hydrogen peroxide-mediated oxidation in vivo in human umbilical vein endothelial cells

Kinumi, T., Kimata, J., Taira, T., Ariga, H., & Niki, E. (2004) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2004.03.110 · Cited by 365 · see citing works

Cysteine-Based Redox Switches in Enzymes

Klomsiri, C., Karplus, P. A., & Poole, L. B. (2010) · Antioxidants and Redox Signaling · doi:10.1089/ars.2010.3376 · Cited by 359 · see citing works

Reactive oxygen species and antioxidant mechanisms in human tissues and their relation to malignancies

Karihtala, P., & Soini, Y. (2007) · Apmis · doi:10.1111/j.1600-0463.2007.apm_514.x · Cited by 342 · see citing works

HDAC6 is a specific deacetylase of peroxiredoxins and is involved in redox regulation

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2-Cys peroxiredoxin function in intracellular signal transduction: therapeutic implications

Kang, S. W., Rhee, S. G., Chang, T.-S., Jeong, W., & Choi, M. H. (2005) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2005.10.006 · Cited by 324 · see citing works

Multiple Functions and Regulation of Mammalian Peroxiredoxins

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Two-dimensional gel electrophoresis in proteomics: A tutorial

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Factors Affecting Protein Thiol Reactivity and Specificity in Peroxide Reduction

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Mining the Thiol Proteome for Sulfenic Acid Modifications Reveals New Targets for Oxidation in Cells

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Nanoisozymes: Crystal‐Facet‐Dependent Enzyme‐Mimetic Activity of V2O5 Nanomaterials

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Human prx1 Gene Is a Target of Nrf2 and Is Up-regulated by Hypoxia/Reoxygenation: Implication to Tumor Biology

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Chemical methods for mapping cysteine oxidation

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Redox Proteomics: Chemical Principles, Methodological Approaches and Biological/Biomedical Promises

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Bacterial defenses against oxidants: mechanistic features of cysteine-based peroxidases and their flavoprotein reductases

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Thiol Chemistry in Peroxidase Catalysis and Redox Signaling

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A cysteine-sulfinic acid in peroxiredoxin regulates H 2 O 2 -sensing by the antioxidant Pap1 pathway

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Thiol–Disulfide Balance: From the Concept of Oxidative Stress to that of Redox Regulation

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Reversible Oxidation of the Active Site Cysteine of Peroxiredoxins to Cysteine Sulfinic Acid

Woo, H. A., Kang, S. W., Kim, H. K., Yang, K., Chae, H. Z., & Rhee, S. G. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.c300428200 · Cited by 241 · see citing works

Peroxiredoxins in breast carcinoma.

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Synthesis, cellular evaluation, and mechanism of action of piperlongumine analogs

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Thioredoxins in chloroplasts

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Redox Control of Liver Function in Health and Disease

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Redox Control Systems in the Nucleus: Mechanisms and Functions

Go, Y., & Jones, D. P. (2010) · Antioxidants and Redox Signaling · doi:10.1089/ars.2009.3021 · Cited by 199 · see citing works

Peroxiredoxin 2 and Peroxide Metabolism in the Erythrocyte

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Protein Quality Control under Oxidative Stress Conditions

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SOD2-deficiency anemia: protein oxidation and altered protein expression reveal targets of damage, stress response, and antioxidant responsiveness

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Reaction Mechanism of Plant 2-Cys Peroxiredoxin

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Irreversible Oxidation of the Active-site Cysteine of Peroxiredoxin to Cysteine Sulfonic Acid for Enhanced Molecular Chaperone Activity

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A method for detection of overoxidation of cysteines: peroxiredoxins are oxidized in vivo at the active-site cysteine during oxidative stress

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Proteomic and Metabolomic Analyses of Atherosclerotic Vessels From Apolipoprotein E-Deficient Mice Reveal Alterations in Inflammation, Oxidative Stress, and Energy Metabolism

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Functional proteomics of nonalcoholic steatohepatitis: Mitochondrial proteins as targets of S -adenosylmethionine

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The proteasome and its role in the degradation of oxidized proteins

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A redox-sensitive peroxiredoxin that is important for longevity has tissue- and stress-specific roles in stress resistance

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Proteomics in brain research: potentials and limitations

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Oxidation of Cofilin Mediates T Cell Hyporesponsiveness under Oxidative Stress Conditions

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Maternal Undernutrition Significantly Impacts Ovarian Follicle Number and Increases Ovarian Oxidative Stress in Adult Rat Offspring

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Proteomic detection of hydrogen peroxide-sensitive thiol proteins in Jurkat cells

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Human Peroxiredoxin 1 and 2 Are Not Duplicate Proteins

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Molecular Mechanism of the Reduction of Cysteine Sulfinic Acid of Peroxiredoxin to Cysteine by Mammalian Sulfiredoxin

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Hydrogen peroxide as an endogenous mediator and exogenous tool in cardiovascular research: issues and considerations

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Regeneration of Peroxiredoxins during Recovery after Oxidative Stress

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Peroxiredoxin IV is an endoplasmic reticulum-localized enzyme forming oligomeric complexes in human cells

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Prx1 Suppresses Radiation-Induced c-Jun NH2-Terminal Kinase Signaling in Lung Cancer Cells through Interaction with the Glutathione S-Transferase Pi/c-Jun NH2-Terminal Kinase Complex

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Peroxiredoxins: a less studied component of hydrogen peroxide detoxification in photosynthetic organisms

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The sulfinic acid switch in proteins

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Redox Regulation of Transcription Factors in Plant Stress Acclimation and Development

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Redox Regulation of Cell Survival by the Thioredoxin Superfamily: An Implication of Redox Gene Therapy in the Heart

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Role of sulfiredoxin as a regulator of peroxiredoxin function and regulation of its expression

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Pathophysiology of sickle cell disease is mirrored by the red blood cell metabolome

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Sulfiredoxin Translocation into Mitochondria Plays a Crucial Role in Reducing Hyperoxidized Peroxiredoxin III

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Aspects of the biological redox chemistry of cysteine: from simple redox responses to sophisticated signalling pathways

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Use of conventional and -omics based methods for health claims of dietary antioxidants: a critical overview

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The Peroxiredoxin and Glutathione Peroxidase Families in Chlamydomonas reinhardtii

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Deglutathionylation of 2-Cys Peroxiredoxin Is Specifically Catalyzed by Sulfiredoxin

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Protein Glutathionylation in the Regulation of Peroxiredoxins: A Family of Thiol-Specific Peroxidases That Function As Antioxidants, Molecular Chaperones, and Signal Modulators

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Analysis of the Cytosolic Proteome in a Cell Culture Model of Familial Amyotrophic Lateral Sclerosis Reveals Alterations to the Proteasome, Antioxidant Defenses, and Nitric Oxide Synthetic Pathways

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Targets of stress-induced oxidative damage in plant mitochondria and their impact on cell carbon/nitrogen metabolism

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Proteomic analysis of antioxidant strategies of Staphylococcus aureus: Diverse responses to different oxidants

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Potato Plants Lacking the CDSP32 Plastidic Thioredoxin Exhibit Overoxidation of the BAS1 2-Cysteine Peroxiredoxin and Increased Lipid Peroxidation in Thylakoids under Photooxidative Stress

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The Catalytic Mechanism of Peroxiredoxins

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Overview of Peroxiredoxins in Oxidant Defense and Redox Regulation

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Subcellular localization of methionine sulphoxide reductase A (MsrA): evidence for mitochondrial and cytosolic isoforms in rat liver cells

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Mitochondrial peroxiredoxin 3 is more resilient to hyperoxidation than cytoplasmic peroxiredoxins

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Islets and their antioxidant defense

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Oxidative Modification of Peroxiredoxin Is Associated with Drug-induced Apoptotic Signaling in Experimental Models of Parkinson Disease

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Proteomic identification of age-dependent protein nitration in rat skeletal muscle

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Peroxiredoxin 2 specifically regulates the oxidative and metabolic stress response of human metastatic breast cancer cells in lungs

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Regulation of Peroxiredoxins by Nitric Oxide in Immunostimulated Macrophages

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Reduction of Cysteine Sulfinic Acid in Eukaryotic, Typical 2-Cys Peroxiredoxins by Sulfiredoxin

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Redox Regulation of Cell-Cycle Re-entry: Cyclin D1 as a Primary Target for the Mitogenic Effects of Reactive Oxygen and Nitrogen Species

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H2O2-dependent Hyperoxidation of Peroxiredoxin 6 (Prdx6) Plays a Role in Cellular Toxicity via Up-regulation of iPLA2 Activity

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A proteomic analysis of the aphid Macrosiphum euphorbiae under heat and radiation stress

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Proteomic study of human umbilical vein endothelial cells in culture

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Biocompatibility, hemocompatibility and antimicrobial properties of xyloglucan-based hydrogel film for wound healing application

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Power and limitations of electrophoretic separations in proteomics strategies

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Proteomic analysis of redox‐ and ErbB2‐dependent changes in mammary luminal epithelial cells using cysteine‐ and lysine‐labelling two‐dimensional difference gel electrophoresis

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A method for detection of overoxidation of cysteines: peroxiredoxins are oxidized in vivo at the active-site cysteine during oxidative stress

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Redox Sensitivities of Global Cellular Cysteine Residues under Reductive and Oxidative Stress

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Redox proteomics reveal a role for peroxiredoxinylation in stress protection

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Inactivation of a Peroxiredoxin by Hydrogen Peroxide Is Critical for Thioredoxin-Mediated Repair of Oxidized Proteins and Cell Survival

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Effect of peroxiredoxin 1 or peroxiredoxin 2 knockout on the thiol proteome of Jurkat cells

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